AR113808A1 - Método para la preparación de compuestos intermedios de azoxistrobina - Google Patents
Método para la preparación de compuestos intermedios de azoxistrobinaInfo
- Publication number
- AR113808A1 AR113808A1 ARP180103151A ARP180103151A AR113808A1 AR 113808 A1 AR113808 A1 AR 113808A1 AR P180103151 A ARP180103151 A AR P180103151A AR P180103151 A ARP180103151 A AR P180103151A AR 113808 A1 AR113808 A1 AR 113808A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- preparation
- addition
- sodium methoxide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 11
- 238000002360 preparation method Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 12
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 10
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 8
- 239000003054 catalyst Substances 0.000 abstract 5
- 239000000543 intermediate Substances 0.000 abstract 5
- 239000005730 Azoxystrobin Substances 0.000 abstract 4
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 abstract 4
- XJPZKYIHCLDXST-UHFFFAOYSA-N 4,6-dichloropyrimidine Chemical compound ClC1=CC(Cl)=NC=N1 XJPZKYIHCLDXST-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002351 wastewater Substances 0.000 abstract 2
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D247/00—Heterocyclic compounds containing rings having two nitrogen atoms as the only ring hetero atoms, according to more than one of groups C07D229/00 - C07D245/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/584—Recycling of catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente proporciona un método para la preparación de compuestos intermedios de azoxistrobina, que comprenden la reacción del compuesto de fórmula (A) y dicloropirimidina en presencia de un catalizador de trimetilamina con la adición de una solución de metóxido de sodio en metanol o la adición de metóxido de sodio y metanol por separado para producir una mezcla del compuesto de fórmula (B) y el compuesto de fórmula (C). El compuesto intermedio de fórmula (B) de azoxistrobina y el compuesto de fórmula (C) se sintetizan a partir del compuesto de fórmula (A) en la presente, que se cataliza por el uso de un catalizador de trimetilamina, para permitir que la reacción tenga alta eficiencia y alto rendimiento. Además, el catalizador de trimetilamina tiene un bajo punto de ebullición y por lo tanto se puede reciclar con facilidad de manera tal que se pueda reducir el contenido de nitrógeno amoniacal en aguas residuales, y las dificultades y altos costos para el procesamiento de aguas residuales también se puedan reducir. El catalizador de trimetilamina reciclado se puede reutilizar en la preparación de compuesto intermedio de fórmula (B), que también tiene un alto efecto catalítico y también puede lograr un alto rendimiento de producto. El método de la presente tiene ventajas significativas de costo y sintéticas, y es adecuado para la producción industrial. Reivindicación 1: Un método de preparación para compuestos intermedios de azoxistrobina, caracterizado porque el método de preparación comprende la reacción del compuesto de fórmula (A) y dicloropirimidina en presencia de un catalizador de trimetilamina con la adición de una solución de metóxido de sodio en metanol o la adición de metóxido de sodio y metanol por separado para producir una mezcla del compuesto intermedio de fórmula (B) de azoxistrobina y el compuesto de fórmula (C), con una ecuación de reacción de acuerdo con lo presentado en el Esquema (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711049390.1A CN109721545B (zh) | 2017-10-31 | 2017-10-31 | 一种嘧菌酯中间体的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR113808A1 true AR113808A1 (es) | 2020-06-10 |
Family
ID=61167920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180103151A AR113808A1 (es) | 2017-10-31 | 2018-10-30 | Método para la preparación de compuestos intermedios de azoxistrobina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10150741B1 (es) |
| EP (1) | EP3476837B1 (es) |
| JP (1) | JP6719527B2 (es) |
| KR (1) | KR102061868B1 (es) |
| CN (1) | CN109721545B (es) |
| AR (1) | AR113808A1 (es) |
| AU (1) | AU2018253450B2 (es) |
| BR (1) | BR102018002949B1 (es) |
| CA (1) | CA3022388C (es) |
| DK (1) | DK3476837T3 (es) |
| EA (1) | EA036250B1 (es) |
| ES (1) | ES2800576T3 (es) |
| HU (1) | HUE049906T2 (es) |
| IL (1) | IL262406B (es) |
| LT (1) | LT3476837T (es) |
| NZ (1) | NZ747549A (es) |
| PL (1) | PL3476837T3 (es) |
| PT (1) | PT3476837T (es) |
| SI (1) | SI3476837T1 (es) |
| TW (1) | TWI685488B (es) |
| UA (1) | UA120333C2 (es) |
| ZA (1) | ZA201807240B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112174897B (zh) * | 2020-09-18 | 2021-08-03 | 广东石油化工学院 | 一种嘧菌酯中间体的制备方法 |
| CN112403514B (zh) * | 2020-11-30 | 2023-05-19 | 河北威远生物化工有限公司 | 一种用于制备嘧菌酯中间体的催化体系及嘧菌酯的制备方法 |
| CN114685376A (zh) * | 2020-12-28 | 2022-07-01 | 北京颖泰嘉和生物科技股份有限公司 | 嘧菌酯中间体的制备方法 |
| WO2023203574A1 (en) * | 2022-04-22 | 2023-10-26 | Nacl Industries Limited | A process for preparation of azoxystrobin |
| CN115557901A (zh) * | 2022-10-21 | 2023-01-03 | 湖北有宜新材料科技有限公司 | 一种嘧啶呋喃酮的高效生产方法 |
| CN116120241A (zh) * | 2023-02-27 | 2023-05-16 | 江苏快达农化股份有限公司 | 一种复合催化剂合成嘧菌酯中间体的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE74711B1 (en) * | 1990-07-27 | 1997-07-30 | Ici Plc | Fungicides |
| GB9122430D0 (en) * | 1990-11-16 | 1991-12-04 | Ici Plc | Chemical process |
| UA53611C2 (uk) * | 1996-03-07 | 2003-02-17 | Амерікан Ціанамід Компані | Спосіб одержання несиметричних 4,6-біс(арилокси)піримідинових сполук |
| CN100564362C (zh) | 2007-10-24 | 2009-12-02 | 北京颖泰嘉和科技股份有限公司 | 嘧菌酯及其类似物的制备方法 |
| CN102311392B (zh) * | 2011-08-24 | 2014-01-22 | 重庆紫光化工股份有限公司 | 嘧菌酯及其合成中专用中间体的合成方法 |
| CN103214423B (zh) * | 2013-03-20 | 2016-03-16 | 北京颖泰嘉和生物科技股份有限公司 | 一种丙烯酸酯类化合物的制备方法 |
| WO2014203270A2 (en) * | 2013-06-19 | 2014-12-24 | Bhagiradha Chemicals & Industries Limited | Process for the preparation of acrylate derivatives |
| CN103467387B (zh) * | 2013-09-05 | 2016-03-16 | 北京颖泰嘉和生物科技股份有限公司 | 一种制备嘧菌酯及其中间体的方法 |
| CN104725321B (zh) * | 2013-12-20 | 2017-11-21 | 上海泰禾国际贸易有限公司 | 一种嘧菌酯中间体的制备方法 |
| WO2015102016A1 (en) * | 2013-12-31 | 2015-07-09 | Bhagiradha Chemicals & Industries Limited | Process for the preparation of methyl 2-[2-(6-chloropyrimidin-4-yloxy) phenyl]-3,3- dimethoxypropionate |
| CN104926736B (zh) | 2015-05-29 | 2019-05-17 | 重庆紫光化工股份有限公司 | 一种嘧菌酯及其中间体的合成方法 |
| CN106810502A (zh) * | 2015-11-29 | 2017-06-09 | 青岛森美克化工技术有限公司 | 一种嘧菌酯中间体的制备方法 |
-
2017
- 2017-10-31 CN CN201711049390.1A patent/CN109721545B/zh active Active
-
2018
- 2018-01-12 US US15/869,186 patent/US10150741B1/en active Active
- 2018-02-06 PL PL18155198T patent/PL3476837T3/pl unknown
- 2018-02-06 LT LTEP18155198.7T patent/LT3476837T/lt unknown
- 2018-02-06 SI SI201830074T patent/SI3476837T1/sl unknown
- 2018-02-06 PT PT181551987T patent/PT3476837T/pt unknown
- 2018-02-06 EP EP18155198.7A patent/EP3476837B1/en active Active
- 2018-02-06 HU HUE18155198A patent/HUE049906T2/hu unknown
- 2018-02-06 ES ES18155198T patent/ES2800576T3/es active Active
- 2018-02-06 DK DK18155198.7T patent/DK3476837T3/da active
- 2018-02-15 BR BR102018002949-5A patent/BR102018002949B1/pt active IP Right Grant
- 2018-10-16 IL IL262406A patent/IL262406B/en active IP Right Grant
- 2018-10-22 AU AU2018253450A patent/AU2018253450B2/en active Active
- 2018-10-23 NZ NZ747549A patent/NZ747549A/en unknown
- 2018-10-26 TW TW107137993A patent/TWI685488B/zh active
- 2018-10-29 JP JP2018203243A patent/JP6719527B2/ja active Active
- 2018-10-29 UA UAA201810611A patent/UA120333C2/uk unknown
- 2018-10-29 EA EA201892204A patent/EA036250B1/ru unknown
- 2018-10-29 CA CA3022388A patent/CA3022388C/en active Active
- 2018-10-30 AR ARP180103151A patent/AR113808A1/es active IP Right Grant
- 2018-10-30 ZA ZA2018/07240A patent/ZA201807240B/en unknown
- 2018-10-30 KR KR1020180131028A patent/KR102061868B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6719527B2 (ja) | 2020-07-08 |
| AU2018253450B2 (en) | 2019-09-26 |
| UA120333C2 (uk) | 2019-11-11 |
| KR102061868B1 (ko) | 2020-01-02 |
| AU2018253450A1 (en) | 2019-05-16 |
| DK3476837T3 (da) | 2020-07-20 |
| CN109721545A (zh) | 2019-05-07 |
| PL3476837T3 (pl) | 2020-09-21 |
| IL262406A (en) | 2019-02-28 |
| BR102018002949B1 (pt) | 2020-10-20 |
| CA3022388A1 (en) | 2019-04-30 |
| HUE049906T2 (hu) | 2020-11-30 |
| EA201892204A3 (ru) | 2019-10-31 |
| CN109721545B (zh) | 2020-09-11 |
| PT3476837T (pt) | 2020-07-15 |
| ZA201807240B (en) | 2019-07-31 |
| EP3476837B1 (en) | 2020-04-08 |
| IL262406B (en) | 2020-09-30 |
| TW201918474A (zh) | 2019-05-16 |
| EA201892204A2 (ru) | 2019-09-30 |
| EP3476837A1 (en) | 2019-05-01 |
| KR20190049569A (ko) | 2019-05-09 |
| JP2019081754A (ja) | 2019-05-30 |
| EA036250B1 (ru) | 2020-10-19 |
| NZ747549A (en) | 2020-01-31 |
| SI3476837T1 (sl) | 2020-08-31 |
| US10150741B1 (en) | 2018-12-11 |
| TWI685488B (zh) | 2020-02-21 |
| LT3476837T (lt) | 2020-09-25 |
| ES2800576T3 (es) | 2020-12-30 |
| CA3022388C (en) | 2020-05-26 |
| BR102018002949A2 (pt) | 2019-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR113808A1 (es) | Método para la preparación de compuestos intermedios de azoxistrobina | |
| MX350892B (es) | Síntesis de compuesto antiviral. | |
| AR118124A2 (es) | Proceso para la preparación de un inhibidor de pde4 | |
| GT201300099A (es) | Produccion de alquenos mediante conversion enzimatica combinada de acidos 3-hidroxialcanoicos | |
| BR112014018756A8 (pt) | Processo para preparo de etil éster de ácido n-(4-ciclo-hexil-3-trifluorometil-benziloxi)-acetimídico | |
| MX2020006306A (es) | Método novedoso para producir 4,5-dihidroisoxazol 5,5-disustituido. | |
| EA201890804A1 (ru) | Способ получения арилзамещенного парафенилендиаминового вещества | |
| AR063747A1 (es) | Definilazetidinona sustituida con acido piperazina-1-sulfonico y que tiene propiedades farmacologicas mejoradas | |
| CO6590210A1 (es) | Complejo obtenido a partir de mezclas de ácido hialurónico o una sal del mismo y sulfato de condroitina | |
| EA201890795A1 (ru) | Способ прямого получения диметилового эфира гликоля и совместного получения этиленгликоля из монометилового эфира этиленгликоля | |
| AR108344A1 (es) | 6-AMINOPIRIDIN-3-IL TIAZOLES COMO MODULADORES DE RORgT | |
| BR112015029714A2 (pt) | processo para preparar derivados de 4,6-bis(ariloxi)pirimidina | |
| CO6341607A2 (es) | Metodo de sintesis de sevoflurano | |
| UA111868C2 (uk) | Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти | |
| AR094054A1 (es) | 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma | |
| CL2013000601A1 (es) | Mezcla estable que comprende particulas modificadas en superficie que se obtienen por la reaccion de particulas de oxido metalico, donde dicho oxido usado es oxido de un metal con al menos un compuesto de formula i y al menos un solvente; proceso para tratar particulas; uso de particulas; y proceso de preparacion de particulas. | |
| CO6511211A2 (es) | Composiciones estable de sns 595 y métodos de preparación | |
| EA201990237A1 (ru) | Новые способы получения стимуляторов растворимой гуанилатциклазы | |
| AR113809A1 (es) | Método para la preparación de azoxistrobina | |
| AR095548A1 (es) | Preparación de ácido 4-amino-2,4-dioxobutanoico | |
| BR112015007821A2 (pt) | processo para a preparação de voriconazol e análogos do mesmo | |
| BR112023000029A2 (pt) | Método de preparação do composto de fenilisoxazolina | |
| MY189951A (en) | Method for preparing azoxystrobin intermediates | |
| EA201791358A1 (ru) | Способ получения блокированного на обоих концах простого эфира этиленгликоля | |
| AR119664A1 (es) | Proceso de conversión de sulfato de potasio a hidrogenosulfato de potasio |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |