BR0010821A - Derivados de benzenossulfonamidas substituìda com cinamoilaminoalquila - Google Patents
Derivados de benzenossulfonamidas substituìda com cinamoilaminoalquilaInfo
- Publication number
- BR0010821A BR0010821A BR0010821-9A BR0010821A BR0010821A BR 0010821 A BR0010821 A BR 0010821A BR 0010821 A BR0010821 A BR 0010821A BR 0010821 A BR0010821 A BR 0010821A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- compounds
- cinnamoylaminoalkyl
- derivatives
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE BENZENOSSULFONAMIDAS SUBSTITUìDA COM CINAMOILAMINOALQUILA". A presente invenção refere-se a derivados de benzenossulfonamida substituída com cinamoilaminoalquila de fórmula (I) onde A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y e Z têm os significados indicados nas reivindicações. Os compostos da fórmula (I) são compostos farmacêuticos ativos valiosos que apresentam, por exemplo, ação inibidora sobre canais de potássio sensíveis a ATP no músculo cardíaco e/ou no nervo cardíaco e são adequados, por exemplo, para o tratamento de distúrbios do sistema cardiovascular tais como doença do coração coronário, arritmias, insuficiência cardíaca ou cardiomiopatias, ou para a prevenção do morte cardíaca súbita ou para melhorar a contratilidade reduzida do coração. A invenção refere-se ainda a processos para a preparação dos compostos da fórmula (1), seu uso e preparações farmacêuticas compreendendo os mesmos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19923086A DE19923086A1 (de) | 1999-05-20 | 1999-05-20 | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19923086.2 | 1999-05-20 | ||
PCT/EP2000/004091 WO2000071513A1 (en) | 1999-05-20 | 2000-05-06 | Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0010821A true BR0010821A (pt) | 2002-03-05 |
BR0010821B1 BR0010821B1 (pt) | 2011-07-12 |
Family
ID=7908577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0010821-9A BR0010821B1 (pt) | 1999-05-20 | 2000-05-06 | derivados de benzenossulfonamida substituìda com cinamoilaminoalquila, processo para a sua preparação e respectiva composição farmacêutica. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6350778B1 (pt) |
EP (1) | EP1183236B1 (pt) |
JP (1) | JP4559640B2 (pt) |
KR (1) | KR100968729B1 (pt) |
CN (1) | CN1243730C (pt) |
AR (1) | AR035625A1 (pt) |
AT (1) | ATE252554T1 (pt) |
AU (1) | AU771675B2 (pt) |
BR (1) | BR0010821B1 (pt) |
CA (1) | CA2374226C (pt) |
CZ (1) | CZ302943B6 (pt) |
DE (2) | DE19923086A1 (pt) |
DK (1) | DK1183236T3 (pt) |
EE (1) | EE04611B1 (pt) |
ES (1) | ES2208342T3 (pt) |
HK (1) | HK1047574B (pt) |
HR (1) | HRP20010845B1 (pt) |
HU (1) | HU229041B1 (pt) |
IL (2) | IL146372A0 (pt) |
ME (1) | MEP41508A (pt) |
MX (1) | MXPA01011725A (pt) |
NO (1) | NO321558B1 (pt) |
PL (1) | PL201560B1 (pt) |
PT (1) | PT1183236E (pt) |
RS (1) | RS50172B (pt) |
RU (1) | RU2242462C2 (pt) |
SK (1) | SK287237B6 (pt) |
TR (1) | TR200103312T2 (pt) |
WO (1) | WO2000071513A1 (pt) |
ZA (1) | ZA200109481B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10054482A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
CN1237185C (zh) * | 2003-06-04 | 2006-01-18 | 中国科学院上海药物研究所 | Sars冠状病毒3cl蛋白酶三维结构模型与抗sars药物 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1185180B (de) | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
DE1518874C3 (de) * | 1964-10-07 | 1975-03-13 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
DE1518816C3 (de) | 1965-03-24 | 1975-05-22 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
DE1545810A1 (de) * | 1965-05-06 | 1969-12-11 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden |
US4066639A (en) | 1965-05-06 | 1978-01-03 | Hoechst Aktiengesellschaft | Benzene-sulfonyl semicarbazides and process for preparing them |
DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
ATE146775T1 (de) * | 1993-02-23 | 1997-01-15 | Hoechst Ag | Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
DE4341655A1 (de) | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
JPH0826995A (ja) * | 1994-07-22 | 1996-01-30 | Nisshin Flour Milling Co Ltd | ベンズイミダゾール誘導体を含有する抗不整脈剤 |
DE19505397A1 (de) * | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
KR100981592B1 (ko) | 1998-09-10 | 2010-09-13 | 사노피-아벤티스 도이칠란트 게엠베하 | 벤젠설포닐(티오)우레아 또는 베타-수용체 차단제와 배합된 벤젠설포닐(티오)우레아를 포함하는 자율신경계 기능부전의 치료 또는 예방을 위한 약제학적 조성물 |
US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
US6194458B1 (en) * | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
-
1999
- 1999-05-20 DE DE19923086A patent/DE19923086A1/de not_active Withdrawn
-
2000
- 2000-05-06 AT AT00938626T patent/ATE252554T1/de active
- 2000-05-06 EE EEP200100609A patent/EE04611B1/xx not_active IP Right Cessation
- 2000-05-06 JP JP2000619770A patent/JP4559640B2/ja not_active Expired - Fee Related
- 2000-05-06 WO PCT/EP2000/004091 patent/WO2000071513A1/en active IP Right Grant
- 2000-05-06 PT PT00938626T patent/PT1183236E/pt unknown
- 2000-05-06 PL PL351751A patent/PL201560B1/pl unknown
- 2000-05-06 EP EP00938626A patent/EP1183236B1/en not_active Expired - Lifetime
- 2000-05-06 CA CA2374226A patent/CA2374226C/en not_active Expired - Fee Related
- 2000-05-06 CN CNB008078203A patent/CN1243730C/zh not_active Expired - Fee Related
- 2000-05-06 ME MEP-415/08A patent/MEP41508A/xx unknown
- 2000-05-06 SK SK1669-2001A patent/SK287237B6/sk not_active IP Right Cessation
- 2000-05-06 CZ CZ20014149A patent/CZ302943B6/cs not_active IP Right Cessation
- 2000-05-06 MX MXPA01011725A patent/MXPA01011725A/es active IP Right Grant
- 2000-05-06 RU RU2001134291/04A patent/RU2242462C2/ru not_active IP Right Cessation
- 2000-05-06 IL IL14637200A patent/IL146372A0/xx active IP Right Grant
- 2000-05-06 BR BRPI0010821-9A patent/BR0010821B1/pt not_active IP Right Cessation
- 2000-05-06 AU AU53933/00A patent/AU771675B2/en not_active Ceased
- 2000-05-06 DE DE60006104T patent/DE60006104T2/de not_active Expired - Lifetime
- 2000-05-06 ES ES00938626T patent/ES2208342T3/es not_active Expired - Lifetime
- 2000-05-06 DK DK00938626T patent/DK1183236T3/da active
- 2000-05-06 TR TR2001/03312T patent/TR200103312T2/xx unknown
- 2000-05-06 KR KR1020017014819A patent/KR100968729B1/ko not_active IP Right Cessation
- 2000-05-06 HU HU0201906A patent/HU229041B1/hu not_active IP Right Cessation
- 2000-05-06 RS YUP-817/01A patent/RS50172B/sr unknown
- 2000-05-19 AR ARP000102388A patent/AR035625A1/es active IP Right Grant
- 2000-05-19 US US09/573,166 patent/US6350778B1/en not_active Expired - Lifetime
-
2001
- 2001-11-06 IL IL146372A patent/IL146372A/en not_active IP Right Cessation
- 2001-11-16 ZA ZA200109481A patent/ZA200109481B/xx unknown
- 2001-11-16 HR HR20010845A patent/HRP20010845B1/xx not_active IP Right Cessation
- 2001-11-19 NO NO20015636A patent/NO321558B1/no not_active IP Right Cessation
-
2002
- 2002-11-29 HK HK02108646.9A patent/HK1047574B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0316234A (pt) | Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos | |
BR0009641A (pt) | Derivados de 1,4-benzotiazepin-1,1-dióxido, substituìdos com radicais de açúcar, processo para produção dos mesmos, medicamentos contendo esses compostos e sua utilização | |
BR9914206A (pt) | Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos | |
BR9916732A (pt) | Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa) | |
ES2188595T3 (es) | Derivados del acido 1-(2-oxo-acetil)-piperidin-2-carboxilico como sensibilizadores de celulas cancerosas resistentes a multiples farmacos. | |
BR9810745A (pt) | Derivados de benzimidazol | |
ATE237324T1 (de) | Dexanabinol-derivate und ihre verwendung als neuroprotektive pharmazeutische zusammensetzungen | |
AR031430A1 (es) | Compuestos de bisarilo orto, meta-sustituidos, procedimientos para su preparacion, su utilizacion como medicamento como tambien los preparados farmaceuticos que los contienen | |
BR0210358A (pt) | Inibidores da protease de hiv, composições contendo os mesmos, seus usos farmacêuticos e materiais para sua sìntese | |
BR0210711A (pt) | Uso de um composto, composição farmacêutica, composto, e, processo para a preparação de um composto | |
BR9910898A (pt) | Indolinonas sibstituìdas, preparação e utilização das mesmas como composições farmacêuticas | |
DK57388A (da) | Thiazolidinonderivater, fremgangsmaade til deres fremstilling samt anvendelsen heraf | |
BR0014465A (pt) | 1,1'-bifenil-2-carbonamidas 2'-substituìdas, processos para a sua preparação,seu emprego como medicamento bem como os preparados farmacêuticos contendo as mesmas | |
OA08455A (fr) | Dérivés de la pyrazoline, leur préparation et leur application à la lutte contre des insectes et des acariens. | |
EP1213026A4 (en) | AGENTS CONTAINING GINSENG FOR PROTECTING CEREBRAL CELLS OR NERVOUS CELLS | |
PT1345892E (pt) | Derivados de benzenossulfonamida substituidos com acilaminoalquilo | |
BR9912218A (pt) | Compostos obtidos de espécies de sálvia possuindo atividade antivirótica | |
BR9916669A (pt) | Uso de derivados de ácidos 4-biarilbutìricos e 5-biarilpentanóicos substituìdos como inibidores de metaloproteases de matriz para o tratamento de doenças respiratórias | |
BR0010821A (pt) | Derivados de benzenossulfonamidas substituìda com cinamoilaminoalquila | |
BR0015186A (pt) | N-guanidinoalquilamidas, sua preparação, seu uso, e preparações farmacêuticas compreendendo-as | |
BR0312702A (pt) | Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, processo de preparação e intermediários desse processo, seu uso como medicamentos e composições farmacêuticas compreendendo os mesmos | |
US3163639A (en) | 4-thio-2'-deoxyuridine | |
BR9912125A (pt) | Benzenossulfoniluréias e - tiouréias 2,5-substituìdas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas | |
BR9916733A (pt) | Derivados de arilalcanoìla, processos para sua preparação, seu uso e composições farmacêuticas que os contêm | |
BR9803974A (pt) | Cromanos substituìdos por sulfonamida, processos para a sua preparação, seu emprego como medicamento e preparados farmacêuticos contendo os mesmos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 16A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |