MX160445A - Procedimiento para preparar derivados de benzoato ester substituido de 3-hidroximorfinanos - Google Patents

Procedimiento para preparar derivados de benzoato ester substituido de 3-hidroximorfinanos

Info

Publication number
MX160445A
MX160445A MX6144A MX614485A MX160445A MX 160445 A MX160445 A MX 160445A MX 6144 A MX6144 A MX 6144A MX 614485 A MX614485 A MX 614485A MX 160445 A MX160445 A MX 160445A
Authority
MX
Mexico
Prior art keywords
hydroximorphin
preparing
procedure
benzoate derivatives
substituted benzoate
Prior art date
Application number
MX6144A
Other languages
English (en)
Spanish (es)
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX160445A publication Critical patent/MX160445A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX6144A 1984-07-05 1985-07-05 Procedimiento para preparar derivados de benzoato ester substituido de 3-hidroximorfinanos MX160445A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (1)

Publication Number Publication Date
MX160445A true MX160445A (es) 1990-03-02

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
MX6144A MX160445A (es) 1984-07-05 1985-07-05 Procedimiento para preparar derivados de benzoato ester substituido de 3-hidroximorfinanos

Country Status (18)

Country Link
US (1) US4668685A (enExample)
EP (1) EP0170090B1 (enExample)
AU (1) AU578391B2 (enExample)
CA (1) CA1301150C (enExample)
DE (1) DE3573251D1 (enExample)
DK (1) DK160501C (enExample)
ES (1) ES8704443A1 (enExample)
FI (1) FI83215C (enExample)
GR (1) GR851653B (enExample)
HK (1) HK39790A (enExample)
HU (1) HU193995B (enExample)
IE (1) IE58136B1 (enExample)
IL (1) IL75721A (enExample)
MX (1) MX160445A (enExample)
NO (1) NO171209C (enExample)
NZ (1) NZ212641A (enExample)
PT (1) PT80773B (enExample)
SU (2) SU1450742A3 (enExample)

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US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
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TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
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US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
TR200001942T2 (tr) 1997-12-22 2000-11-21 Euro-Celtique, S.A. Opioid agonist/antagonist kombinasyonlar
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
ES2188481T3 (es) * 2000-04-27 2003-07-01 Oliver Yoa-Pu Hu Derivados de polinalbufina.
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
US7435817B2 (en) * 2001-08-23 2008-10-14 N.V. Organon C-14 oxidation of morphine derivatives
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
LT2425821T (lt) 2002-04-05 2017-07-25 Euro-Celtique S.A. Farmacinis preparatas, turintis oksikodono ir naloksono
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20060069086A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
KR100905511B1 (ko) * 2005-01-28 2009-07-01 유로-셀띠끄 소시에떼 아노님 알코올 저항성 제형
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
CN101627014B (zh) * 2007-03-09 2013-04-24 株式会社绿十字 用于预防或治疗帕金森病的(+)-3-羟基吗啡喃的口服可生物利用前药
SI2317991T1 (sl) * 2008-07-07 2017-09-29 Euro-Celtique S.A. Uporaba opioidnih antagonistov za zdravljenje retencije urina
PL2405915T3 (pl) 2009-03-10 2019-05-31 Euro Celtique Sa Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
AU2011327113B9 (en) 2010-11-12 2015-07-30 Shionogi & Co., Ltd. Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
IN2014DN03009A (enExample) 2011-10-26 2015-05-08 Kempharm Inc
KR20160034352A (ko) 2013-07-23 2016-03-29 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
MX2017006520A (es) 2014-11-25 2017-08-09 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
CA2969221C (en) 2014-12-02 2021-01-12 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
CA3149152A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates

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US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
HK39790A (en) 1990-06-01
SU1508960A3 (ru) 1989-09-15
PT80773A (en) 1985-08-01
DE3573251D1 (en) 1989-11-02
DK306885A (da) 1986-01-06
FI852659L (fi) 1986-01-06
DK306885D0 (da) 1985-07-04
ES8704443A1 (es) 1987-04-01
NO171209B (no) 1992-11-02
DK160501C (da) 1991-08-26
FI852659A0 (fi) 1985-07-04
IL75721A (en) 1990-04-29
IE851683L (en) 1986-01-05
EP0170090B1 (en) 1989-09-27
SU1450742A3 (ru) 1989-01-07
IL75721A0 (en) 1985-11-29
EP0170090A1 (en) 1986-02-05
NO852699L (no) 1986-01-06
US4668685A (en) 1987-05-26
AU578391B2 (en) 1988-10-20
HUT40132A (en) 1986-11-28
FI83215B (fi) 1991-02-28
CA1301150C (en) 1992-05-19
HU193995B (en) 1987-12-28
DK160501B (da) 1991-03-18
NZ212641A (en) 1988-10-28
FI83215C (fi) 1991-06-10
ES544852A0 (es) 1987-04-01
IE58136B1 (en) 1993-07-14
GR851653B (enExample) 1985-11-26
AU4451685A (en) 1986-01-09
NO171209C (no) 1993-02-10
PT80773B (pt) 1987-10-20

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