MX173308B - Procedimiento para la preparacion de indolinas 3,3-disustuidas - Google Patents

Procedimiento para la preparacion de indolinas 3,3-disustuidas

Info

Publication number
MX173308B
MX173308B MX005978A MX597887A MX173308B MX 173308 B MX173308 B MX 173308B MX 005978 A MX005978 A MX 005978A MX 597887 A MX597887 A MX 597887A MX 173308 B MX173308 B MX 173308B
Authority
MX
Mexico
Prior art keywords
alkyl
indolines
pyridyl
chem
independently
Prior art date
Application number
MX005978A
Other languages
English (en)
Inventor
Melvyn John Myers
Victor Johannes Nickolson
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of MX173308B publication Critical patent/MX173308B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de indolinas 3,3-disustituidas, en la que p es 0 ó 1; Z es 0 ó S; R es alquilo de C1-C10, cicloalquilo de C3-C8, 1-piridilo, 3-piridilo, 4-piridilo, ó un anillo aromático con V y W como sustituyentes V, W, X y Y,independientemente, son H, halo, alquilo de C1-C3,OR1,NO2,CF3,CN ó NR1R2; R1 Y R2, independientemente son, H alquilo de C1-C3; H y H, independientemente, son anillos aromáticos heterocíclicos de 6 miembros que contienen cuando menos un átomo de nitrógeno con parte del anillo opcionalmente substituido con un substituyente seleccionado a partir del grupo de alquilo de C1-C3, halo, OR1 ó NR1R2, ó una sal de adición de ácido farmaceuticamente aceptable o N-óxido del mismo, caracterizado porque comprende: (a) poner en contacto un oxindol.
MX005978A 1986-04-10 1987-04-02 Procedimiento para la preparacion de indolinas 3,3-disustuidas MX173308B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85001586A 1986-04-10 1986-04-10
US06/944,953 US4760083A (en) 1986-04-10 1987-01-05 3,3-disubstituted indolines

Publications (1)

Publication Number Publication Date
MX173308B true MX173308B (es) 1994-02-15

Family

ID=27126891

Family Applications (1)

Application Number Title Priority Date Filing Date
MX005978A MX173308B (es) 1986-04-10 1987-04-02 Procedimiento para la preparacion de indolinas 3,3-disustuidas

Country Status (18)

Country Link
US (1) US4760083A (es)
EP (1) EP0241006B1 (es)
JP (1) JPH068293B2 (es)
KR (1) KR960007528B1 (es)
AT (1) ATE50572T1 (es)
AU (1) AU599370B2 (es)
CA (1) CA1301151C (es)
DE (1) DE3761768D1 (es)
DK (1) DK170164B1 (es)
ES (1) ES2054627T3 (es)
FI (1) FI89482C (es)
GR (1) GR3000359T3 (es)
HU (1) HU196792B (es)
IE (1) IE59680B1 (es)
MX (1) MX173308B (es)
NO (1) NO167661C (es)
NZ (1) NZ219928A (es)
PT (1) PT84651B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300642A (en) * 1986-04-10 1994-04-05 The Du Pont Merck Pharmaceutical Company α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4806651A (en) * 1987-10-07 1989-02-21 E. I. Du Pont De Nemours And Company Process for preparing 3,3-disubstituted indolines
US4965066A (en) * 1989-06-06 1990-10-23 E. I. Du Pont De Nemours And Company Intranasal administration of 3,3-disubstituted indolines
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5087628A (en) * 1990-01-12 1992-02-11 Du Pont Merck Pharmaceutical Company 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
US5171745A (en) * 1990-07-13 1992-12-15 Du Pont Merck Pharmaceutical Company Method of treating neurological dysfunction using neutrotransmitter enhancers
US5698559A (en) * 1992-01-16 1997-12-16 The Dupont Merck Pharmaceutical Company Disubstituted polycyclic systems as cognition enhancers
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
CA2128233A1 (en) * 1992-01-16 1993-07-22 Wendell Wilkie Wilkerson Novel neurotransmitter releasers useful for cognition enhancement
JPH07507772A (ja) * 1992-04-16 1995-08-31 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 認識欠損治療用の置換された窒素含有スピロ化合物
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
CA2146000A1 (en) * 1992-10-13 1994-04-28 Richard Alan Earl 3,3-disubstituted tri-and tetracyclic indolin-2-ones useful for the treatment of cognitive disorders
JP3419539B2 (ja) * 1993-02-17 2003-06-23 中外製薬株式会社 インドリン−２−オン誘導体
US5594001A (en) * 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
CN1058495C (zh) * 1993-04-08 2000-11-15 杜邦药品公司 在治疗识别障碍中用作神经递质释放增强剂的多环体系类化合物及其衍生物和含有它们的药物组合物及其用途
US5308851A (en) * 1993-06-03 1994-05-03 The Du Pont Merck Pharmaceutical Company Bispyridyl-containing heterocycles useful for treating cognitive disorders
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
PT757685E (pt) * 1994-04-29 2004-10-29 Pfizer Novas amidas ciclicas como incrementadores de libertacao de neurotransmissores
US5948781A (en) * 1997-05-27 1999-09-07 Pfizer Inc Adamantyl substituted oxindoles as pharmaceutical agents
US6262081B1 (en) 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
ATE252580T1 (de) 1999-07-30 2003-11-15 Zenyaku Kogyo Kk Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten
FR2804115B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
RS53599B1 (en) 2005-05-10 2015-02-27 Intermune, Inc. PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
CN108658834B (zh) * 2017-03-31 2021-03-23 烟台药物研究所 一种吲哚酮衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
ES426436A1 (es) * 1974-05-18 1976-07-01 Andreu Sa Dr Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona.
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
JPS55129284A (en) * 1979-03-27 1980-10-06 Shionogi & Co Ltd 3-(1-imipazolyl)indolin-2-one
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4452990A (en) * 1982-11-15 1984-06-05 Warner-Lambert Company 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US4434169A (en) * 1983-01-03 1984-02-28 Warner-Lambert Company Pharmaceutical compositions and methods

Also Published As

Publication number Publication date
DK182087D0 (da) 1987-04-09
NO871492L (no) 1987-10-12
NO167661B (no) 1991-08-19
PT84651A (en) 1987-05-01
FI89482B (fi) 1993-06-30
US4760083A (en) 1988-07-26
NO167661C (no) 1991-11-27
KR870009996A (ko) 1987-11-30
KR960007528B1 (ko) 1996-06-05
IE870921L (en) 1987-10-10
EP0241006A2 (en) 1987-10-14
GR3000359T3 (en) 1991-06-07
DE3761768D1 (de) 1990-04-05
FI871556A0 (fi) 1987-04-09
DK170164B1 (da) 1995-06-06
DK182087A (da) 1987-10-11
HU196792B (en) 1989-01-30
FI89482C (fi) 1993-10-11
PT84651B (pt) 1989-12-29
JPS62277381A (ja) 1987-12-02
AU599370B2 (en) 1990-07-19
EP0241006A3 (en) 1988-08-10
AU7133487A (en) 1987-10-15
EP0241006B1 (en) 1990-02-28
ATE50572T1 (de) 1990-03-15
JPH068293B2 (ja) 1994-02-02
NZ219928A (en) 1989-08-29
FI871556A (fi) 1987-10-11
HUT44028A (en) 1988-01-28
ES2054627T3 (es) 1994-08-16
CA1301151C (en) 1992-05-19
IE59680B1 (en) 1994-03-23
NO871492D0 (no) 1987-04-09

Similar Documents

Publication Publication Date Title
MX173308B (es) Procedimiento para la preparacion de indolinas 3,3-disustuidas
DE69022078T2 (de) Pyridazinon Derivate und Verfahren zur deren Herstellung.
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DE3777735D1 (de) Imid-derivate, ihre herstellung und ihre verwendung.
ES2099703T3 (es) Derivados de piridina.
KR900004720A (ko) 새로운 피리딜 및 피리미딜 유도체와 그의 제조방법 및 동물의 치료방법
BG105855A (en) 2-aminopyridines containing fused ring substituents
ATE58536T1 (de) 5-aminoalkyl-beta-carbolinderivate, ihre herstellung und verwendung als arzneimittel.
EA199800720A1 (ru) Гетероциклические производные эрголина в качестве лигандов 5-htia рецептора
ES2042567T3 (es) Un procedimiento para la preparacion de un derivado de ergolina.
ATE160144T1 (de) Pyridazinon derivate, herstellungsverfahren und verwendung