MX2016003636A - Animales no humanos que tienen un gen de proteina reguladora de señal humanizado. - Google Patents

Animales no humanos que tienen un gen de proteina reguladora de señal humanizado.

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Publication number
MX2016003636A
MX2016003636A MX2016003636A MX2016003636A MX2016003636A MX 2016003636 A MX2016003636 A MX 2016003636A MX 2016003636 A MX2016003636 A MX 2016003636A MX 2016003636 A MX2016003636 A MX 2016003636A MX 2016003636 A MX2016003636 A MX 2016003636A
Authority
MX
Mexico
Prior art keywords
human animals
regulatory protein
protein gene
humanized
sirpî
Prior art date
Application number
MX2016003636A
Other languages
English (en)
Other versions
MX368931B (es
Inventor
Andrew J Murphy
Cagan Gurer
O Gavin Thurston
Bindu Varghese
Original Assignee
Regeneron Pharma
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Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016003636A publication Critical patent/MX2016003636A/es
Publication of MX368931B publication Critical patent/MX368931B/es

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Abstract

Se proveen animales no humanos genéticamente modificados y métodos y composiciones para producir y usar los mismos, en donde la modificación genética comprende la humanización de un gen endógeno de la proteína reguladora de señal, en particular la humanización de un gen SIRPa. Se describen ratones modificados genéticamente que incluyen ratones que expresan una proteína SIRPa humana o humanizada a partir de un locus de SIRPa endógeno.
MX2016003636A 2013-09-23 2014-09-23 Animales no humanos que tienen un gen de proteina reguladora de señal humanizado. MX368931B (es)

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PCT/US2014/056910 WO2015042557A1 (en) 2013-09-23 2014-09-23 Non-human animals having a humanized signal-regulatory protein gene

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US20180139941A1 (en) 2018-05-24
WO2015042557A1 (en) 2015-03-26
KR102407354B1 (ko) 2022-06-10
EP2922394A1 (en) 2015-09-30
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US20160050896A1 (en) 2016-02-25
US9462794B2 (en) 2016-10-11
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EP3175706B1 (en) 2018-11-07
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