CO6341607A2 - Metodo de sintesis de sevoflurano - Google Patents

Metodo de sintesis de sevoflurano

Info

Publication number
CO6341607A2
CO6341607A2 CO11011833A CO11011833A CO6341607A2 CO 6341607 A2 CO6341607 A2 CO 6341607A2 CO 11011833 A CO11011833 A CO 11011833A CO 11011833 A CO11011833 A CO 11011833A CO 6341607 A2 CO6341607 A2 CO 6341607A2
Authority
CO
Colombia
Prior art keywords
sevoflurane
isopropanol
halomethyl
generate
sevofluran
Prior art date
Application number
CO11011833A
Other languages
English (en)
Inventor
Zhao Zhiquan
Original Assignee
Lunan Pharm Group Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lunan Pharm Group Corp filed Critical Lunan Pharm Group Corp
Publication of CO6341607A2 publication Critical patent/CO6341607A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C07C43/123—Saturated ethers containing halogen both carbon chains are substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención proporciona un método de síntesis de sevoflurano, que comprende las siguientes etapas: tomar hexafluoro isopropanol como material de partida y hacerlo reaccionar con trioximetileno (o paraformaldehido) en presencia de ácido para generar formal-derivados del dihexafluoro isopropanol, agregar trihaluro de aluminio anhidro para generar halometil 2, 2, 2-trifluoro-1- (trifluorometil) etil éter, luego hacer reaccionar el compuesto halometil con fluoruro metálico para formar el sevoflurano. El método es de bajo costo, y la condición de reacción es fácil de implementar, y se produce sevoflurano a gran escala.
CO11011833A 2008-07-02 2011-02-02 Metodo de sintesis de sevoflurano CO6341607A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200810129596XA CN101314560B (zh) 2008-07-02 2008-07-02 七氟烷的合成方法

Publications (1)

Publication Number Publication Date
CO6341607A2 true CO6341607A2 (es) 2011-11-21

Family

ID=40105714

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11011833A CO6341607A2 (es) 2008-07-02 2011-02-02 Metodo de sintesis de sevoflurano

Country Status (9)

Country Link
US (1) US20110105803A1 (es)
EP (1) EP2308819B1 (es)
JP (1) JP2011526253A (es)
KR (1) KR20110027826A (es)
CN (1) CN101314560B (es)
BR (1) BRPI0913926A2 (es)
CO (1) CO6341607A2 (es)
HK (1) HK1126182A1 (es)
WO (1) WO2010000136A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729313B2 (en) * 2011-08-15 2014-05-20 Baxter International Inc. Process for the manufacturing of sevoflurane
CN103804151A (zh) * 2012-11-07 2014-05-21 东莞市长安东阳光铝业研发有限公司 一种七氟醚的制备方法
DE202013105758U1 (de) 2013-12-18 2014-02-07 Holger Müller Halte-, Hebe- und Sicherungsvorrichtung zur Anbringung an hohen, turmartigen Bauwerken
RU2656210C1 (ru) * 2017-10-17 2018-06-01 Федеральное государственное унитарное предприятие "Российский научный центр "Прикладная химия" Способ получения 2-(фторметокси)-1,1,1,3,3,3-гексафторизопропана (севофлурана)
CN107698430B (zh) * 2017-11-01 2021-01-08 华东医药（西安）博华制药有限公司 一种七氟烷反应液的后处理方法
CN114539035B (zh) * 2021-03-10 2023-08-18 山东新时代药业有限公司 一种七氟烷的合成方法
CN114890875A (zh) * 2022-06-27 2022-08-12 山东华安新材料有限公司 一种七氟烷的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250334A (en) * 1979-12-26 1981-02-10 Baxter Travenol Laboratories, Inc. Method of synthesizing fluoromethylhexafluoroisopropyl ether
US4874901A (en) * 1988-05-06 1989-10-17 Boc, Inc. Process for the production of polyfluorinated ethers
JP3441735B2 (ja) * 1996-02-21 2003-09-02 セントラル硝子株式会社 フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルの製造方法
US6100434A (en) * 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
US6245949B1 (en) * 2000-06-01 2001-06-12 Abbott Laboratories Synthetic method for the fluoromethylation of alcohols
GB0031301D0 (en) * 2000-12-21 2001-01-31 Ici Plc Process for the production of fluoromethyl hexafluoroisopropyl ether
CN1293030C (zh) * 2005-05-25 2007-01-03 山东新时代药业有限公司 一氟代甲基醚的制备方法
BRPI0622034B1 (pt) * 2006-09-29 2021-06-22 Cristália Produtos Químicos Farmacêuticos Ltda Processo para preparação do éter fluorometil 2,2,2-trifluoro-1-(trifluorometil) etílico
CN101535231B (zh) * 2006-09-29 2012-12-19 克里斯泰利亚化学药物产品有限公司 制备氯甲基2,2,2-三氟-1-(三氟甲基)乙基醚的方法
CN101058533A (zh) * 2006-12-30 2007-10-24 上海沪梅化工科技发展有限公司 一种氟甲基－1,1,1,3,3,3－六氟异丙基醚的合成方法
CN100590111C (zh) * 2008-10-14 2010-02-17 重庆福安药业有限公司 一种七氟烷的新合成方法

Also Published As

Publication number Publication date
WO2010000136A1 (zh) 2010-01-07
JP2011526253A (ja) 2011-10-06
HK1126182A1 (en) 2009-08-28
CN101314560B (zh) 2011-06-15
BRPI0913926A2 (pt) 2015-10-20
US20110105803A1 (en) 2011-05-05
EP2308819A1 (en) 2011-04-13
KR20110027826A (ko) 2011-03-16
EP2308819A4 (en) 2012-02-29
EP2308819B1 (en) 2014-04-16
CN101314560A (zh) 2008-12-03

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