AR064049A1 - Derivados de acidos carboxilicos unidos a heterociclos, composiciones farmaceuticas que los contienen, y usos como promotores de la secrecion de insulina en el tratamiento de la diabetes mellitus. - Google Patents

Derivados de acidos carboxilicos unidos a heterociclos, composiciones farmaceuticas que los contienen, y usos como promotores de la secrecion de insulina en el tratamiento de la diabetes mellitus.

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Publication number
AR064049A1
AR064049A1 ARP070105327A ARP070105327A AR064049A1 AR 064049 A1 AR064049 A1 AR 064049A1 AR P070105327 A ARP070105327 A AR P070105327A AR P070105327 A ARP070105327 A AR P070105327A AR 064049 A1 AR064049 A1 AR 064049A1
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AR
Argentina
Prior art keywords
aryl
heterocyclic group
lower alkylene
lower alkyl
alkylene
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ARP070105327A
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English (en)
Inventor
Norio Asai
Yasuhiro Yonetoku
Kei Ohnuki
Shigeru Yoshida
Kenji Negoro
Fumiyoshi Iwasaki
Takatoshi Soga
Kazuyuki Tsuchiya
Toshio Kurosaki
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Astellas Pharma Inc
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Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of AR064049A1 publication Critical patent/AR064049A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Reivindicacion 1: Un derivado de ácido carboxílico representado por la siguiente formula (1), o una sal farmacéuticamente aceptable del mismo (los símbolos de la formula representan los siguientes significados; R1: -H, alquilo inferior, halogeno- alquilo inferior, cicloalquilo, arilo, grupo heterocíclico, alquileno inferior-RA, C(O)RB, -CO2RB o -S(O)pRB, con la condicion de que el alquileno inferior, arilo y grupo heterocíclico de R1 puedan estar respectivamente sustituidos, RA: cicloalquilo, arilo, grupo heterocíclico, -S(O)pR0, -S(O)p-arilo, -S(O)p-grupo heterocíclico, -C(O)R0, -C(O)-arilo, -C(O)-grupo heterocíclico, -CO2R0, -OR0, -O-arilo, -O-grupo heterocíclico, -N(R0)2, -N(R0)-arilo, -N(R0)-grupo heterocíclico, - CO(R0)(arilo)2, -C(O)N(R0)-cicloalquilo o -C(O)N(R0)-arilo, con la condicion de que el arilo y el grupo heterocíclico de RA puedan estar respectivamente sustituidos, RB: alquilo inferior, halogeno-alquilo inferior, cicloalquilo, arilo, grupo heterocíclico, alquileno inferior-cicloalquilo, alquileno inferior-arilo, alquileno inferior-grupo heterocíclico, alquileno inferior-OR0, alquileno inferior-O-arilo o alquileno inferior-S(O)2NH2, con la condicion de que el arilo y el grupo heterocíclico de RB puedan estar respectivamente sustituidos, R0: -H o alquilo inferior, n y p: son iguales o diferentes entre sí y cada uno de ellos representa 0, 1 o 2, J: -C(R6)(R7)-, -O- o -S-, R2, R3, R6 y R7: son iguales o diferentes entre sí y cada uno de ellos representa -H, halogeno, alquilo inferior, -OR0 o arilo, con la condicion de que R2 y R3, R3 y R6, y R6 y R7 pueden formar juntos un alquileno inferior, R4: -H o alquilo inferior, X: enlace sencillo, -CH2-, -(CH2)2-, -O-, -S-, - S(O)- o -S(O)2-, Y: -CH2- o -C(O)-, Z: C(-*), C(R8), N o N(O), con la condicion de que el * de Z signifiqué union a L, X1 y X2: son iguales o diferentes entre sí y cada uno de ellos representa C(R9), N o N(O), X3 y X4: son iguales o diferentes entre sí y cada uno de ellos representa C(R10), N o N(O), R5: alquilo inferior, halogeno, halogeno-alquilo inferior, -OR0 o -O-halogeno-alquilo inferior, R8, R9 y R10: son iguales o diferentes entre sí y cada uno de ellos representa -H, alquilo inferior, halogeno, halogeno-alquilo inferior, -OR0 o -O- halogeno-alquilo inferior, con la condicion de que R6 y R10 pueden formar juntos un alquileno inferior, -O-alquileno inferior o alquileno inferior-O-, L: -O-alquileno inferior, alquileno inferior-O-, - N(R11)-alquileno inferior, alquileno inferior-N(R11), -O-alquileno inferior-O-, -N(R11)-alquileno inferior-N(R11)-, -O-alquileno inferior-N(R11)- o -N(R11)-alquileno inferior-O-, y R11: -H, alquilo inferior o -C(O)R0).
ARP070105327A 2006-12-01 2007-11-30 Derivados de acidos carboxilicos unidos a heterociclos, composiciones farmaceuticas que los contienen, y usos como promotores de la secrecion de insulina en el tratamiento de la diabetes mellitus. AR064049A1 (es)

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US (1) US20100152165A1 (es)
EP (1) EP2096109A1 (es)
JP (1) JPWO2008066097A1 (es)
KR (1) KR20090083935A (es)
CN (1) CN101553469A (es)
AR (1) AR064049A1 (es)
AU (1) AU2007326449A1 (es)
CA (1) CA2671080A1 (es)
IL (1) IL198970A0 (es)
MX (1) MX2009005797A (es)
NO (1) NO20092471L (es)
RU (1) RU2009125019A (es)
TW (1) TW200838526A (es)
WO (1) WO2008066097A1 (es)
ZA (1) ZA200903646B (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR074760A1 (es) * 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
CN102421739A (zh) * 2009-04-22 2012-04-18 安斯泰来制药株式会社 羧酸化合物
US20120172351A1 (en) 2009-06-09 2012-07-05 Nobuyuki Negoro Novel fused cyclic compound and use thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2820005A1 (en) * 2012-02-28 2015-01-07 Piramal Enterprises Limited Phenyl alkanoic acid derivatives as gpr agonists
EP2872127A1 (en) 2012-07-11 2015-05-20 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
CA2880901A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2911655A1 (en) 2012-10-24 2015-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Tpl2 kinase inhibitors for preventing or treating diabetes and for promoting -cell survival
TWI692469B (zh) * 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
EP2746259A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746260A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
WO2014130608A1 (en) 2013-02-22 2014-08-28 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US10519115B2 (en) 2013-11-15 2019-12-31 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
EP3092240B1 (en) * 2014-01-10 2018-12-05 Eli Lilly and Company Isopropyl triazolo pyridine compounds
EP3102198B1 (en) 2014-02-06 2020-08-26 Merck Sharp & Dohme Corp. Antidiabetic compounds
WO2015176267A1 (en) * 2014-05-22 2015-11-26 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US10100042B2 (en) 2014-08-08 2018-10-16 Merck Sharp & Dohme Corp. [5,6]—fused bicyclic antidiabetic compounds
EP3177282B1 (en) 2014-08-08 2021-10-06 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
US10968193B2 (en) 2014-08-08 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
DK3186242T3 (da) 2014-08-29 2021-12-20 Tes Pharma S R L Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
DK3325490T3 (da) * 2015-07-23 2020-02-03 Takeda Pharmaceuticals Co 1-substituerede 1,2,3,4-tetrahydro-1,7-naphthyridin-8-aminderivater og deres anvendelse som ep4-receptorantagonister
US10703712B2 (en) 2015-09-16 2020-07-07 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US20190062277A1 (en) * 2015-09-16 2019-02-28 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2017049172A1 (en) 2015-09-16 2017-03-23 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
EP3350166A4 (en) 2015-09-16 2019-05-01 Metacrine, Inc. FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF
US10676458B2 (en) 2016-03-29 2020-06-09 Merch Sharp & Dohne Corp. Rahway Antidiabetic bicyclic compounds
CN110088089B (zh) * 2016-10-25 2023-08-29 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷甲酸、药物组合物及其用途
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
CN110312714B (zh) * 2017-01-26 2022-12-09 勃林格殷格翰国际有限公司 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途
JP7050791B2 (ja) 2017-01-26 2022-04-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンジルオキシピリジルシクロプロパンカルボン酸、その医薬組成物及び使用
EP3573959B1 (en) * 2017-01-26 2021-07-28 Boehringer Ingelheim International GmbH Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
EP3573952B1 (en) * 2017-01-26 2021-07-14 Boehringer Ingelheim International GmbH Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceuticalcompositions and uses thereof
EP3580222B1 (en) 2017-02-08 2021-04-07 Boehringer Ingelheim International GmbH Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
EP3709995A4 (en) 2017-11-16 2021-04-14 Merck Sharp & Dohme Corp. BICYCLIC ANTIDIABETIC COMPOUNDS
CN110092774B (zh) * 2018-01-29 2022-04-08 中国科学院上海药物研究所 芳香丙酸类衍生物、及其制备方法和用途
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN112041311B (zh) 2018-04-19 2023-10-03 吉利德科学公司 Pd-1/pd-l1抑制剂
EP4234030A3 (en) 2018-07-13 2023-10-18 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN114163426B (zh) * 2020-09-10 2024-03-19 上海爱博医药科技有限公司 苯并含氧杂环类化合物及其医药应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960369B2 (en) 2002-11-08 2011-06-14 Takeda Pharmaceutical Company Limited Receptor function regulator
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
US7192970B2 (en) 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
CA2527691C (en) 2003-05-30 2013-01-22 Takeda Pharmaceutical Company Limited Condensed ring compound
WO2005019151A1 (en) 2003-08-20 2005-03-03 Eli Lilly And Company Ppar modulators
US20070093476A1 (en) 2003-10-28 2007-04-26 Bhunia Debnath Novel compounds and their use in medicine,as antidiabetic and hypolipidemic agents, process for their preparation and pharmaceutical compositions containing them
WO2005051890A1 (en) 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
RU2006126978A (ru) 2003-12-25 2008-01-27 Такеда Фармасьютикал Компани Лимитед (Jp) Производные 3-(4-бензилоксифенил)пропановой кислоты
JP4855777B2 (ja) 2003-12-26 2012-01-18 武田薬品工業株式会社 フェニルプロパン酸誘導体
CN1946666A (zh) 2004-02-27 2007-04-11 埃姆艮股份有限公司 用于治疗代谢性疾病的化合物、药物组合物和方法
WO2005087710A1 (ja) 2004-03-15 2005-09-22 Takeda Pharmaceutical Company Limited アミノフェニルプロパン酸誘導体
WO2005095338A1 (ja) 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited アルコキシフェニルプロパン酸誘導体

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