MX168598B - Metodo de membrana enzimatica para la sintesis y separacion de peptidos. - Google Patents

Metodo de membrana enzimatica para la sintesis y separacion de peptidos.

Info

Publication number
MX168598B
MX168598B MX007808A MX780887A MX168598B MX 168598 B MX168598 B MX 168598B MX 007808 A MX007808 A MX 007808A MX 780887 A MX780887 A MX 780887A MX 168598 B MX168598 B MX 168598B
Authority
MX
Mexico
Prior art keywords
reaction mixture
compound
peptides
membrane
synthesis
Prior art date
Application number
MX007808A
Other languages
English (en)
Inventor
Guillermo A Iacobucci
Original Assignee
Cocacola Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/897,679 external-priority patent/US5037741A/en
Application filed by Cocacola Company filed Critical Cocacola Company
Publication of MX168598B publication Critical patent/MX168598B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/819—Fermentation vessels in series

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La precente invención se refiere a un método para la síntesis enzimática de los péptidos; dicho método caracterizado porque comprende las etapas de: condenzar enzimáticamente los compuestos aminoácidos primero y segundo en una mezcla acuosa inicial de reacción para formar un compuesto no cargado; transportar el compuesto no cargado mediante difución hacia una segunda mezcla acuosa de reacción, através de una membrana que no transporta cantidades considerables de los compuestos aminoácidos; convertir el compuesto no cargado y transportado, en na forma que no puede volver a transportarse, atraves de la membrana, a la mezcla inicial de reacción y remover la forma del compuesto que no puede volver a transportarse a la mezcla inicial de reacción a través de la membrana.
MX007808A 1986-08-18 1987-08-18 Metodo de membrana enzimatica para la sintesis y separacion de peptidos. MX168598B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/897,679 US5037741A (en) 1986-08-18 1986-08-18 Enzymatic method for the synthesis and separation of peptides
US07/078,504 US5002871A (en) 1986-08-18 1987-07-28 Enzymatic membrane method for the synthesis and separation of peptides

Publications (1)

Publication Number Publication Date
MX168598B true MX168598B (es) 1993-06-01

Family

ID=26760616

Family Applications (1)

Application Number Title Priority Date Filing Date
MX007808A MX168598B (es) 1986-08-18 1987-08-18 Metodo de membrana enzimatica para la sintesis y separacion de peptidos.

Country Status (22)

Country Link
US (1) US5002871A (es)
EP (1) EP0321479B1 (es)
JP (1) JPH06319592A (es)
KR (1) KR900004070B1 (es)
CN (1) CN1026498C (es)
AR (1) AR242264A1 (es)
AT (1) ATE102654T1 (es)
AU (1) AU610520B2 (es)
DE (1) DE3789309T2 (es)
DK (1) DK209388A (es)
EG (1) EG18454A (es)
ES (1) ES2007103A6 (es)
FI (1) FI884359A7 (es)
GB (1) GB2218991B (es)
GR (1) GR871290B (es)
IL (2) IL98061A (es)
MX (1) MX168598B (es)
NZ (2) NZ221467A (es)
PH (1) PH26764A (es)
PT (1) PT85548B (es)
SG (1) SG35491G (es)
WO (1) WO1988001298A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244791A (en) * 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5055399A (en) * 1985-01-15 1991-10-08 Genentech, Inc. Enzymatic synthesis of alpha-L-aspartyl-L-phenyalanine lower alkyl esters
US5202235A (en) * 1986-08-18 1993-04-13 The Coca-Cola Company Enzymatic method for the synthesis and separation of peptides
US5336601A (en) * 1986-08-18 1994-08-09 The Coca-Cola Company Enzymatic membrane method for the snythesis and separation of peptides
US5350681A (en) * 1986-08-18 1994-09-27 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
FI915012A0 (fi) * 1989-04-24 1991-10-23 Coca Cola Co Enzymatiskt membranfoerfarande foer syntetisering och separering av peptider.
US5314807A (en) * 1991-03-29 1994-05-24 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Method for producing an angiotensin converting enzyme inhibitor-containing composition
EP0533913A1 (en) * 1991-04-12 1993-03-31 The Children's Hospital Of Philadelphia Novel endopeptidase
US6271023B1 (en) * 1997-02-04 2001-08-07 Akzo Nobel N.V. Module made of at least two-type hollow fibres, and production of same
FR2777803B1 (fr) * 1998-04-24 2000-07-28 Univ Claude Bernard Lyon Procede d'elimination active et selective de petites molecules par pompage enzymatique : dialyse active
US6500571B2 (en) * 1998-08-19 2002-12-31 Powerzyme, Inc. Enzymatic fuel cell
AU2001255521A1 (en) * 2000-04-21 2001-11-07 University Of Rochester Biphasic reaction vessel and methods of use
US6485650B1 (en) * 2000-08-28 2002-11-26 Facilichem, Inc. Liquid membrane separation of enantiomers
US20020114906A1 (en) * 2000-11-20 2002-08-22 Bridgestone Corporation Base body for photosensitive drum and photosensitive drum using the same
CN117820437B (zh) * 2023-03-24 2024-07-05 东阿辰康药业有限公司 菊芋肽、其制备方法及其在护肾辅助糖尿病治疗抗氧化产品中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL60227C (es) * 1943-02-23
US3625734A (en) * 1969-10-16 1971-12-07 Usa Ultra-thin liquid membrane construction
US3779907A (en) * 1970-04-13 1973-12-18 Exxon Research Engineering Co Liquid membrane process for the separation of aqueous mixtures
CA947214A (en) * 1971-04-02 1974-05-14 Canadian Patents And Development Limited Resolution of racemates of ring-substituted phenylalanines
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
US4119493A (en) * 1975-10-23 1978-10-10 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide
DE2804892A1 (de) * 1977-02-09 1978-08-10 Procter & Gamble Verfahren zur herstellung von l-threonin und dessen n-acylderivat
US4187086A (en) * 1977-06-15 1980-02-05 General Electric Company Packaged membrane system and replenishment method
US4119408A (en) * 1977-06-22 1978-10-10 General Electric Company Apparatus for maintaining the separation efficiency of immobilized liquid membranes in gas separation
US4251631A (en) * 1978-02-23 1981-02-17 Research Products Rehovot Ltd. Cross-linked enzyme membrane
GB2047564B (en) * 1978-03-27 1983-01-26 Bend Res Inc Separator membrane and process using such membrane for removing ions from an aqueous solution
DE2907450A1 (de) * 1979-02-26 1980-09-04 Rehovot Res Prod Verfahren zur trennung eines waessrigen loesungsgemisches durch elektrodialyse
ZA801929B (en) * 1979-04-06 1981-11-25 Forenede Bryggerier As A process for enzymatic production of peptides
EP0075160B1 (en) * 1981-09-21 1987-01-07 Toyo Soda Manufacturing Co., Ltd. Process for recovering a dipeptide derivative
US4455210A (en) * 1982-03-04 1984-06-19 General Electric Company Multi layer ion exchanging membrane with protected interior hydroxyl ion rejection layer
JPS59183825A (ja) * 1983-04-04 1984-10-19 Nippon Oil & Fats Co Ltd 不均一系反応方法
EP0124313B1 (en) * 1983-04-28 1989-08-02 Ajinomoto Co., Inc. Process for the production of l-aspartyl-l-phenylalanine methyl ester or l-aspartyl-l-phenylalanine
JPS60164495A (ja) * 1984-01-16 1985-08-27 モンサント　コンパニー Ｎ‐ホルミルアミノ酸とペプチド残基の酵素的結合法
DE3438189A1 (de) * 1984-10-18 1986-04-24 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung aromatisch substituierter l-aminosaeuren
DE3685223D1 (de) * 1985-01-15 1992-06-17 Genentech Inc Verfahren und vorrichtung fuer enzymatische synthese.
US4743547A (en) * 1985-04-09 1988-05-10 Kuraray Co., Ltd. Method of producing L-phenylalanine

Also Published As

Publication number Publication date
DK209388D0 (da) 1988-04-15
JPH06319592A (ja) 1994-11-22
DK209388A (da) 1988-04-15
AU610520B2 (en) 1991-05-23
ATE102654T1 (de) 1994-03-15
GB2218991B (en) 1991-02-13
AR242264A1 (es) 1993-03-31
WO1988001298A2 (en) 1988-02-25
PT85548A (en) 1987-09-01
DE3789309T2 (de) 1994-10-06
US5002871A (en) 1991-03-26
AU7854387A (en) 1988-03-08
CN87106791A (zh) 1988-05-04
KR900004070B1 (ko) 1990-06-11
IL83564A (en) 1992-03-29
WO1988001298A3 (en) 1988-04-07
ES2007103A6 (es) 1989-06-01
PH26764A (en) 1992-09-28
EG18454A (en) 1994-10-30
SG35491G (en) 1991-06-21
IL98061A (en) 1992-03-29
GR871290B (en) 1987-12-23
GB2218991A (en) 1989-11-29
EP0321479B1 (en) 1994-03-09
GB8903271D0 (en) 1989-08-23
EP0321479A1 (en) 1989-06-28
NZ221467A (en) 1990-07-26
CN1026498C (zh) 1994-11-09
PT85548B (pt) 1990-05-31
FI884359A0 (fi) 1988-09-22
NZ231657A (en) 1991-07-26
DE3789309D1 (de) 1994-04-14
IL83564A0 (en) 1988-01-31
KR880701778A (ko) 1988-11-05
FI884359A7 (fi) 1988-09-22

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