MX2014015855A - Pro-farmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)m etil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida. - Google Patents

Pro-farmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)m etil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida.

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Publication number
MX2014015855A
MX2014015855A MX2014015855A MX2014015855A MX2014015855A MX 2014015855 A MX2014015855 A MX 2014015855A MX 2014015855 A MX2014015855 A MX 2014015855A MX 2014015855 A MX2014015855 A MX 2014015855A MX 2014015855 A MX2014015855 A MX 2014015855A
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MX
Mexico
Prior art keywords
methylbenzofuran
naphthyridin
tetrahydro
oxo
ethyl
Prior art date
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MX2014015855A
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English (en)
Other versions
MX356695B (es
Inventor
John J Partridge
John Colucci
Yves Gareau
Michel Therien
Robert Zamboni
Barry Hafkin
Anthony Marfat
Helmi Zaghdane
Original Assignee
Debiopharm Int Sa
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Application filed by Debiopharm Int Sa filed Critical Debiopharm Int Sa
Publication of MX2014015855A publication Critical patent/MX2014015855A/es
Publication of MX356695B publication Critical patent/MX356695B/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/60Quinoline or hydrogenated quinoline ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En parte, la presente descripción está dirigida a derivados pro-fármaco de los compuestos (E)-N-metil-N-((3-metilbenzofuran-2- il)metil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)acrilam ida con perfiles de solubilidad y biodisponibilidad significativos.
MX2014015855A 2012-06-19 2013-06-19 Profarmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)me til)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida. MX356695B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661559P 2012-06-19 2012-06-19
PCT/IB2013/001780 WO2013190384A1 (en) 2012-06-19 2013-06-19 Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide

Publications (2)

Publication Number Publication Date
MX2014015855A true MX2014015855A (es) 2015-03-05
MX356695B MX356695B (es) 2018-06-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015855A MX356695B (es) 2012-06-19 2013-06-19 Profarmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)me til)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida.

Country Status (34)

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US (2) US8901105B2 (es)
EP (1) EP2861608B8 (es)
JP (2) JP6085026B2 (es)
KR (1) KR101720885B1 (es)
CN (1) CN104684922B (es)
AU (1) AU2013279021C1 (es)
BR (2) BR112014031635B1 (es)
CA (1) CA2875916C (es)
CL (1) CL2014003472A1 (es)
CY (1) CY1122006T1 (es)
DK (1) DK2861608T3 (es)
EA (1) EA028136B1 (es)
ES (1) ES2731474T3 (es)
HK (1) HK1208226A1 (es)
HR (1) HRP20190980T1 (es)
HU (1) HUE043836T2 (es)
IL (1) IL236066A (es)
IN (1) IN2014KN02915A (es)
LT (1) LT2861608T (es)
MA (1) MA37625B1 (es)
ME (1) ME03392B (es)
MX (1) MX356695B (es)
MY (1) MY170437A (es)
NZ (1) NZ702695A (es)
PH (1) PH12014502823B1 (es)
PL (1) PL2861608T3 (es)
PT (1) PT2861608T (es)
RS (1) RS58898B1 (es)
SG (1) SG11201408100YA (es)
SI (1) SI2861608T1 (es)
TN (1) TN2014000506A1 (es)
TR (1) TR201909016T4 (es)
UA (1) UA113215C2 (es)
WO (1) WO2013190384A1 (es)

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JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーDebiopharm International Sa (e)−n−メチル−n−((3−メチルベンゾフラン−2−イル)メチル)−3−(7−オキソ−5,6,7,8−テトラヒドロ−1,8−ナフチリジン−3−イル)アクリルアミドのプロドラッグ誘導体
UA123705C2 (uk) * 2016-02-26 2021-05-19 Дебіофарм Інтернешнл С.А. Лікарський засіб для лікування інфекцій на фоні діабетичної стопи
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
CA3082033A1 (en) 2017-08-24 2019-02-28 Novo Nordisk A\S Glp-1 compositions and uses thereof
WO2019177975A1 (en) * 2018-03-12 2019-09-19 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
AU2019380568A1 (en) 2018-11-12 2021-06-17 Debiopharm International S.A. Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof
JP2022515775A (ja) 2018-12-21 2022-02-22 アクルクス ファーマシューティカルズ エルエルシー Dnaポリメラーゼiiic阻害剤及びその使用
EP3923914B1 (en) 2019-02-14 2023-04-12 Debiopharm International S.A. Afabicin formulation, method for making the same
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス.エー. バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用
MX2022007412A (es) 2019-12-19 2022-09-19 Debiopharm Int Sa Compuestos novedosos y sus usos.
PE20230819A1 (es) 2020-02-18 2023-05-19 Novo Nordisk As Composiciones y usos de glp-1
CA3223459A1 (en) 2021-06-23 2022-12-29 Vincent Gerusz Novel compounds and their use

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