ME01475B - Derivati amino nikotinske iizonikotinske kiseline kao inhibitori dhodh - Google Patents

Derivati amino nikotinske iizonikotinske kiseline kao inhibitori dhodh

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Publication number
ME01475B
ME01475B MEP-2012-104A MEP10412A ME01475B ME 01475 B ME01475 B ME 01475B ME P10412 A MEP10412 A ME P10412A ME 01475 B ME01475 B ME 01475B
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Montenegro
Prior art keywords
ylamino
kiselina
nicotinska
group
groups
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MEP-2012-104A
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English (en)
Inventor
Palomino Laria Julio Cesar Castro
Sola Montserrat Erra
Toribio Maria Estrella Lozoya
Romero Eloisa Navarro
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Almirall Sa
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Priority claimed from ES200701086A external-priority patent/ES2327372B1/es
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of ME01475B publication Critical patent/ME01475B/me

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

"(12) PATENTNI SPIS<br /> 1 <br />me<br />B 01475 ME<br />(11)<br />ME 01475B (19) Crna Gora<br />(21) Broj prijave: P-2012-104<br />(22) Datum podnošenja prijave: 21. 12. 2007<br />(43) Datum objavljivanja prijave:<br />(45) Datum objavljivanja patenta:<br />20. 04. 2014<br />20. 04. 2014<br /> Glasnik : 14/2014<br /> (51) Me dunarodna klasifikacija MKP<br />C07D213/79<br />(2006.01)<br />C07D213/80<br />(2006.01)<br />A61K31/465<br />(2006.01)<br />A61P35/00<br />(2006.01)<br />(30) Me dunarodno pravo prvenstva<br />ES<br />20060003250<br />22. 12. 2006<br />ES<br />20070001086<br />23. 04. 2007<br />(73) Nosilac Patenta<br />Almirall, S.A.<br />Ronda del General Mitre 151<br />08022 Barcelona<br />ES<br />(74) Zastupnik:<br />attorney<br />ÐAKONOVI C, Vido<br />Bajova br. 9<br />Cetinje<br />81250<br />ME<br /> (72) Pronalaza c<br />CASTRO PALOMINO LARIA, Julio Cesar<br />c/ Enrique Granados 29, 4<br />E-08330 Premia De Mar (barcelona)<br />ES<br />ERRA SOLA, Montserrat<br />Riera Blanca 46, Atico 1a, Esc. A<br />E-08903 L' Hospitalet (Barcelona)<br />ES<br />LOZOYA TORIBIO, Maria Estrella<br />C/ Brodadores, 6F<br />E-08100 Mollet del Valles (Barcelona)<br />ES<br />NAVARRO ROMERO, Eloisa<br />c/Comte d'Urgell 20, 1 2<br />E-08011 Barcelona<br />ES<br />(54) Naziv:<br />me<br />DERIVATI AMINO NIKOTINSKE IIZONIKOTINSKE KISELINE KAO INHIBITORI DHODH<br />en<br />AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS<br />(57) Apstrakt:"

Claims (15)

1. Jedinjenje formule (I) pri čemu •    jedna od grupa G1 predstavlja atom azota ili grupu CRc i druga predstavlja grupu CRc •    G2 predstavlja atom azota ili grupu CRd •    R1 predstavlja grupu koja je izabrana između atoma vodonika, atoma halogena, alkil grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, i C3-8 cikloalkil grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa •    R2 predstavlja grupu koja je izabrana između atoma vodonika, atoma halogena, hidroksil grupa, alkil grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, C1-4 alkoksi grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, i C3-8 cikloalkil grupa koje mogu biti eventualno supstituisane sa 1,2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa •    Ra, Rb i Rc nezavisno predstavljaju grupe koje su izabrane između atoma vodonika, atoma halogena, alkil grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, i alkoksi grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa •    Rd predstavlja grupu koja je izabrana između atoma vodonika, atoma halogena, hidroksil grupa, C1-4 alkil grupa koje mogu biti eventualno supstituisane sa 1,2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, i alkoksi grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, i C3-8 cikloalkoksi grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa •    jedna od grupa G3 i G4 je atom azota i druga je CH grupa, •    M je atom vodonika ili farmaceutski prihvatljiv katjon uz uslov da, kada najmanje jedna od grupa Ra i Rb predstavlja atom vodonika i G2 je grupa CRd, onda Rd predstavlja grupe koje su izabrane između alkoksi grupa koje mogu biti eventualno supstituisane sa 1, 2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa, C3-8 cikloalkoksi grupa koje mogu biti eventualno supstituisane sa 1,2 ili 3 supstituenta izabrana između atoma halogena i hidroksi grupa; i njihove farmaceutski prihvatljive soli i N-oksidi.
2.    Jedinjenje prema zahtevu 1 pri čemu je svaka od C1-4 alkil grupa, C3-8 cikloalkil grupa, C1-4 alkoksi grupa i C3-8 cikloalkoksi grupa eventualno supstituisana sa 1, 2 ili 3 atoma halogena.
3. Jedinjenje prema zahtevu 1 ili 2 pri čemu je R1 izabrano iz grupe koja se sastoji od atoma vodonika, broma i fluora, metila, etila, ciklopropila i ciklobutila; i/ili pri čemu obe grupe G1 predstavljaju grupu CRc; i/ili pri čemu each je Rc nezavisno izabrano iz grupa koje se sastoje od atoma vodonika, atoma fluora, atoma hlora i alkil grupa.
4.    Jedinjenje prema bilo kom od prethodnih zahteva pri čemu (a) G3 predstavlja atom azota i G4 predstavlja grupu CH; ili (b) pri čemu G3 predstavlja grupu CH i G4 predstavlja atom azota.
5.    Jedinjenje prema bilo kom od prethodnih zahteva pri čemu grupa G2 predstavlja CRd grupa, pri čemu je Rd je prvenstveno izabrano iz grupe koja se sastoji od hidroksi grupa, alkoksi grupa, 2,2,2-trifluoroetoksi i C3-4cikloalkoksi grupa, i pri čemu je Rd još poželjnije izabrano iz grupe koja se sastoji od C1-3 alkoksi grupa, 2,2,2-trifluoroetoksi i C3-4 cikloalkoksi grupa.
6.    Jedinjenje prema bilo kom od prethodnih zahteva pri čemu je Ra izabrano iz grupe koja se sastoji od atoma fluora, metil grupa i trifluorometoksi grupa, i Rb je prvenstveno izabrano iz grupe koja se sastoji od atoma vodonika, atomi fluora i atoma hlora.
7.    Jedinjenje prema bilo kom od prethodnih zahteva pri čemu je R2 izabrano iz grupe koja se sastoji od atoma vodonika i atoma halogena, i prvenstveno je izabrano iz grupe koja se sastoji od atoma vodonika i atomi fluora.
8.    Jedinjenje prema zahtevu 1 ili 2 pri čemu obe grupe G1 predstavljaju C(Rc) grupe, G2 predstavlja C(Rd) grupu, Ra je atom fluora, Rb izabrano iz grupe koja se sastoji od atoma vodonika i atoma fluora i R1 je izabrano iz grupe koja se sastoji od atoma vodonika, broma i fluora, metil, etil i ciklopropil grupa.
9.    Jedinjenje prema zahtevu 8 pri čemu je G2 grupa koja je izabrana između C(OH), C(OMe) i C(OEt), pri čemu oba G1 prvenstveno predstavljaju CH grupe i G2 je grupa izabrana između C(OMe) i C(OEt).
10.    Jedinjenje prema zahtevu 8, pri čemu je Rc atom vodonika, Rd je izabrano iz grupe koja se sastoji od C1-3 alkoksi i C3-4 cikloalkoksi, i R2 je atom vodonika, pri čemu je Rd prvenstveno hidroksi grupa ili C1-3 alkoksi grupa, još poželjnije je alkoksi grupa.
11.    Jedinjenje prema zahtevu 10 pri čemu (a) G3 predstavlja atom azota, G4 predstavlja grupu CH i Rb je atom fluora; ili (b) pri čemu G3 predstavlja grupu CH, i G4 predstavlja atom azota.
12.    Jedinjenje prema zahtevu 1 ili 2 koje je jedno od sledećih: 2-(3-fluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(3’-etoksi-3-fluorobifenil-4-ilamino)nikotinska kiselina 2-(3-fluoro-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3'-etoksi-3-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3'-metoksi-3-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(2,5-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(3’-etoksi-2,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(2\3-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(2-metil-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3-hloro-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3-hloro-3'-etoksibifenil-4-ilamino)nikotinska kiselina 2-(3-metil-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3-hloro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(3'-(difluorometoksi)-3-fluorobifenil-4-ilamino)nikotinska kiselina 2-(3'-ciklobutoksi-3-fluorobifenil-4-ilamino)nikotinska kiselina 2-(3-fluoro-3'-(2,2,2-trifluoroetoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3'-ciklobutoksi-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-3’-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3'-etoksi-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina litijum 3-(3'-etoksi-3-fluorobifenil-4-ilamino) izonikotinat litijum 3-(3-fluoro-3'-metoksibifenil-4-ilamino)izonikotinat litijum 3-(3'-metoksi-3-(trifluorometoksi)bifenil-4-ilamino)izonikotinat litijum 3-(3-fluoro-3'-(trifluorometoksi)bifenil-4-ilamino)izonikotinat 2-(3'-etoksibifenil-4-ilamino)nikotinska kiselina 2-(5-fluoro-2-metil-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(2',3-difluoro-5'-izopropoksibifenil-4-ilamino)nikotinska kiselina 2-(3-fluoro-3'-metoksibifenil-4-ilamino)-5-metilnikotinska kiselina 2-(3,5-difluoro-3'-hidroksibifenil-4-ilamino)nikotinska kiselina 5-bromo-2-(3-fluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 5-bromo-2-(3,5-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 5-bromo-2-(3-fluoro-3'-(trifluorometoksi)bifenil-4-ilamino)nikotinska kiselina 2-(3-fluoro-3'-(trifluorometoksi)bifenil-4-ilamino)-5-metilnikotinska kiselina 5-ciklopropil-2-(3-fluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-3'-metoksibifenil-4-ilamino)-5-metilnikotinska kiselina 2-(3'-etoksi-5-fluoro-2-metilbifenil-4-ilamino)nikotinska kiselina 2-(5-fluoro-3'-metoksi-2-metilbifenil-4-ilamino)nikotinska kiselina 2-(3'-etoksi-3,5-difluorobifenil-4-ilamino)-5-metilnikotinska kiselina 5-ciklopropil-2-(3'-etoksi-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-3'-metoksibifenil-4-ilamino)-5-etilnikotinska kiselina 5-bromo-2-(3'-etoksi-2,5-difluorobifenil-4-ilamino)nikotinska kiselina 5-ciklopropil-2-(3'-etoksi-2,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(5-fluoro-3'-metoksi-2-metilbifenil-4-ilamino)-5-metilnikotinska kiselina 5-ciklopropil-2-(5-fluoro-3'-metoksi-2-metilbifenil-4-ilamino)nikotinska kiselina 2-(2',3,5-trifluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(2'-hloro-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(3'-ciklopropoksi-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-2-metilbifenil-4-ilamino)nikotinska kiselina 5-ciklopropil-2-(2,5-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(3'-ciklopropoksi-3,5-difluorobifenil-4-ilamino)-5-ciklopropilnikotinska kiselina 5-hloro-2-(3,5-difluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 5-ciklopropil-2-(3,5-difluoro-3'-(trifluoronnetoksi)bifenil-4-ilamino)nikotinska kiselina 2-(2,3,5-trifluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2-(2'-hloro-3,5-difluorobifenil-4-ilamino)-5-ciklopropilnikotinska kiselina 2-(3,5-difluoro-3'-metoksi-2-metilbifenil-4-ilamino)nikotinska kiselina 2-(3,5-difluoro-2-metil-3'-(trifluorometoksi)bifenil=4-ilamino)nikotinska kiselina 2-(2,-hloro-3,5-difluoro-2-metilbifenil-4-ilamino)nikotinska kiselina 5-hloro-2-(3,5-difluorobifenil-4-ilamino)nikotinska kiselina 5-hloro-2-(2'-hloro-3,5-difluorobifenil-4-ilamino)nikotinska kiselina 2-(2,3,5,6-tetrafluoro-3'-metoksibifenil-4-ilamino)nikotinska kiselina 2- (3,5-difluoro-2'-metilbifenil-4-ilamino)nikotinska kiselina 3- (3'-ciklopropoksi-3-fluorobifenil-4-ilamino)izonikotinska kiselina
13.    Jedinjenje prema bilo kom od zahteva 1 do 12 za primenu za lečenje patoloških stanja ili boiesti koji se mogu ublažiti inhibicijom dehidroorotat dehidrogenaze i pri čemu je to patološko stanje ili bolest prvenstveno izabrano između sledećih: reumatoidni artritis, psorijatički artritis, ankilozirajući spondilitis, multipla skleroza, Vegenerova granulomatoza, sistemski lupus eritematozus, psorijaza i sarkoidoza.
14.    Farmaceutska kompozicija koja sadrži jedinjenje koje je definisani u bilo kom od zahteva 1 do 12 zajedno sa farmaceutski prihvatljivim razređivačem ili nosačem.
15. Kombinovani proizvod koji sadrži (i) jedinjenje prema bilo kom od zahteva 1 do 12; i (ii) drugo jedinjenje koje je izabrano između sledećih: a)    anti-TNF-alfa monoklonalna antitela, kao što su infliksimab, certolizumab pegol, golimumab, adalimumab i AME-527 proizvođača Applied Molecular Evolution b)    TNF-alfa antagonisti, kao što su etanercept, lenercept, onercept i pegsunercept c)    inhibitori kalcineurina (PP-2B) / inhibitori ekspresije INS, kao što su ciklosporin A, takrolimus i ISA-247 proizvođača Isotechnika d)    antagonisti IL-1 receptora, kao što su anakinra i AMG-719 proizvođača Amgen e)    anti-CD20 monoklonalna antitela, kao što su rituksimab, ofatumumab, okrelizumab i TRU-015 proizvođača Trubion Pharmaceuticals f)    p38 inhibitori, kao što su AMG-548 (proizvođač Amgen), ARRY-797 (proizvođač Array Biopharma), hlormetiazol edisilat, doramapimod, PS-540446 (proizvođač BMS), SB-203580, SB-242235, SB-235699, SB-281832, SB-681323, SB-856553 (svi od proizvođača GlaxoSmithKline), KC-706 (proizvođač Kemia), LEO-1606, LEO-15520 (svi od proizvođača Leo), SC-80036, SD-06 (svi od proizvođača Pfizer), RVVJ-67657 (proizvođač R.W. Johnson), RO-3201195, RO-4402257 (svi od proizvođača Roche), AVE-9940 (proizvođač Aventis), SCIO-323, SCIO-469 (svi od proizvođača Scios), TA-5493 (proizvođač Tanabe Seiyaku), i VX-745 i VX-702 (svi od proizvođača Vertex) g)    inhibitori aktivacije NF-kappaB (NFKB), kao što su sulfasalazin i iguratimod h)    inhibitori dihidrofolat reduktaze (DHFR), kao što su metroteksat, aminopterin i CH-1504 proizvođača Chelsea.
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