IL236006A0 - Macrocyclic inhibitors of flavoviride viruses - Google Patents

Macrocyclic inhibitors of flavoviride viruses

Info

Publication number
IL236006A0
IL236006A0 IL236006A IL23600614A IL236006A0 IL 236006 A0 IL236006 A0 IL 236006A0 IL 236006 A IL236006 A IL 236006A IL 23600614 A IL23600614 A IL 23600614A IL 236006 A0 IL236006 A0 IL 236006A0
Authority
IL
Israel
Prior art keywords
flaviviridae viruses
macrocyclic inhibitors
macrocyclic
inhibitors
flaviviridae
Prior art date
Application number
IL236006A
Other languages
English (en)
Hebrew (he)
Original Assignee
Gilead Sciences Inc
Selcia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Selcia Ltd filed Critical Gilead Sciences Inc
Publication of IL236006A0 publication Critical patent/IL236006A0/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Pharmacology & Pharmacy (AREA)
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IL236006A 2012-06-08 2014-11-30 Macrocyclic inhibitors of flavoviride viruses IL236006A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657553P 2012-06-08 2012-06-08
PCT/US2013/044809 WO2013185090A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
IL236006A0 true IL236006A0 (en) 2015-01-29

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IL236006A IL236006A0 (en) 2012-06-08 2014-11-30 Macrocyclic inhibitors of flavoviride viruses

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US (3) US9090653B2 (enEXAMPLES)
EP (1) EP2859009B1 (enEXAMPLES)
JP (1) JP6209600B2 (enEXAMPLES)
KR (1) KR20150040266A (enEXAMPLES)
CN (1) CN104662033B (enEXAMPLES)
AU (1) AU2013271413B2 (enEXAMPLES)
BR (1) BR112014030649A2 (enEXAMPLES)
CA (1) CA2875718A1 (enEXAMPLES)
EA (1) EA201492205A1 (enEXAMPLES)
ES (1) ES2656087T3 (enEXAMPLES)
HK (1) HK1210483A1 (enEXAMPLES)
IL (1) IL236006A0 (enEXAMPLES)
IN (1) IN2014MN02658A (enEXAMPLES)
MX (1) MX2014014768A (enEXAMPLES)
NO (1) NO2887898T3 (enEXAMPLES)
NZ (2) NZ724616A (enEXAMPLES)
PL (1) PL2859009T3 (enEXAMPLES)
PT (1) PT2859009T (enEXAMPLES)
SG (1) SG11201408045UA (enEXAMPLES)
SI (1) SI2859009T1 (enEXAMPLES)
WO (1) WO2013185090A1 (enEXAMPLES)

Families Citing this family (68)

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Publication number Priority date Publication date Assignee Title
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
SI2859009T1 (sl) 2012-06-08 2017-12-29 Gilead Sciences, Inc. Makrociklični inhibitorji flaviviridae virusov
PT2861604T (pt) 2012-06-08 2017-05-05 Gilead Sciences Inc Inibidores macrocíclicos de vírus flaviridae
EP3239143B1 (en) * 2014-12-24 2023-03-22 LG Chem, Ltd. Biaryl derivative as gpr120 agonist
LT3236972T (lt) 2014-12-26 2021-11-10 Emory University Antivirusiniai n4-hidroksicitidino dariniai
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