IL236006A0 - Macrocyclic inhibitors of flavoviride viruses - Google Patents

Macrocyclic inhibitors of flavoviride viruses

Info

Publication number
IL236006A0
IL236006A0 IL236006A IL23600614A IL236006A0 IL 236006 A0 IL236006 A0 IL 236006A0 IL 236006 A IL236006 A IL 236006A IL 23600614 A IL23600614 A IL 23600614A IL 236006 A0 IL236006 A0 IL 236006A0
Authority
IL
Israel
Prior art keywords
flaviviridae viruses
macrocyclic inhibitors
macrocyclic
inhibitors
flaviviridae
Prior art date
Application number
IL236006A
Other languages
English (en)
Hebrew (he)
Original Assignee
Gilead Sciences Inc
Selcia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc, Selcia Ltd filed Critical Gilead Sciences Inc
Publication of IL236006A0 publication Critical patent/IL236006A0/en

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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/504Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Virology (AREA)
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  • AIDS & HIV (AREA)
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IL236006A 2012-06-08 2014-11-30 Macrocyclic inhibitors of flavoviride viruses IL236006A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657553P 2012-06-08 2012-06-08
PCT/US2013/044809 WO2013185090A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
IL236006A0 true IL236006A0 (en) 2015-01-29

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Application Number Title Priority Date Filing Date
IL236006A IL236006A0 (en) 2012-06-08 2014-11-30 Macrocyclic inhibitors of flavoviride viruses

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US (3) US9090653B2 (enEXAMPLES)
EP (1) EP2859009B1 (enEXAMPLES)
JP (1) JP6209600B2 (enEXAMPLES)
KR (1) KR20150040266A (enEXAMPLES)
CN (1) CN104662033B (enEXAMPLES)
AU (1) AU2013271413B2 (enEXAMPLES)
BR (1) BR112014030649A2 (enEXAMPLES)
CA (1) CA2875718A1 (enEXAMPLES)
EA (1) EA201492205A1 (enEXAMPLES)
ES (1) ES2656087T3 (enEXAMPLES)
HK (1) HK1210483A1 (enEXAMPLES)
IL (1) IL236006A0 (enEXAMPLES)
IN (1) IN2014MN02658A (enEXAMPLES)
MX (1) MX2014014768A (enEXAMPLES)
NO (1) NO2887898T3 (enEXAMPLES)
NZ (2) NZ703066A (enEXAMPLES)
PL (1) PL2859009T3 (enEXAMPLES)
PT (1) PT2859009T (enEXAMPLES)
SG (1) SG11201408045UA (enEXAMPLES)
SI (1) SI2859009T1 (enEXAMPLES)
WO (1) WO2013185090A1 (enEXAMPLES)

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AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
BR112014030630A2 (pt) 2012-06-08 2017-06-27 Gilead Sciences Inc inibidores macrocíclicos de vírus flaviviridae
US9090653B2 (en) 2012-06-08 2015-07-28 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
RU2683648C2 (ru) * 2014-12-24 2019-04-01 ЭлДжи КЕМ, ЛТД. Биарильное производное в качестве агониста gpr120
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
HUE050029T2 (hu) 2015-03-04 2020-11-30 Gilead Sciences Inc 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként
CA2995004A1 (en) 2015-08-26 2017-03-02 Gilead Sciences, Inc. Deuterated toll-like receptor modulators
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
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