AR068403A1 - Proceso e intermediarios para la preparacion de inhibidores de integrasa - Google Patents
Proceso e intermediarios para la preparacion de inhibidores de integrasaInfo
- Publication number
- AR068403A1 AR068403A1 ARP080103928A ARP080103928A AR068403A1 AR 068403 A1 AR068403 A1 AR 068403A1 AR P080103928 A ARP080103928 A AR P080103928A AR P080103928 A ARP080103928 A AR P080103928A AR 068403 A1 AR068403 A1 AR 068403A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- integrasa
- intermediaries
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97139507P | 2007-09-11 | 2007-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068403A1 true AR068403A1 (es) | 2009-11-18 |
Family
ID=39887255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103928A AR068403A1 (es) | 2007-09-11 | 2008-09-10 | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8153801B2 (OSRAM) |
| EP (1) | EP2190804B1 (OSRAM) |
| JP (2) | JP5202635B2 (OSRAM) |
| KR (1) | KR101488550B1 (OSRAM) |
| CN (1) | CN101821223B (OSRAM) |
| AP (1) | AP2785A (OSRAM) |
| AR (1) | AR068403A1 (OSRAM) |
| AU (1) | AU2008298943B2 (OSRAM) |
| BR (1) | BRPI0816694A2 (OSRAM) |
| CA (1) | CA2698245C (OSRAM) |
| CO (1) | CO6270255A2 (OSRAM) |
| EA (1) | EA019431B1 (OSRAM) |
| ES (1) | ES2562080T3 (OSRAM) |
| MX (1) | MX2010002783A (OSRAM) |
| NZ (1) | NZ583647A (OSRAM) |
| PT (1) | PT2190804E (OSRAM) |
| TW (1) | TWI419867B (OSRAM) |
| UA (1) | UA101956C2 (OSRAM) |
| WO (1) | WO2009036161A1 (OSRAM) |
| ZA (1) | ZA201002066B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60329318D1 (de) * | 2002-11-20 | 2009-10-29 | Japan Tobacco Inc | 4-oxochinolinverbindungen und deren verwendung als hiv-integrase-inhibitoren |
| SG170795A1 (en) * | 2005-12-30 | 2011-05-30 | Gilead Sciences Inc | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| CN101437801B (zh) | 2006-03-06 | 2013-02-06 | 日本烟草产业株式会社 | 制备4-氧代喹啉化合物的方法 |
| BRPI0708685B8 (pt) | 2006-03-06 | 2021-05-25 | Japan Tobacco Inc | composto de 4-oxoquinolina, seu uso e método para produção dos mesmos |
| TWI411602B (zh) | 2006-09-12 | 2013-10-11 | Gilead Sciences Inc | 製造整合酶抑制劑的方法及彼所用的中間物 |
| TW200914011A (en) * | 2007-06-29 | 2009-04-01 | Gilead Sciences Inc | Therapeutic compositions and methods |
| NZ582089A (en) * | 2007-06-29 | 2013-01-25 | Gilead Sciences Inc | Antiviral Combination of elvitegravir, lopinavir and optionally ritonavir |
| AR068403A1 (es) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
| CN102212032B (zh) * | 2011-04-20 | 2013-07-31 | 复旦大学 | 一种5-羟基喹诺酮类衍生物及其制备方法和用途 |
| WO2013082476A1 (en) | 2011-11-30 | 2013-06-06 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
| AU2013296289B2 (en) * | 2012-08-03 | 2017-10-05 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| CZ304983B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Způsob výroby a nové intermediáty syntézy elvitegraviru |
| CZ304984B6 (cs) * | 2012-10-12 | 2015-03-11 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy elvitegraviru |
| PE20151499A1 (es) | 2012-12-21 | 2015-10-29 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico |
| NO2865735T3 (OSRAM) | 2013-07-12 | 2018-07-21 | ||
| EP3252058B1 (en) | 2013-07-12 | 2021-01-20 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (OSRAM) | 2014-06-20 | 2018-06-23 | ||
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| KR20190057158A (ko) | 2015-04-02 | 2019-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| CN111733133B (zh) * | 2020-07-22 | 2020-12-01 | 华夏源(上海)生命科技有限公司 | 一种促进表皮干细胞分化和生长的方法 |
| CN111944761B (zh) * | 2020-08-23 | 2021-03-26 | 泉州伟业生物医学科技有限公司 | 促进表皮干细胞分化和生长的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564210A (en) * | 1925-12-08 | Obin d | ||
| DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
| CZ20031379A3 (cs) * | 2000-12-14 | 2003-11-12 | The Procter & Gamble Company | Cyklizační postupový krok při výrobě chinolonů a nafthyridinů |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| US20050104233A1 (en) * | 2002-05-31 | 2005-05-19 | Shinji Kato | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) * | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| DE60329318D1 (de) * | 2002-11-20 | 2009-10-29 | Japan Tobacco Inc | 4-oxochinolinverbindungen und deren verwendung als hiv-integrase-inhibitoren |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| EP1582524B1 (en) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Method of preparing organomagnesium compounds |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| WO2005113509A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| EP3287130A1 (en) | 2004-05-21 | 2018-02-28 | Japan Tobacco Inc. | Combinations comprising a 4-isoquinolone derivative and protease inhibitors |
| WO2007063869A1 (ja) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | 高純度キノロン化合物の製造方法 |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| CN101437801B (zh) | 2006-03-06 | 2013-02-06 | 日本烟草产业株式会社 | 制备4-氧代喹啉化合物的方法 |
| BRPI0708685B8 (pt) * | 2006-03-06 | 2021-05-25 | Japan Tobacco Inc | composto de 4-oxoquinolina, seu uso e método para produção dos mesmos |
| TW200811153A (en) * | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| TWI411602B (zh) * | 2006-09-12 | 2013-10-11 | Gilead Sciences Inc | 製造整合酶抑制劑的方法及彼所用的中間物 |
| NZ582089A (en) * | 2007-06-29 | 2013-01-25 | Gilead Sciences Inc | Antiviral Combination of elvitegravir, lopinavir and optionally ritonavir |
| TW200914011A (en) * | 2007-06-29 | 2009-04-01 | Gilead Sciences Inc | Therapeutic compositions and methods |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2008
- 2008-09-10 AR ARP080103928A patent/AR068403A1/es unknown
- 2008-09-11 ES ES08830255.9T patent/ES2562080T3/es active Active
- 2008-09-11 EP EP08830255.9A patent/EP2190804B1/en active Active
- 2008-09-11 US US12/676,553 patent/US8153801B2/en active Active
- 2008-09-11 AP AP2010005187A patent/AP2785A/xx active
- 2008-09-11 BR BRPI0816694 patent/BRPI0816694A2/pt not_active IP Right Cessation
- 2008-09-11 JP JP2010524261A patent/JP5202635B2/ja not_active Expired - Fee Related
- 2008-09-11 TW TW097134842A patent/TWI419867B/zh not_active IP Right Cessation
- 2008-09-11 EA EA201070256A patent/EA019431B1/ru not_active IP Right Cessation
- 2008-09-11 KR KR1020107007731A patent/KR101488550B1/ko not_active Expired - Fee Related
- 2008-09-11 CA CA2698245A patent/CA2698245C/en not_active Expired - Fee Related
- 2008-09-11 AU AU2008298943A patent/AU2008298943B2/en not_active Ceased
- 2008-09-11 US US12/208,952 patent/US20090099366A1/en not_active Abandoned
- 2008-09-11 MX MX2010002783A patent/MX2010002783A/es active IP Right Grant
- 2008-09-11 CN CN200880106554.2A patent/CN101821223B/zh not_active Expired - Fee Related
- 2008-09-11 PT PT88302559T patent/PT2190804E/pt unknown
- 2008-09-11 NZ NZ583647A patent/NZ583647A/en not_active IP Right Cessation
- 2008-09-11 WO PCT/US2008/076002 patent/WO2009036161A1/en not_active Ceased
- 2008-11-09 UA UAA201003978A patent/UA101956C2/uk unknown
-
2010
- 2010-03-24 ZA ZA2010/02066A patent/ZA201002066B/en unknown
- 2010-04-05 CO CO10037836A patent/CO6270255A2/es active IP Right Grant
-
2012
- 2012-03-06 US US13/413,518 patent/US8440831B2/en active Active
-
2013
- 2013-02-12 JP JP2013024589A patent/JP2013129659A/ja not_active Withdrawn
- 2013-04-23 US US13/868,836 patent/US8759525B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |