AR078627A1 - N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg - Google Patents

N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg

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Publication number
AR078627A1
AR078627A1 ARP100103741A ARP100103741A AR078627A1 AR 078627 A1 AR078627 A1 AR 078627A1 AR P100103741 A ARP100103741 A AR P100103741A AR P100103741 A ARP100103741 A AR P100103741A AR 078627 A1 AR078627 A1 AR 078627A1
Authority
AR
Argentina
Prior art keywords
terc
crystalline form
oxopirrolidin
butilpirazolo
butilamino
Prior art date
Application number
ARP100103741A
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English (en)
Inventor
Percy H Carter
Robert J Cherney
Victor W Rosso
Jun Li
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Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR078627A1 publication Critical patent/AR078627A1/es

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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

Reivindicacion 1. Un compuesto caracterizado porque tiene la formula (1) o su sal. Reivindicacion 2: El compuesto de la reivindicacion 1, caracterizado porque que es una forma cristalina de dicho compuesto. Reivindicacion 3: La forma cristalina de la reivindicacion 2, caracterizada porque la forma cristalina comprende la forma N-1. Reivindicacion 4: La forma cristalina de acuerdo con la reivindicacion 3, caracterizada porque dicha forma N-1 está en forma sustancialmente pura. Reivindicacion 5: La forma cristalina de la reivindicacion 3, caracterizada porque la forma N-1 se caracteriza por parámetros de celda unitaria sustancialmente igual a las siguientes dimensiones: Dimensiones de la celda a = 7,3085(6), b = 16,257(1), c = 22,688(2), alfas = 90, betas = 90, gamma° = 90, Grupo de espacio P212121, Moléculas/celda unitaria (Z):1, Densidad, calc g-cm-3:1,194 en la que dicho cristal está a una temperatura de aproximadamente -70sC.
ARP100103741A 2009-10-13 2010-10-13 N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg AR078627A1 (es)

Applications Claiming Priority (1)

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US25097809P 2009-10-13 2009-10-13

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AR078627A1 true AR078627A1 (es) 2011-11-23

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US (3) US8383812B2 (es)
EP (2) EP2664620A3 (es)
JP (1) JP5759999B2 (es)
KR (1) KR20120102052A (es)
CN (1) CN102648201B (es)
AR (1) AR078627A1 (es)
AU (1) AU2010306968B2 (es)
BR (1) BR112012008650B1 (es)
CA (1) CA2777563A1 (es)
CL (1) CL2014000753A1 (es)
CO (1) CO6460737A2 (es)
DK (1) DK2488523T3 (es)
EA (2) EA020486B1 (es)
ES (1) ES2442897T3 (es)
HK (1) HK1174614A1 (es)
HR (1) HRP20140072T1 (es)
IL (2) IL219121A0 (es)
MX (1) MX2012003720A (es)
NZ (2) NZ613580A (es)
PE (1) PE20121349A1 (es)
PL (1) PL2488523T3 (es)
PT (1) PT2488523E (es)
RS (1) RS53131B (es)
SI (1) SI2488523T1 (es)
SM (1) SMT201400020B (es)
TN (1) TN2012000132A1 (es)
TW (1) TW201120042A (es)
WO (1) WO2011046916A1 (es)
ZA (1) ZA201305994B (es)

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TW201120042A (en) 2011-06-16
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CN102648201A (zh) 2012-08-22
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