MEP38008A - Drospirenone for hormone replacement therapy - Google Patents

Drospirenone for hormone replacement therapy

Info

Publication number
MEP38008A
MEP38008A MEP-380/08A MEP38008A MEP38008A ME P38008 A MEP38008 A ME P38008A ME P38008 A MEP38008 A ME P38008A ME P38008 A MEP38008 A ME P38008A
Authority
ME
Montenegro
Prior art keywords
estrogen
drospirenone
hormone replacement
replacement therapy
drsp
Prior art date
Application number
MEP-380/08A
Other languages
English (en)
Croatian (hr)
Inventor
Juergen Hilmann
Ralph Lipp
Rolf Schuermann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26071749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP38008(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MEP38008A publication Critical patent/MEP38008A/xx
Publication of ME00292B publication Critical patent/ME00292B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Farmaceutska kompozicija koja obuhvata kao prvi aktivni sastojak estrogen, kao što je estradiol ili estradiol valerat, u dovoljnim količinama za tretiranje poremećaja i simptoma asociranih sa deficijentima endogenima nivoima estrogena kod žena, i kao drugi aktivni sastojak 6β, 7β; 15 β; 16 β- dimetilen-3-okso-17ά-preg-4-ene-21, 17- karabalakton (drospirenon, DRSP) u dovoljnim količinama da zaštiti ednometrijum od negativnih efekata estrogena korisna, pored drugog, za tretiranje perimenupauzalnih, menopauzalnih i post-menupauzalnih žena. Ova kompozicija može da se upotrebi za terapiju zamjene hormona i može da se primjenjuje kao multi-fazovan farmaceutski preparat. Ova kombinaciona terapija može da obuhvati kontiunalnu, sekvencionalnu ili isprekidanu primjenu, ilči njihove kombinacije, DRSP i estrogen, svaki opciono u mikronizovanom obliku.
MEP-2008-380A 2000-01-18 2001-01-18 Drospirenon za terapiju zamjene hormona ME00292B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48402600A 2000-01-18 2000-01-18
EP00200183 2000-01-18
PCT/IB2001/000041 WO2001052857A1 (en) 2000-01-18 2001-01-18 Drospirenone for hormone replacement therapy

Publications (2)

Publication Number Publication Date
MEP38008A true MEP38008A (en) 2011-02-10
ME00292B ME00292B (me) 2011-05-10

Family

ID=26071749

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-380A ME00292B (me) 2000-01-18 2001-01-18 Drospirenon za terapiju zamjene hormona

Country Status (30)

Country Link
EP (2) EP1257280B1 (bs)
JP (2) JP5128743B2 (bs)
KR (2) KR100747965B1 (bs)
CN (2) CN1395488A (bs)
AT (2) ATE442147T1 (bs)
AU (3) AU2001225413B2 (bs)
BG (1) BG65849B1 (bs)
BR (1) BR0107683A (bs)
CA (1) CA2394165C (bs)
CY (1) CY1109567T1 (bs)
CZ (1) CZ20022411A3 (bs)
DE (2) DE60113809T2 (bs)
DK (2) DK1257280T3 (bs)
EE (1) EE05533B1 (bs)
ES (2) ES2247054T3 (bs)
HK (2) HK1047248B (bs)
HU (1) HUP0204291A3 (bs)
IL (3) IL150775A0 (bs)
ME (1) ME00292B (bs)
MX (1) MXPA02006613A (bs)
NO (1) NO335570B1 (bs)
NZ (1) NZ520630A (bs)
PL (1) PL201878B1 (bs)
PT (1) PT1611892E (bs)
RS (1) RS52149B (bs)
RU (2) RU2275198C2 (bs)
SI (2) SI1611892T1 (bs)
SK (2) SK287719B6 (bs)
WO (1) WO2001052857A1 (bs)
ZA (2) ZA200206551B (bs)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1380301B1 (en) * 1999-08-31 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical combination of ethinylestradiol and dropirenone for use as a contraceptive
EP1216713A1 (en) * 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
CN1652798A (zh) * 2002-03-11 2005-08-10 詹森药业有限公司 连续抑制硫酸酯酶的孕激素的激素替代疗法
NZ548754A (en) * 2002-04-26 2008-06-30 Schering Aktiengellschaft Treatment of hypertension in women receiving hormone replacement therapy
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
ATE454155T1 (de) * 2002-11-05 2010-01-15 Bayer Schering Pharma Ag Verwendung von drospirenon zur behandlung von hypertension
AU2002368326A1 (en) * 2002-11-05 2004-06-07 Schering Aktiengesellschaft Hormone replacement therapy with drospirenone
JP2007528388A (ja) * 2004-03-10 2007-10-11 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 分子分散されたドロスピレノンを含む組成物
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
DE102004023984A1 (de) * 2004-05-14 2005-12-08 Hf Arzneimittelforschung Gmbh Filmförmiges, oral zu verabreichendes Arzneimittel, enthaltend Estriol
US8022053B2 (en) 2004-11-02 2011-09-20 Bayer Schering Pharma Aktiengesellschaft Oral solid dosage forms containing a low dose of estradiol
CA2614187A1 (en) * 2005-07-15 2007-01-25 Bayer Schering Pharma Aktiengesellschaft Drospirenone containing transdermal drug delivery devices and methods of delivery thereof
DE102005056527A1 (de) * 2005-11-25 2007-07-12 Grünenthal GmbH Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
DE102007011105A1 (de) * 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
CN101623287B (zh) * 2008-07-07 2012-02-08 天津金耀集团有限公司 一种屈螺酮类似物的治疗更年期综合症的药物组合物
ES2344675B1 (es) * 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
CA2796139A1 (en) * 2010-04-15 2011-10-20 Bayer Intellectual Property Gmbh Low-dosed solid oral dosage forms for hrt
EA026095B1 (ru) * 2010-04-15 2017-03-31 Байер Интеллекчуал Проперти Гмбх Очень низкодозированные твердые пероральные лекарственные формы для гормонозаместительной терапии (гзт)
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EA201400537A1 (ru) 2011-11-04 2014-10-30 Байер Фарма Акциенгезельшафт 18-МЕТИЛ-6,7-МЕТИЛЕН-3-ОКСО-17-ПРЕГН-4-ЕН-21,17β-КАРБОЛАКТОНЫ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЭНДОМЕТРИОЗА
TW201350122A (zh) * 2012-04-23 2013-12-16 Bayer Pharma AG １８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
ME03728B (me) 2015-06-18 2021-01-20 Estetra Sprl Orodisperzibilna dozna jedinica koja sadrži komponentu estetrola
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CN110809473A (zh) * 2017-06-01 2020-02-18 延世大学校产学协力团 用于预防或治疗骨相关疾病的药物组合物
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) * 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث

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JP4022269B2 (ja) * 1995-05-26 2007-12-12 協和醗酵工業株式会社 医薬組成物
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Also Published As

Publication number Publication date
RU2275198C2 (ru) 2006-04-27
ES2332226T3 (es) 2010-01-29
CY1109567T1 (el) 2014-08-13
JP5128743B2 (ja) 2013-01-23
YU54602A (sh) 2006-01-16
MXPA02006613A (es) 2003-10-15
BR0107683A (pt) 2002-11-12
DE60113809T2 (de) 2006-06-22
IL191131A (en) 2010-12-30
NO20022966D0 (no) 2002-06-20
CA2394165C (en) 2010-04-13
ATE305789T1 (de) 2005-10-15
AU2005209600B2 (en) 2008-08-07
CN1395488A (zh) 2003-02-05
WO2001052857A1 (en) 2001-07-26
DK1611892T3 (da) 2009-11-02
CZ20022411A3 (cs) 2003-02-12
RU2402331C2 (ru) 2010-10-27
HK1082433A1 (en) 2006-06-09
IL150775A (en) 2008-08-07
AU2001225413B2 (en) 2005-06-23
EP1611892A2 (en) 2006-01-04
KR100913910B1 (ko) 2009-08-26
KR20070051956A (ko) 2007-05-18
HK1047248A1 (en) 2003-02-14
SK288129B6 (sk) 2013-10-02
BG106915A (bg) 2003-04-30
AU2541301A (en) 2001-07-31
EP1611892A3 (en) 2006-02-01
HK1047248B (zh) 2005-12-30
CA2394165A1 (en) 2001-07-26
KR20020088066A (ko) 2002-11-25
DK1257280T3 (da) 2005-12-12
JP2003520239A (ja) 2003-07-02
BG65849B1 (bg) 2010-03-31
SK287719B6 (en) 2011-07-06
PT1611892E (pt) 2009-11-20
AU2005209600A1 (en) 2005-09-29
ZA200206551B (en) 2006-04-29
HUP0204291A2 (hu) 2003-04-28
NO335570B1 (no) 2014-12-29
IL150775A0 (en) 2003-02-12
EP1611892B1 (en) 2009-09-09
NO20022966L (no) 2002-09-18
EE200200401A (et) 2003-10-15
ES2247054T3 (es) 2006-03-01
SK10322002A3 (sk) 2003-03-04
HUP0204291A3 (en) 2003-05-28
KR100747965B1 (ko) 2007-08-08
SI1257280T1 (sl) 2006-02-28
SI1611892T1 (sl) 2010-01-29
CN101934078A (zh) 2011-01-05
IL191131A0 (en) 2008-11-03
ZA200601285B (en) 2008-01-08
EP1257280B1 (en) 2005-10-05
PL356987A1 (en) 2004-07-12
EP1257280A1 (en) 2002-11-20
RU2002122113A (ru) 2004-03-10
PL201878B1 (pl) 2009-05-29
DE60113809D1 (de) 2006-02-16
NZ520630A (en) 2004-09-24
ATE442147T1 (de) 2009-09-15
DE60139907D1 (de) 2009-10-22
EE05533B1 (et) 2012-04-16
RU2005140938A (ru) 2007-07-10
RS52149B (sr) 2012-08-31
ME00292B (me) 2011-05-10
JP2009120615A (ja) 2009-06-04
JP5563227B2 (ja) 2014-07-30

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