MX2008013728A - Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo. - Google Patents
Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo.Info
- Publication number
- MX2008013728A MX2008013728A MX2008013728A MX2008013728A MX2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A MX 2008013728 A MX2008013728 A MX 2008013728A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- salt
- therapeutic agent
- amino
- alkyl ether
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se divulga un agente que consta de un derivado de éter de alquil-benzotiofeno representado por la fórmula general que se describe abajo o una sal del mismo: (ver fórmula I) en donde R1 y R2 representan de manera independiente por lo menos uno de los grupos seleccionados de un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo, un grupo arilo, un grupo aralquilo, un grupo alcoxi, un grupo ariloxi, un grupo alquiltio, un grupo ariltio, un grupo alquenilo, un grupo alqueniloxi, un grupo alquilsulfonilo, un grupo carbamoilo, un grupo heterocíclico, un grupo amino, grupo hidroxilo, un grupo carboxilo, un grupo nitro, un grupo oxo y similares; R3 representa un grupo alquilamino que puede ser sustituido o un grupo amino o un grupo hidroxilo que se puede proteger; y m y n representan de manera independiente un número entero de 1 a 6. El agente es útil como inductor de neurogénesis o un agente terapéutico para neuropatía.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006122080 | 2006-04-26 | ||
PCT/JP2007/058841 WO2007125913A1 (ja) | 2006-04-26 | 2007-04-24 | アルキルエーテル誘導体またはその塩を含有する神経細胞新生誘導剤および精神障害治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008013728A true MX2008013728A (es) | 2009-01-07 |
Family
ID=38655439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008013728A MX2008013728A (es) | 2006-04-26 | 2007-04-24 | Inductor de neurogenesis o agente terapeutico de neuropatia que abarca el derivado del eter alkilico o sal del mismo. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20090093453A1 (es) |
EP (1) | EP2011796B1 (es) |
JP (2) | JP5695293B2 (es) |
KR (1) | KR101374593B1 (es) |
CN (1) | CN101432280B (es) |
AU (1) | AU2007244409B2 (es) |
BR (1) | BRPI0710239A2 (es) |
CA (1) | CA2648898C (es) |
CY (1) | CY1115643T1 (es) |
DK (1) | DK2011796T3 (es) |
ES (1) | ES2518371T3 (es) |
IL (1) | IL194569A (es) |
MX (1) | MX2008013728A (es) |
NO (1) | NO342153B1 (es) |
NZ (1) | NZ571975A (es) |
PL (1) | PL2011796T3 (es) |
PT (1) | PT2011796E (es) |
SI (1) | SI2011796T1 (es) |
WO (1) | WO2007125913A1 (es) |
ZA (1) | ZA200808728B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101643470B (zh) | 2001-10-19 | 2012-08-01 | 富山化学工业株式会社 | 烷基醚衍生物或其盐 |
IL165589A (en) | 2002-06-14 | 2012-04-30 | Toyama Chemical Co Ltd | Pharmaceutical preparation to improve brain function and use |
CA2799659C (en) * | 2005-03-28 | 2014-12-02 | Toyama Chemical Co., Ltd. | Process for production of 1-(3-(2-(1-benzothiophen-5-yl) ethoxy)propyl) azetidin-3-ol or salts thereof |
CA2659835A1 (en) * | 2006-08-04 | 2008-02-07 | Toyama Chemical Co., Ltd. | Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof |
ES2465005T3 (es) * | 2008-05-28 | 2014-06-04 | Toyama Chemical Co., Ltd. | Derivado de óxido de benzotiofeno y sus sales |
EP3044207B1 (en) * | 2013-09-12 | 2017-10-18 | F. Hoffmann-La Roche AG | Indol-carboxamide derivatives |
ES2792950T3 (es) | 2014-01-31 | 2020-11-12 | Fujifilm Toyama Chemical Co Ltd | Agente potenciador del efecto de rehabilitación después de una lesión nerviosa que comprende un derivado alquil éter o una sal del mismo |
US10238632B2 (en) | 2015-06-11 | 2019-03-26 | Fujifilm Toyama Chemical Co., Ltd. | Sigma receptor-binding agent |
JP6860502B2 (ja) * | 2015-12-25 | 2021-04-14 | 富士フイルム富山化学株式会社 | 1−(3−(2−(1−ベンゾチオフェン−5−イル)エトキシ)プロピル)アゼチジン−3−オールまたはその塩を含む錠剤 |
CN110139641B (zh) * | 2016-12-28 | 2022-09-09 | 富士胶片富山化学株式会社 | 外用组合物 |
RU2019138538A (ru) | 2017-06-02 | 2021-07-09 | ФУДЖИФИЛМ Тояма Кемикал Ко., Лтд. | СРЕДСТВО ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА АМИЛОИДНОГО β-БЕЛКА |
RU2759727C2 (ru) * | 2017-06-02 | 2021-11-17 | ФУДЖИФИЛМ Тояма Кемикал Ко., Лтд. | Средство для профилактики или лечения атрофии головного мозга |
WO2018221728A1 (ja) | 2017-06-02 | 2018-12-06 | 富山化学工業株式会社 | アルツハイマー型認知症予防または治療剤 |
KR20190138696A (ko) * | 2017-06-02 | 2019-12-13 | 후지필름 도야마 케미컬 가부시키가이샤 | 척수 소뇌 변성증 예방 또는 치료제 |
JP7227914B2 (ja) | 2017-10-30 | 2023-02-22 | 富士フイルム富山化学株式会社 | エモパミル結合タンパク質結合剤およびその利用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294346B1 (en) * | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
JPH05284992A (ja) * | 1992-04-14 | 1993-11-02 | Sagami Chem Res Center | 神経成長因子産生促進剤及びその製造法 |
GB9309749D0 (en) * | 1993-05-12 | 1993-06-23 | Boots Co Plc | Therapeutic agents |
JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物am5221 |
JP2733207B2 (ja) * | 1995-05-18 | 1998-03-30 | 工業技術院長 | 繊維芽細胞成長因子キメラ蛋白質を含有する医薬組成物 |
AU1506499A (en) * | 1997-12-12 | 1999-07-05 | Toyama Chemical Co. Ltd. | Alkyl ether derivatives or salts thereof and calcium antagonists containing the same |
IL129178A0 (en) * | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Induction of nerve generation |
NZ515706A (en) * | 1999-06-11 | 2003-08-29 | Toyama Chemical Co Ltd | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
US20040030131A1 (en) * | 2000-10-04 | 2004-02-12 | Martine Keenan | Pharmaceutical compounds |
GB2367554A (en) * | 2000-10-04 | 2002-04-10 | Lilly Co Eli | Pharmacologically active amines |
JP4303435B2 (ja) * | 2001-02-26 | 2009-07-29 | 富山化学工業株式会社 | ミトコンドリア機能賦活剤 |
US7208495B2 (en) * | 2001-07-05 | 2007-04-24 | Takeda Pharmaceutical Company Limited | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof |
JP4357802B2 (ja) * | 2001-07-05 | 2009-11-04 | 武田薬品工業株式会社 | ベンゼン環縮合5員複素環式化合物、その製造法および用途 |
JP4905752B2 (ja) * | 2001-07-24 | 2012-03-28 | エスティー・ラボ株式会社 | 揮発性有機塩素化合物センサ |
CN101643470B (zh) * | 2001-10-19 | 2012-08-01 | 富山化学工业株式会社 | 烷基醚衍生物或其盐 |
JP4537011B2 (ja) * | 2002-03-01 | 2010-09-01 | 武田薬品工業株式会社 | 抗うつ剤 |
IL165589A (en) * | 2002-06-14 | 2012-04-30 | Toyama Chemical Co Ltd | Pharmaceutical preparation to improve brain function and use |
JP2004256428A (ja) * | 2003-02-25 | 2004-09-16 | Science Univ Of Tokyo | 神経栄養因子様プリン系化合物含有作用剤 |
KR101096528B1 (ko) * | 2003-04-17 | 2011-12-20 | 토야마 케미칼 컴퍼니 리미티드 | 알킬에테르 유도체 또는 그 염을 함유하는 망막신경질환의예방·치료제 |
WO2005032535A1 (ja) * | 2003-10-03 | 2005-04-14 | Ono Pharmaceutical Co., Ltd. | 神経再生促進剤 |
-
2007
- 2007-04-24 CN CN2007800147663A patent/CN101432280B/zh active Active
- 2007-04-24 MX MX2008013728A patent/MX2008013728A/es active IP Right Grant
- 2007-04-24 ZA ZA200808728A patent/ZA200808728B/xx unknown
- 2007-04-24 DK DK07742276.4T patent/DK2011796T3/da active
- 2007-04-24 JP JP2008513218A patent/JP5695293B2/ja active Active
- 2007-04-24 WO PCT/JP2007/058841 patent/WO2007125913A1/ja active Application Filing
- 2007-04-24 US US12/298,656 patent/US20090093453A1/en not_active Abandoned
- 2007-04-24 NZ NZ571975A patent/NZ571975A/en unknown
- 2007-04-24 SI SI200731584T patent/SI2011796T1/sl unknown
- 2007-04-24 PL PL07742276T patent/PL2011796T3/pl unknown
- 2007-04-24 BR BRPI0710239-9A patent/BRPI0710239A2/pt not_active Application Discontinuation
- 2007-04-24 CA CA2648898A patent/CA2648898C/en active Active
- 2007-04-24 KR KR1020087027617A patent/KR101374593B1/ko active IP Right Grant
- 2007-04-24 PT PT77422764T patent/PT2011796E/pt unknown
- 2007-04-24 EP EP07742276.4A patent/EP2011796B1/en active Active
- 2007-04-24 ES ES07742276.4T patent/ES2518371T3/es active Active
- 2007-04-24 AU AU2007244409A patent/AU2007244409B2/en active Active
-
2008
- 2008-10-06 IL IL194569A patent/IL194569A/en active IP Right Grant
- 2008-10-16 NO NO20084338A patent/NO342153B1/no unknown
-
2013
- 2013-05-07 JP JP2013097429A patent/JP2013177410A/ja active Pending
-
2014
- 2014-10-10 CY CY20141100826T patent/CY1115643T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200808728B (en) | 2010-01-27 |
CY1115643T1 (el) | 2017-01-04 |
PT2011796E (pt) | 2014-11-26 |
CN101432280A (zh) | 2009-05-13 |
CA2648898C (en) | 2015-01-20 |
DK2011796T3 (da) | 2014-10-27 |
KR20080111131A (ko) | 2008-12-22 |
JP2013177410A (ja) | 2013-09-09 |
CN101432280B (zh) | 2012-11-21 |
NO20084338L (no) | 2008-11-19 |
AU2007244409B2 (en) | 2011-12-01 |
KR101374593B1 (ko) | 2014-03-17 |
AU2007244409A1 (en) | 2007-11-08 |
CA2648898A1 (en) | 2007-11-08 |
EP2011796A1 (en) | 2009-01-07 |
JP5695293B2 (ja) | 2015-04-01 |
BRPI0710239A2 (pt) | 2011-08-09 |
PL2011796T3 (pl) | 2015-03-31 |
US20090093453A1 (en) | 2009-04-09 |
JPWO2007125913A1 (ja) | 2009-09-10 |
SI2011796T1 (sl) | 2015-02-27 |
IL194569A0 (en) | 2009-08-03 |
EP2011796B1 (en) | 2014-10-08 |
IL194569A (en) | 2014-09-30 |
NZ571975A (en) | 2011-04-29 |
WO2007125913A1 (ja) | 2007-11-08 |
EP2011796A4 (en) | 2010-07-07 |
NO342153B1 (no) | 2018-04-03 |
ES2518371T3 (es) | 2014-11-05 |
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Legal Events
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