MX2015009105A - Composiciones en solucion solida y su uso en inflamacion cronica. - Google Patents

Composiciones en solucion solida y su uso en inflamacion cronica.

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Publication number
MX2015009105A
MX2015009105A MX2015009105A MX2015009105A MX2015009105A MX 2015009105 A MX2015009105 A MX 2015009105A MX 2015009105 A MX2015009105 A MX 2015009105A MX 2015009105 A MX2015009105 A MX 2015009105A MX 2015009105 A MX2015009105 A MX 2015009105A
Authority
MX
Mexico
Prior art keywords
chronic inflammation
solid solution
solution compositions
pharmaceutical compositions
methods
Prior art date
Application number
MX2015009105A
Other languages
English (en)
Inventor
John Brew
Robin Mark Bannister
Wilson Caparrós-Wanderley
Richard Robert Reiley
Original Assignee
Infirst Healthcare Ltd
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Filing date
Publication date
Application filed by Infirst Healthcare Ltd filed Critical Infirst Healthcare Ltd
Publication of MX2015009105A publication Critical patent/MX2015009105A/es

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    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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Abstract

La presente descripción revela composiciones farmacéuticas, métodos de preparación de tales composiciones farmacéuticas, y métodos y usos en el tratamiento de la inflamación crónica y/o una enfermedad inflamatoria en un individuo que utilice tales composiciones farmacéuticas.
MX2015009105A 2013-01-14 2014-01-14 Composiciones en solucion solida y su uso en inflamacion cronica. MX2015009105A (es)

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PCT/EP2014/050637 WO2014108573A1 (en) 2013-01-14 2014-01-14 Solid solution compositions and use in chronic inflammation

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MX2015009104A MX2015009104A (es) 2013-01-14 2014-01-14 Composiciones en solución sólida y uso en el tratamiento de enfermedades cardiovasculares.
MX2015009105A MX2015009105A (es) 2013-01-14 2014-01-14 Composiciones en solucion solida y su uso en inflamacion cronica.
MX2015009106A MX2015009106A (es) 2013-01-14 2014-01-14 Composiciones de solución sólida y su uso en el tratamiento del dolor intenso.

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US8895536B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating chronic inflammation and inflammatory diseases
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
IL295091B2 (en) * 2013-01-14 2023-08-01 Infirst Healthcare Ltd Solid solution mixtures
CN108025078A (zh) * 2015-08-07 2018-05-11 因佛斯特医疗有限公司 用于nsaid的固体溶液组合物
US10307388B2 (en) * 2016-12-29 2019-06-04 The United States Of America As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of inflammation
WO2019083816A1 (en) 2017-10-23 2019-05-02 Epitracker, Inc. FATTY ACID ANALOGUES AND THEIR USE IN THE TREATMENT OF STATES RELATED TO METABOLIC SYNDROME
CN108653273A (zh) * 2018-07-13 2018-10-16 昆明医科大学第附属医院 青蒿素类化合物作为制备治疗贝赫切特病药物的应用
CN110251549B (zh) * 2019-06-24 2021-12-03 浙江省肿瘤医院 淫羊藿总黄酮提取物在制备防治桥本甲状腺炎的药物中的应用
US20220249375A1 (en) * 2019-06-28 2022-08-11 Jiangsu Hengrui Medicine Co., Ltd. Sustained-release lipid composition and preparation method therefor
WO2021012046A1 (en) * 2019-07-21 2021-01-28 Scf Pharma Inc. Cannabinoids compositions with polyunsaturated fatty acid monoglycerides, methods and uses thereof
WO2021158517A1 (en) * 2020-02-03 2021-08-12 Curemast, Inc. Compositions and methods of use thereof for treatment of mastitis
RU2752764C1 (ru) * 2020-12-14 2021-08-03 Общество с ограниченной ответственностью "Тривиум-ХХI" (ООО "Тривиум-ХХI") Фармацевтическая композиция, обладающая противовоспалительным действием
CN114601843A (zh) * 2022-03-22 2022-06-10 重庆医科大学附属第一医院 淫羊藿苷在制备治疗自身免疫性葡萄膜炎药物中的用途
GB202208911D0 (en) * 2022-06-17 2022-08-10 Ravan Bio Limtied Treatments

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800038A (en) * 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier
US5143934A (en) * 1990-11-21 1992-09-01 A/S Dumex (Dumex Ltd.) Method and composition for controlled delivery of biologically active agents
GB9613858D0 (en) * 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
JP2002511099A (ja) * 1997-07-29 2002-04-09 ファルマシア・アンド・アップジョン・カンパニー 親油性化合物用の自己乳化性処方
US6063768A (en) 1997-09-04 2000-05-16 First; Eric R. Application of botulinum toxin to the management of neurogenic inflammatory disorders
GB2331458B (en) * 1997-11-21 2002-07-31 Gursharan Singh Moonga Solubilising systems for difficult pharmaceutical actives for preparing concentrated stable solutions for encapsulation into soft gelatine
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US8663692B1 (en) * 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
TR200103188T2 (tr) * 1999-05-07 2002-04-22 Pharmasol Gmbh Sıvı ve katı lipit karışımları temelli lipid parçacıklar.
EP1183014B1 (en) * 1999-06-14 2003-10-08 Cosmo S.p.A. Controlled release and taste masking oral pharmaceutical compositions
ES2241663T3 (es) * 1999-09-21 2005-11-01 Skyepharma Canada Inc. Composiciones particuladas modificadas superficialmente de substancias biologicamente activas.
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US20060034937A1 (en) * 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
US6455067B1 (en) * 2000-05-24 2002-09-24 Sang-A Pharmaceutical Co., Ltd. Transdermal patch for nonsteroidal antiinflammatory drug(s)
JP2002284705A (ja) * 2001-01-19 2002-10-03 Shiseido Co Ltd 刺激緩和剤
US20030105141A1 (en) * 2001-04-17 2003-06-05 Ping Gao Finely self-emulsifiable pharmaceutical composition
BRPI0412581A (pt) * 2003-07-31 2006-09-19 Pharmacia & Upjohn Co Llc formulação dispersável de um agente antiinflamatório
JP5069001B2 (ja) * 2003-10-10 2012-11-07 ベロクシス ファーマシューティカルズ エー/エス フィブラートを含む固体投与形態
WO2005048927A2 (en) * 2003-11-13 2005-06-02 Combinatorx, Incorporated Methods and reagents for the treatment of inflammatory disorders
EP1694305B1 (en) * 2003-12-01 2019-10-16 Recordati Ireland Limited Pharmaceutical compositions comprising lercanidipine
US20070196396A1 (en) * 2004-02-11 2007-08-23 Rubicon Research Private Limited Controlled release pharmaceutical compositions with improved bioavailability
JP5032300B2 (ja) * 2004-03-22 2012-09-26 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物
AU2005309808A1 (en) * 2004-11-24 2006-06-01 Merck & Co., Inc. Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide
US20060138059A1 (en) 2004-12-28 2006-06-29 Vair Larry L Jr Corona-treated polypropylene liquid filtration media
JP2008539230A (ja) * 2005-04-28 2008-11-13 ガレニカ テクノロジー アンチエボラグ 脂質相を含む薬学的投与形態
GB0610867D0 (en) * 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
GB0704846D0 (en) * 2007-03-13 2007-04-18 Futura Medical Dev Ltd Topical pharmaceutical formulation
RU2353349C2 (ru) * 2007-04-18 2009-04-27 Общество с ограниченной ответственностью "Фармацевтические технологии" Средство для лечения болезней суставов
CN101129335B (zh) * 2007-07-17 2010-09-22 浙江大学 一种纳米结构脂质载体给药系统的用途
WO2009153496A2 (fr) 2008-05-26 2009-12-23 Genfit Composés agonistes ppar, préparation et utilisations
GB201018289D0 (en) * 2010-10-29 2010-12-15 Biocopea Ltd Treatment of respiratory disorders
EP3494961B1 (en) * 2011-02-04 2024-04-10 InFirst Healthcare Limited Compositions and methods for treating chronic inflammation and inflammatory diseases
JP2014508796A (ja) * 2011-03-24 2014-04-10 レオ ファーマ アクティーゼルスカブ 脂質ナノ粒子とコルチコステロイドまたはビタミンd誘導体とを含む組成物
CN102793628B (zh) * 2012-08-23 2014-07-02 东华大学 用于化妆品的液-固混合脂质纳米缓释系统及其制备方法
IL295091B2 (en) * 2013-01-14 2023-08-01 Infirst Healthcare Ltd Solid solution mixtures

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