EA201000820A1 - Способ получения фармацевтических промежуточных соединений - Google Patents

Способ получения фармацевтических промежуточных соединений

Info

Publication number
EA201000820A1
EA201000820A1 EA201000820A EA201000820A EA201000820A1 EA 201000820 A1 EA201000820 A1 EA 201000820A1 EA 201000820 A EA201000820 A EA 201000820A EA 201000820 A EA201000820 A EA 201000820A EA 201000820 A1 EA201000820 A1 EA 201000820A1
Authority
EA
Eurasian Patent Office
Prior art keywords
halogenation
aqueous solution
chlorine
intermediate compounds
mixture
Prior art date
Application number
EA201000820A
Other languages
English (en)
Other versions
EA016762B1 (ru
Inventor
Тибор Мезеи
Дьюла Лукач
Эникё Мольнар
Йосеф Баркоци
Балаж Вольк
Марта Порч-Маккаи
Янош Суладьи
Мария Вайон
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Publication of EA201000820A1 publication Critical patent/EA201000820A1/ru
Publication of EA016762B1 publication Critical patent/EA016762B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к способу получения соединений общей формулы III, где R представляет собой атом фтора или хлора и Х представляет собой атом хлора или брома, путем галогенирования циклопропилбензилкетона общей формулы II, где R представляет собой атом хлора или брома, и галогенирование выполняют в смеси водного раствора галогеноводорода и водного раствора пероксида водорода в присутствии растворителя, смешивающегося с водой, либо в присутствии катализатора фазового переноса, либо галогенирование выполняют в смеси серной кислоты и соли щелочного металла с водным раствором галогеноводорода. Способ можно выполнять предпочтительно в промышленном масштабе.
EA201000820A 2007-11-27 2008-11-27 Способ получения фармацевтических промежуточных соединений EA016762B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700757A HU230261B1 (hu) 2007-11-27 2007-11-27 Eljárás gyógyszeripari intermedierek előállítására
PCT/HU2008/000139 WO2009068924A1 (en) 2007-11-27 2008-11-27 Process for the preparation of pharmaceutical i nterm ediates

Publications (2)

Publication Number Publication Date
EA201000820A1 true EA201000820A1 (ru) 2010-10-29
EA016762B1 EA016762B1 (ru) 2012-07-30

Family

ID=89987892

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000820A EA016762B1 (ru) 2007-11-27 2008-11-27 Способ получения фармацевтических промежуточных соединений

Country Status (9)

Country Link
US (1) US20110040093A1 (ru)
EP (1) EP2242736B1 (ru)
CN (1) CN101888988A (ru)
AT (1) ATE524428T1 (ru)
EA (1) EA016762B1 (ru)
ES (1) ES2374787T3 (ru)
HU (1) HU230261B1 (ru)
UA (1) UA100397C2 (ru)
WO (1) WO2009068924A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101928208B (zh) * 2010-08-05 2013-06-05 河北大学 一种过氧化氢氧化溴化法合成α-溴代酮类化合物的方法
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102268009A (zh) * 2011-06-13 2011-12-07 陕西瑞科新材料股份有限公司 氢化吡啶衍生物的制备方法
CN107602365B (zh) * 2017-09-27 2021-01-05 长治市晋宁化工有限公司 一种2-氯-1-(1-氯环丙基)乙酮的制备方法
CN112661659A (zh) * 2021-01-08 2021-04-16 浙江苏泊尔制药有限公司 一种盐酸安非他酮的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
IN182838B (ru) * 1994-07-27 1999-07-31 Council Scient Ind Res
US5670582A (en) * 1996-07-24 1997-09-23 Exxon Chemical Patents Inc. Process for halogenation of isomonoolefin/para-alkylstyrene copolymers
KR20100105763A (ko) * 2000-07-06 2010-09-29 다이이찌 산쿄 가부시키가이샤 히드로피리딘 유도체 산부가염
PL2007362T3 (pl) * 2006-04-04 2019-02-28 Kg Acquisition Llc Doustne postacie leku obejmujące czynnik przeciwpłytkowy i inhibitor kwasu
TWI392681B (zh) * 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd 高純度普拉格雷及其酸加成鹽之製法

Also Published As

Publication number Publication date
WO2009068924A8 (en) 2010-06-24
US20110040093A1 (en) 2011-02-17
UA100397C2 (ru) 2012-12-25
HUP0700757A2 (en) 2010-04-28
WO2009068924A1 (en) 2009-06-04
HU0700757D0 (en) 2008-02-28
ATE524428T1 (de) 2011-09-15
CN101888988A (zh) 2010-11-17
HU230261B1 (hu) 2015-11-30
EP2242736B1 (en) 2011-09-14
ES2374787T3 (es) 2012-02-22
EP2242736A1 (en) 2010-10-27
EA016762B1 (ru) 2012-07-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU