MX2018005096A - Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular. - Google Patents

Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.

Info

Publication number
MX2018005096A
MX2018005096A MX2018005096A MX2018005096A MX2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A
Authority
MX
Mexico
Prior art keywords
gemcabene
combinations
treatment
cardiovascular disease
cardiovascular
Prior art date
Application number
MX2018005096A
Other languages
English (en)
Spanish (es)
Inventor
Carmen Oniciu Daniela
L Bisgaier Charles
Original Assignee
Gemphire Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemphire Therapeutics Inc filed Critical Gemphire Therapeutics Inc
Publication of MX2018005096A publication Critical patent/MX2018005096A/es

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
MX2018005096A 2015-11-06 2016-11-07 Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular. MX2018005096A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252195P 2015-11-06 2015-11-06
US201562252147P 2015-11-06 2015-11-06
PCT/US2016/060849 WO2017079755A1 (en) 2015-11-06 2016-11-07 Gemcabene combinations for the treatment of cardiovascular disease

Publications (1)

Publication Number Publication Date
MX2018005096A true MX2018005096A (es) 2018-08-15

Family

ID=58663111

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005540A MX2018005540A (es) 2015-11-06 2016-11-07 Tratamiento de dislipemia mixta.
MX2018005096A MX2018005096A (es) 2015-11-06 2016-11-07 Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018005540A MX2018005540A (es) 2015-11-06 2016-11-07 Tratamiento de dislipemia mixta.

Country Status (16)

Country Link
US (4) US9849104B2 (enExample)
EP (2) EP3370703A4 (enExample)
JP (2) JP2018532808A (enExample)
KR (2) KR20180073597A (enExample)
CN (2) CN108366957A (enExample)
AU (2) AU2016349634A1 (enExample)
BR (2) BR112018007857A2 (enExample)
CA (2) CA3000016A1 (enExample)
HK (2) HK1259458A1 (enExample)
IL (2) IL258819A (enExample)
MA (1) MA43190A (enExample)
MX (2) MX2018005540A (enExample)
PH (1) PH12018500972A1 (enExample)
RU (2) RU2018120599A (enExample)
SG (2) SG11201803442UA (enExample)
WO (2) WO2017079755A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
WO2016077832A2 (en) 2014-11-14 2016-05-19 Gemphire Therapeutics Inc. PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
KR20180073597A (ko) * 2015-11-06 2018-07-02 젬파이어 세러퓨틱스 인코포레이티드 혼합 이상지질혈증의 치료
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
US10588880B2 (en) 2016-09-28 2020-03-17 Eiger Biopharmaceuticals, Inc. Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
CA3059073A1 (en) * 2017-04-18 2018-10-25 Daniela Carmen Oniciu Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
US20180338922A1 (en) * 2017-05-26 2018-11-29 Esperion Therapeutics, Inc. Fixed dose formulations
JP6937195B2 (ja) * 2017-09-01 2021-09-22 興和株式会社 医薬組成物
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
BR112020008514A2 (pt) 2017-10-31 2020-10-20 Staten Biotechnology B.V. anticorpos anti-apoc3 e métodos de uso dos mesmos
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
EP3716975A4 (en) * 2017-11-28 2022-01-12 Eiger Biopharmaceuticals, Inc. METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
WO2020056158A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
BR112021005086A2 (pt) 2018-09-18 2021-06-08 1Globe Biomedical Co., Ltd. tratamento para doença hepática gordurosa não alcoólica
US20210330684A1 (en) * 2018-10-12 2021-10-28 Icahn School Of Medicine At Mount Sinai Azd3355 (lesogaberan) for treatment and prevention of nonalcoholic steatohepatitis (nash), liver fibrosis, and other liver conditions
CN113396138A (zh) * 2018-10-18 2021-09-14 燿石治疗公司 吉卡宾、其药学上可接受的盐、其组合物和其使用方法
CN112851660B (zh) * 2019-11-12 2022-03-18 广东药科大学 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途
CN114957119B (zh) * 2022-05-05 2023-06-16 武汉大学中南医院 一种四氢喹啉螺1,3-茚二酮类衍生物及其制备方法与应用
WO2025186785A1 (en) * 2024-03-08 2025-09-12 TECNIMEDE - Sociedade Técnico-medicinal, SA Oral pharmaceutical composition of pitavastatin, method and uses thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT381664B (de) 1984-02-07 1986-11-10 Steyr Daimler Puch Ag Einrichtung zur ueberwachung elektrischer, von einer gesteuerten wechselstromquelle gespeister widerstandsschweissvorgaenge, insbesondere punktschweissungen
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
CA2039763A1 (en) 1990-04-30 1991-10-31 Henry Y. Pan Combination of pravastatin and a fibric acid derivative, and method for treating dyslipidemia using such combination
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
NZ286920A (en) 1995-07-03 1997-06-24 Sankyo Co Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma
WO1997016187A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine antagonists
WO1997016181A1 (en) 1995-11-03 1997-05-09 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
ATE359785T1 (de) * 1997-07-31 2007-05-15 Kos Life Sciences Inc Manteltablette enthaltend nikotinsäure oder einen stoff, der zu nikotinsäure metabolisiert wird, in verzögert freigesetzter form, und einen hmg-coa reduktasehemmer im mantel zur sofortigen freisetzung
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
US20040002537A1 (en) * 2002-03-29 2004-01-01 Zamvil Scott S. Use of statins in the treatment of autoimmune disease
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
BR0315629A (pt) * 2002-11-15 2005-08-23 Warner Lambert Co Método para baixar a cpr e reduzir a inflamação sistêmica
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
CA2588216A1 (en) * 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
US20060211763A1 (en) * 2005-03-08 2006-09-21 Abdel Fawzy Treatment with Statin and Omega-3 Fatty Acids and a Combination Product Thereof
US20090186834A1 (en) * 2005-03-24 2009-07-23 Microbia, Inc. Diphenylheterocycle cholesterol absorption inhibitors
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
WO2007075702A2 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
WO2007112581A1 (en) * 2006-04-03 2007-10-11 Isa Odidi Controlled release delivery device comprising an organosol coat
CA2659747C (en) 2006-08-03 2015-09-08 Trustees Of Tufts College Non-flushing niacin analogues, and methods of use thereof
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
FI20080353A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi erittäin korkean lääkepitoisuuden tabletin valmistamiseksi
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2008124505A2 (en) * 2007-04-05 2008-10-16 Ironwood Pharmaceuticals,Inc. Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders
US8969514B2 (en) * 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US9307371B2 (en) 2008-01-18 2016-04-05 Verizon Patent And Licensing Inc. Method and system for SMS/MMS messaging to a connected device
RU2010151944A (ru) * 2008-05-20 2012-06-27 Серенис Терапьютикс С.А. (Fr) Ниацин и нспвс для комбинированной терапии
JPWO2009151116A1 (ja) * 2008-06-13 2011-11-17 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
EP2488180A4 (en) 2009-10-12 2013-03-27 Ipca Lab Ltd PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT / PROPHYLAXIS OF NON ALCOHOLIC HEPATIC STEATOSIS
CN106146591B (zh) * 2010-01-08 2020-07-31 Ionis制药公司 血管生成素样3表达的调节
JP5925770B2 (ja) * 2010-06-24 2016-05-25 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法
TR201005325A2 (tr) * 2010-06-30 2012-01-23 Bi̇lgi̇ç Mahmut Atorvastatin ve aspirin içeren farmasötik formülasyonlar
EP2658536B1 (en) * 2010-12-27 2016-10-19 Gemphire Therapeutics Inc. Gemcabene and derivatives for treating pancreatitis
EP2604256B1 (en) * 2011-12-14 2016-04-13 Hexal AG Multi layer coatings
CN102525942A (zh) * 2012-01-05 2012-07-04 金陵药业股份有限公司 一种阿托伐他汀钙肠溶微丸及其制备方法
AU2013207423B2 (en) * 2012-01-06 2017-10-12 Gemphire Therapeutics Inc. Methods of reducing risk of cardiovascular disease
WO2015143276A1 (en) * 2014-03-20 2015-09-24 Esperion Therapeutics, Inc. Carboxy-cyclopropyl undecanol compounds for treatment of liver disease and other medical disorders
CN104127391B (zh) * 2014-08-05 2016-08-24 李宝齐 一种含有阿托伐他汀钙的固体药物组合物
KR20180073597A (ko) * 2015-11-06 2018-07-02 젬파이어 세러퓨틱스 인코포레이티드 혼합 이상지질혈증의 치료
CN105434391A (zh) * 2016-01-18 2016-03-30 上海蓝心医药科技有限公司 阿托伐他汀钙肠溶片及其制备方法和应用

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