MEP8009A - Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors - Google Patents
Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitorsInfo
- Publication number
- MEP8009A MEP8009A MEP-80/09A MEP8009A MEP8009A ME P8009 A MEP8009 A ME P8009A ME P8009 A MEP8009 A ME P8009A ME P8009 A MEP8009 A ME P8009A
- Authority
- ME
- Montenegro
- Prior art keywords
- inhibitors
- compounds
- pyrido
- phosphoinosit
- synthesis
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- UDJFFSGCRRMVFH-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine Chemical compound N1=CN=CC2=CC=CN=C21 UDJFFSGCRRMVFH-UHFFFAOYSA-N 0.000 title 1
- FQIOVOFFAYUEJN-UHFFFAOYSA-N 4-methyl-3h-pyrido[3,2-d]pyrimidin-2-one Chemical class C1=CN=C2C(C)=NC(=O)NC2=C1 FQIOVOFFAYUEJN-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84506506P | 2006-09-15 | 2006-09-15 | |
| US94785207P | 2007-07-03 | 2007-07-03 | |
| US95262807P | 2007-07-30 | 2007-07-30 | |
| PCT/IB2007/002578 WO2008032162A1 (en) | 2006-09-15 | 2007-09-03 | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP8009A true MEP8009A (en) | 2011-12-20 |
Family
ID=38859750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-80/09A MEP8009A (en) | 2006-09-15 | 2007-09-03 | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors |
Country Status (41)
| Country | Link |
|---|---|
| US (3) | US7696213B2 (2) |
| EP (1) | EP2074122B9 (2) |
| JP (1) | JP4718637B2 (2) |
| KR (1) | KR101099926B1 (2) |
| CN (1) | CN101573358B (2) |
| AP (1) | AP2710A (2) |
| AR (1) | AR062785A1 (2) |
| AT (1) | ATE514695T1 (2) |
| AU (1) | AU2007297212B8 (2) |
| BR (1) | BRPI0716749B8 (2) |
| CA (1) | CA2663401C (2) |
| CL (1) | CL2007002682A1 (2) |
| CR (1) | CR10662A (2) |
| CU (1) | CU23783B7 (2) |
| CY (1) | CY1111911T1 (2) |
| DK (1) | DK2074122T5 (2) |
| DO (1) | DOP2009000039A (2) |
| EA (1) | EA016388B1 (2) |
| ES (1) | ES2366489T3 (2) |
| GE (1) | GEP20115306B (2) |
| GT (1) | GT200700077A (2) |
| HN (1) | HN2007000267A (2) |
| HR (1) | HRP20110621T2 (2) |
| IL (1) | IL197243A (2) |
| MA (1) | MA30709B1 (2) |
| ME (1) | MEP8009A (2) |
| MX (1) | MX2009002927A (2) |
| MY (1) | MY146420A (2) |
| NI (1) | NI200900032A (2) |
| NO (1) | NO342357B1 (2) |
| NZ (1) | NZ575167A (2) |
| PE (1) | PE20080670A1 (2) |
| PL (1) | PL2074122T3 (2) |
| PT (1) | PT2074122E (2) |
| RS (2) | RS51927B (2) |
| SI (1) | SI2074122T1 (2) |
| TN (1) | TN2009000085A1 (2) |
| TW (1) | TWI334353B (2) |
| UY (1) | UY30588A1 (2) |
| WO (1) | WO2008032162A1 (2) |
| ZA (1) | ZA200901477B (2) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20115306B (2) * | 2006-09-15 | 2011-10-10 | Pfizer Prod Inc | |
| PL2139484T3 (pl) * | 2007-04-10 | 2013-12-31 | Exelixis Inc | Sposoby leczenia raka z zastosowaniem pirydopirymidynonów jako inhibitorów PI3K alfa |
| KR20090130104A (ko) * | 2007-04-11 | 2009-12-17 | 엑셀리시스, 인코포레이티드 | 암 치료를 위한 ｐｉ３ｋ－알파의 억제제로서의 피리도〔２，３ｄ〕피리미딘７온 화합물 |
| KR20110028651A (ko) * | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (ａ) 포스포이노시타이드 3-키나제 억제제 및 (ｂ) ｒａｓ/ｒａｆ/ｍｅｋ 경로의 조절제의 조합물 |
| AU2009282574B2 (en) * | 2008-08-20 | 2014-08-21 | Merck Sharp & Dohme Corp. | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| AR072937A1 (es) | 2008-08-20 | 2010-09-29 | Schering Corp | Derivados de piridina y pirimidina sustituida y su uso en el tratamiento de infecciones virales |
| JP5654990B2 (ja) | 2008-08-20 | 2015-01-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アゾ置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| JP5674661B2 (ja) | 2008-08-20 | 2015-02-25 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | エチニル置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| UY32153A (es) * | 2008-09-30 | 2011-04-29 | Exelixis Inc | Inhibidores de piridomidinona de pi13ka(alfa) y mtor |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| RS53768B1 (sr) | 2010-12-16 | 2015-06-30 | F. Hoffmann-La Roche Ag. | Triciklična pi3k inhibitorna jedinjenja i postupci korišćenja |
| US8664230B2 (en) * | 2011-03-17 | 2014-03-04 | The Asan Foundation | Pyridopyrimidine derivatives and use thereof |
| TW201306842A (zh) * | 2011-06-15 | 2013-02-16 | Exelixis Inc | 使用ｐｉ３ｋ／ｍｔｏｒ吡啶並嘧啶酮抑制劑及苯達莫司汀及／或利妥昔單抗治療惡性血液疾病之組合療法 |
| JP6058009B2 (ja) | 2011-08-31 | 2017-01-11 | ノバルティス アーゲー | Ｐｉ３ｋ−およびｍｅｋ−阻害剤の相乗的な組合せ |
| CN104829609B (zh) * | 2014-02-11 | 2016-08-03 | 北大方正集团有限公司 | 取代的吡啶并嘧啶化合物及其制备方法和应用 |
| US9828373B2 (en) | 2014-07-26 | 2017-11-28 | Sunshine Lake Pharma Co., Ltd. | 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof |
| CN105330699B (zh) * | 2014-08-13 | 2018-12-04 | 山东汇睿迪生物技术有限公司 | 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用 |
| BR112017006113A8 (pt) | 2014-10-10 | 2018-04-24 | Pfizer | usos de auristatina, composições farmacêuticas, formas de dosagem para o tratamento de câncer e kits. |
| AU2016272881C1 (en) | 2015-06-04 | 2019-10-03 | Pfizer Inc. | Solid dosage forms of palbociclib |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| JP2019519593A (ja) | 2016-07-06 | 2019-07-11 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
| US10233188B2 (en) | 2016-08-15 | 2019-03-19 | Pfizer Inc. | CDK2/4/6 inhibitors |
| US11241500B2 (en) * | 2016-12-14 | 2022-02-08 | Tarveda Therapeutics, Inc. | HSP90-targeting conjugates and formulations thereof |
| WO2019157516A1 (en) | 2018-02-12 | 2019-08-15 | resTORbio, Inc. | Combination therapies |
| FI3813946T3 (fi) | 2018-06-15 | 2024-06-25 | Janssen Pharmaceutica Nv | Rapamysiinianalogeja ja niiden käyttötapoja |
| WO2020140055A1 (en) * | 2018-12-28 | 2020-07-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| WO2020140053A1 (en) * | 2018-12-28 | 2020-07-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
| US11583538B2 (en) | 2019-04-08 | 2023-02-21 | Venenum Biodesign, LLC | Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors |
| WO2021113665A1 (en) | 2019-12-05 | 2021-06-10 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| CN114901664B (zh) * | 2020-01-10 | 2024-07-02 | 南京再明医药有限公司 | 吡啶酮化合物及应用 |
| WO2022075974A1 (en) * | 2020-10-06 | 2022-04-14 | Venenum Biodesign, LLC | Cyclic trex1 inhibitors |
| KR20230121758A (ko) | 2020-11-18 | 2023-08-21 | 데시페라 파마슈티칼스, 엘엘씨. | Gcn2 및 perk 키나제 억제제 및 그의 사용 방법 |
| AU2022389984A1 (en) * | 2021-11-18 | 2024-06-13 | Traws Pharma, Inc. | Methods and compositions for treating cancer |
| JP2024544632A (ja) | 2021-12-03 | 2024-12-03 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２及びｐｅｒｋキナーゼ阻害剤としての複素環式化合物 |
| TW202502345A (zh) | 2023-06-08 | 2025-01-16 | 美商林伯士瓦吉特公司 | Wrn抑制劑 |
| US20250206738A1 (en) * | 2023-12-21 | 2025-06-26 | Nimbus Wadjet, Inc. | Wrn inhibitors |
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| GEP20115306B (2) | 2006-09-15 | 2011-10-10 | Pfizer Prod Inc | |
| CA2680796A1 (en) * | 2007-03-14 | 2008-09-18 | Exelixis, Inc. | Inhibitors of the hedgehog pathway |
| KR20090130104A (ko) | 2007-04-11 | 2009-12-17 | 엑셀리시스, 인코포레이티드 | 암 치료를 위한 ｐｉ３ｋ－알파의 억제제로서의 피리도〔２，３ｄ〕피리미딘７온 화합물 |
| UY32153A (es) | 2008-09-30 | 2011-04-29 | Exelixis Inc | Inhibidores de piridomidinona de pi13ka(alfa) y mtor |
| CA2795952A1 (en) * | 2010-04-16 | 2011-10-20 | Curis, Inc. | Treatment of cancers having k-ras mutations |
-
2007
- 2007-09-03 GE GEAP200711157A patent/GEP20115306B/en unknown
- 2007-09-03 SI SI200730715T patent/SI2074122T1/sl unknown
- 2007-09-03 ME MEP-80/09A patent/MEP8009A/xx unknown
- 2007-09-03 CA CA2663401A patent/CA2663401C/en not_active Expired - Fee Related
- 2007-09-03 DK DK07804890.7T patent/DK2074122T5/da active
- 2007-09-03 EP EP07804890.7A patent/EP2074122B9/en active Active
- 2007-09-03 ES ES07804890T patent/ES2366489T3/es active Active
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