MX2014014768A - Inhibidores macrociclicos de virus flaviviridae. - Google Patents

Inhibidores macrociclicos de virus flaviviridae.

Info

Publication number
MX2014014768A
MX2014014768A MX2014014768A MX2014014768A MX2014014768A MX 2014014768 A MX2014014768 A MX 2014014768A MX 2014014768 A MX2014014768 A MX 2014014768A MX 2014014768 A MX2014014768 A MX 2014014768A MX 2014014768 A MX2014014768 A MX 2014014768A
Authority
MX
Mexico
Prior art keywords
mmol
compound
mixture
ethyl acetate
solution
Prior art date
Application number
MX2014014768A
Other languages
English (en)
Spanish (es)
Inventor
Aciro Caroline
Alexandra Steadman Victoria
Neil Pettit Simon
G Poullennec Karine
Lazarides Linos
Kenneth Dean David
Andrew Dunbar Neil
John Highton Adrian
John Keats Andres
Scott Siegel Dustin
Kumar Karki Kapil
James Schrier Adan
Jansa Petr
Mackman Richard
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2014014768A publication Critical patent/MX2014014768A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
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    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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MX2014014768A 2012-06-08 2013-06-07 Inhibidores macrociclicos de virus flaviviridae. MX2014014768A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657553P 2012-06-08 2012-06-08
PCT/US2013/044809 WO2013185090A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
MX2014014768A true MX2014014768A (es) 2015-05-11

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MX2014014768A MX2014014768A (es) 2012-06-08 2013-06-07 Inhibidores macrociclicos de virus flaviviridae.

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US (3) US9090653B2 (enEXAMPLES)
EP (1) EP2859009B1 (enEXAMPLES)
JP (1) JP6209600B2 (enEXAMPLES)
KR (1) KR20150040266A (enEXAMPLES)
CN (1) CN104662033B (enEXAMPLES)
AU (1) AU2013271413B2 (enEXAMPLES)
BR (1) BR112014030649A2 (enEXAMPLES)
CA (1) CA2875718A1 (enEXAMPLES)
EA (1) EA201492205A1 (enEXAMPLES)
ES (1) ES2656087T3 (enEXAMPLES)
HK (1) HK1210483A1 (enEXAMPLES)
IL (1) IL236006A0 (enEXAMPLES)
IN (1) IN2014MN02658A (enEXAMPLES)
MX (1) MX2014014768A (enEXAMPLES)
NO (1) NO2887898T3 (enEXAMPLES)
NZ (2) NZ703066A (enEXAMPLES)
PL (1) PL2859009T3 (enEXAMPLES)
PT (1) PT2859009T (enEXAMPLES)
SG (1) SG11201408045UA (enEXAMPLES)
SI (1) SI2859009T1 (enEXAMPLES)
WO (1) WO2013185090A1 (enEXAMPLES)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104703991B (zh) * 2012-06-08 2018-03-23 吉利德科学公司 黄病毒科病毒的大环抑制剂
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