MC1998A1 - Composes pour le traitement des maladies hyperproliferatibes et procede de preparation - Google Patents

Composes pour le traitement des maladies hyperproliferatibes et procede de preparation

Info

Publication number
MC1998A1
MC1998A1 MC902029A MC2029A MC1998A1 MC 1998 A1 MC1998 A1 MC 1998A1 MC 902029 A MC902029 A MC 902029A MC 2029 A MC2029 A MC 2029A MC 1998 A1 MC1998 A1 MC 1998A1
Authority
MC
Monaco
Prior art keywords
hyperproliferatible
diseases
compounds
preparation
treatment
Prior art date
Application number
MC902029A
Other languages
English (en)
French (fr)
Inventor
Giuseppe Baggiolini Enrico
Michael Hennessy Bernard
Shiuey Shian-Jan
Arthur Truitt Gary
Radoje Uskokovic Milan
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1998A1 publication Critical patent/MC1998A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MC902029A 1988-01-20 1989-01-19 Composes pour le traitement des maladies hyperproliferatibes et procede de preparation MC1998A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (1)

Publication Number Publication Date
MC1998A1 true MC1998A1 (fr) 1990-01-26

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
MC902029A MC1998A1 (fr) 1988-01-20 1989-01-19 Composes pour le traitement des maladies hyperproliferatibes et procede de preparation

Country Status (23)

Country Link
EP (1) EP0325279B1 (da)
JP (1) JPH0764806B2 (da)
KR (1) KR960009119B1 (da)
AR (1) AR247551A1 (da)
AT (1) ATE74350T1 (da)
AU (1) AU622139B2 (da)
BG (1) BG60530B2 (da)
CA (1) CA1337529C (da)
DE (1) DE58901056D1 (da)
DK (1) DK169945B1 (da)
ES (1) ES2033467T3 (da)
FI (1) FI90764C (da)
GR (1) GR3004786T3 (da)
HU (1) HU201007B (da)
IE (1) IE60921B1 (da)
IL (1) IL88989A (da)
MC (1) MC1998A1 (da)
NO (1) NO175429C (da)
NZ (1) NZ227641A (da)
PH (1) PH25605A (da)
PT (1) PT89486B (da)
YU (1) YU47298B (da)
ZA (1) ZA8923B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ATE141914T1 (de) * 1992-05-20 1996-09-15 Hoffmann La Roche Fluorierte analoge vitamins d3
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (da) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
US8906888B2 (en) * 2005-04-25 2014-12-09 Cytochroma Inc. Low-calcemic 16,23-diene 25-oxime analogs of 1α,25-dihydroxy vitamin D3
CN101287705A (zh) * 2005-08-18 2008-10-15 拜奥艾克塞尔股份公司 1α-氟-25-羟基-16-23E-二烯-26,27-双高-20-表-胆骨化醇的合成

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7803154A (nl) * 1977-03-24 1978-09-26 Wisconsin Alumni Res Found Vitamine d-antagonisten, werkwijze voor de be- reiding daarvan, en preparaten die ze bevatten.
DE2920092A1 (de) * 1978-05-19 1979-11-29 Wisconsin Alumni Res Found Antivitamin d-verbindungen und diese enthaltende pharmazeutische zusammensetzungen
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
DK0398217T3 (da) * 1989-05-18 1994-02-14 Hoffmann La Roche Dehydrocholecalciferolderivater

Also Published As

Publication number Publication date
IL88989A0 (en) 1989-08-15
NO890239D0 (no) 1989-01-19
IE890157L (en) 1989-07-20
NO890239L (no) 1989-07-21
ATE74350T1 (de) 1992-04-15
AR247551A1 (es) 1995-01-31
IL88989A (en) 1993-08-18
JPH0764806B2 (ja) 1995-07-12
ES2033467T3 (es) 1993-03-16
FI890283A (fi) 1989-07-21
FI890283A0 (fi) 1989-01-19
NO175429B (no) 1994-07-04
EP0325279A1 (de) 1989-07-26
BG60530B2 (bg) 1995-07-28
EP0325279B1 (de) 1992-04-01
IE60921B1 (en) 1994-09-07
GR3004786T3 (da) 1993-04-28
ZA8923B (en) 1989-09-27
DK19789D0 (da) 1989-01-17
DK19789A (da) 1989-07-21
KR890011838A (ko) 1989-08-22
NO175429C (no) 1994-10-12
AU622139B2 (en) 1992-04-02
PH25605A (en) 1991-08-08
YU11789A (en) 1991-04-30
FI90764C (fi) 1994-03-25
YU47298B (sh) 1995-01-31
NZ227641A (en) 1991-06-25
DE58901056D1 (de) 1992-05-07
DK169945B1 (da) 1995-04-10
JPH029861A (ja) 1990-01-12
HUT49317A (en) 1989-09-28
FI90764B (fi) 1993-12-15
PT89486A (pt) 1989-10-04
HU201007B (en) 1990-09-28
CA1337529C (en) 1995-11-07
PT89486B (pt) 1993-12-31
AU2864489A (en) 1989-07-20
KR960009119B1 (en) 1996-07-13

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