MX2018011345A - Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos. - Google Patents
Métodos y composiciones para transducir linfocitos y expansión regulada de los mismos.Info
- Publication number
- MX2018011345A MX2018011345A MX2018011345A MX2018011345A MX2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A MX 2018011345 A MX2018011345 A MX 2018011345A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- lymphocytes
- car
- cells
- translate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 210000004698 lymphocyte Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 3
- 108020004422 Riboswitch Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001589 lymphoproliferative effect Effects 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000002463 transducing effect Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
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Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2279253T3 (en) | 2008-04-09 | 2017-02-13 | Maxcyte Inc | Construction and application of therapeutic compositions of freshly isolated cells |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| WO2019055946A1 (en) * | 2017-09-18 | 2019-03-21 | F1 Oncology, Inc. | METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY THEREOF |
| WO2020047527A2 (en) | 2018-09-02 | 2020-03-05 | F1 Bioventures, Llc | Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs |
| WO2021042072A1 (en) * | 2019-09-01 | 2021-03-04 | Exuma Biotech Corp. | Methods and compositions for the modification and delivery of lymphocytes |
| WO2021178701A1 (en) * | 2020-03-05 | 2021-09-10 | Exuma Biotech Corp. | Methods and compositions for the delivery of modified lymphocyte aggregates |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CA3020923A1 (en) | 2016-04-15 | 2017-10-19 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
| WO2017180842A1 (en) | 2016-04-15 | 2017-10-19 | Bioatla, Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
| EP3235908A1 (en) * | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| GB201614093D0 (en) * | 2016-08-17 | 2016-09-28 | Autolus Ltd | Vector |
| CN116970630A (zh) | 2016-08-26 | 2023-10-31 | 贝勒医学院 | 用于细胞治疗的组成型活性细胞因子受体 |
| US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| US11261428B2 (en) | 2018-03-15 | 2022-03-01 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| CN110249046A (zh) * | 2016-12-05 | 2019-09-17 | 朱诺治疗学股份有限公司 | 用于过继细胞疗法的工程化细胞的产生 |
| US20190367876A1 (en) * | 2017-01-18 | 2019-12-05 | F1 Oncology, Inc. | Methods of transducing and expanding immune cells and uses thereof |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| WO2018161026A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
| EP3589733A1 (en) * | 2017-03-03 | 2020-01-08 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| JP2020530454A (ja) | 2017-08-07 | 2020-10-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 安全な細胞治療薬を生成するためのプラットフォーム |
| US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
| EP3723787A4 (en) * | 2017-12-14 | 2021-09-01 | Bluebird Bio, Inc. | DARIC INTERLEUKIN RECEPTORS |
| WO2019136288A1 (en) * | 2018-01-05 | 2019-07-11 | Maxcyte, Inc. | Chronic car treatment for cancer |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| SG11202007606QA (en) * | 2018-02-17 | 2020-09-29 | Flagship Pioneering Innovations V Inc | Compositions and methods for membrane protein delivery |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| BR112020020887A2 (pt) * | 2018-04-12 | 2021-04-06 | Umoja Biopharma, Inc | Vetores virais e linhagens celulares de empacotamento |
| JP7447014B2 (ja) | 2018-04-13 | 2024-03-11 | サンガモ セラピューティクス フランス | インターロイキン23受容体に特異的なキメラ抗原受容体 |
| CN110499291B (zh) * | 2018-05-16 | 2023-11-24 | 上海赛比曼生物科技有限公司 | 无血清培养制备嵌合抗原受体t细胞的方法 |
| CN112867498A (zh) * | 2018-05-31 | 2021-05-28 | 华盛顿大学 | 使用嵌合抗原受体基因组编辑和转导t细胞以用于治疗t和b细胞恶性肿瘤的方法 |
| AU2019284911A1 (en) | 2018-06-13 | 2020-12-17 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| CA3105953A1 (en) | 2018-07-09 | 2020-01-16 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| ES3042082T3 (en) * | 2018-08-31 | 2025-11-18 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| CA3111084A1 (en) * | 2018-09-02 | 2020-03-05 | Exuma Biotech, Corp | Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs |
| JP7257508B2 (ja) | 2018-10-08 | 2023-04-13 | アンバーストーン・バイオサイエンシーズ・インコーポレイテッド | 二重特異性および多重特異性生物学的物質の区画化されたアッセイ |
| WO2020092696A1 (en) * | 2018-10-31 | 2020-05-07 | Musc Foundation For Research Development | Ex vivo activation and expansion of t cells for adoptive cell transfer therapy |
| KR20210131991A (ko) * | 2018-11-14 | 2021-11-03 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 구획-특이적 카고 전달을 위한 조성물 및 방법 |
| US20230043255A1 (en) * | 2018-11-14 | 2023-02-09 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
| AU2019385873A1 (en) * | 2018-11-26 | 2021-06-03 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
| US20220136004A1 (en) * | 2019-01-11 | 2022-05-05 | Chan Zuckerberg Biohub, Inc. | Targeted In Vivo Genome Modification |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| US12440513B2 (en) | 2019-03-22 | 2025-10-14 | Albany Medical College | Methods for improving cognitive function |
| AU2020264760A1 (en) * | 2019-05-02 | 2021-11-11 | Celyad | Cells with multiplexed inhibitory RNA |
| CN114206928B (zh) * | 2019-05-08 | 2025-08-08 | 印希彼生物科学公司 | Cd33靶向免疫疗法 |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| CN114981441A (zh) * | 2019-10-16 | 2022-08-30 | 优莫佳生物制药股份有限公司 | 用于通用受体疗法的逆转录病毒载体 |
| CN112779223B (zh) * | 2019-11-08 | 2024-06-11 | 浙江煦顼技术有限公司 | 偶联嵌合抗原受体细胞及其用途 |
| CN114945382A (zh) | 2019-11-26 | 2022-08-26 | 诺华股份有限公司 | Cd19和cd22嵌合抗原受体及其用途 |
| CA3159944A1 (en) * | 2019-12-02 | 2021-06-10 | David HUSS | Therapeutic editing |
| KR20220137882A (ko) * | 2019-12-05 | 2022-10-12 | 바이셀릭스, 인크. | 보편적 세포 요법을 위한 면역 회피 기작의 조절제 |
| KR20220139319A (ko) * | 2020-01-08 | 2022-10-14 | 옵시디안 테라퓨틱스, 인크. | 조정 가능한 전사의 조절을 위한 조성물 및 방법 |
| IL295129A (en) | 2020-01-30 | 2022-09-01 | Umoja Biopharma Inc | Bispecific transduction enhancer |
| KR20230010231A (ko) * | 2020-05-11 | 2023-01-18 | 아빈투스 바이오, 인코포레이티드 | 생체내 형질도입을 위한 벡터 및 방법 |
| CN111848797B (zh) * | 2020-07-20 | 2021-02-09 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| CN115380112B (zh) * | 2020-11-02 | 2024-03-29 | 上海医药集团生物治疗技术有限公司 | 两个或多个靶点嵌合抗原受体基因工程载体及其应用 |
| CA3206009A1 (en) | 2021-01-27 | 2022-08-04 | Umoja Biopharma, Inc. | Lentivirus for generating cells expressing anti-cd19 chimeric antigen receptor |
| TW202246517A (zh) | 2021-01-28 | 2022-12-01 | 美商異基因治療有限公司 | 用於轉導免疫細胞之方法 |
| WO2022187289A1 (en) | 2021-03-01 | 2022-09-09 | Exuma Biotech Corp. | Methods and compositions for the delivery of retroviral particles |
| WO2022216906A1 (en) * | 2021-04-08 | 2022-10-13 | The Scripps Research Institute | Novel therapies with engineered effector cells |
| US11535869B2 (en) | 2021-04-08 | 2022-12-27 | Sana Biotechnology, Inc. | CD8-specific antibody constructs and compositions thereof |
| WO2022254337A1 (en) | 2021-06-01 | 2022-12-08 | Novartis Ag | Cd19 and cd22 chimeric antigen receptors and uses thereof |
| EP4377453A4 (en) * | 2021-07-26 | 2025-09-03 | Georgia Tech Res Inst | COMPOSITIONS AND METHODS FOR IN VIVO PROTEASE PROFILING BY DISPLAYING IMMUNE CELLS |
| EP4435101A4 (en) * | 2021-11-17 | 2025-11-12 | Shanghai Juncell Therapeutics Co Ltd | MEMBRANE SURFACE PROTEIN CONTAINING A GPI ANCHOR REGION |
| AR128077A1 (es) * | 2021-12-22 | 2024-03-20 | Kure Ai Inc | Método para una rápida producción de células t modificadas genéticamente |
| EP4469586A1 (en) | 2022-03-01 | 2024-12-04 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
| CA3266371A1 (en) * | 2022-09-02 | 2024-03-07 | Myeloid Therapeutics Inc | Compositions for cell-specific expression and their uses |
| GB2639327A (en) * | 2022-09-22 | 2025-09-24 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of use thereof |
| CN115807020A (zh) * | 2022-09-23 | 2023-03-17 | 卡瑞济(北京)生命科技有限公司 | 白介素15受体α装甲CAR-T细胞在降低白介素15诱导的细胞毒性中的用途 |
| CN116731974B (zh) * | 2023-05-23 | 2024-11-29 | 杭州荣谷生物科技有限公司 | 病毒的制备方法和应用 |
| WO2024259051A1 (en) * | 2023-06-14 | 2024-12-19 | The Children's Medical Center Corporation | Systems and methods for modifying a polynucleotide |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| CA2592997A1 (en) | 1992-12-03 | 1994-06-09 | Genzyme Corporation | Pseudo-adenovirus vectors |
| JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
| JP3875990B2 (ja) | 1993-10-25 | 2007-01-31 | カンジ,インコーポレイテッド | 組換えアデノウイルスベクターおよび使用方法 |
| FR2713657B1 (fr) * | 1993-12-13 | 1996-03-01 | Transgene Sa | Nouveaux vecteurs pour le traitement du sida. |
| KR100445103B1 (ko) | 1994-12-09 | 2004-12-04 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의동정 |
| AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| JP2008504821A (ja) * | 2004-07-01 | 2008-02-21 | バイレクシス コーポレイション | ベクター・パッケージング細胞系列 |
| WO2006055351A2 (en) * | 2004-11-08 | 2006-05-26 | Yale University | Structure-based compound design involving riboswitches |
| WO2008156987A2 (en) * | 2007-05-29 | 2008-12-24 | Yale University | Riboswitches and methods and compositions for use of and with riboswitches |
| ES2661310T3 (es) | 2009-03-09 | 2018-03-28 | Bioatla, Llc | Proteínas mirac |
| ES2911246T3 (es) | 2009-11-03 | 2022-05-18 | Hope City | Receptor del factor de crecimiento epidérmico truncado (EGFRT) para selección de células T transducidas |
| NZ723731A (en) * | 2011-04-08 | 2020-05-29 | Baylor College Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| GB201107768D0 (en) * | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
| EP2794662A1 (en) | 2011-12-22 | 2014-10-29 | F.Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| EP3868888A1 (en) * | 2012-02-29 | 2021-08-25 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Retroviral transduction using poloxamers |
| JP6420776B2 (ja) | 2013-03-05 | 2018-11-07 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 免疫療法のためのエンゲージャー細胞 |
| WO2014186169A1 (en) * | 2013-05-14 | 2014-11-20 | 3M Innovative Properties Company | Adhesive composition |
| KR102238226B1 (ko) * | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (car) t-세포의 인간 적용 |
| JP6588024B2 (ja) | 2013-10-28 | 2019-10-09 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 腫瘍溶解性hsvベクター |
| BR112017001821A2 (pt) | 2014-07-29 | 2017-11-21 | Cellectis | receptores de antígenos quiméricos específicos de ror1 (ntrkr1) para imunoterapia de câncer |
| EP3186284B1 (en) * | 2014-08-28 | 2022-04-06 | BioAtla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| GB201503500D0 (en) * | 2015-03-02 | 2015-04-15 | Ucl Business Plc | Cell |
| MA42895A (fr) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| CN109563507B (zh) * | 2016-07-08 | 2024-03-05 | 埃克苏马生物技术公司 | 用于转导淋巴细胞及调节其活性的方法及组合物 |
| EP3589733A1 (en) * | 2017-03-03 | 2020-01-08 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
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2017
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| SG10202104509PA (en) | 2021-06-29 |
| WO2017165245A3 (en) | 2017-11-02 |
| JP2022093363A (ja) | 2022-06-23 |
| CA3017378A1 (en) | 2017-09-28 |
| JP2019509063A (ja) | 2019-04-04 |
| CU24649B1 (es) | 2023-02-13 |
| RU2018136607A (ru) | 2020-04-20 |
| JP2024086884A (ja) | 2024-06-28 |
| AU2017236796A1 (en) | 2018-09-13 |
| AU2017236796B2 (en) | 2021-07-15 |
| JP7474281B2 (ja) | 2024-04-24 |
| US10596274B2 (en) | 2020-03-24 |
| BR112018069075A2 (pt) | 2019-01-29 |
| EP3430136A2 (en) | 2019-01-23 |
| KR102457098B9 (ko) | 2025-02-14 |
| JP7108551B2 (ja) | 2022-07-28 |
| IL261713B2 (en) | 2023-09-01 |
| CU20180109A7 (es) | 2019-05-03 |
| US20170296678A1 (en) | 2017-10-19 |
| RU2018136607A3 (enExample) | 2020-12-14 |
| AU2021250935A1 (en) | 2021-11-11 |
| KR102457098B1 (ko) | 2022-10-21 |
| CN108884460A (zh) | 2018-11-23 |
| IL261713B1 (en) | 2023-05-01 |
| WO2017165245A2 (en) | 2017-09-28 |
| CN108884460B (zh) | 2023-04-28 |
| IL261713A (en) | 2018-10-31 |
| CN116426490A (zh) | 2023-07-14 |
| KR20180127638A (ko) | 2018-11-29 |
| MX2025000222A (es) | 2025-02-10 |
| RU2755059C2 (ru) | 2021-09-13 |
| SG11201807286WA (en) | 2018-10-30 |
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