WO2004065392A8 - Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands - Google Patents
Condensed pyridines and pyrimidines and their use as alk-5 receptor ligandsInfo
- Publication number
- WO2004065392A8 WO2004065392A8 PCT/EP2004/000650 EP2004000650W WO2004065392A8 WO 2004065392 A8 WO2004065392 A8 WO 2004065392A8 EP 2004000650 W EP2004000650 W EP 2004000650W WO 2004065392 A8 WO2004065392 A8 WO 2004065392A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrimidines
- alk
- receptor ligands
- therapy
- condensed pyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0301719.1 | 2003-01-24 | ||
GB0301719A GB0301719D0 (en) | 2003-01-24 | 2003-01-24 | Compounds |
GB0308706A GB0308706D0 (en) | 2003-04-15 | 2003-04-15 | Novel compounds |
GB0308706.1 | 2003-04-15 | ||
GB0315519A GB0315519D0 (en) | 2003-07-02 | 2003-07-02 | Novel compounds |
GB0315519.9 | 2003-07-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004065392A1 WO2004065392A1 (en) | 2004-08-05 |
WO2004065392A8 true WO2004065392A8 (en) | 2004-10-07 |
Family
ID=32776625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/000650 WO2004065392A1 (en) | 2003-01-24 | 2004-01-26 | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004065392A1 (en) |
Families Citing this family (63)
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US7223766B2 (en) * | 2003-03-28 | 2007-05-29 | Scios, Inc. | Bi-cyclic pyrimidine inhibitors of TGFβ |
CA2520323C (en) * | 2003-04-09 | 2013-07-09 | Exelixis, Inc. | Tie-2 modulators and methods of use |
GB0326963D0 (en) * | 2003-11-19 | 2003-12-24 | Glaxo Group Ltd | Compounds |
WO2006035061A1 (en) * | 2004-09-30 | 2006-04-06 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting bi-cyclic pyrimidines |
WO2006045010A2 (en) | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
JP4966958B2 (en) * | 2005-03-14 | 2012-07-04 | ノイロサーチ アクティーゼルスカブ | Potassium channel modulators and medical use |
WO2006100310A1 (en) | 2005-03-25 | 2006-09-28 | Tibotec Pharmaceuticals Ltd | Heterobicylic inhibitors of hcv |
AR056347A1 (en) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | USE OF PTERIDINE COMPOUNDS TO MANUFACTURE PHARMACEUTICAL MEDICINES AND COMPOSITIONS |
WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
US7932257B2 (en) | 2005-07-22 | 2011-04-26 | Sunesis Pharmaceuticals, Inc. | Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors |
WO2007070866A2 (en) * | 2005-12-16 | 2007-06-21 | Alcon, Inc. | Control of intraocular pressure using alk5 modulation agents |
EP1971611B1 (en) | 2005-12-21 | 2012-10-10 | Abbott Laboratories | Anti-viral compounds |
CN101384591A (en) * | 2005-12-21 | 2009-03-11 | 艾博特公司 | Anti-viral compounds |
CN102702194A (en) | 2005-12-21 | 2012-10-03 | 雅培制药有限公司 | Anti-viral compounds |
US7910595B2 (en) | 2005-12-21 | 2011-03-22 | Abbott Laboratories | Anti-viral compounds |
CA2652341A1 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc. | Identification of cdki pathway inhibitors |
EP1878733A1 (en) * | 2006-07-14 | 2008-01-16 | Novartis AG | Pyrimidine derivatives as ALK-5 inhibitors |
AU2007271964B2 (en) | 2006-07-14 | 2012-01-19 | Novartis Ag | Pyrimidine derivatives as ALK-5 inhibitors |
WO2008009077A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
WO2008009078A2 (en) * | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
JP4937666B2 (en) * | 2006-08-01 | 2012-05-23 | 東ソー株式会社 | 2-trifluoromethylquinolines and process for producing the same |
WO2008133753A2 (en) | 2006-12-20 | 2008-11-06 | Abbott Laboratories | Anti-viral compounds |
DK2118074T3 (en) | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
AR070127A1 (en) * | 2008-01-11 | 2010-03-17 | Novartis Ag | PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS |
CN101531638B (en) * | 2008-03-13 | 2011-12-28 | 中国科学院广州生物医药与健康研究院 | Compound used as a regulator of estrogen-related receptor and applications thereof |
RU2520098C2 (en) | 2008-06-26 | 2014-06-20 | Ресверлоджикс Корп. | Method of producing quinazolinone derivatives |
JP5635535B2 (en) | 2009-01-08 | 2014-12-03 | レスバーロジックス コーポレイション | Compounds for the prevention and treatment of cardiovascular disease |
CA2992231C (en) | 2009-03-18 | 2022-03-29 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
KR20190091564A (en) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | Novel anti-inflammatory agents |
MX2011012581A (en) * | 2009-05-29 | 2012-01-30 | Syngenta Participations Ag | Substituted quinazolines as fungicides. |
KR20120079111A (en) * | 2009-09-24 | 2012-07-11 | 에프. 호프만-라 로슈 아게 | Heterocyclic antiviral compounds |
CN102596200A (en) * | 2009-11-07 | 2012-07-18 | 默克专利有限公司 | Heteroarylaminoquinolines as tgf-beta receptor kinase inhibitors |
AR079814A1 (en) * | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | HETEROCICLICAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES |
WO2011104183A1 (en) * | 2010-02-24 | 2011-09-01 | Syngenta Participations Ag | Novel microbicides |
US9073918B2 (en) | 2010-05-20 | 2015-07-07 | Takeda Pharmaceutical Company Limited | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 |
WO2012079079A1 (en) * | 2010-12-10 | 2012-06-14 | President And Fellows Of Harvard College | Production of induced pluripotent stem cells |
KR20140048216A (en) * | 2011-06-29 | 2014-04-23 | 오츠카 세이야쿠 가부시키가이샤 | Quinazolines as therapeutic compounds and related methods of use |
JP6121658B2 (en) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | Therapeutic compounds and related methods of use |
CN103945848B (en) | 2011-11-01 | 2016-09-07 | 雷斯韦洛吉克斯公司 | The oral immediate release formulations of the quinazolinone being replaced |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
JP2016506944A (en) | 2013-02-01 | 2016-03-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | Substituted pyrazolopyrimidinylamino-indazole |
SI3089971T1 (en) | 2014-01-01 | 2020-11-30 | Medivation Technologies Llc | Compounds and methods of use |
CA2978188C (en) | 2015-03-04 | 2020-05-12 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
KR102662814B1 (en) | 2015-03-13 | 2024-05-03 | 리스버로직스 코퍼레이션 | Compositions and treatment methods for treating complement-related diseases |
EP3325484A1 (en) * | 2015-07-23 | 2018-05-30 | Bristol-Myers Squibb Company | Tgf beta receptor antagonists |
BR112018012914B1 (en) | 2015-12-22 | 2023-04-18 | SHY Therapeutics LLC | COMPOUND, USE OF A COMPOUND AND PHARMACEUTICAL COMPOSITION |
WO2018045144A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
JOP20190257A1 (en) | 2017-04-28 | 2019-10-28 | Novartis Ag | 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors |
SG11201911929XA (en) | 2017-06-21 | 2020-01-30 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
CN112566906A (en) | 2018-07-26 | 2021-03-26 | 多曼治疗学公司 | Substituted quinazolinone derivatives and their use as positive allosteric modulators of MGLUR4 |
CN109503550B (en) * | 2018-11-20 | 2022-11-29 | 江西师范大学 | 2-azaaryl-6-substituted amino quinazolinone compound and preparation method and application thereof |
EP3887364A1 (en) * | 2018-11-30 | 2021-10-06 | Celularity Inc. | Aromatic compounds for use in activating hematopoietic stem and progenitor cells |
TW202212339A (en) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202210480A (en) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | Solid forms of a toll-like receptor modulator |
TW202115056A (en) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | Processes for preparing toll-like receptor modulator compounds |
JP2023509760A (en) | 2020-01-08 | 2023-03-09 | シンシス セラピューティクス,インコーポレイテッド | ALK5 inhibitor complexes and uses thereof |
CN113620956B (en) * | 2020-05-06 | 2023-06-13 | 赛诺哈勃药业(成都)有限公司 | Transforming growth factor receptor antagonist, preparation method and application thereof |
CN113698395B (en) * | 2020-05-22 | 2023-12-08 | 赛诺哈勃药业(成都)有限公司 | Transforming growth factor receptor antagonist, preparation method and application thereof |
EP4284377A1 (en) * | 2021-01-27 | 2023-12-06 | Shy Therapeutics LLC | Methods for the treatment of fibrotic disease |
US20240309015A1 (en) * | 2021-01-27 | 2024-09-19 | Shy Therapeutics, Llc | Methods for the Treatment of Fibrotic Disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
GB0102672D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
-
2004
- 2004-01-26 WO PCT/EP2004/000650 patent/WO2004065392A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2004065392A1 (en) | 2004-08-05 |
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Free format text: IN GAZETTE 28/2004 UNDER (30) REPLACE "20 NOVEMBER 2002 (20.11.2002)" BY "21 NOVEMBER 2002 (21.11.2002)" |
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