ES2054627T3 - Indolinas 3,3-disustituidas. - Google Patents

Indolinas 3,3-disustituidas.

Info

Publication number
ES2054627T3
ES2054627T3 ES87105190T ES87105190T ES2054627T3 ES 2054627 T3 ES2054627 T3 ES 2054627T3 ES 87105190 T ES87105190 T ES 87105190T ES 87105190 T ES87105190 T ES 87105190T ES 2054627 T3 ES2054627 T3 ES 2054627T3
Authority
ES
Spain
Prior art keywords
alkyl
indolines
pyridyl
chem
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87105190T
Other languages
English (en)
Inventor
Melvyn John Myers
Victor Johannes Nickolson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2054627T3 publication Critical patent/ES2054627T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LAS DEFICIENCIAS COGNITIVAS Y/O LOS DEFICITS DE FUNCION NEUROLOGICA Y/O LAS PERTURBACIONES DEL HUMOR Y/O DE LA MENTE SON TRATADAS MEDIANTE LA ADMINISTRACION DE INDOLINAS 3,3-DISUSTITUIDAS. LAS INDOLINAS TIENEN LA FORMULA (I) EN LA QUE P ES 0 O 1; Z ES O O S; R ES ALQUILO C1-C10, CICLOALQUILO C3-C8, 2-PIRIDIL, 3-PIRIDIL, 4-PIRIDIL O (II); V,W,X E Y SON, INDEPENDIENTEMENTE, H, HALOGENO, ALQUILO C1-C3, OR1, NO2, CF3, CN O NR1R2; R1 Y R2 SON, INDEPENDIENTEMENTE, H O C1-C3; (III) SON INDEPENDIENTEMENTE ANILLOS AROMATICOS, HETEROCICLICOS, DE SEIS MIEMBROS, QUE CONTIENEN POR LO MENOS UN ATOMO DE NITROGENO COMO PARTE DEL ANILLO OPCIONALMENTE SUSTITUIDO CON UN SUSTITUYENTE SELECCIONADO DEL GRUPO DE ALQUILO C1-C3, HALOGENO, OR1 O NR1R2; O UN N-OXIDO O UNA SAL DE ADICION DEL ISMO, FARMACEUTICAMENTE ADECUADA.
ES87105190T 1986-04-10 1987-04-08 Indolinas 3,3-disustituidas. Expired - Lifetime ES2054627T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85001586A 1986-04-10 1986-04-10
US06/944,953 US4760083A (en) 1986-04-10 1987-01-05 3,3-disubstituted indolines

Publications (1)

Publication Number Publication Date
ES2054627T3 true ES2054627T3 (es) 1994-08-16

Family

ID=27126891

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87105190T Expired - Lifetime ES2054627T3 (es) 1986-04-10 1987-04-08 Indolinas 3,3-disustituidas.

Country Status (18)

Country Link
US (1) US4760083A (es)
EP (1) EP0241006B1 (es)
JP (1) JPH068293B2 (es)
KR (1) KR960007528B1 (es)
AT (1) ATE50572T1 (es)
AU (1) AU599370B2 (es)
CA (1) CA1301151C (es)
DE (1) DE3761768D1 (es)
DK (1) DK170164B1 (es)
ES (1) ES2054627T3 (es)
FI (1) FI89482C (es)
GR (1) GR3000359T3 (es)
HU (1) HU196792B (es)
IE (1) IE59680B1 (es)
MX (1) MX173308B (es)
NO (1) NO167661C (es)
NZ (1) NZ219928A (es)
PT (1) PT84651B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5300642A (en) * 1986-04-10 1994-04-05 The Du Pont Merck Pharmaceutical Company α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4806651A (en) * 1987-10-07 1989-02-21 E. I. Du Pont De Nemours And Company Process for preparing 3,3-disubstituted indolines
US4965066A (en) * 1989-06-06 1990-10-23 E. I. Du Pont De Nemours And Company Intranasal administration of 3,3-disubstituted indolines
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5087628A (en) * 1990-01-12 1992-02-11 Du Pont Merck Pharmaceutical Company 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
US5171745A (en) * 1990-07-13 1992-12-15 Du Pont Merck Pharmaceutical Company Method of treating neurological dysfunction using neutrotransmitter enhancers
DE69218795T2 (de) * 1992-01-16 1997-07-10 Du Pont Merck Pharma Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
US5698559A (en) * 1992-01-16 1997-12-16 The Dupont Merck Pharmaceutical Company Disubstituted polycyclic systems as cognition enhancers
EP0636132A1 (en) * 1992-04-16 1995-02-01 The Du Pont Merck Pharmaceutical Company Substituted nitrogen containing spiro compounds for use in treating cognitive deficits
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
AU6242294A (en) * 1992-10-13 1994-05-09 Du Pont Merck Pharmaceutical Company, The 3,3-disubstituted tri- and tetracyclic indolin-2-ones useful for the treatment of cognitive disorders
JP3419539B2 (ja) * 1993-02-17 2003-06-23 中外製薬株式会社 インドリン−２−オン誘導体
US5594001A (en) * 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
AU690906B2 (en) * 1993-04-08 1998-05-07 Du Pont Pharmaceuticals Company Novel polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disoders
US5308851A (en) * 1993-06-03 1994-05-03 The Du Pont Merck Pharmaceutical Company Bispyridyl-containing heterocycles useful for treating cognitive disorders
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
CA2188427C (en) * 1994-04-29 2000-06-27 Robert A. Volkmann Neurotransmitter release enhancers
US5948781A (en) * 1997-05-27 1999-09-07 Pfizer Inc Adamantyl substituted oxindoles as pharmaceutical agents
US6262081B1 (en) * 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
AU766122B2 (en) 1999-07-30 2003-10-09 Zenyaku Kogyo Kabushiki Kaisha Azaindolizinone derivatives and cognitive enhancers comprising the same as effective components
FR2804115B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
KR20080023680A (ko) 2005-05-10 2008-03-14 인터뮨, 인크. 스트레스-활성화 단백질 키나제 시스템을 조절하기 위한피리돈 유도체
MX2010012848A (es) 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
CN108658834B (zh) * 2017-03-31 2021-03-23 烟台药物研究所 一种吲哚酮衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
ES426436A1 (es) * 1974-05-18 1976-07-01 Andreu Sa Dr Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona.
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
JPS55129284A (en) * 1979-03-27 1980-10-06 Shionogi & Co Ltd 3-(1-imipazolyl)indolin-2-one
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4452990A (en) * 1982-11-15 1984-06-05 Warner-Lambert Company 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US4434169A (en) * 1983-01-03 1984-02-28 Warner-Lambert Company Pharmaceutical compositions and methods

Also Published As

Publication number Publication date
AU599370B2 (en) 1990-07-19
NO167661B (no) 1991-08-19
KR960007528B1 (ko) 1996-06-05
EP0241006B1 (en) 1990-02-28
MX173308B (es) 1994-02-15
PT84651A (en) 1987-05-01
AU7133487A (en) 1987-10-15
IE59680B1 (en) 1994-03-23
DK182087D0 (da) 1987-04-09
EP0241006A3 (en) 1988-08-10
ATE50572T1 (de) 1990-03-15
FI871556A (fi) 1987-10-11
US4760083A (en) 1988-07-26
EP0241006A2 (en) 1987-10-14
GR3000359T3 (en) 1991-06-07
DK170164B1 (da) 1995-06-06
NZ219928A (en) 1989-08-29
IE870921L (en) 1987-10-10
HUT44028A (en) 1988-01-28
DE3761768D1 (de) 1990-04-05
HU196792B (en) 1989-01-30
NO167661C (no) 1991-11-27
DK182087A (da) 1987-10-11
FI871556A0 (fi) 1987-04-09
JPS62277381A (ja) 1987-12-02
FI89482C (fi) 1993-10-11
NO871492L (no) 1987-10-12
CA1301151C (en) 1992-05-19
FI89482B (fi) 1993-06-30
JPH068293B2 (ja) 1994-02-02
PT84651B (pt) 1989-12-29
NO871492D0 (no) 1987-04-09
KR870009996A (ko) 1987-11-30

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