WO2004065392A8 - Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands - Google Patents
Condensed pyridines and pyrimidines and their use as alk-5 receptor ligandsInfo
- Publication number
- WO2004065392A8 WO2004065392A8 PCT/EP2004/000650 EP2004000650W WO2004065392A8 WO 2004065392 A8 WO2004065392 A8 WO 2004065392A8 EP 2004000650 W EP2004000650 W EP 2004000650W WO 2004065392 A8 WO2004065392 A8 WO 2004065392A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrimidines
- alk
- receptor ligands
- therapy
- condensed pyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0301719.1 | 2003-01-24 | ||
GB0301719A GB0301719D0 (en) | 2003-01-24 | 2003-01-24 | Compounds |
GB0308706A GB0308706D0 (en) | 2003-04-15 | 2003-04-15 | Novel compounds |
GB0308706.1 | 2003-04-15 | ||
GB0315519A GB0315519D0 (en) | 2003-07-02 | 2003-07-02 | Novel compounds |
GB0315519.9 | 2003-07-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004065392A1 WO2004065392A1 (en) | 2004-08-05 |
WO2004065392A8 true WO2004065392A8 (en) | 2004-10-07 |
Family
ID=32776625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/000650 WO2004065392A1 (en) | 2003-01-24 | 2004-01-26 | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004065392A1 (en) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006521398A (en) * | 2003-03-28 | 2006-09-21 | サイオス・インコーポレーテツド | Bicyclic pyrimidine inhibitors of TGFβ |
AU2004230928B2 (en) * | 2003-04-09 | 2010-12-02 | Exelixis, Inc. | Tie-2 modulators and methods of use |
GB0326963D0 (en) * | 2003-11-19 | 2003-12-24 | Glaxo Group Ltd | Compounds |
EP1799218A1 (en) * | 2004-09-30 | 2007-06-27 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting bi-cyclic pyrimidines |
WO2006045010A2 (en) | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
US8252806B2 (en) * | 2005-03-14 | 2012-08-28 | Neurosearch A/S | Potassium channel modulating agents and their medical use |
CA2602294C (en) | 2005-03-25 | 2015-02-24 | Tibotec Pharmaceuticals Ltd. | Heterobicylic inhibitors of hvc |
AR056347A1 (en) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | USE OF PTERIDINE COMPOUNDS TO MANUFACTURE PHARMACEUTICAL MEDICINES AND COMPOSITIONS |
WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
WO2007013964A1 (en) | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
CN101330914A (en) * | 2005-12-16 | 2008-12-24 | 爱尔康公司 | Control of intraocular pressure using ALK5 modulation agents |
DE602006015861D1 (en) | 2005-12-21 | 2010-09-09 | Abbott Lab | ANTIVIRAL CONNECTIONS |
ES2395386T3 (en) | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Antiviral compounds |
AU2006330924B2 (en) * | 2005-12-21 | 2012-03-15 | Abbvie Inc. | Anti-viral compounds |
JP2009521460A (en) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | Antiviral compounds |
CA2652341A1 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc. | Identification of cdki pathway inhibitors |
AR061974A1 (en) | 2006-07-14 | 2008-08-10 | Novartis Ag | PIRIMIDINE DERIVATIVES AS ALK INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND OBTAINING PROCESSES |
EP1878733A1 (en) * | 2006-07-14 | 2008-01-16 | Novartis AG | Pyrimidine derivatives as ALK-5 inhibitors |
US8673929B2 (en) | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
JP4937666B2 (en) * | 2006-08-01 | 2012-05-23 | 東ソー株式会社 | 2-trifluoromethylquinolines and process for producing the same |
TWI399380B (en) | 2006-12-20 | 2013-06-21 | Abbott Lab | Anti-viral compounds |
CA2676984C (en) * | 2007-02-01 | 2015-03-17 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
AR070127A1 (en) * | 2008-01-11 | 2010-03-17 | Novartis Ag | PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS |
CN101531638B (en) * | 2008-03-13 | 2011-12-28 | 中国科学院广州生物医药与健康研究院 | Compound used as a regulator of estrogen-related receptor and applications thereof |
US8114995B2 (en) | 2008-06-26 | 2012-02-14 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
ES2542835T3 (en) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
JP5795304B2 (en) | 2009-03-18 | 2015-10-14 | レスバーロジックス コーポレイション | New anti-inflammatory agent |
KR101892987B1 (en) | 2009-04-22 | 2018-08-30 | 리스버로직스 코퍼레이션 | Novel anti-inflammatory agents |
MX2011012581A (en) * | 2009-05-29 | 2012-01-30 | Syngenta Participations Ag | Substituted quinazolines as fungicides. |
KR20120079111A (en) * | 2009-09-24 | 2012-07-11 | 에프. 호프만-라 로슈 아게 | Heterocyclic antiviral compounds |
US8987301B2 (en) * | 2009-11-07 | 2015-03-24 | Merck Patent Gmbh | Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors |
AR079814A1 (en) * | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | HETEROCICLICAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES |
EP2539338A1 (en) * | 2010-02-24 | 2013-01-02 | Syngenta Participations AG | Novel microbicides |
US9073918B2 (en) | 2010-05-20 | 2015-07-07 | Takeda Pharmaceutical Company Limited | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 |
WO2012079079A1 (en) * | 2010-12-10 | 2012-06-14 | President And Fellows Of Harvard College | Production of induced pluripotent stem cells |
AR086798A1 (en) * | 2011-06-29 | 2014-01-22 | Otsuka Pharma Co Ltd | USEFUL QUINAZOLINIC DERIVATIVES TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP6121658B2 (en) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | Therapeutic compounds and related methods of use |
CA2851996C (en) | 2011-11-01 | 2020-01-07 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
EP2935253B1 (en) | 2012-12-21 | 2018-08-01 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
ES2653419T3 (en) | 2013-02-01 | 2018-02-07 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
CN106132950B (en) | 2014-01-01 | 2018-11-09 | 麦迪威森技术有限责任公司 | Aminopyridines and application method |
SI3321265T1 (en) | 2015-03-04 | 2020-07-31 | Gilead Sciences, Inc. | 4,6-diamino-pyrido(3,2-d)pyrimidine compounds and their utilisation as modulators of toll-like receptors |
CA2977308A1 (en) | 2015-03-13 | 2016-09-22 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
KR20180032611A (en) * | 2015-07-23 | 2018-03-30 | 브리스톨-마이어스 스큅 컴퍼니 | TGF beta receptor antagonist |
CA3008171A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
MA46093A (en) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | TOLL-TYPE RECEIVER MODULATING COMPOUNDS |
JOP20190257A1 (en) | 2017-04-28 | 2019-10-28 | Novartis Ag | 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors |
EP4331679A3 (en) | 2017-06-21 | 2024-04-03 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
IL280213B2 (en) | 2018-07-26 | 2024-06-01 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
CN109503550B (en) * | 2018-11-20 | 2022-11-29 | 江西师范大学 | 2-azaaryl-6-substituted amino quinazolinone compound and preparation method and application thereof |
WO2020113178A1 (en) * | 2018-11-30 | 2020-06-04 | Celularity, Inc. | Aromatic compounds for use in activating hematopoietic stem and progenitor cells |
TWI751516B (en) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202212339A (en) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202115056A (en) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | Processes for preparing toll-like receptor modulator compounds |
EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
CN113620956B (en) * | 2020-05-06 | 2023-06-13 | 赛诺哈勃药业(成都)有限公司 | Transforming growth factor receptor antagonist, preparation method and application thereof |
CN113698395B (en) * | 2020-05-22 | 2023-12-08 | 赛诺哈勃药业(成都)有限公司 | Transforming growth factor receptor antagonist, preparation method and application thereof |
EP4284377A1 (en) * | 2021-01-27 | 2023-12-06 | Shy Therapeutics LLC | Methods for the treatment of fibrotic disease |
US20240309015A1 (en) * | 2021-01-27 | 2024-09-19 | Shy Therapeutics, Llc | Methods for the Treatment of Fibrotic Disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
GB0102672D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
-
2004
- 2004-01-26 WO PCT/EP2004/000650 patent/WO2004065392A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2004065392A1 (en) | 2004-08-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004065392A8 (en) | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands | |
WO2005018557A3 (en) | Substituted pyridinones | |
WO2000021926A3 (en) | 6-SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES USEFUL AS CYCLIN DEPENDENT KINASE INHIBITORS | |
SG179430A1 (en) | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | |
MY140872A (en) | 5,7-diaminopyrazolo[4,3-d]pyrimidines with pde-5 inhibitory activity, compositions containing such derivatives and the use of such derivatives in the treatment of hypertension and other disorders | |
EA200400466A1 (en) | DERIVATIVES OF PIPERAZINE WITH ANTAGONISTIC ACTIVITY TO CCR1 RECEPTOR | |
MXPA03000428A (en) | Tetrahydro-heterocycloazepinyl pyrimidine derivatives. | |
WO2004087677A3 (en) | Pyrimidin-4-one derivatives and their use as p38 kinase modulators | |
ATE370138T1 (en) | NEW IMIDAZOPYRIDINES AND THEIR USE | |
AP1822A (en) | Substituted pyridinones as modulators of P38 MAP kinase. | |
NO20084496L (en) | Pyridyl and pyrimidinyl substituted pyrrole, thiophene and furan derivatives as kinase inhibitors | |
WO2007058832A3 (en) | Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors | |
WO2005080352A3 (en) | Quinazoline derivatives and therapeutic use thereof | |
MX337817B (en) | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES. | |
WO2002062794A3 (en) | Compounds | |
NZ604345A (en) | Pyrazolo[1,5-a]pyrimidines as antiviral agents | |
WO2007044724A3 (en) | Aminopyrimidine, aminopyridine and aniline derivatives inhibitors of pim-i and/or pim-3 | |
WO2005037836A3 (en) | Imidazo ‘1, 5 - a ! pyrazine tyrosine kinase inhibitors | |
WO2006065590A3 (en) | Pyridine and pyrimidine antiviral compositions | |
WO2007120752A3 (en) | 4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders | |
MX2010006748A (en) | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS. | |
WO2003087088A3 (en) | (condensed) pyrimidone and (condensed) pyridone compounds, processes for their preparation, and pharmaceutical compositions containing them | |
WO2008068507A3 (en) | 2 -phenylamino, 6- (pyrid-3-yl) quinazoline derivatives as raf-protein kinase inhibitors in cancer treatment | |
NO20080418L (en) | Pyrido [2,3-D] pyrimidiride derivatives, process for their preparation and therapeutic use of the same | |
WO2007110340A3 (en) | Pyrimidine, quinazoline, pteridine and triazine derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
CFP | Corrected version of a pamphlet front page | ||
CR1 | Correction of entry in section i |
Free format text: IN GAZETTE 28/2004 UNDER (30) REPLACE "20 NOVEMBER 2002 (20.11.2002)" BY "21 NOVEMBER 2002 (21.11.2002)" |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase |