MX2010002783A - Proceso e intermediarios para la preparacion de inhibidores de integrasa. - Google Patents
Proceso e intermediarios para la preparacion de inhibidores de integrasa.Info
- Publication number
- MX2010002783A MX2010002783A MX2010002783A MX2010002783A MX2010002783A MX 2010002783 A MX2010002783 A MX 2010002783A MX 2010002783 A MX2010002783 A MX 2010002783A MX 2010002783 A MX2010002783 A MX 2010002783A MX 2010002783 A MX2010002783 A MX 2010002783A
- Authority
- MX
- Mexico
- Prior art keywords
- intermediates
- integrase inhibitors
- preparing integrase
- preparing
- prepare
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 229940124524 integrase inhibitor Drugs 0.000 title 1
- 239000002850 integrase inhibitor Substances 0.000 title 1
- YZMVLKJJJCMVGX-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline-2,4-dione Chemical class C1=CC=C2NC(=O)CC(=O)C2=C1 YZMVLKJJJCMVGX-UHFFFAOYSA-N 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010061833 Integrases Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97139507P | 2007-09-11 | 2007-09-11 | |
| PCT/US2008/076002 WO2009036161A1 (en) | 2007-09-11 | 2008-09-11 | Process and intermediates for preparing integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002783A true MX2010002783A (es) | 2010-03-31 |
Family
ID=39887255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002783A MX2010002783A (es) | 2007-09-11 | 2008-09-11 | Proceso e intermediarios para la preparacion de inhibidores de integrasa. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8153801B2 (OSRAM) |
| EP (1) | EP2190804B1 (OSRAM) |
| JP (2) | JP5202635B2 (OSRAM) |
| KR (1) | KR101488550B1 (OSRAM) |
| CN (1) | CN101821223B (OSRAM) |
| AP (1) | AP2785A (OSRAM) |
| AR (1) | AR068403A1 (OSRAM) |
| AU (1) | AU2008298943B2 (OSRAM) |
| BR (1) | BRPI0816694A2 (OSRAM) |
| CA (1) | CA2698245C (OSRAM) |
| CO (1) | CO6270255A2 (OSRAM) |
| EA (1) | EA019431B1 (OSRAM) |
| ES (1) | ES2562080T3 (OSRAM) |
| MX (1) | MX2010002783A (OSRAM) |
| NZ (1) | NZ583647A (OSRAM) |
| PT (1) | PT2190804E (OSRAM) |
| TW (1) | TWI419867B (OSRAM) |
| UA (1) | UA101956C2 (OSRAM) |
| WO (1) | WO2009036161A1 (OSRAM) |
| ZA (1) | ZA201002066B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1564210T1 (sl) * | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
| SG170795A1 (en) * | 2005-12-30 | 2011-05-30 | Gilead Sciences Inc | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| WO2007102499A1 (ja) * | 2006-03-06 | 2007-09-13 | Japan Tobacco Inc. | ４－オキソキノリン化合物の製造方法 |
| BRPI0708685B8 (pt) | 2006-03-06 | 2021-05-25 | Japan Tobacco Inc | composto de 4-oxoquinolina, seu uso e método para produção dos mesmos |
| CA2661943C (en) | 2006-09-12 | 2015-11-03 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| EP2167088A1 (en) * | 2007-06-29 | 2010-03-31 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| JP5547067B2 (ja) * | 2007-06-29 | 2014-07-09 | ギリアード サイエンシーズ， インコーポレイテッド | 治療組成物およびその使用 |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
| CN102212032B (zh) * | 2011-04-20 | 2013-07-31 | 复旦大学 | 一种5-羟基喹诺酮类衍生物及其制备方法和用途 |
| CA2856722C (en) | 2011-11-30 | 2022-11-22 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
| EA026089B1 (ru) * | 2012-08-03 | 2017-02-28 | Джилид Сайэнс, Инк. | Способ и промежуточные соединения для получения ингибиторов интегразы |
| CZ304984B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru |
| CZ304983B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Způsob výroby a nové intermediáty syntézy elvitegraviru |
| AU2013361401C1 (en) | 2012-12-21 | 2018-08-09 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| PL3019503T3 (pl) | 2013-07-12 | 2018-01-31 | Gilead Sciences Inc | Policykliczne związki karbamoilopirydonowe i ich zastosowanie do leczenia infekcji hiv |
| NO2865735T3 (OSRAM) | 2013-07-12 | 2018-07-21 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (OSRAM) | 2014-06-20 | 2018-06-23 | ||
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| CN110790773A (zh) | 2015-04-02 | 2020-02-14 | 吉利德科学公司 | 多环氨甲酰基吡啶酮化合物及其药物用途 |
| CN111733133B (zh) * | 2020-07-22 | 2020-12-01 | 华夏源(上海)生命科技有限公司 | 一种促进表皮干细胞分化和生长的方法 |
| CN111944761B (zh) * | 2020-08-23 | 2021-03-26 | 泉州伟业生物医学科技有限公司 | 促进表皮干细胞分化和生长的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564210A (en) * | 1925-12-08 | Obin d | ||
| DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
| AU2002229057B2 (en) * | 2000-12-14 | 2005-04-21 | Warner Chilcott Company, Llc | Cyclization process step in the making of quinolones and naphthyridines |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| US20050104233A1 (en) * | 2002-05-31 | 2005-05-19 | Shinji Kato | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| SI1564210T1 (sl) * | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
| EP1582524B1 (en) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Method of preparing organomagnesium compounds |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| EP2332538A1 (en) | 2004-05-21 | 2011-06-15 | Japan Tobacco, Inc. | Combinations comprising a 4-isoquinolone derivative and anti-HIV agents |
| WO2007063869A1 (ja) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | 高純度キノロン化合物の製造方法 |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| WO2007102499A1 (ja) | 2006-03-06 | 2007-09-13 | Japan Tobacco Inc. | ４－オキソキノリン化合物の製造方法 |
| BRPI0708685B8 (pt) * | 2006-03-06 | 2021-05-25 | Japan Tobacco Inc | composto de 4-oxoquinolina, seu uso e método para produção dos mesmos |
| TW200811153A (en) * | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| CA2661943C (en) * | 2006-09-12 | 2015-11-03 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| EP2167088A1 (en) * | 2007-06-29 | 2010-03-31 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| JP5547067B2 (ja) * | 2007-06-29 | 2014-07-09 | ギリアード サイエンシーズ， インコーポレイテッド | 治療組成物およびその使用 |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2008
- 2008-09-10 AR ARP080103928A patent/AR068403A1/es unknown
- 2008-09-11 WO PCT/US2008/076002 patent/WO2009036161A1/en not_active Ceased
- 2008-09-11 MX MX2010002783A patent/MX2010002783A/es active IP Right Grant
- 2008-09-11 AU AU2008298943A patent/AU2008298943B2/en not_active Ceased
- 2008-09-11 CN CN200880106554.2A patent/CN101821223B/zh not_active Expired - Fee Related
- 2008-09-11 EA EA201070256A patent/EA019431B1/ru not_active IP Right Cessation
- 2008-09-11 US US12/676,553 patent/US8153801B2/en active Active
- 2008-09-11 JP JP2010524261A patent/JP5202635B2/ja not_active Expired - Fee Related
- 2008-09-11 NZ NZ583647A patent/NZ583647A/en not_active IP Right Cessation
- 2008-09-11 CA CA2698245A patent/CA2698245C/en not_active Expired - Fee Related
- 2008-09-11 KR KR1020107007731A patent/KR101488550B1/ko not_active Expired - Fee Related
- 2008-09-11 TW TW097134842A patent/TWI419867B/zh not_active IP Right Cessation
- 2008-09-11 BR BRPI0816694 patent/BRPI0816694A2/pt not_active IP Right Cessation
- 2008-09-11 US US12/208,952 patent/US20090099366A1/en not_active Abandoned
- 2008-09-11 EP EP08830255.9A patent/EP2190804B1/en active Active
- 2008-09-11 AP AP2010005187A patent/AP2785A/xx active
- 2008-09-11 PT PT88302559T patent/PT2190804E/pt unknown
- 2008-09-11 ES ES08830255.9T patent/ES2562080T3/es active Active
- 2008-11-09 UA UAA201003978A patent/UA101956C2/uk unknown
-
2010
- 2010-03-24 ZA ZA2010/02066A patent/ZA201002066B/en unknown
- 2010-04-05 CO CO10037836A patent/CO6270255A2/es active IP Right Grant
-
2012
- 2012-03-06 US US13/413,518 patent/US8440831B2/en active Active
-
2013
- 2013-02-12 JP JP2013024589A patent/JP2013129659A/ja not_active Withdrawn
- 2013-04-23 US US13/868,836 patent/US8759525B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |