MX2009003354A - Proceso para la preparacion de fluorometil 2,2,2,-trifluoro-1-(tri fluorometil) etil eter. - Google Patents

Proceso para la preparacion de fluorometil 2,2,2,-trifluoro-1-(tri fluorometil) etil eter.

Info

Publication number
MX2009003354A
MX2009003354A MX2009003354A MX2009003354A MX2009003354A MX 2009003354 A MX2009003354 A MX 2009003354A MX 2009003354 A MX2009003354 A MX 2009003354A MX 2009003354 A MX2009003354 A MX 2009003354A MX 2009003354 A MX2009003354 A MX 2009003354A
Authority
MX
Mexico
Prior art keywords
fluoromethyl
trifluoro
preparation
ethyl ether
sevoflurane
Prior art date
Application number
MX2009003354A
Other languages
English (en)
Inventor
Ogari Pacheco
Antonio Carlos Teixeira
Edson Luiz Lima
Maria Alice Boeckelmann
Original Assignee
Cristalia Prod Quimicos Farm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cristalia Prod Quimicos Farm filed Critical Cristalia Prod Quimicos Farm
Publication of MX2009003354A publication Critical patent/MX2009003354A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/44—Separation; Purification; Stabilisation; Use of additives by treatments giving rise to a chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de fluorometil 2,2,2-trifluoro-1-(trifluorometil) etil éter (sevoflurano) que incluye un paso que consiste en reaccionar hexafluoroisopropanol con un equivalente de formaldehído seleccionado entre el paraformaldehído o 1,3,5-trioxano, un agente de cloración seleccionado del grupo que consiste en cloruro de oxalilo, tricloruro de fósforo, pentacloruro fósforo, oxicloruro de fósforo, cloruro de sulfurilo y cloruro de tionilo, y un ácido fuerte seleccionado del grupo que consiste en ácido sulfúrico concentrado o fumante resultando en la formación de sevoclorano intermediario que es convertido en sevoflurano en un segundo paso que consiste en reaccionar sevoclorano con un fluoruro de metal alcalino, o un fluoruro de amonio cuaternario tetra-alquilo de cadena lineal o ramificada en presencia de una cantidad subestequiométrica de un yoduro de metal alcalino, o yoduro de amonio cuaternario tetra-alquilo de cadena lineal o ramificada, preferentemente en un solvente.
MX2009003354A 2006-09-29 2006-09-29 Proceso para la preparacion de fluorometil 2,2,2,-trifluoro-1-(tri fluorometil) etil eter. MX2009003354A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2006/000198 WO2008037040A2 (en) 2006-09-29 2006-09-29 Process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether

Publications (1)

Publication Number Publication Date
MX2009003354A true MX2009003354A (es) 2009-04-14

Family

ID=39230552

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003354A MX2009003354A (es) 2006-09-29 2006-09-29 Proceso para la preparacion de fluorometil 2,2,2,-trifluoro-1-(tri fluorometil) etil eter.

Country Status (8)

Country Link
US (1) US8044247B2 (es)
EP (1) EP2066609B1 (es)
JP (1) JP5021745B2 (es)
CN (1) CN101679169B (es)
BR (1) BRPI0622034B1 (es)
HK (1) HK1142588A1 (es)
MX (1) MX2009003354A (es)
WO (1) WO2008037040A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2069278B1 (en) * 2006-09-29 2016-01-06 Cristália Produtos Químicos Farmacêuticos Ltda. Process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether
CN101314560B (zh) * 2008-07-02 2011-06-15 鲁南制药集团股份有限公司 七氟烷的合成方法
CN101462929B (zh) * 2009-01-08 2011-07-20 中国中化集团公司 用作吸入麻醉剂的异氟醚的制备方法
CA2769797A1 (en) 2009-08-10 2011-02-17 Solvay Fluor Gmbh Process for the manufacture of sevoflurane
CN102199076B (zh) * 2010-03-25 2014-05-14 上海源力生物技术有限公司 制备七氟烷的方法
US8729313B2 (en) * 2011-08-15 2014-05-20 Baxter International Inc. Process for the manufacturing of sevoflurane
RU2479566C1 (ru) * 2012-01-11 2013-04-20 Общество с ограниченной ответственностью "Пермская химическая компания" Способ получения севофлурана
CN103360222A (zh) * 2013-07-29 2013-10-23 中国科学院上海有机化学研究所 2,2,2-三氟乙基1,1,2,3,3,3-六氟丙基醚的制备
CN107698430B (zh) * 2017-11-01 2021-01-08 华东医药（西安）博华制药有限公司 一种七氟烷反应液的后处理方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL32586A (en) 1968-10-28 1973-11-28 Baxter Laboratories Inc 1,3-polyhalo-2-propyl methyl and halomethyl ethers and their preparation
US3689571A (en) 1970-07-31 1972-09-05 Baxter Laboratories Inc Fluorinated ether
FR2416237A1 (fr) * 1978-02-01 1979-08-31 Dia Prosim Procede de chloromethylation de polymeres en vue de la preparation de resines echangeuses d'ions anioniques
JPS6049170B2 (ja) * 1979-10-31 1985-10-31 株式会社クラレ β−アルコキシエトキシメチルハライドの製造方法
JP3441735B2 (ja) * 1996-02-21 2003-09-02 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルの製造方法
US6100434A (en) * 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
MX2007005899A (es) * 2004-11-17 2007-07-24 Minrad Inc Metodo para la preparacion de sevoflurano.

Also Published As

Publication number Publication date
US20090247791A1 (en) 2009-10-01
HK1142588A1 (en) 2010-12-10
WO2008037040A2 (en) 2008-04-03
WO2008037040A3 (en) 2009-02-12
EP2066609A4 (en) 2010-04-28
EP2066609B1 (en) 2016-01-06
CN101679169B (zh) 2012-12-19
JP5021745B2 (ja) 2012-09-12
US8044247B2 (en) 2011-10-25
EP2066609A2 (en) 2009-06-10
BRPI0622034B1 (pt) 2021-06-22
CN101679169A (zh) 2010-03-24
JP2010504917A (ja) 2010-02-18
BRPI0622034A2 (pt) 2014-04-22

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