DK182087D0 - 3,3-disubstituerede indoliner eller n-oxider eller farmaceutiske acceptable syreadditonssalte deraf, deres fremstilling og anvendelse - Google Patents

3,3-disubstituerede indoliner eller n-oxider eller farmaceutiske acceptable syreadditonssalte deraf, deres fremstilling og anvendelse

Info

Publication number
DK182087D0
DK182087D0 DK182087A DK182087A DK182087D0 DK 182087 D0 DK182087 D0 DK 182087D0 DK 182087 A DK182087 A DK 182087A DK 182087 A DK182087 A DK 182087A DK 182087 D0 DK182087 D0 DK 182087D0
Authority
DK
Denmark
Prior art keywords
alkyl
indolines
oxides
preparation
pyridyl
Prior art date
Application number
DK182087A
Other languages
English (en)
Other versions
DK170164B1 (da
DK182087A (da
Inventor
Melvyn John Myers
Victor Johannes Nickolson
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK182087D0 publication Critical patent/DK182087D0/da
Publication of DK182087A publication Critical patent/DK182087A/da
Application granted granted Critical
Publication of DK170164B1 publication Critical patent/DK170164B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK182087A 1986-04-10 1987-04-09 3,3-Heterocyclisk disubstituerede indoliner samt N-oxider og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmåde til deres fremstilling og farmaceutisk præparat indeholdende dem DK170164B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85001586A 1986-04-10 1986-04-10
US85001586 1986-04-10
US94495387 1987-01-05
US06/944,953 US4760083A (en) 1986-04-10 1987-01-05 3,3-disubstituted indolines

Publications (3)

Publication Number Publication Date
DK182087D0 true DK182087D0 (da) 1987-04-09
DK182087A DK182087A (da) 1987-10-11
DK170164B1 DK170164B1 (da) 1995-06-06

Family

ID=27126891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK182087A DK170164B1 (da) 1986-04-10 1987-04-09 3,3-Heterocyclisk disubstituerede indoliner samt N-oxider og farmaceutisk acceptable syreadditionssalte deraf, fremgangsmåde til deres fremstilling og farmaceutisk præparat indeholdende dem

Country Status (18)

Country Link
US (1) US4760083A (da)
EP (1) EP0241006B1 (da)
JP (1) JPH068293B2 (da)
KR (1) KR960007528B1 (da)
AT (1) ATE50572T1 (da)
AU (1) AU599370B2 (da)
CA (1) CA1301151C (da)
DE (1) DE3761768D1 (da)
DK (1) DK170164B1 (da)
ES (1) ES2054627T3 (da)
FI (1) FI89482C (da)
GR (1) GR3000359T3 (da)
HU (1) HU196792B (da)
IE (1) IE59680B1 (da)
MX (1) MX173308B (da)
NO (1) NO167661C (da)
NZ (1) NZ219928A (da)
PT (1) PT84651B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300642A (en) * 1986-04-10 1994-04-05 The Du Pont Merck Pharmaceutical Company α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4806651A (en) * 1987-10-07 1989-02-21 E. I. Du Pont De Nemours And Company Process for preparing 3,3-disubstituted indolines
US4965066A (en) * 1989-06-06 1990-10-23 E. I. Du Pont De Nemours And Company Intranasal administration of 3,3-disubstituted indolines
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5087628A (en) * 1990-01-12 1992-02-11 Du Pont Merck Pharmaceutical Company 4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function
US5171745A (en) * 1990-07-13 1992-12-15 Du Pont Merck Pharmaceutical Company Method of treating neurological dysfunction using neutrotransmitter enhancers
DE69218795T2 (de) * 1992-01-16 1997-07-10 Du Pont Merck Pharma Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
US5698559A (en) * 1992-01-16 1997-12-16 The Dupont Merck Pharmaceutical Company Disubstituted polycyclic systems as cognition enhancers
EP0636132A1 (en) * 1992-04-16 1995-02-01 The Du Pont Merck Pharmaceutical Company Substituted nitrogen containing spiro compounds for use in treating cognitive deficits
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
CA2146000A1 (en) * 1992-10-13 1994-04-28 Richard Alan Earl 3,3-disubstituted tri-and tetracyclic indolin-2-ones useful for the treatment of cognitive disorders
TW281669B (da) * 1993-02-17 1996-07-21 Chugai Pharmaceutical Co Ltd
US5594001A (en) * 1993-04-08 1997-01-14 The Dupont Merck Pharmaceutical Company Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders
WO1994024131A1 (en) * 1993-04-08 1994-10-27 The Du Pont Merck Pharmaceutical Company Novel polycyclic systems, and derivatives thereof, as neurotransmitter release enhancer useful in the treatment of cognitive disorders
US5308851A (en) * 1993-06-03 1994-05-03 The Du Pont Merck Pharmaceutical Company Bispyridyl-containing heterocycles useful for treating cognitive disorders
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
ES2223049T3 (es) * 1994-04-29 2005-02-16 Pfizer Inc. Amidas aciclicas y ciclicas novedosas como estimuladores de la liberacion de neurotransmisores.
US5948781A (en) * 1997-05-27 1999-09-07 Pfizer Inc Adamantyl substituted oxindoles as pharmaceutical agents
US6262081B1 (en) 1998-07-10 2001-07-17 Dupont Pharmaceuticals Company Composition for and method of treating neurological disorders
CN1179962C (zh) 1999-07-30 2004-12-15 全药工业株式会社 氮杂吲哚嗪酮衍生物和以其为有效成分的脑功能改善剂
FR2804115B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン
CN108658834B (zh) * 2017-03-31 2021-03-23 烟台药物研究所 一种吲哚酮衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
ES426436A1 (es) * 1974-05-18 1976-07-01 Andreu Sa Dr Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona.
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
JPS55129284A (en) * 1979-03-27 1980-10-06 Shionogi & Co Ltd 3-(1-imipazolyl)indolin-2-one
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4452990A (en) * 1982-11-15 1984-06-05 Warner-Lambert Company 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US4434169A (en) * 1983-01-03 1984-02-28 Warner-Lambert Company Pharmaceutical compositions and methods

Also Published As

Publication number Publication date
EP0241006A3 (en) 1988-08-10
AU599370B2 (en) 1990-07-19
ATE50572T1 (de) 1990-03-15
MX173308B (es) 1994-02-15
DE3761768D1 (de) 1990-04-05
US4760083A (en) 1988-07-26
NO871492D0 (no) 1987-04-09
PT84651A (en) 1987-05-01
NO167661B (no) 1991-08-19
ES2054627T3 (es) 1994-08-16
FI89482B (fi) 1993-06-30
FI871556A0 (fi) 1987-04-09
FI89482C (fi) 1993-10-11
DK170164B1 (da) 1995-06-06
NO167661C (no) 1991-11-27
IE59680B1 (en) 1994-03-23
IE870921L (en) 1987-10-10
NO871492L (no) 1987-10-12
EP0241006A2 (en) 1987-10-14
NZ219928A (en) 1989-08-29
PT84651B (pt) 1989-12-29
GR3000359T3 (en) 1991-06-07
JPH068293B2 (ja) 1994-02-02
HUT44028A (en) 1988-01-28
JPS62277381A (ja) 1987-12-02
DK182087A (da) 1987-10-11
FI871556A (fi) 1987-10-11
EP0241006B1 (en) 1990-02-28
KR960007528B1 (ko) 1996-06-05
KR870009996A (ko) 1987-11-30
HU196792B (en) 1989-01-30
AU7133487A (en) 1987-10-15
CA1301151C (en) 1992-05-19

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)