HK1222673A1 - 載體和用於抗 腺相關病毒 中和抗體的檢測 - Google Patents
載體和用於抗 腺相關病毒 中和抗體的檢測Info
- Publication number
- HK1222673A1 HK1222673A1 HK16110663.7A HK16110663A HK1222673A1 HK 1222673 A1 HK1222673 A1 HK 1222673A1 HK 16110663 A HK16110663 A HK 16110663A HK 1222673 A1 HK1222673 A1 HK 1222673A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- aav
- adeno
- assay
- associated virus
- neutralizing antibodies
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/075—Adenoviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361845841P | 2013-07-12 | 2013-07-12 | |
| PCT/US2014/046428 WO2015006743A1 (en) | 2013-07-12 | 2014-07-11 | Aav vector and assay for anti-aav (adeno-associated virus) neutralizing antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1222673A1 true HK1222673A1 (zh) | 2017-07-07 |
Family
ID=52280652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16110663.7A HK1222673A1 (zh) | 2013-07-12 | 2016-09-08 | 載體和用於抗 腺相關病毒 中和抗體的檢測 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11408899B2 (zh) |
| EP (2) | EP4039813A1 (zh) |
| JP (4) | JP2016525347A (zh) |
| KR (1) | KR102445330B1 (zh) |
| CN (2) | CN116004721A (zh) |
| AU (1) | AU2014287005C1 (zh) |
| CA (1) | CA2918038C (zh) |
| HK (1) | HK1222673A1 (zh) |
| IL (1) | IL243438B (zh) |
| MX (2) | MX2016000345A (zh) |
| RU (1) | RU2705249C2 (zh) |
| WO (1) | WO2015006743A1 (zh) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016164920A1 (en) * | 2015-04-09 | 2016-10-13 | Cornell University | Gene therapy to prevent reactions to allergens |
| AU2016282781A1 (en) | 2015-06-23 | 2018-01-18 | The Children's Hospital Of Philadelphia | Modified Factor IX, and compositions, methods and uses for gene transfer to cells, organs and tissues |
| US10548947B2 (en) | 2015-11-05 | 2020-02-04 | Bamboo Therapeutics, Inc. | Modified Friedreich ataxia genes and vectors for gene therapy |
| CA3006569A1 (en) | 2015-12-02 | 2017-06-08 | Voyager Therapeutics, Inc. | Assays for the detection of aav neutralizing antibodies |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
| CN107828821A (zh) * | 2017-11-15 | 2018-03-23 | 四川大学 | 一种腺相关病毒感染敏感的细胞系的构建方法及腺相关病毒中和抗体含量测定的检测方法 |
| WO2019132624A1 (ko) * | 2017-12-29 | 2019-07-04 | 주식회사 헬릭스미스 | 하이브리드 hgf 유전자가 도입된 aav(아데노-연관 바이러스) 벡터 |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| US11306329B2 (en) | 2018-02-19 | 2022-04-19 | City Of Hope | Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof |
| CA3093347A1 (en) * | 2018-04-05 | 2019-10-10 | Genethon | Hybrid recombinant adeno-associated virus serotype between aav9 and aavrh74 with reduced liver tropism |
| CN110846392A (zh) * | 2018-08-20 | 2020-02-28 | 武汉纽福斯生物科技有限公司 | 一种重组腺相关病毒或含其的试剂盒及其应用 |
| WO2020102753A1 (en) * | 2018-11-16 | 2020-05-22 | Spark Therapeutics, Inc. | In vitro assay for detecting enhancers and inhibitors of adeno associated virus (aav) vector transduction and/or detecting or quantitating anti-aav binding antibodies |
| US20220120759A1 (en) * | 2019-01-31 | 2022-04-21 | Rajiv Mahadevan | Methods for detection and characterization of anti-viral vector antibodies |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
| KR20220133969A (ko) | 2020-01-28 | 2022-10-05 | 프리라인 테라퓨틱스 리미티드 | 바이러스 벡터에 대한 중화 항체 역가를 결정하기 위한 개선된 분석법 |
| TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法 |
| EP4421179A2 (en) * | 2020-09-10 | 2024-08-28 | Genethon | Peptide-modified aav capsid |
| CN112143712B (zh) * | 2020-09-30 | 2022-11-01 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒及其制备方法和在抗体检测的应用 |
| WO2023114816A1 (en) | 2021-12-14 | 2023-06-22 | Neurogene, Inc. | Recombinant optimized galc constructs and methods for treating galc-associated disorders |
| CN114277090A (zh) * | 2021-12-17 | 2022-04-05 | 宁波熙宁检测技术有限公司 | Aav8中和抗体检测方法和检测试剂盒 |
| GB202201242D0 (en) | 2022-01-31 | 2022-03-16 | Univ Edinburgh | Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders |
| WO2023207918A1 (en) * | 2022-04-25 | 2023-11-02 | Beijing Hanmoluojie Technology Co., Ltd. | Aav capsid 3d molecular surface feature mapping |
| GB202206336D0 (en) | 2022-04-29 | 2022-06-15 | Univ Edinburgh | Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders |
| WO2023220386A1 (en) * | 2022-05-13 | 2023-11-16 | The Children's Hospital Of Philadelphia | Adeno-associated viral vectors for targeting brain microvasculature |
| CN117802161A (zh) * | 2022-06-30 | 2024-04-02 | 苏州吉恒基因科技有限公司 | 精准重组腺相关病毒载体及其用途 |
| WO2024098054A1 (en) * | 2022-11-04 | 2024-05-10 | The Children's Hospital Of Philadelphia | Compositions and methods for b cell directed immunotherapies for anti-aav neutralizing alloantibodies |
| CN117285620B (zh) * | 2023-11-27 | 2024-02-13 | 恺佧生物科技(上海)有限公司 | 抗aav9抗体及aav9滴度测定elisa试剂盒 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU722624B2 (en) | 1996-09-06 | 2000-08-10 | Trustees Of The University Of Pennsylvania, The | An inducible method for production of recombinant adeno-associated viruses utilizing T7 polymerase |
| DE69841982D1 (de) * | 1997-03-14 | 2010-12-16 | Philadelphia Children Hospital | Zusammensetzungen zum einsatz in einer gentherapie zur behandlung von hämophilie |
| JP4025400B2 (ja) * | 1997-04-16 | 2007-12-19 | 財団法人化学及血清療法研究所 | 新規免疫制御分子及びその製造方法 |
| CA2745131C (en) * | 1998-05-28 | 2016-08-09 | John A. Chiorini | Aav5 vector and uses thereof |
| JP4573437B2 (ja) | 1998-11-05 | 2010-11-04 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | アデノ随伴ウイルス血清型１核酸配列、ベクターおよび同一物を含有する宿主細胞 |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| DK1035133T3 (da) * | 1999-02-17 | 2005-05-02 | Pfizer Prod Inc | Fusionsproteiner, der omfatter bærere, som kan inducere et dobbelt immunrespons |
| WO2001025462A1 (en) * | 1999-10-01 | 2001-04-12 | Genovo, Incorporated | Production of recombinant aav using adenovirus comprising aav rep/cap genes |
| US7241447B1 (en) | 1999-10-07 | 2007-07-10 | University Of Iowa Research Foundation | Adeno-associated virus vectors and uses thereof |
| DE60117550T2 (de) | 2000-06-01 | 2006-12-07 | University Of North Carolina At Chapel Hill | Doppelsträngige parvovirus-vektoren |
| DE50304957D1 (de) | 2002-04-15 | 2006-10-19 | Universitaetsklinikum Hamburg | Rekombinante virale vektoren zur tetracyclinregulierbaren genexpression |
| US20070015238A1 (en) * | 2002-06-05 | 2007-01-18 | Snyder Richard O | Production of pseudotyped recombinant AAV virions |
| EP1369491A1 (en) | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
| EA200500012A1 (ru) | 2002-06-13 | 2006-04-28 | Уайт Холдингз Корпорейшн | Ингибиторы активности генов воспаления и биосинтеза холестерина |
| JP2012503771A (ja) * | 2008-09-25 | 2012-02-09 | デューク ユニバーシティー | 抗体および抗体−ｈｉｖビリオン複合体を検出する方法 |
| CN107083400A (zh) | 2009-05-02 | 2017-08-22 | 建新公司 | 神经退行性疾病的基因治疗 |
| KR101464902B1 (ko) * | 2010-08-20 | 2014-11-24 | 나이키 이노베이트 씨.브이. | 골프 클럽 및 골프 클럽 헤드 |
| JP4916596B1 (ja) | 2010-10-01 | 2012-04-11 | パナソニック株式会社 | 脂質二重膜の表側から裏側にカリウムイオンを輸送する方法 |
| US8202687B2 (en) | 2010-10-01 | 2012-06-19 | Panasonic Corporation | Method for transporting potassium ions from front side to back side of lipid bilayer membrane |
| CN103370319B (zh) | 2010-11-02 | 2016-08-24 | 普罗美加公司 | 新型腔肠素底物及其使用方法 |
| EP2675484B1 (en) * | 2011-02-14 | 2018-05-30 | The Children's Hospital of Philadelphia | Improved aav8 vector with enhanced functional activity and methods of use thereof |
| CN103014064A (zh) | 2011-09-22 | 2013-04-03 | 北京五加和分子医学研究所有限公司 | Itr同向排列的aav载体构建及其应用 |
| US10640785B2 (en) * | 2011-11-22 | 2020-05-05 | The Children's Hospital Of Philadelphia | Virus vectors for highly efficient transgene delivery |
-
2014
- 2014-07-11 EP EP21209775.2A patent/EP4039813A1/en active Pending
- 2014-07-11 JP JP2016525827A patent/JP2016525347A/ja active Pending
- 2014-07-11 KR KR1020167003572A patent/KR102445330B1/ko active IP Right Grant
- 2014-07-11 CN CN202310061410.6A patent/CN116004721A/zh active Pending
- 2014-07-11 CA CA2918038A patent/CA2918038C/en active Active
- 2014-07-11 EP EP14823769.6A patent/EP3019620A4/en not_active Withdrawn
- 2014-07-11 RU RU2016104614A patent/RU2705249C2/ru not_active Application Discontinuation
- 2014-07-11 WO PCT/US2014/046428 patent/WO2015006743A1/en active Application Filing
- 2014-07-11 MX MX2016000345A patent/MX2016000345A/es unknown
- 2014-07-11 AU AU2014287005A patent/AU2014287005C1/en active Active
- 2014-07-11 CN CN201480039270.1A patent/CN105518145A/zh active Pending
- 2014-07-11 US US14/904,205 patent/US11408899B2/en active Active
-
2015
- 2015-12-31 IL IL243438A patent/IL243438B/en active IP Right Grant
-
2016
- 2016-01-11 MX MX2021000675A patent/MX2021000675A/es unknown
- 2016-09-08 HK HK16110663.7A patent/HK1222673A1/zh unknown
-
2019
- 2019-04-04 JP JP2019072287A patent/JP2019162109A/ja active Pending
-
2021
- 2021-12-02 JP JP2021195840A patent/JP2022037027A/ja active Pending
-
2022
- 2022-06-30 US US17/855,571 patent/US20220334126A1/en active Pending
-
2023
- 2023-12-01 JP JP2023204220A patent/JP2024026253A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016104614A3 (zh) | 2018-03-05 |
| CN116004721A (zh) | 2023-04-25 |
| MX2016000345A (es) | 2016-06-21 |
| CA2918038C (en) | 2023-03-28 |
| KR102445330B1 (ko) | 2022-09-19 |
| AU2014287005B2 (en) | 2020-12-17 |
| WO2015006743A1 (en) | 2015-01-15 |
| US20160123990A1 (en) | 2016-05-05 |
| AU2014287005A1 (en) | 2016-01-28 |
| US20220334126A1 (en) | 2022-10-20 |
| AU2014287005C1 (en) | 2021-06-03 |
| US11408899B2 (en) | 2022-08-09 |
| JP2024026253A (ja) | 2024-02-28 |
| IL243438B (en) | 2020-02-27 |
| EP3019620A4 (en) | 2017-01-18 |
| CA2918038A1 (en) | 2015-01-15 |
| JP2016525347A (ja) | 2016-08-25 |
| IL243438A0 (en) | 2016-03-31 |
| EP3019620A1 (en) | 2016-05-18 |
| MX2021000675A (es) | 2021-03-25 |
| JP2022037027A (ja) | 2022-03-08 |
| RU2016104614A (ru) | 2017-08-18 |
| RU2705249C2 (ru) | 2019-11-06 |
| CN105518145A (zh) | 2016-04-20 |
| JP2019162109A (ja) | 2019-09-26 |
| KR20160034332A (ko) | 2016-03-29 |
| EP4039813A1 (en) | 2022-08-10 |
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