MX2007014082A - Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. - Google Patents

Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Info

Publication number
MX2007014082A
MX2007014082A MX2007014082A MX2007014082A MX2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A
Authority
MX
Mexico
Prior art keywords
pyrido
preparation
methods
pyrimidines
hcv
Prior art date
Application number
MX2007014082A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Dominique Louis Nest Surleraux
Kenneth Alan Simmen
Tse-I Lin
Oliver Lenz
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2007014082A publication Critical patent/MX2007014082A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere al uso de pirido[2,3-d]pirimidina s como inhibidores de replicacion de 10 HCV asi como tambien a su empleo en composiciones farmaceuticas destinadas a tratar o combatir infecciones con HCV; ademas, la presente invencion se refiere a los compuestos de prido[2,3-d]pirimidinas en si mismos y a su uso como medicinas; la presente invencion tambien se refiere a procesos para la preparacion de tales compuestos, a composiciones farmaceuticas que los comprenden, y a combinaciones de dichos compuestos 15 con otros agentes anti-HCV.
MX2007014082A 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. MX2007014082A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68040505P 2005-05-12 2005-05-12
EP05106214 2005-07-07
EP06075855 2006-04-06
PCT/EP2006/062290 WO2006120252A2 (en) 2005-05-12 2006-05-12 Pyrido[2,3-d]pyrimidines useful as hcv inhibitors, and methods for the preparation thereof

Publications (1)

Publication Number Publication Date
MX2007014082A true MX2007014082A (es) 2008-04-17

Family

ID=37198763

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014082A MX2007014082A (es) 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Country Status (20)

Country Link
US (1) US8022077B2 (es)
EP (1) EP1888580B1 (es)
JP (1) JP5464686B2 (es)
KR (1) KR20080007268A (es)
CN (1) CN101203515B (es)
AR (1) AR054122A1 (es)
AT (1) ATE459623T1 (es)
AU (1) AU2006245676B2 (es)
BR (1) BRPI0609098A2 (es)
CA (1) CA2608301C (es)
DE (1) DE602006012666D1 (es)
DK (1) DK1888580T3 (es)
ES (1) ES2341572T3 (es)
IL (1) IL186881A (es)
MX (1) MX2007014082A (es)
RU (1) RU2444522C2 (es)
SI (1) SI1888580T1 (es)
TW (1) TW200716631A (es)
WO (1) WO2006120252A2 (es)
ZA (1) ZA200709689B (es)

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AP2007003923A0 (en) * 2004-09-30 2007-02-28 Tibotec Pharm Ltd Hcv inhibiting bi-cyclic pyrimidines
ATE517897T1 (de) * 2005-03-25 2011-08-15 Tibotec Pharm Ltd Heterobicyclische inhibitoren von hvc
AR056347A1 (es) 2005-05-12 2007-10-03 Tibotec Pharm Ltd Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
CA2633752A1 (en) * 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
WO2007076034A2 (en) 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
EP1971611B1 (en) 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
ATE475660T1 (de) 2005-12-21 2010-08-15 Abbott Lab Antivirale verbindungen
EP2094276A4 (en) 2006-12-20 2011-01-05 Abbott Lab ANTIVIRAL COMPOUNDS
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
PA8855801A1 (es) 2008-12-23 2010-07-27 Sintesis de nucleosidos de purina
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
WO2011112558A2 (en) * 2010-03-10 2011-09-15 Abbott Laboratories Solid compositions
ES2551944T3 (es) 2010-03-31 2015-11-24 Gilead Pharmasset Llc (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2H)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato de isopropilo cristalino
SI2609923T1 (sl) 2010-03-31 2017-10-30 Gilead Pharmasset Llc Postopek za kristalizacijo (s)-izopropil 2-(((s)-(perfluorofenoksi) (fenoksi)fosforil)amino)propanoata
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
ME03782B (me) 2011-04-08 2021-04-20 Janssen Sciences Ireland Unlimited Co Derivati pirimidina za tretman virusnih infekcija
LT2776439T (lt) 2011-11-09 2018-10-10 Janssen Sciences Ireland Uc Purino dariniai, skirti virusinų infekcijų gydymui
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2014009509A1 (en) 2012-07-13 2014-01-16 Janssen R&D Ireland Macrocyclic purines for the treatment of viral infections
ES2670513T3 (es) 2012-10-10 2018-05-30 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidínicos para el tratamiento de infecciones víricas y otras enfermedades
MX361585B (es) 2012-11-16 2018-12-11 Janssen Sciences Ireland Uc Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas.
UA118751C2 (uk) 2013-02-21 2019-03-11 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Похідні 2-амінопіримідину для лікування вірусних інфекцій
EA202090547A3 (ru) 2013-03-29 2020-12-30 Янссен Сайенсиз Айрлэнд Юси Макроциклические деаза-оксипурины для лечения вирусных инфекций
EP3004074B1 (en) 2013-05-24 2017-10-25 Janssen Sciences Ireland UC Pyridone derivatives for the treatment of viral infections and further diseases
DK3030563T3 (da) 2013-06-27 2017-11-20 Janssen Sciences Ireland Uc Pyrrolo-[3,2-d]-pyrimidin-derivater til behandling af virale infektioner og andre sygdomme
MX368625B (es) 2013-07-30 2019-10-08 Janssen Sciences Ireland Uc Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales.
ES2900570T3 (es) 2013-08-27 2022-03-17 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
AU2014373773C1 (en) 2014-01-01 2019-06-27 Medivation Technologies Llc Compounds and methods of use
EP2905024A1 (en) 2014-02-07 2015-08-12 Institut Quimic De Sarriá Cets, Fundació Privada Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae
US11053256B2 (en) 2016-07-01 2021-07-06 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
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Also Published As

Publication number Publication date
CA2608301A1 (en) 2006-11-16
US8022077B2 (en) 2011-09-20
EP1888580A2 (en) 2008-02-20
TW200716631A (en) 2007-05-01
RU2007146173A (ru) 2009-06-20
BRPI0609098A2 (pt) 2010-02-17
CN101203515A (zh) 2008-06-18
CA2608301C (en) 2014-04-22
SI1888580T1 (sl) 2010-06-30
AR054122A1 (es) 2007-06-06
KR20080007268A (ko) 2008-01-17
WO2006120252A3 (en) 2007-02-22
IL186881A (en) 2015-06-30
IL186881A0 (en) 2008-02-09
US20090131460A1 (en) 2009-05-21
RU2444522C2 (ru) 2012-03-10
DK1888580T3 (da) 2010-06-14
AU2006245676A1 (en) 2006-11-16
JP5464686B2 (ja) 2014-04-09
ZA200709689B (en) 2009-07-29
WO2006120252A2 (en) 2006-11-16
CN101203515B (zh) 2014-02-26
JP2008540494A (ja) 2008-11-20
DE602006012666D1 (de) 2010-04-15
ES2341572T3 (es) 2010-06-22
AU2006245676B2 (en) 2012-08-02
EP1888580B1 (en) 2010-03-03
ATE459623T1 (de) 2010-03-15

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