MX2012003720A - N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[ 1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)a cetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos. - Google Patents

N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[ 1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)a cetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos.

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Publication number
MX2012003720A
MX2012003720A MX2012003720A MX2012003720A MX2012003720A MX 2012003720 A MX2012003720 A MX 2012003720A MX 2012003720 A MX2012003720 A MX 2012003720A MX 2012003720 A MX2012003720 A MX 2012003720A MX 2012003720 A MX2012003720 A MX 2012003720A
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Mexico
Prior art keywords
tert
oxopyrrolidin
triazin
ylamino
butylamino
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MX2012003720A
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English (en)
Inventor
Percy H Carter
Robert J Cherney
Victor W Rosso
Li Jun
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Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012003720A publication Critical patent/MX2012003720A/es

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Abstract

La presente invención proporciona un antagonista novedoso: N-((1R,2S,5R)-5-(tert-butilamino)-2-((S)-3-(7-tert-butilpirazolo[ 1,5-a] [1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)a cetamida: (ver fórmula) o su sal, solvato o profármaco, farmacéuticamente aceptable, que tiene una actividad del receptor dual de CCR-2 y CCR-5 inesperada. También se describen formas cristalinas, metabolitos, composiciones farmacéuticas que contienen los mismos y procesos de uso de los mismos como agentes para el tratamiento de enfermedades inflamatorias, alérgicas, autoinmunes, metabólicas, cáncer y/o cardiovasculares. La presente invención también proporciona procesos de preparación de compuestos de Fórmula (I) como los provistos en la presente, incluyendo N-((1R,2S,5R)-5-(tert-butilamino)-2-((S)-3-(7-tert-buti lpirazolo[1,5-a] [1,3,S]triazin-4-ilamino)-2-oxopirrolidin-1-il)ci clohexil)acetamida. También se proporcionan en la presente compuestos que son intermediarios útiles del proceso.
MX2012003720A 2009-10-13 2010-10-12 N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[ 1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)a cetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos. MX2012003720A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25097809P 2009-10-13 2009-10-13
PCT/US2010/052288 WO2011046916A1 (en) 2009-10-13 2010-10-12 N-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes

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MX2012003720A true MX2012003720A (es) 2012-04-30

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MX2012003720A MX2012003720A (es) 2009-10-13 2010-10-12 N-((1r,2s,5r)-5-(tert-butilamino)-2-((s)-3-(7-tert-butilpirazolo[ 1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)a cetamida, un modulador dual de la actividad del receptor de quimiocinas, formas cristalinas y procesos.

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US (3) US8383812B2 (es)
EP (2) EP2664620A3 (es)
JP (1) JP5759999B2 (es)
KR (1) KR20120102052A (es)
CN (1) CN102648201B (es)
AR (1) AR078627A1 (es)
AU (1) AU2010306968B2 (es)
BR (1) BR112012008650B1 (es)
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CL (1) CL2014000753A1 (es)
CO (1) CO6460737A2 (es)
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EA (2) EA201490744A1 (es)
ES (1) ES2442897T3 (es)
HK (1) HK1174614A1 (es)
HR (1) HRP20140072T1 (es)
IL (2) IL219121A0 (es)
MX (1) MX2012003720A (es)
NZ (2) NZ599311A (es)
PE (1) PE20121349A1 (es)
PL (1) PL2488523T3 (es)
PT (1) PT2488523E (es)
RS (1) RS53131B (es)
SI (1) SI2488523T1 (es)
SM (1) SMT201400020B (es)
TN (1) TN2012000132A1 (es)
TW (1) TW201120042A (es)
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US8383812B2 (en) 2013-02-26
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