MX2009005797A - Derivado de acido carboxilico. - Google Patents

Derivado de acido carboxilico.

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Publication number
MX2009005797A
MX2009005797A MX2009005797A MX2009005797A MX2009005797A MX 2009005797 A MX2009005797 A MX 2009005797A MX 2009005797 A MX2009005797 A MX 2009005797A MX 2009005797 A MX2009005797 A MX 2009005797A MX 2009005797 A MX2009005797 A MX 2009005797A
Authority
MX
Mexico
Prior art keywords
carboxylic acid
acid derivative
remedy
preventive
diabetes
Prior art date
Application number
MX2009005797A
Other languages
English (en)
Inventor
Norio Asai
Kei Ohnuki
Daisuke Suzuki
Yasuhiro Yonetoku
Kazuyuki Tsuchiya
Kenji Negoro
Fumiyoshi Iwasaki
Toshio Kurosaki
Shigeru Yoshida
Takatoshi Soga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009005797A publication Critical patent/MX2009005797A/es

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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/161,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

[PROBLEMAS] Proporcionar un compuesto que se puede usar como un fármaco, en particular un secretagogo de insulina o un preventivo o remedio para una enfermedad en la cual participa el GPR40, tal como la diabetes o similares. [MEDIOS PARA RESOLVER LOS PROBLEMAS] Se encontró que un novedoso derivado de ácido carboxílico, que se caracteriza porque un ácido carboxílico está unido por medo de dos átomos a un anillo aromático monocíclico de 6 miembros y este anillo aromático está unido además por medio de un enlazante a un anillo bicíclico que contiene nitrógeno, o su sal, tiene una excelente actividad agonista de GPR40. Debido a que presenta excelentes efectos para promover la secreción de insulina y para disminuir el nivel de glucosa en sangre, este derivado de ácido carboxílico es útil como un secretagogo de insulina o como un preventivo o un remedio para la diabetes.
MX2009005797A 2006-12-01 2007-11-29 Derivado de acido carboxilico. MX2009005797A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006325388 2006-12-01
PCT/JP2007/073014 WO2008066097A1 (en) 2006-12-01 2007-11-29 Carboxylic acid derivative

Publications (1)

Publication Number Publication Date
MX2009005797A true MX2009005797A (es) 2009-06-08

Family

ID=39467887

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005797A MX2009005797A (es) 2006-12-01 2007-11-29 Derivado de acido carboxilico.

Country Status (15)

Country Link
US (1) US20100152165A1 (es)
EP (1) EP2096109A1 (es)
JP (1) JPWO2008066097A1 (es)
KR (1) KR20090083935A (es)
CN (1) CN101553469A (es)
AR (1) AR064049A1 (es)
AU (1) AU2007326449A1 (es)
CA (1) CA2671080A1 (es)
IL (1) IL198970A0 (es)
MX (1) MX2009005797A (es)
NO (1) NO20092471L (es)
RU (1) RU2009125019A (es)
TW (1) TW200838526A (es)
WO (1) WO2008066097A1 (es)
ZA (1) ZA200903646B (es)

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