EA201992094A1 - Композиция для применения в лечении гиперхолестеринемии и в профилактике сердечно-сосудистых заболеваний - Google Patents

Композиция для применения в лечении гиперхолестеринемии и в профилактике сердечно-сосудистых заболеваний

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Publication number
EA201992094A1
EA201992094A1 EA201992094A EA201992094A EA201992094A1 EA 201992094 A1 EA201992094 A1 EA 201992094A1 EA 201992094 A EA201992094 A EA 201992094A EA 201992094 A EA201992094 A EA 201992094A EA 201992094 A1 EA201992094 A1 EA 201992094A1
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EA
Eurasian Patent Office
Prior art keywords
composition
treatment
hypercholesteremia
prevention
application
Prior art date
Application number
EA201992094A
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English (en)
Inventor
Умберто Ди Майо
Original Assignee
Нейлос С.Р.Л.
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Application filed by Нейлос С.Р.Л. filed Critical Нейлос С.Р.Л.
Publication of EA201992094A1 publication Critical patent/EA201992094A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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    • A61K36/13—Coniferophyta (gymnosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/2004—Excipients; Inactive ingredients
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    • A61K9/2022—Organic macromolecular compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
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  • Inorganic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Vascular Medicine (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Настоящее изобретение относится к синергической композиции из встречающихся в природе веществ, которая является особенно эффективной в лечении гиперхолестеринемии. Композиция по настоящему изобретению содержит по меньшей мере одно вещество, характеризующееся ингибирующей активностью в отношении 3-гидрокси-3-метилглутарилкоэнзим A редуктазы, вещества, характеризующегося активностью в отношении повышения экспрессии цитохрома CYP7A1, вещества, характеризующегося ингибирующей активностью в отношении изоформ фермента AcylCoA:холестеринацилтрансферазы ACAT1 и ACAT2, процианидинов и необязательно коэнзима Qи фитостеролов.
EA201992094A 2017-03-08 2018-03-08 Композиция для применения в лечении гиперхолестеринемии и в профилактике сердечно-сосудистых заболеваний EA201992094A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102017000025666A IT201700025666A1 (it) 2017-03-08 2017-03-08 Composizione per l’uso nel trattamento dell’ipercolesterolemia e nella prevenzione di patologie cardiovascolari.
PCT/IB2018/051510 WO2018163095A1 (en) 2017-03-08 2018-03-08 Compositions for the treatment of cardiovascular disease

Publications (1)

Publication Number Publication Date
EA201992094A1 true EA201992094A1 (ru) 2020-02-03

Family

ID=59521408

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992094A EA201992094A1 (ru) 2017-03-08 2018-03-08 Композиция для применения в лечении гиперхолестеринемии и в профилактике сердечно-сосудистых заболеваний

Country Status (5)

Country Link
EP (1) EP3592340A1 (ru)
CN (1) CN110520115A (ru)
EA (1) EA201992094A1 (ru)
IT (1) IT201700025666A1 (ru)
WO (1) WO2018163095A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900019972A1 (it) * 2019-10-29 2021-04-29 Neilos S R L Composizioni per la riduzione del rischio cardiovascolare
WO2021123280A1 (en) * 2019-12-18 2021-06-24 Pantea Gmbh Dietary supplement for lipedema patients
CN114010773A (zh) * 2021-10-26 2022-02-08 江苏协合转化医学研究院有限公司 一种降血压且无副作用的组合物配方及其制备工艺和用途
CN114164249B (zh) * 2021-12-01 2022-11-15 南京医科大学 一种筛选抑制肠道脂肪酸摄取及防治脂肪肝的药物靶点及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001022962A1 (en) * 1999-09-30 2001-04-05 Merck & Co., Inc. Anti-hypercholesterolemic drug combination
WO2008049196A1 (en) * 2006-10-27 2008-05-02 Iomedix Development International Srl Composition for improving blood cholesterol levels
EP2812005B8 (en) * 2012-05-16 2018-10-31 Prairie Berry Europe GmbH Polyhydroxylated pentacyclic triterpene acids as hmg-coa reductase inhibitors
US20140314729A1 (en) * 2013-04-12 2014-10-23 Creative Medical Health Inc. Nutraceutical formulation for treatment of elevated cholesterol and cardiovascular disease
WO2017024033A1 (en) * 2015-08-03 2017-02-09 Atmovita, Llc Compositions and kits for vapor phase delivery of active compounds, methods of making and using same

Also Published As

Publication number Publication date
CN110520115A (zh) 2019-11-29
IT201700025666A1 (it) 2018-09-08
EP3592340A1 (en) 2020-01-15
WO2018163095A1 (en) 2018-09-13

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