MEP41508A - Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives - Google Patents
Cinnamoylaminoalkyl-substituted benzenesulfonamide derivativesInfo
- Publication number
- MEP41508A MEP41508A MEP-415/08A MEP41508A MEP41508A ME P41508 A MEP41508 A ME P41508A ME P41508 A MEP41508 A ME P41508A ME P41508 A MEP41508 A ME P41508A
- Authority
- ME
- Montenegro
- Prior art keywords
- compounds
- formula
- cinnamoylaminoalkyl
- benzenesulfonamide derivatives
- substituted benzenesulfonamide
- Prior art date
Links
- 150000008331 benzenesulfonamides Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010019280 Heart failures Diseases 0.000 abstract 2
- 230000000747 cardiac effect Effects 0.000 abstract 2
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19923086A DE19923086A1 (de) | 1999-05-20 | 1999-05-20 | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP2000/004091 WO2000071513A1 (en) | 1999-05-20 | 2000-05-06 | Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP41508A true MEP41508A (en) | 2011-02-10 |
Family
ID=7908577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-415/08A MEP41508A (en) | 1999-05-20 | 2000-05-06 | Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6350778B1 (de) |
| EP (1) | EP1183236B1 (de) |
| JP (1) | JP4559640B2 (de) |
| KR (1) | KR100968729B1 (de) |
| CN (1) | CN1243730C (de) |
| AR (1) | AR035625A1 (de) |
| AT (1) | ATE252554T1 (de) |
| AU (1) | AU771675B2 (de) |
| BR (1) | BR0010821B1 (de) |
| CA (1) | CA2374226C (de) |
| CZ (1) | CZ302943B6 (de) |
| DE (2) | DE19923086A1 (de) |
| DK (1) | DK1183236T3 (de) |
| EE (1) | EE04611B1 (de) |
| ES (1) | ES2208342T3 (de) |
| HK (1) | HK1047574B (de) |
| HR (1) | HRP20010845B1 (de) |
| HU (1) | HU229041B1 (de) |
| IL (2) | IL146372A0 (de) |
| ME (1) | MEP41508A (de) |
| MX (1) | MXPA01011725A (de) |
| NO (1) | NO321558B1 (de) |
| PL (1) | PL201560B1 (de) |
| PT (1) | PT1183236E (de) |
| RS (1) | RS50172B (de) |
| RU (1) | RU2242462C2 (de) |
| SK (1) | SK287237B6 (de) |
| TR (1) | TR200103312T2 (de) |
| WO (1) | WO2000071513A1 (de) |
| ZA (1) | ZA200109481B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10054482A1 (de) * | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| CN1237185C (zh) * | 2003-06-04 | 2006-01-18 | 中国科学院上海药物研究所 | Sars冠状病毒3cl蛋白酶三维结构模型与抗sars药物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518874C3 (de) * | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1518816C3 (de) | 1965-03-24 | 1975-05-22 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DE1545810A1 (de) * | 1965-05-06 | 1969-12-11 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden |
| US4066639A (en) | 1965-05-06 | 1978-01-03 | Hoechst Aktiengesellschaft | Benzene-sulfonyl semicarbazides and process for preparing them |
| DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE59401361D1 (de) | 1993-02-23 | 1997-02-06 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE4341655A1 (de) | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| JPH0826995A (ja) * | 1994-07-22 | 1996-01-30 | Nisshin Flour Milling Co Ltd | ベンズイミダゾール誘導体を含有する抗不整脈剤 |
| DE19505397A1 (de) * | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| HK1040187B (zh) | 1998-09-10 | 2005-09-02 | 萨诺费－阿文蒂斯德国有限公司 | 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途 |
| US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
| US6194458B1 (en) * | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
-
1999
- 1999-05-20 DE DE19923086A patent/DE19923086A1/de not_active Withdrawn
-
2000
- 2000-05-06 CZ CZ20014149A patent/CZ302943B6/cs not_active IP Right Cessation
- 2000-05-06 RU RU2001134291/04A patent/RU2242462C2/ru not_active IP Right Cessation
- 2000-05-06 HU HU0201906A patent/HU229041B1/hu not_active IP Right Cessation
- 2000-05-06 RS YUP-817/01A patent/RS50172B/sr unknown
- 2000-05-06 ES ES00938626T patent/ES2208342T3/es not_active Expired - Lifetime
- 2000-05-06 IL IL14637200A patent/IL146372A0/xx active IP Right Grant
- 2000-05-06 ME MEP-415/08A patent/MEP41508A/xx unknown
- 2000-05-06 SK SK1669-2001A patent/SK287237B6/sk not_active IP Right Cessation
- 2000-05-06 AT AT00938626T patent/ATE252554T1/de active
- 2000-05-06 WO PCT/EP2000/004091 patent/WO2000071513A1/en not_active Ceased
- 2000-05-06 MX MXPA01011725A patent/MXPA01011725A/es active IP Right Grant
- 2000-05-06 DK DK00938626T patent/DK1183236T3/da active
- 2000-05-06 HR HR20010845A patent/HRP20010845B1/xx not_active IP Right Cessation
- 2000-05-06 JP JP2000619770A patent/JP4559640B2/ja not_active Expired - Fee Related
- 2000-05-06 HK HK02108646.9A patent/HK1047574B/zh not_active IP Right Cessation
- 2000-05-06 TR TR2001/03312T patent/TR200103312T2/xx unknown
- 2000-05-06 CA CA2374226A patent/CA2374226C/en not_active Expired - Fee Related
- 2000-05-06 PT PT00938626T patent/PT1183236E/pt unknown
- 2000-05-06 EP EP00938626A patent/EP1183236B1/de not_active Expired - Lifetime
- 2000-05-06 EE EEP200100609A patent/EE04611B1/xx not_active IP Right Cessation
- 2000-05-06 AU AU53933/00A patent/AU771675B2/en not_active Ceased
- 2000-05-06 DE DE60006104T patent/DE60006104T2/de not_active Expired - Lifetime
- 2000-05-06 BR BRPI0010821-9A patent/BR0010821B1/pt not_active IP Right Cessation
- 2000-05-06 CN CNB008078203A patent/CN1243730C/zh not_active Expired - Fee Related
- 2000-05-06 PL PL351751A patent/PL201560B1/pl unknown
- 2000-05-06 KR KR1020017014819A patent/KR100968729B1/ko not_active Expired - Fee Related
- 2000-05-19 US US09/573,166 patent/US6350778B1/en not_active Expired - Lifetime
- 2000-05-19 AR ARP000102388A patent/AR035625A1/es active IP Right Grant
-
2001
- 2001-11-06 IL IL146372A patent/IL146372A/en not_active IP Right Cessation
- 2001-11-16 ZA ZA200109481A patent/ZA200109481B/xx unknown
- 2001-11-19 NO NO20015636A patent/NO321558B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1148053A4 (de) | 2h-phthalazin-1-on derivate und drogenzusammensetzungen die diese derivate als aktive inhaltsstoffe enthalten | |
| AR031430A1 (es) | Compuestos de bisarilo orto, meta-sustituidos, procedimientos para su preparacion, su utilizacion como medicamento como tambien los preparados farmaceuticos que los contienen | |
| MEP60908A (en) | 2'-substituted 1,1'-biphenyl-2-carbonamides, method for the production thereof, use thereof as a medicament and pharmaceutical preparations containing said compounds | |
| DE68906609D1 (de) | Dopamin-vorlaeufer. | |
| ATE290525T1 (de) | Acylaminoalkyl-substituierte benzolsulfonamidderivate | |
| HUP0104718A2 (hu) | Mikronizált eplerenon kompozíciók és eljárás az előállításukra | |
| DE69624813T2 (de) | Robustaflavon und dessen derivate als antivirales mittel | |
| DK1150963T3 (da) | Substituerede 4-amino-2-aryltetrahydroquinazoliner, fremstilling og anvendelse deraf og farmaceutiske præparater indeholdende dem | |
| RU2225403C2 (ru) | Сульфонамидозамещенные бензопирановые производные, способ их получения и фармацевтическая композиция на их основе | |
| RU2223264C2 (ru) | Сульфонамидзамещенные аннелированные семичленные циклические соединения, их применение в качестве лекарственного средства, а также содержащие их фармацевтические композиции | |
| YU81701A (sh) | Cinamoilaminoalkil-supstituisani derivati benzensulfonamida | |
| MXPA02008213A (es) | Compuestos piperazina sustituidos. | |
| RU2223951C2 (ru) | Сульфонамидзамещенные анеллированные пятичленные циклические соединения, их применение в качестве лекарственного средства, а также содержащие их фармацевтические композиции | |
| SA96160669B1 (ar) | علاج مشترك لعدوى فيروس نقص المناعة الذاتية المكتسب للبشر HIV باستخداممثبط الإنزيم protease inhibitor ومثبط الإنزيم الناسخ العكسي reverse transcriptase inhibitor مع AZT | |
| RU98119955A (ru) | Сульфонамидзамещенные бензопирановые производные, способ их получения, их применение в качестве лекарственного средства, а также содержащие их фармацевтические композиции | |
| CA2337397A1 (en) | 2,5-substituted benzolsulfonylureas and thioureas, methods for the production thereof, use thereof and pharmaceutical preparations containing the same | |
| WO2001085709A3 (en) | New compounds having anticancer activity: process for their preparation and pharmaceutical compositions containing them | |
| WO2001062711A3 (en) | Substituted alkylene diamine compounds | |
| IL183807A0 (en) | Piperidinesulfonylureas and-thioureas, their preparation, their use and pharmaceutical compositions comprising them | |
| ATE410414T1 (de) | Heteroarylacryloylaminoalkyl-substituierte benzolsulfonamidderivate, deren herstellung, deren verwendung und pharmazeutische zusammensetzungen, die diese verbindungen enthalten | |
| DE69713648D1 (de) | Benzopyranderivate und ihre Verwendung zur Behandlung von Herzkrankheiten | |
| UA27973C2 (uk) | Лікарський засіб для лікування серцевої недостатності | |
| JPH07206822A (ja) | 新規な非対称チオ尿素化合物及びそれを有効成分とする抗ヒト免疫不全症ウイルス剤 | |
| DE19961302A1 (de) | Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen | |
| ECSP961652A (es) | Derivados de la 4- mercapto-benzoilguanidina |