MX2020010773A - Metodo para la preparacion del compuesto de pirroloaminopiridazino na y sus intermedios. - Google Patents
Metodo para la preparacion del compuesto de pirroloaminopiridazino na y sus intermedios.Info
- Publication number
- MX2020010773A MX2020010773A MX2020010773A MX2020010773A MX2020010773A MX 2020010773 A MX2020010773 A MX 2020010773A MX 2020010773 A MX2020010773 A MX 2020010773A MX 2020010773 A MX2020010773 A MX 2020010773A MX 2020010773 A MX2020010773 A MX 2020010773A
- Authority
- MX
- Mexico
- Prior art keywords
- intermediates
- preparing
- compound
- pyrroloaminopyridazinone
- starting materials
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/42—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
Abstract
La presente invención se refiere a un método para preparar un compuesto de pirroloaminopiridazinona e intermedios del mismo. Específicamente relacionado con un método para preparar el compuesto de fórmula (I), el producto objetivo se prepara mediante el cambio de materiales de partida e intermedios; el presente método tiene las ventajas de reactivos tales como que los materiales de partida son fáciles de adquirir, las condiciones de reacción son simples y controlables, el método de tratamiento posterior a la reacción es simple, el rendimiento es alto y es beneficioso para la producción industrial. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810328604 | 2018-04-13 | ||
PCT/CN2019/082367 WO2019196915A1 (zh) | 2018-04-13 | 2019-04-12 | 一种吡咯并氨基哒嗪酮化合物的制备方法及其中间体 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020010773A true MX2020010773A (es) | 2021-03-02 |
Family
ID=68163088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020010773A MX2020010773A (es) | 2018-04-13 | 2019-04-12 | Metodo para la preparacion del compuesto de pirroloaminopiridazino na y sus intermedios. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210147428A1 (es) |
JP (1) | JP2021521208A (es) |
KR (1) | KR20200144546A (es) |
CN (1) | CN111094274A (es) |
AU (1) | AU2019251278A1 (es) |
BR (1) | BR112020020876A2 (es) |
CA (1) | CA3096414A1 (es) |
MX (1) | MX2020010773A (es) |
TW (1) | TW201943711A (es) |
WO (1) | WO2019196915A1 (es) |
ZA (1) | ZA202006128B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021057998A1 (zh) * | 2019-09-29 | 2021-04-01 | 上海森辉医药有限公司 | 一种吡咯并氨基哒嗪酮化合物的制备方法 |
CN112745255A (zh) * | 2019-10-30 | 2021-05-04 | 江苏恒瑞医药股份有限公司 | 一种btk激酶抑制剂的制备方法 |
CN114751850B (zh) * | 2022-06-06 | 2023-08-25 | 上海再启生物技术有限公司 | 一种btk激酶抑制剂关键中间体的制备方法 |
CN114989062A (zh) * | 2022-07-04 | 2022-09-02 | 上海再启生物技术有限公司 | 一种btk激酶抑制剂中间体的晶型及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
BR112017000470B1 (pt) | 2014-07-07 | 2022-11-29 | Jiangsu Hengrui Medicine Co., Ltd | Compostos, composição farmacêutica e uso do composto ou da composição |
CN105837576B (zh) * | 2015-01-14 | 2019-03-26 | 湖北生物医药产业技术研究院有限公司 | Btk抑制剂 |
CN106939002B (zh) * | 2016-01-05 | 2019-09-24 | 江苏恒瑞医药股份有限公司 | 一种btk激酶抑制剂的结晶形式及其制备方法 |
BR112018012106B1 (pt) * | 2016-01-05 | 2023-12-12 | Jiangsu Hengrui Medicine Co., Ltd | Forma cristalina i de (r)-4-amino-1-(1-(but-2-inoil)pirrolidin-3-il)-3-(4- (2,6- difluorofenoxi)fenil)-1h-pirrolo[2,3-d]piridazin-7(6h)-ona, método de preparar a forma cristalina i, composição farmacêutica e uso da forma cristalina i |
-
2019
- 2019-04-12 TW TW108112896A patent/TW201943711A/zh unknown
- 2019-04-12 KR KR1020207029524A patent/KR20200144546A/ko unknown
- 2019-04-12 MX MX2020010773A patent/MX2020010773A/es unknown
- 2019-04-12 BR BR112020020876-0A patent/BR112020020876A2/pt not_active Application Discontinuation
- 2019-04-12 WO PCT/CN2019/082367 patent/WO2019196915A1/zh active Application Filing
- 2019-04-12 US US17/045,115 patent/US20210147428A1/en not_active Abandoned
- 2019-04-12 AU AU2019251278A patent/AU2019251278A1/en not_active Abandoned
- 2019-04-12 CA CA3096414A patent/CA3096414A1/en not_active Abandoned
- 2019-04-12 CN CN201980004505.6A patent/CN111094274A/zh active Pending
- 2019-04-12 JP JP2020556254A patent/JP2021521208A/ja active Pending
-
2020
- 2020-10-02 ZA ZA2020/06128A patent/ZA202006128B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20210147428A1 (en) | 2021-05-20 |
EP3778591A1 (en) | 2021-02-17 |
WO2019196915A1 (zh) | 2019-10-17 |
ZA202006128B (en) | 2022-01-26 |
JP2021521208A (ja) | 2021-08-26 |
KR20200144546A (ko) | 2020-12-29 |
CA3096414A1 (en) | 2019-10-17 |
TW201943711A (zh) | 2019-11-16 |
AU2019251278A1 (en) | 2020-10-08 |
CN111094274A (zh) | 2020-05-01 |
BR112020020876A2 (pt) | 2021-01-26 |
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