MX2016000345A - Vector aav y ensayo para anticuerpos neutralizantes anti-aav (virus adenoasociado). - Google Patents
Vector aav y ensayo para anticuerpos neutralizantes anti-aav (virus adenoasociado).Info
- Publication number
- MX2016000345A MX2016000345A MX2016000345A MX2016000345A MX2016000345A MX 2016000345 A MX2016000345 A MX 2016000345A MX 2016000345 A MX2016000345 A MX 2016000345A MX 2016000345 A MX2016000345 A MX 2016000345A MX 2016000345 A MX2016000345 A MX 2016000345A
- Authority
- MX
- Mexico
- Prior art keywords
- virus
- aav
- adeno
- assay
- associated virus
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/075—Adenoviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Abstract
Se proporcionan vectores virales, partículas virales y métodos y usos para seleccionar, detectar, analizar y determinar cantidades de anticuerpo antiviral, o actividad de anticuerpos neutralizantes de diversas muestras. Tales vectores virales, partículas virales, y métodos y usos, son aplicables a una amplia variedad de tipos virales, tales como serotipos de lentivirus, adenovirus y virus adenoasociados (AAV). Los métodos y usos incluyen la selección de anticuerpos antivirales, tales como inmunoglobulinas antivirales seleccionadas, detectadas, analizadas y con cantidades determinadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361845841P | 2013-07-12 | 2013-07-12 | |
PCT/US2014/046428 WO2015006743A1 (en) | 2013-07-12 | 2014-07-11 | Aav vector and assay for anti-aav (adeno-associated virus) neutralizing antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016000345A true MX2016000345A (es) | 2016-06-21 |
Family
ID=52280652
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000345A MX2016000345A (es) | 2013-07-12 | 2014-07-11 | Vector aav y ensayo para anticuerpos neutralizantes anti-aav (virus adenoasociado). |
MX2021000675A MX2021000675A (es) | 2013-07-12 | 2016-01-11 | Vector aav y ensayo para anticuerpos neutralizantes anti-aav (virus adenoasociado). |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000675A MX2021000675A (es) | 2013-07-12 | 2016-01-11 | Vector aav y ensayo para anticuerpos neutralizantes anti-aav (virus adenoasociado). |
Country Status (12)
Country | Link |
---|---|
US (2) | US11408899B2 (es) |
EP (2) | EP4039813A1 (es) |
JP (4) | JP2016525347A (es) |
KR (1) | KR102445330B1 (es) |
CN (2) | CN116004721A (es) |
AU (1) | AU2014287005C1 (es) |
CA (1) | CA2918038C (es) |
HK (1) | HK1222673A1 (es) |
IL (1) | IL243438B (es) |
MX (2) | MX2016000345A (es) |
RU (1) | RU2705249C2 (es) |
WO (1) | WO2015006743A1 (es) |
Families Citing this family (26)
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WO2016164920A1 (en) * | 2015-04-09 | 2016-10-13 | Cornell University | Gene therapy to prevent reactions to allergens |
CA2990193A1 (en) | 2015-06-23 | 2016-12-29 | The Children's Hospital Of Philadelphia | Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues |
MX2018005084A (es) | 2015-11-05 | 2019-05-16 | Bamboo Therapeutics Inc | Genes de ataxia de friedreich modificados y vectores para terapia genica. |
US10983110B2 (en) | 2015-12-02 | 2021-04-20 | Voyager Therapeutics, Inc. | Assays for the detection of AAV neutralizing antibodies |
EP3645021A4 (en) | 2017-06-30 | 2021-04-21 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
CN107828821A (zh) * | 2017-11-15 | 2018-03-23 | 四川大学 | 一种腺相关病毒感染敏感的细胞系的构建方法及腺相关病毒中和抗体含量测定的检测方法 |
JP7140353B2 (ja) * | 2017-12-29 | 2022-09-22 | ヘリックスミス カンパニー, リミテッド | ハイブリッドhgf遺伝子が導入されたaav(アデノ-関連ウイルス)ベクター |
US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
EP3755795A4 (en) | 2018-02-19 | 2022-07-20 | Homology Medicines, Inc. | ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RECOVERING F8 GENE FUNCTION AND METHODS OF USE THEREOF |
AU2019249890A1 (en) * | 2018-04-05 | 2020-09-24 | Association Institut De Myologie | Hybrid recombinant adeno-associated virus serotype between AAV9 and AAVrh74 with reduced liver tropism |
CN110846392A (zh) * | 2018-08-20 | 2020-02-28 | 武汉纽福斯生物科技有限公司 | 一种重组腺相关病毒或含其的试剂盒及其应用 |
WO2020102753A1 (en) * | 2018-11-16 | 2020-05-22 | Spark Therapeutics, Inc. | In vitro assay for detecting enhancers and inhibitors of adeno associated virus (aav) vector transduction and/or detecting or quantitating anti-aav binding antibodies |
US20220120759A1 (en) * | 2019-01-31 | 2022-04-21 | Rajiv Mahadevan | Methods for detection and characterization of anti-viral vector antibodies |
TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
AU2021213956A1 (en) | 2020-01-28 | 2022-08-25 | Freeline Therapeutics Limited | Improved assay for determining neutralising antibody titre to a viral vector |
BR112023004176A2 (pt) * | 2020-09-10 | 2023-04-11 | Genethon | Capsídeo de aav modificado por peptídeo |
CN112143712B (zh) * | 2020-09-30 | 2022-11-01 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒及其制备方法和在抗体检测的应用 |
WO2023114816A1 (en) | 2021-12-14 | 2023-06-22 | Neurogene, Inc. | Recombinant optimized galc constructs and methods for treating galc-associated disorders |
CN114277090A (zh) * | 2021-12-17 | 2022-04-05 | 宁波熙宁检测技术有限公司 | Aav8中和抗体检测方法和检测试剂盒 |
GB202201242D0 (en) | 2022-01-31 | 2022-03-16 | Univ Edinburgh | Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders |
WO2023207918A1 (en) * | 2022-04-25 | 2023-11-02 | Beijing Hanmoluojie Technology Co., Ltd. | Aav capsid 3d molecular surface feature mapping |
GB202206336D0 (en) | 2022-04-29 | 2022-06-15 | Univ Edinburgh | Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders |
WO2023220386A1 (en) * | 2022-05-13 | 2023-11-16 | The Children's Hospital Of Philadelphia | Adeno-associated viral vectors for targeting brain microvasculature |
CN117802161A (zh) * | 2022-06-30 | 2024-04-02 | 苏州吉恒基因科技有限公司 | 精准重组腺相关病毒载体及其用途 |
CN117285620B (zh) * | 2023-11-27 | 2024-02-13 | 恺佧生物科技(上海)有限公司 | 抗aav9抗体及aav9滴度测定elisa试剂盒 |
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IL128780A0 (en) | 1996-09-06 | 2000-01-31 | Univ Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing T7 polymerase |
WO1998041240A1 (en) * | 1997-03-14 | 1998-09-24 | The Children's Hospital Of Philadelphia | Methods and compositions for use in gene therapy for treatment of hemophilia |
JP4025400B2 (ja) * | 1997-04-16 | 2007-12-19 | 財団法人化学及血清療法研究所 | 新規免疫制御分子及びその製造方法 |
WO1999061601A2 (en) * | 1998-05-28 | 1999-12-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Aav5 vector and uses thereof |
DE69936104T2 (de) * | 1998-11-05 | 2008-01-17 | The Trustees Of The University Of Pennsylvania | Nukleinsäuresequenzen des adeno-assoziierten virus des serotyps i, und vektoren und wirtszellen, die diese enthalten |
US6759237B1 (en) * | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
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WO2010036339A2 (en) * | 2008-09-25 | 2010-04-01 | Duke University | A method of detecting antibodies and antibody-hiv virion complexes |
EP3421603B1 (en) | 2009-05-02 | 2021-10-06 | Genzyme Corporation | Gene therapy for neurodegenerative disorders |
KR101464902B1 (ko) * | 2010-08-20 | 2014-11-24 | 나이키 이노베이트 씨.브이. | 골프 클럽 및 골프 클럽 헤드 |
CN102576029A (zh) | 2010-10-01 | 2012-07-11 | 松下电器产业株式会社 | 从脂质双层膜的外侧向内侧输送钾离子的方法 |
US8202687B2 (en) | 2010-10-01 | 2012-06-19 | Panasonic Corporation | Method for transporting potassium ions from front side to back side of lipid bilayer membrane |
BR112013010855A2 (pt) | 2010-11-02 | 2017-06-27 | Promega Corp | luciferases derivadas de oplophorus, novos substratos de coelenterazina e métodos de uso |
EP2675484B1 (en) | 2011-02-14 | 2018-05-30 | The Children's Hospital of Philadelphia | Improved aav8 vector with enhanced functional activity and methods of use thereof |
CN103014064A (zh) | 2011-09-22 | 2013-04-03 | 北京五加和分子医学研究所有限公司 | Itr同向排列的aav载体构建及其应用 |
JP6348064B2 (ja) * | 2011-11-22 | 2018-06-27 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | 効率の高いトランスジーン送達のためのウイルスベクター |
-
2014
- 2014-07-11 RU RU2016104614A patent/RU2705249C2/ru not_active Application Discontinuation
- 2014-07-11 KR KR1020167003572A patent/KR102445330B1/ko active IP Right Grant
- 2014-07-11 MX MX2016000345A patent/MX2016000345A/es unknown
- 2014-07-11 CA CA2918038A patent/CA2918038C/en active Active
- 2014-07-11 EP EP21209775.2A patent/EP4039813A1/en active Pending
- 2014-07-11 CN CN202310061410.6A patent/CN116004721A/zh active Pending
- 2014-07-11 JP JP2016525827A patent/JP2016525347A/ja active Pending
- 2014-07-11 WO PCT/US2014/046428 patent/WO2015006743A1/en active Application Filing
- 2014-07-11 US US14/904,205 patent/US11408899B2/en active Active
- 2014-07-11 CN CN201480039270.1A patent/CN105518145A/zh active Pending
- 2014-07-11 EP EP14823769.6A patent/EP3019620A4/en not_active Withdrawn
- 2014-07-11 AU AU2014287005A patent/AU2014287005C1/en active Active
-
2015
- 2015-12-31 IL IL243438A patent/IL243438B/en active IP Right Grant
-
2016
- 2016-01-11 MX MX2021000675A patent/MX2021000675A/es unknown
- 2016-09-08 HK HK16110663.7A patent/HK1222673A1/zh unknown
-
2019
- 2019-04-04 JP JP2019072287A patent/JP2019162109A/ja active Pending
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2021
- 2021-12-02 JP JP2021195840A patent/JP2022037027A/ja active Pending
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2022
- 2022-06-30 US US17/855,571 patent/US20220334126A1/en active Pending
-
2023
- 2023-12-01 JP JP2023204220A patent/JP2024026253A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2019162109A (ja) | 2019-09-26 |
EP3019620A4 (en) | 2017-01-18 |
US20220334126A1 (en) | 2022-10-20 |
AU2014287005A1 (en) | 2016-01-28 |
JP2016525347A (ja) | 2016-08-25 |
AU2014287005B2 (en) | 2020-12-17 |
KR102445330B1 (ko) | 2022-09-19 |
IL243438B (en) | 2020-02-27 |
CN105518145A (zh) | 2016-04-20 |
JP2022037027A (ja) | 2022-03-08 |
KR20160034332A (ko) | 2016-03-29 |
CA2918038C (en) | 2023-03-28 |
RU2016104614A (ru) | 2017-08-18 |
HK1222673A1 (zh) | 2017-07-07 |
IL243438A0 (en) | 2016-03-31 |
AU2014287005C1 (en) | 2021-06-03 |
EP4039813A1 (en) | 2022-08-10 |
WO2015006743A1 (en) | 2015-01-15 |
MX2021000675A (es) | 2021-03-25 |
US11408899B2 (en) | 2022-08-09 |
EP3019620A1 (en) | 2016-05-18 |
RU2705249C2 (ru) | 2019-11-06 |
US20160123990A1 (en) | 2016-05-05 |
JP2024026253A (ja) | 2024-02-28 |
CA2918038A1 (en) | 2015-01-15 |
CN116004721A (zh) | 2023-04-25 |
RU2016104614A3 (es) | 2018-03-05 |
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