EA201892204A2 - Способ получения промежуточных соединений для получения азоксистробина - Google Patents

Способ получения промежуточных соединений для получения азоксистробина

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Publication number
EA201892204A2
EA201892204A2 EA201892204A EA201892204A EA201892204A2 EA 201892204 A2 EA201892204 A2 EA 201892204A2 EA 201892204 A EA201892204 A EA 201892204A EA 201892204 A EA201892204 A EA 201892204A EA 201892204 A2 EA201892204 A2 EA 201892204A2
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EA
Eurasian Patent Office
Prior art keywords
compound
azoxystrobin
producing
preparation
trimethylamine catalyst
Prior art date
Application number
EA201892204A
Other languages
English (en)
Other versions
EA036250B1 (ru
EA201892204A3 (ru
Inventor
Хайшуй Ван
Бинлянь Ян
Симянь Се
Сяохун Тянь
Цзиван Сюй
Original Assignee
Сиэйси Наньтун Кемикал Ко., Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сиэйси Наньтун Кемикал Ко., Лтд filed Critical Сиэйси Наньтун Кемикал Ко., Лтд
Publication of EA201892204A2 publication Critical patent/EA201892204A2/ru
Publication of EA201892204A3 publication Critical patent/EA201892204A3/ru
Publication of EA036250B1 publication Critical patent/EA036250B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235Nitrogen containing compounds
    • B01J31/0237Amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D247/00Heterocyclic compounds containing rings having two nitrogen atoms as the only ring hetero atoms, according to more than one of groups C07D229/00 - C07D245/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/584Recycling of catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение предусматривает способ получения промежуточных соединений для получения азоксистробина, включающий проведение реакции соединения A и дихлорпиримидина в присутствии триметиламинового катализатора с добавлением раствора метоксида натрия в метаноле или добавлением метоксида натрия и метанола по отдельности с получением смеси соединения B и соединения C. В настоящем изобретении соединение B и соединение C, представляющие собой промежуточные соединения для получения азоксистробина, синтезируют из соединения A, при этом катализ осуществляют посредством применения триметиламинового катализатора, обеспечивающего протекание реакции с высокой эффективностью и высоким выходом. Кроме того, триметиламиновый катализатор характеризуется низкой точкой кипения и, таким образом, его можно легко регенерировать, благодаря чему содержание аммиачного азота в сточных водах может быть снижено и могут быть также снижены сложности и высокая стоимость обработки сточных вод. Регенерированный триметиламиновый катализатор может быть использован повторно в получении промежуточного соединения B, при этом он также характеризуется высокой каталитической активностью и также может обеспечивать высокий выход продуктов. Способ согласно настоящему изобретению имеет значительные преимущества по затратам при синтезе и является подходящим для производства в промышленном масштабе.
EA201892204A 2017-10-31 2018-10-29 Способ получения промежуточных соединений для получения азоксистробина EA036250B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711049390.1A CN109721545B (zh) 2017-10-31 2017-10-31 一种嘧菌酯中间体的制备方法

Publications (3)

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EA201892204A2 true EA201892204A2 (ru) 2019-09-30
EA201892204A3 EA201892204A3 (ru) 2019-10-31
EA036250B1 EA036250B1 (ru) 2020-10-19

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US (1) US10150741B1 (ru)
EP (1) EP3476837B1 (ru)
JP (1) JP6719527B2 (ru)
KR (1) KR102061868B1 (ru)
CN (1) CN109721545B (ru)
AR (1) AR113808A1 (ru)
AU (1) AU2018253450B2 (ru)
BR (1) BR102018002949B1 (ru)
CA (1) CA3022388C (ru)
DK (1) DK3476837T3 (ru)
EA (1) EA036250B1 (ru)
ES (1) ES2800576T3 (ru)
HU (1) HUE049906T2 (ru)
IL (1) IL262406B (ru)
LT (1) LT3476837T (ru)
NZ (1) NZ747549A (ru)
PL (1) PL3476837T3 (ru)
PT (1) PT3476837T (ru)
SI (1) SI3476837T1 (ru)
TW (1) TWI685488B (ru)
UA (1) UA120333C2 (ru)
ZA (1) ZA201807240B (ru)

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CN112174897B (zh) * 2020-09-18 2021-08-03 广东石油化工学院 一种嘧菌酯中间体的制备方法
CN112403514B (zh) * 2020-11-30 2023-05-19 河北威远生物化工有限公司 一种用于制备嘧菌酯中间体的催化体系及嘧菌酯的制备方法
CN114685376B (zh) * 2020-12-28 2024-06-07 北京颖泰嘉和生物科技股份有限公司 嘧菌酯中间体的制备方法
WO2023203574A1 (en) * 2022-04-22 2023-10-26 Nacl Industries Limited A process for preparation of azoxystrobin
CN115557901A (zh) * 2022-10-21 2023-01-03 湖北有宜新材料科技有限公司 一种嘧啶呋喃酮的高效生产方法
CN116120241A (zh) * 2023-02-27 2023-05-16 江苏快达农化股份有限公司 一种复合催化剂合成嘧菌酯中间体的方法

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IE74711B1 (en) * 1990-07-27 1997-07-30 Ici Plc Fungicides
GB9122430D0 (en) 1990-11-16 1991-12-04 Ici Plc Chemical process
SG63694A1 (en) * 1996-03-07 1999-03-30 American Cyanamid Co Process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds
CN100564362C (zh) 2007-10-24 2009-12-02 北京颖泰嘉和科技股份有限公司 嘧菌酯及其类似物的制备方法
CN102311392B (zh) * 2011-08-24 2014-01-22 重庆紫光化工股份有限公司 嘧菌酯及其合成中专用中间体的合成方法
CN103214423B (zh) * 2013-03-20 2016-03-16 北京颖泰嘉和生物科技股份有限公司 一种丙烯酸酯类化合物的制备方法
WO2014203270A2 (en) * 2013-06-19 2014-12-24 Bhagiradha Chemicals & Industries Limited Process for the preparation of acrylate derivatives
CN103467387B (zh) * 2013-09-05 2016-03-16 北京颖泰嘉和生物科技股份有限公司 一种制备嘧菌酯及其中间体的方法
CN104725321B (zh) * 2013-12-20 2017-11-21 上海泰禾国际贸易有限公司 一种嘧菌酯中间体的制备方法
WO2015102016A1 (en) * 2013-12-31 2015-07-09 Bhagiradha Chemicals & Industries Limited Process for the preparation of methyl 2-[2-(6-chloropyrimidin-4-yloxy) phenyl]-3,3- dimethoxypropionate
CN104926736B (zh) 2015-05-29 2019-05-17 重庆紫光化工股份有限公司 一种嘧菌酯及其中间体的合成方法
CN106810502A (zh) * 2015-11-29 2017-06-09 青岛森美克化工技术有限公司 一种嘧菌酯中间体的制备方法

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Publication number Publication date
EP3476837B1 (en) 2020-04-08
DK3476837T3 (da) 2020-07-20
EA036250B1 (ru) 2020-10-19
KR102061868B1 (ko) 2020-01-02
BR102018002949A2 (pt) 2019-06-04
EA201892204A3 (ru) 2019-10-31
SI3476837T1 (sl) 2020-08-31
UA120333C2 (uk) 2019-11-11
JP6719527B2 (ja) 2020-07-08
EP3476837A1 (en) 2019-05-01
CA3022388A1 (en) 2019-04-30
PL3476837T3 (pl) 2020-09-21
AU2018253450B2 (en) 2019-09-26
HUE049906T2 (hu) 2020-11-30
CA3022388C (en) 2020-05-26
CN109721545B (zh) 2020-09-11
AU2018253450A1 (en) 2019-05-16
JP2019081754A (ja) 2019-05-30
LT3476837T (lt) 2020-09-25
ES2800576T3 (es) 2020-12-30
NZ747549A (en) 2020-01-31
TWI685488B (zh) 2020-02-21
BR102018002949B1 (pt) 2020-10-20
IL262406B (en) 2020-09-30
KR20190049569A (ko) 2019-05-09
AR113808A1 (es) 2020-06-10
PT3476837T (pt) 2020-07-15
ZA201807240B (en) 2019-07-31
TW201918474A (zh) 2019-05-16
CN109721545A (zh) 2019-05-07
IL262406A (en) 2019-02-28
US10150741B1 (en) 2018-12-11

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