MA54693A - Néo-antigènes de la prostate et leurs utilisations - Google Patents

Néo-antigènes de la prostate et leurs utilisations

Info

Publication number
MA54693A
MA54693A MA054693A MA54693A MA54693A MA 54693 A MA54693 A MA 54693A MA 054693 A MA054693 A MA 054693A MA 54693 A MA54693 A MA 54693A MA 54693 A MA54693 A MA 54693A
Authority
MA
Morocco
Prior art keywords
neo
antigens
prostate
prostate neo
Prior art date
Application number
MA054693A
Other languages
English (en)
Inventor
Kurtis E Bachman
Vipul Bhargava
Darryl L Davis
Marco Gottardis
Vinod Krishna
Guido Leoni
David Pocalyko
Pegah Safabakhsh
Manuel Sepulveda
Derick Siegel
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MA54693A publication Critical patent/MA54693A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001195—Prostate specific membrane antigen [PSMA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/884—Vaccine for a specifically defined cancer prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA054693A 2019-01-10 2020-01-09 Néo-antigènes de la prostate et leurs utilisations MA54693A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962790673P 2019-01-10 2019-01-10
US201962851273P 2019-05-22 2019-05-22
US201962883786P 2019-08-07 2019-08-07
US201962913969P 2019-10-11 2019-10-11

Publications (1)

Publication Number Publication Date
MA54693A true MA54693A (fr) 2021-11-17

Family

ID=69191089

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054693A MA54693A (fr) 2019-01-10 2020-01-09 Néo-antigènes de la prostate et leurs utilisations

Country Status (21)

Country Link
US (2) US11793843B2 (fr)
EP (1) EP3908311A1 (fr)
JP (1) JP2022516770A (fr)
KR (1) KR20210113655A (fr)
CN (1) CN113573729A (fr)
AU (1) AU2020207641A1 (fr)
BR (1) BR112021013507A2 (fr)
CA (1) CA3126462A1 (fr)
CL (2) CL2021001835A1 (fr)
CO (1) CO2021010006A2 (fr)
CR (1) CR20210370A (fr)
EC (1) ECSP21056536A (fr)
IL (1) IL284561A (fr)
JO (1) JOP20210186A1 (fr)
MA (1) MA54693A (fr)
MX (1) MX2021008392A (fr)
PE (1) PE20211660A1 (fr)
SG (1) SG11202107274VA (fr)
TW (1) TW202043256A (fr)
UY (1) UY38542A (fr)
WO (2) WO2020144614A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
TW202144388A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在卵巢癌中表現之新抗原及其用途
US20230035403A1 (en) * 2020-07-06 2023-02-02 Janssen Biotech, Inc. Method For Determining Responsiveness To Prostate Cancer Treatment
US20230029453A1 (en) * 2020-07-06 2023-02-02 Janssen Biotech, Inc. Prostate Neoantigens And Their Uses
WO2022179568A1 (fr) * 2021-02-25 2022-09-01 Westlake Therapeutics (Hangzhou) Co., Limited Peptide néoantigénique et son utilisation pour le traitement de maladies associées à une mutation du gène braf
WO2023111861A1 (fr) * 2021-12-16 2023-06-22 Janssen Biotech, Inc. Vaccins contre le cancer de la prostate et leurs utilisations
WO2024112821A1 (fr) * 2022-11-22 2024-05-30 Elixirgen Therapeutics, Inc. Antigènes pour immunothérapie anticancéreuse

Family Cites Families (320)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US563536A (en) 1896-07-07 Bracket for swinging stages
US914623A (en) 1908-08-19 1909-03-09 Henry H Williams Process in the manufacture of generating-plates for x-ray machines.
US1051266A (en) 1910-09-26 1913-01-21 George I Rockwood Apparatus for operating alarms or other devices.
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4897445A (en) 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
EP0281604B1 (fr) 1986-09-02 1993-03-31 Enzon Labs Inc. Molecules de liaison de chaines de polypeptide simples
DE3642912A1 (de) 1986-12-16 1988-06-30 Leybold Ag Messeinrichtung fuer paramagnetische messgeraete mit einer messkammer
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
CA1341245C (fr) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Virus recombinant de la vaccine derive du virus modifie ankara
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5744166A (en) 1989-02-25 1998-04-28 Danbiosyst Uk Limited Drug delivery compositions
US5100587A (en) 1989-11-13 1992-03-31 The United States Of America As Represented By The Department Of Energy Solid-state radioluminescent zeolite-containing composition and light sources
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5179993A (en) 1991-03-26 1993-01-19 Hughes Aircraft Company Method of fabricating anisometric metal needles and birefringent suspension thereof in dielectric fluid
CA2103059C (fr) 1991-06-14 2005-03-22 Paul J. Carter Methode de production d'anticorps humanises
US6011146A (en) 1991-11-15 2000-01-04 Institut Pasteur Altered major histocompatibility complex (MHC) determinant and methods of using the determinant
US5734023A (en) 1991-11-19 1998-03-31 Anergen Inc. MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5747323A (en) 1992-12-31 1998-05-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Retroviral vectors comprising a VL30-derived psi region
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2707091B1 (fr) 1993-06-30 1997-04-04 Cohen Haguenauer Odile Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes.
US5820866A (en) 1994-03-04 1998-10-13 National Jewish Center For Immunology And Respiratory Medicine Product and process for T cell regulation
DE699079T1 (de) 1994-03-07 1997-09-25 Dendritech Inc Bioaktive und/oder gezielte dendrimere-konjugate
FR2719316B1 (fr) 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
EP0784690B1 (fr) 1994-06-10 2006-08-16 Genvec, Inc. Systemes de vecteurs adenoviraux et lignees cellulaires complementaires
EP0769063A1 (fr) 1994-06-27 1997-04-23 The Johns Hopkins University Systeme de transport de gene cible
US5972707A (en) 1994-06-27 1999-10-26 The Johns Hopkins University Gene delivery system
FR2722506B1 (fr) 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
US7074904B2 (en) 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
FR2727689A1 (fr) 1994-12-01 1996-06-07 Transgene Sa Nouveau procede de preparation d'un vecteur viral
EP0790837A1 (fr) 1994-12-21 1997-08-27 Novartis AG Conjugues oligonucleotide-dendrimere
US5635363A (en) 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5837520A (en) 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
IL122290A0 (en) 1995-06-07 1998-04-05 Inex Pharmaceuticals Corp Lipid-nucleic acid complex its preparation and use
US5981501A (en) 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
SI0833934T2 (sl) 1995-06-15 2013-04-30 Crucell Holland B.V. Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji
FR2737222B1 (fr) 1995-07-24 1997-10-17 Transgene Sa Nouveaux vecteurs viraux et lignee pour la therapie genique
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
WO1997035996A1 (fr) 1996-03-25 1997-10-02 Transgene S.A. Lignee cellulaire d'encapsidation a base de cellules 293 humaines
CA2177085C (fr) 1996-04-26 2007-08-14 National Research Council Of Canada Lignees de cellules complements e1 de l'adenovirus
CZ438398A3 (cs) 1996-07-01 1999-03-17 Rhone-Poulenc Rorer S. A. Způsob přípravy rekombinantních adenovirů
US6211342B1 (en) 1996-07-18 2001-04-03 Children's Hospital Medical Center Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function
US6348584B1 (en) 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
DE69739961D1 (de) 1996-12-13 2010-09-23 Schering Corp Methoden zur Virus-Reinigung
FR2759382A1 (fr) 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
FR2760193B1 (fr) 1997-02-28 1999-05-28 Transgene Sa Lipides et complexes de lipides cationiques et de substances actives, notamment pour la transfection de cellules
EP0973866A4 (fr) 1997-03-04 2000-04-19 Baxter Int Lignees cellulaires de complementation de la region e1 d'un adenovirus
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US6673901B2 (en) 1997-06-12 2004-01-06 Research Corporation Technologies, Inc. Artificial antibody polypeptides
WO1998056370A2 (fr) 1997-06-13 1998-12-17 Johns Hopkins University School Of Medicine Nanospheres therapeutiques
AU741130B2 (en) 1997-09-16 2001-11-22 Oregon Health Sciences University Recombinant MHC molecules useful for manipulation of antigen-specific T-cells
US6232445B1 (en) 1997-10-29 2001-05-15 Sunol Molecular Corporation Soluble MHC complexes and methods of use thereof
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
US6440442B1 (en) 1998-06-29 2002-08-27 Hydromer, Inc. Hydrophilic polymer blends used for dry cow therapy
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
DE60029195T2 (de) 1999-02-22 2007-06-28 Transgene S.A. Verfahren zur Gewinnung von purifizierter Virenzusammensetzung
DE60043126D1 (de) 1999-05-17 2009-11-19 Crucell Holland Bv Von Adenovirus abgeleitete Gentransfervehikel, die zumindest ein Element des Adenovirus Typ 35 enthalten
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
EP1964573B1 (fr) 1999-10-22 2014-11-26 Aventis Pasteur Limited Procédé d'induction et/ou amélioration d'une réponse immune vers des antigènes de tumeurs
DE19955558C2 (de) 1999-11-18 2003-03-20 Stefan Kochanek Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren
US20030198953A1 (en) 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
US20020192763A1 (en) 2000-04-17 2002-12-19 Jiangchun Xu Compositions and methods for the therapy and diagnosis of prostate cancer
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1598425A1 (fr) 2000-11-23 2005-11-23 Bavarian Nordic A/S Variant modifié du virus de la vaccine ankara
US7041870B2 (en) 2000-11-30 2006-05-09 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US20150329617A1 (en) 2001-03-14 2015-11-19 Dynal Biotech Asa Novel MHC molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of MHC molecules
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
EP2298809A3 (fr) 2001-07-12 2012-02-15 FOOTE, Jefferson Anticorps super humanisés
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
ATE290020T1 (de) 2001-08-31 2005-03-15 Avidex Ltd Löslicher t zell rezeptor
EP1483381A2 (fr) * 2002-03-14 2004-12-08 Exonhit Therapeutics S.A. Variants de kallikrein-2 et kallikreine-3 humaines et leurs utilisations
ES2288609T5 (es) 2002-04-19 2017-11-13 Bavarian Nordic A/S Virus vaccinia ankara modificado para la vacunación de neonatos
DE10244457A1 (de) 2002-09-24 2004-04-01 Johannes-Gutenberg-Universität Mainz Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren
US7569664B2 (en) 2002-10-09 2009-08-04 Immunocore Limited Single chain recombinant T cell receptors
KR101114784B1 (ko) 2002-11-12 2012-02-27 예일 유니버시티 아데노바이러스 벡터 백신
WO2005048957A2 (fr) 2003-02-20 2005-06-02 Therion Biologics Corporation Nouveaux sites d'insertion dans des vecteurs de variole
WO2004113571A2 (fr) 2003-06-26 2004-12-29 Exonhit Therapeutics Sa Genes specifiques de la prostate et leur utilisation comme cibles dans le traitement et le diagnostic du cancer de la prostate
EP1675607B1 (fr) 2003-09-05 2015-10-21 Oregon Health & Science University Molecules mhc monomeres de recombinaison utiles pour la manipulation de lymphocytes t specifiques d'antigenes
GB2408507B (en) 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
US20050208020A1 (en) 2003-11-12 2005-09-22 Doolan Denise L Enhancement of vaccine-induced immune responses and protection by heterologous boosting with alphavirus replicon vaccines
CA2544946A1 (fr) 2003-11-24 2005-03-06 Sidney Kimmel Cancer Center Vaccin d'antigene de mucine
US20050244851A1 (en) 2004-01-13 2005-11-03 Affymetrix, Inc. Methods of analysis of alternative splicing in human
ATE449105T1 (de) 2004-01-23 2009-12-15 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
CA2588705A1 (fr) 2004-11-24 2006-06-01 St. George's Enterprises Limited Diagnostic du cancer de la prostate
EP1683808A1 (fr) 2005-01-25 2006-07-26 Het Nederlands Kanker Instituut Moyens et méthodes pour résoudre des interactiones non covalentes entre les molécules
EP3623473A1 (fr) 2005-03-31 2020-03-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
CA2622295C (fr) 2005-09-12 2019-01-15 The Regents Of The University Of Michigan Fusion geniques recurrentes dans le cancer de la prostate
US9732131B2 (en) 2006-02-27 2017-08-15 Calviri, Inc. Identification and use of novopeptides for the treatment of cancer
US20100143302A1 (en) 2006-03-16 2010-06-10 Crucell Holland B.V. Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof
PT1999154E (pt) 2006-03-24 2013-01-24 Merck Patent Gmbh Domínios proteicos heterodiméricos modificados
WO2007147901A1 (fr) 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
EP1878744A1 (fr) 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-tag pour des récepteurs de cellules T exprimés en surface, leurs utilisations et méthode de selection de cellules hôtes les exprimant
GB2442048B (en) 2006-07-25 2009-09-30 Proimmune Ltd Biotinylated MHC complexes and their uses
GB2440529B (en) 2006-08-03 2009-05-13 Proimmune Ltd MHC Oligomer, Components Therof, And Methods Of Making The Same
US7910565B2 (en) 2006-09-01 2011-03-22 Wisconsin Alumni Research Foundation Prostate cancer vaccine
ES2500465T3 (es) 2006-10-06 2014-09-30 Bavarian Nordic Inc. Virus vaccinia Ankara modificado recombinante que codifica antígeno HER-2 en combinación con un taxano para uso en el tratamiento del cáncer
WO2008106615A1 (fr) 2007-02-28 2008-09-04 Numenta, Inc. Algorithmes d'apprentissage spatiotemporel dans des réseaux temporels hiérarchiques
EP3539567A1 (fr) 2007-07-02 2019-09-18 Etubics Corporation Procédés et compositions permettant de produire un vecteur d'adénovirus destiné à être utilisé avec des vaccinations multiples
KR20160065985A (ko) 2007-10-18 2016-06-09 버베리안 노딕 에이/에스 전립선 암 치료를 위한 ｍｖａ의 용도
US8748356B2 (en) 2007-10-19 2014-06-10 Janssen Biotech, Inc. Methods for use in human-adapting monoclonal antibodies
JP5710261B2 (ja) 2007-11-19 2015-04-30 トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． ポックスウイルス腫瘍細胞崩壊性ベクター
JP2011507519A (ja) 2007-12-19 2011-03-10 セントコア・オーソ・バイオテツク・インコーポレーテツド ｐＩＸ又はｐＶＩＩへの融合を介したヒトデノボｐＩＸファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
DK2235064T3 (en) 2008-01-07 2016-01-11 Amgen Inc A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
US10131921B2 (en) 2008-03-06 2018-11-20 Mayo Foundation For Medical Education And Research Single cycle replicating adenovirus vectors
CN102119217B (zh) 2008-04-15 2015-06-03 普洛体维生物治疗公司 用于核酸递送的新型制剂
EP3062106B1 (fr) 2008-04-16 2020-11-11 The Johns Hopkins University Méthode pour déterminer androgènes recepteur variantes dans le cancer de la prostate
US9029508B2 (en) 2008-04-29 2015-05-12 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
JP5421374B2 (ja) 2008-09-03 2014-02-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 悪性神経膠腫におけるイソクエン酸デヒドロゲナーゼ遺伝子および他の遺伝子の遺伝子変化
US8133724B2 (en) 2008-09-17 2012-03-13 University Of Maryland, Baltimore Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
EP2347038A4 (fr) 2008-10-14 2013-06-12 Janssen Biotech Inc Procédés d humanisation et de maturation d affinité d anticorps
AU2009308935B2 (en) 2008-10-31 2015-02-26 Janssen Biotech, Inc. Fibronectin type III domain based scaffold compositions, methods and uses
WO2010051367A1 (fr) 2008-10-31 2010-05-06 The Trustees Of The University Of Pennsylvania Adénovirus simiens sadv-43, -45, -48, -49 et –50 et leurs utilisations
CN102639709A (zh) 2009-01-09 2012-08-15 密歇根大学董事会 癌症中的复现性基因融合体
AU2010209938A1 (en) 2009-02-02 2011-08-25 Glaxosmithkline Biologicals Sa Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
CN102596992B (zh) 2009-02-12 2015-09-09 詹森生物科技公司 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途
US8394385B2 (en) 2009-03-13 2013-03-12 Bavarian Nordic A/S Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines
CN102459346B (zh) 2009-04-27 2016-10-26 昂考梅德药品有限公司 制造异源多聚体分子的方法
JP5797190B2 (ja) 2009-05-15 2015-10-21 アイ アール エックス セーラピューティクス， インコーポレイテッド ワクチン免疫療法
CA2766907A1 (fr) 2009-07-06 2011-01-13 Novartis Ag Molecules d'arn autorepliquantes et leurs utilisations
US10464987B2 (en) 2009-10-06 2019-11-05 Abbvie Inc. Human single-chain T cell receptors
NZ700688A (en) 2009-12-01 2016-02-26 Shire Human Genetic Therapies Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
GB201002730D0 (en) 2010-02-18 2010-04-07 Uni I Oslo Product
EP2550529B1 (fr) 2010-03-23 2021-11-17 Iogenetics, LLC. Procédés bioinformatiques pour déterminer la liaison de peptides
US20170039314A1 (en) 2010-03-23 2017-02-09 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
MX362513B (es) 2010-03-23 2019-01-22 Intrexon Corp Vectores que expresan de manera condicional proteinas terapeuticas, celulas hospedadoras que comprenden vectores, y usos de los mismos.
US9150663B2 (en) 2010-04-20 2015-10-06 Genmab A/S Heterodimeric antibody Fc-containing proteins and methods for production thereof
EP2569337A1 (fr) 2010-05-14 2013-03-20 Rinat Neuroscience Corp. Protéines hétérodimériques et leurs procédés de production et de purification
WO2012006369A2 (fr) 2010-07-06 2012-01-12 Novartis Ag Immunisation de grands mammifères à l'aide de faibles doses d'arn
RS63817B1 (sr) 2010-07-06 2023-01-31 Glaxosmithkline Biologicals Sa Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk
US9770463B2 (en) 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
EP2590626B1 (fr) 2010-07-06 2015-10-28 GlaxoSmithKline Biologicals SA Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn
EP2420253A1 (fr) 2010-08-20 2012-02-22 Leadartis, S.L. Synthèse de molécules polyvalentes et multifonctionnelles avec un domaine de trimérisation de collagène XV
EP4119155A1 (fr) 2010-08-31 2023-01-18 GlaxoSmithKline Biologicals S.A. Liposomes pegylés pour la délivrance d'arn codant pour un immunogène
PL2611467T3 (pl) 2010-08-31 2022-08-16 Glaxosmithkline Biologicals Sa Małe liposomy do dostarczania rna kodującego immunogen
CN105497883A (zh) 2010-09-29 2016-04-20 乌第有限合伙公司 使用生物相容性的生物可吸收纳米球治疗自身免疫病的方法
WO2012044999A2 (fr) 2010-10-01 2012-04-05 Ludwig Institute For Cancer Research Ltd. Multimères de protéines réversibles, et leurs procédés de production et d'utilisation
RS59589B1 (sr) 2010-11-05 2019-12-31 Zymeworks Inc Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu
WO2012089225A1 (fr) 2010-12-29 2012-07-05 Curevac Gmbh Combinaison de vaccination et d'inhibition de la présentation des antigènes restreinte par le cmh de classe i
EP2502934B1 (fr) 2011-03-24 2018-01-17 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Constructions reconnaissant les antigènes à chaîne unique stabilisées par l'introduction de nouvelles liaisons disulfure
WO2012149522A1 (fr) 2011-04-28 2012-11-01 Baylor College Of Medicine Arn chimériques récurrents enrichis dans le cancer humain de la prostate tenant lieu de biomarqueurs
GB201108879D0 (en) 2011-05-25 2011-07-06 Isis Innovation Vector
EP2723381A4 (fr) 2011-06-21 2015-03-18 Univ Johns Hopkins Rayonnement focalisé pour améliorer les thérapies basées sur l'immunité contre les néoplasmes
JP2014520806A (ja) 2011-07-06 2014-08-25 ノバルティス アーゲー Ｒｎａ分子の送達のための有用なｎ：ｐ比を有するリポソーム
CA2841047A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Compositions immunogenes et leurs utilisations
CA2840989A1 (fr) 2011-07-06 2013-01-10 Novartis Ag Compositions de combinaisons immunogenes et utilisations de celles-ci
MX366055B (es) 2011-08-31 2019-06-26 Novartis Ag Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno.
CA2851251C (fr) 2011-10-05 2023-09-12 Genvec, Inc. Adenovirus simiens ou vecteurs adenoviraux simiens et procedes d'utilisation
AU2012322704B2 (en) 2011-10-11 2017-09-07 Novartis Ag Recombinant self-replicating polycistronic RNA molecules
EP2771364B1 (fr) 2011-10-27 2019-05-22 Genmab A/S Production de protéines hétérodimères
CN104080811B (zh) 2011-11-04 2019-09-27 酵活有限公司 在Fc结构域中具有突变的稳定异源二聚的抗体设计
DK2794905T3 (da) 2011-12-20 2020-07-06 Medimmune Llc Modificerede polypeptider til bispecifikke antistofgrundstrukturer
EP2809788B1 (fr) 2012-02-02 2019-09-04 Board Of Regents, The University Of Texas System Adénovirus exprimants des antigènes hétérologues associés aux tumeurs
US20160078168A1 (en) 2012-02-13 2016-03-17 Splicingcodes.Com Fusion transcript detection methods and fusion transcripts identified thereby
US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
NZ772318A (en) 2012-04-20 2023-06-30 Merus Nv Methods and means for the production of ig-like molecules
DK3401400T3 (da) * 2012-05-25 2019-06-03 Univ California Fremgangsmåder og sammensætninger til rna-styret mål-dna-modifikation og til rna-styret transskriptionsmodulering
US20150190505A1 (en) 2012-07-30 2015-07-09 Alex Wah Hin Yeung Live and in-vivo tumor specific cancer vaccine system developed by co-administration of either at least two or all three of the following components such as tumor cells, an oncolytic virus vector with transgenic expression of gm-csf and an immune checkpoint modulator
US10973892B2 (en) 2012-09-04 2021-04-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
WO2014082729A1 (fr) 2012-11-28 2014-06-05 Biontech Ag Vaccins individualisés contre le cancer
BR112015018989B1 (pt) 2013-02-22 2023-11-14 Curevac Ag Combinação de vacina/inibidor da via de pd-1, inibidor da via de pd-1 e vacina de rna
EP3015477B1 (fr) 2013-06-26 2021-08-18 XLifeSc, Ltd. Récepteur de lymphocytes t de haute stabilité et son procédé de préparation et son application
US10350275B2 (en) 2013-09-21 2019-07-16 Advantagene, Inc. Methods of cytotoxic gene therapy to treat tumors
US10035832B2 (en) 2013-10-23 2018-07-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HLA-A24 agonist epitopes of MUC1-C oncoprotein and compositions and methods of use
CN105828834A (zh) 2013-11-05 2016-08-03 同源生物服务股份有限公司 检查点抑制剂和治疗剂的组合以治疗癌症
NZ719232A (en) 2013-11-05 2022-04-29 Bavarian Nordic As Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor
WO2015074085A1 (fr) 2013-11-18 2015-05-21 Arcturus Therapeutics, Inc. Lipide cationique ionisable pour administration d'arn
CN106029889A (zh) 2013-11-22 2016-10-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
NZ719934A (en) 2013-11-28 2022-10-28 Bavarian Nordic As Compositions and methods vectors for inducing an enhanced immune response using poxvirus vectors
US20170106065A1 (en) 2013-12-31 2017-04-20 Bavarian Nordic A/S Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist of TIM-3
US9884075B2 (en) 2014-01-16 2018-02-06 California Institute Of Technology Domain-swap T cell receptors
BR112016018521A2 (pt) 2014-02-14 2017-10-17 Immune Design Corp composição, e, kit.
CA2941116A1 (fr) 2014-02-28 2015-09-03 Janssen Vaccines & Prevention B.V. Vecteurs adenoviaux recombines se repliquant, compositions et procedes pour les utiliser
US10441643B2 (en) 2014-03-19 2019-10-15 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
PT3134131T (pt) 2014-04-23 2022-03-24 Modernatx Inc Vacinas de ácidos nucleicos
US20170266270A1 (en) 2014-05-13 2017-09-21 Bavarian Nordic A/S Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist and/or Agonist of an Immune Checkpoint Inhibitor
ES2851451T3 (es) 2014-05-13 2021-09-07 Bavarian Nordic As Terapia de combinación para tratar cáncer con un poxvirus que expresa un antígeno de tumor y un anticuerpo monoclonal contra TIM-3
CA2949121A1 (fr) 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Traitement du cancer du poumon a l'aide d'une combinaison d'un anticorps anti-pd-1 et d'un autre agent anticancereux
US20170106067A1 (en) 2014-06-12 2017-04-20 The Johns Hopkins University Combinatorial immunotherapy for pancreatic cancer treatment
NZ729519A (en) 2014-09-26 2024-02-23 Bavarian Nordic As Methods and compositions for intra-nasal immunization with recombinant mva encoding flagellin
WO2016071343A1 (fr) 2014-11-03 2016-05-12 Immures S.R.L. Récepteurs de lymphocytes t
CN107949397A (zh) 2015-02-13 2018-04-20 特兰斯吉恩股份有限公司 免疫治疗疫苗和抗体组合治疗
WO2016168862A1 (fr) 2015-04-17 2016-10-20 Memorial Sloan-Kettering Cancer Center Utilisation de mva ou de mvadeltae3l en tant qu'agents immunothérapeutiques contre des tumeurs solides
GB201506642D0 (en) 2015-04-20 2015-06-03 Ucl Business Plc T cell receptor
US10293058B2 (en) 2015-04-22 2019-05-21 Curevac Ag RNA containing composition for treatment of tumor diseases
EP3286361A4 (fr) 2015-04-23 2019-05-08 Nantomics, LLC Néo-épitopes de cancer
BR112017023853A2 (pt) 2015-05-06 2018-07-17 Uti Limited Partnership composições de nanopartícula para terapia sustentada.
DK3294326T3 (da) 2015-05-15 2021-05-31 Curevac Ag Prime-boost-regimer indbefattende indgivelse af mindst én mrna-konstruktion
CN116196401A (zh) * 2015-05-20 2023-06-02 博德研究所 共有的新抗原
AU2016270823B2 (en) 2015-06-01 2020-09-03 California Institute Of Technology Compositions and methods for screening T cells with antigens for specific populations
WO2016197067A1 (fr) 2015-06-05 2016-12-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Vaccin gm-csf/cd40l et polythérapie d'inhibiteur de point de contrôle
US20180296663A1 (en) 2015-06-17 2018-10-18 Curevac Ag Vaccine composition
CN107847544B (zh) 2015-07-20 2021-10-15 小利兰·斯坦福大学董事会 用多聚体结合试剂检测细胞表型和定量
GB201513176D0 (en) * 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
EP3328394A4 (fr) * 2015-07-30 2019-03-13 ModernaTX, Inc. Arn épitope peptidiques concatémériques
CN107921110B (zh) 2015-08-20 2021-10-15 扬森疫苗与预防公司 治疗性hpv18疫苗
US20180318365A1 (en) 2015-10-19 2018-11-08 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
WO2017070618A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins anticancéreux
CN108473950A (zh) 2015-10-30 2018-08-31 美国政府卫生与公众服务部 靶向癌症治疗
KR20180069070A (ko) 2015-11-03 2018-06-22 얀센 바이오테크 인코포레이티드 Tim-3과 특이적으로 결합하는 항체 및 그의 용도
EP3383893A4 (fr) 2015-12-02 2019-06-26 Innovative Targeting Solutions Inc. Récepteur de lymphocytes t à domaine variable unique
MX2018010204A (es) 2016-02-25 2019-05-06 Memorial Sloan Kettering Cancer Center Virus de la vaccinia atenuada competentes para replicacion con la supresion de timidina quinasa con y sin la expresion del flt3l o gm-csf humanos para inmunoterapia del cancer.
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
CA3015530A1 (fr) 2016-03-04 2017-09-08 New York University Vecteurs viraux exprimant de multiples epitopes d'antigenes associes a une tumeur pour induire une immunite antitumorale
WO2017162266A1 (fr) 2016-03-21 2017-09-28 Biontech Rna Pharmaceuticals Gmbh Réplicon d'arn pour une expression génique polyvalente et efficace
KR20180129899A (ko) 2016-03-31 2018-12-05 네온 테라퓨틱스, 인크. 신생항원 및 이것의 사용 방법
CA3056212A1 (fr) 2016-04-07 2017-10-12 Bostongene Corporation Elaboration et methodes d'utilisation d'une banque de vaccins therapeutiques contre le cancer contenant des vaccins specifiques de fusions
EP3443001A4 (fr) 2016-04-11 2020-04-29 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
CA3020426A1 (fr) 2016-04-13 2017-10-19 Synthetic Genomics, Inc. Systemes de replicon d'arterivirus recombinant et utilisations correspondantes
US20180126003A1 (en) 2016-05-04 2018-05-10 Curevac Ag New targets for rna therapeutics
KR102482867B1 (ko) 2016-05-18 2023-01-02 모더나티엑스, 인크. 면역 조정 폴리펩타이드를 암호화하는 mRNA의 조합물 및 이의 용도
MX2018013509A (es) 2016-05-18 2019-03-28 Modernatx Inc Polinucleotidos que codifican interleucina-12 (il12) y sus usos de los mismos.
MA45037A (fr) 2016-05-18 2019-03-27 Modernatx Inc Polythérapie à base d'arnm pour le traitement du cancer
MX2018014602A (es) 2016-05-27 2019-06-10 Etubics Corp Composiciones de vacunas neoepitopos y metodos de uso de las mismas.
WO2017218689A1 (fr) 2016-06-14 2017-12-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Expression de protéines de ligand d'activation de nkg2d pour sensibiliser les cellules cancéreuses à une attaque par des cellules immunitaires cytotoxiques
MX2018015540A (es) 2016-06-20 2019-04-11 Janssen Vaccines & Prevention Bv Promotor bidireccional potente y equilibrado.
SG11201811432WA (en) 2016-08-19 2019-03-28 Curevac Ag Rna for cancer therapy
TWI796299B (zh) * 2016-08-26 2023-03-21 德商英麥提克生物技術股份有限公司 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架
CA3035759A1 (fr) 2016-09-02 2018-03-08 Janssen Vaccines & Prevention B.V. Procedes pour induire une reponse immunitaire contre une infection par le virus de l'immunodeficience humaine chez des sujets subissant un traitement antiretroviral
SI3293201T1 (sl) 2016-09-12 2021-03-31 Targovax Oy Kombinacija zaviralcev adenovirusa in zaviralcev kontrolnih točk za zdravljenje raka
KR102605505B1 (ko) 2016-09-28 2023-11-22 버베리안 노딕 에이/에스 폭스바이러스에서 이식유전자의 안정성을 강화시키는 조성물 및 방법
JP7022123B2 (ja) 2016-09-30 2022-02-17 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｃｄ３に対する二重特異性抗体
EP3526332B1 (fr) 2016-10-17 2024-06-26 Janssen Pharmaceuticals, Inc. Système réplicon recombinant de virus et leurs utilisations
EP3532103A1 (fr) 2016-10-26 2019-09-04 Acuitas Therapeutics, Inc. Formulations de nanoparticules lipidiques
WO2018093907A1 (fr) 2016-11-16 2018-05-24 PrimeVax Immuno-Oncology, Inc. Immunothérapies d'association pour le traitement du cancer
EP3544607A4 (fr) * 2016-11-23 2020-10-14 Gritstone Oncology, Inc. Administration virale de néo-antigènes
NZ753307A (en) 2016-11-30 2023-10-27 Advaxis Inc Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
WO2018102585A1 (fr) 2016-11-30 2018-06-07 Advaxis, Inc. Immunothérapie personnalisée en association avec une immunothérapie ciblant des mutations de cancer récurrentes
EP3548625B1 (fr) 2016-12-05 2024-06-26 Janssen Pharmaceuticals, Inc. Compositions et méthodes d'activation d'expression génique
WO2018107011A1 (fr) 2016-12-08 2018-06-14 City Of Hope Vaccins ciblant p53 et inhibiteurs de la voie pd -1 et leurs procédés d'utilisation
US10459372B2 (en) 2017-01-31 2019-10-29 Hewlett-Packard Development Company, L.P. Binary ink developer (BID) assembly for liquid electrophotography (LEP) printing device
CN110505877A (zh) 2017-02-01 2019-11-26 摩登纳特斯有限公司 Rna癌症疫苗
EP3579885A4 (fr) 2017-02-07 2020-12-16 Nantcell, Inc. Maximisation de la mémoire de cellules t, compositions et méthodes associées
CA3053212C (fr) 2017-02-09 2021-04-13 Janssen Vaccines & Prevention B.V. Promoteur puissant et court pour l'expression de genes heterologues
JP7229538B2 (ja) 2017-02-10 2023-03-01 ザ ロックフェラー ユニバーシティー 薬物標的を特定するための細胞型特異的プロファイリング方法
US20200377598A1 (en) 2017-03-03 2020-12-03 New York University Induction and Enhancement of Antitumor Immunity Involving Virus Vectors Expressing Multiple Epitopes of Tumor Associated Antigens and Immune Checkpoint Inhibitors or Proteins
WO2018167320A1 (fr) 2017-03-17 2018-09-20 Curevac Ag Vaccin à arn et inhibiteurs de points de contrôle immunitaires pour une thérapie anticancéreuse combinée
US20230241207A1 (en) 2017-04-03 2023-08-03 Neon Therapeutics, Inc. Protein antigens and uses thereof
US20200121774A1 (en) 2017-04-19 2020-04-23 University Of Iowa Research Foundation Cancer vaccines and methods of producing and using same
JP2020518648A (ja) 2017-05-08 2020-06-25 グリットストーン オンコロジー インコーポレイテッド アルファウイルス新生抗原ベクター
CN111107872A (zh) 2017-05-12 2020-05-05 纪念斯隆-凯特林癌症中心 有用于癌症免疫疗法的牛痘病毒突变体
JP2020522477A (ja) 2017-06-02 2020-07-30 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 汎用癌ワクチンおよびそれを製造ならびに使用する方法
WO2018234506A2 (fr) 2017-06-21 2018-12-27 Transgene Sa Vaccin personnalisé
CN111108192B (zh) 2017-07-05 2023-12-15 Nouscom股份公司 非人类人猿腺病毒核酸序列和氨基酸序列、含有其的载体及其用途
FI3652606T3 (fi) 2017-07-12 2023-03-16 Nouscom Ag Jaettuihin tuumorineoantigeeneihin perustuva yleisrokote epästabiilien mikrosatelliitti (msi) -syöpien ennaltaehkäisyyn ja hoitoon
CN111093699A (zh) 2017-07-12 2020-05-01 Nouscom股份公司 用于治疗癌症的新抗原疫苗组合物
US11235051B2 (en) 2017-07-28 2022-02-01 Janssen Vaccines & Prevention B.V. Methods and compositions for heterologous repRNA immunizations
GB201713163D0 (en) * 2017-08-16 2017-09-27 Univ Oxford Innovation Ltd HPV vaccine
WO2019038388A1 (fr) 2017-08-24 2019-02-28 Bavarian Nordic A/S Polythérapie pour le traitement du cancer par administration intraveineuse d'un mva de recombinaison et d'un anticorps
US11839655B2 (en) 2017-09-01 2023-12-12 Microvax, Llc Combination cancer therapy
JP7389741B2 (ja) 2017-09-13 2023-11-30 バイオエヌテック セル アンド ジーン セラピーズ ゲーエムベーハー Ｔ細胞受容体または人工ｔ細胞受容体を発現するためのｒｎａレプリコン
BR112020008308A2 (pt) 2017-11-03 2020-11-17 Nouscom Ag polipeptídeo, polinucleotídeo, vetor, coleção de dois ou mais vetores, composição farmacêutica e kit
WO2019094396A1 (fr) 2017-11-07 2019-05-16 Nektar Therapeutics Polyimmunothérapies pour le traitement du cancer
GB201721068D0 (en) 2017-12-15 2018-01-31 Glaxosmithkline Biologicals Sa Hepatitis B immunisation regimen and compositions
MX2020007010A (es) 2018-01-05 2020-12-10 Ottawa Hospital Res Inst Vectores modificados de orthopoxvirus.
AU2019205627B2 (en) 2018-01-06 2024-05-09 Emergex Vaccines Holding Limited MHC class I associated peptides for prevention and treatment of multiple flavi virus
EP3737386A1 (fr) 2018-01-11 2020-11-18 BioNTech RNA Pharmaceuticals GmbH Formulation d'administration d'arn
EP3740245A4 (fr) 2018-01-19 2022-01-05 Janssen Pharmaceuticals, Inc. Induction et amélioration des réponses immunitaires à l'aide de systèmes de réplicon de recombinaison
CN111918660A (zh) 2018-01-24 2020-11-10 复诺健生物科技加拿大有限公司 重组病毒疫苗
KR20200116086A (ko) 2018-01-26 2020-10-08 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 종양 치료를 개선하기 위한 종양 미세환경에서 대사 조절인자의 발현
US20190367568A1 (en) 2018-02-05 2019-12-05 Nantbio, Inc. Calreticulin and fusion proteins
US11376290B2 (en) 2018-03-14 2022-07-05 Wuhan Boweid Biotechnology Co., Ltd. Recombinant oncolytic virus, synthetic DNA sequence, and application thereof
EP3773649A4 (fr) 2018-03-28 2022-02-23 EpicentRx, Inc. Vaccins anticancéreux personnalisés
US20230149310A1 (en) 2018-03-30 2023-05-18 Arcturus Therapeutics, Inc. Lipid particles for nucleic acid delivery
TWI816603B (zh) 2018-04-23 2023-09-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
GB201807932D0 (en) 2018-05-16 2018-06-27 Redchenko Irina Compositions and methods for inducing an immune response
EP3796927A4 (fr) 2018-05-23 2022-04-20 Gritstone bio, Inc. Antigènes partagés
EP3796930A4 (fr) 2018-05-23 2022-05-04 Gritstone bio, Inc. Vecteurs de co-expression d'inhibiteurs de points de contrôle immunitaires
AU2019277361A1 (en) 2018-05-30 2020-12-17 Translate Bio, Inc. Messenger RNA vaccines and uses thereof
WO2019238023A1 (fr) * 2018-06-11 2019-12-19 Chineo Medical Technology Co., Ltd. Vaccins néoantigènes et leurs utilisations
EP3587581A1 (fr) 2018-06-26 2020-01-01 GlaxoSmithKline Biologicals S.A. Formulations pour vecteurs adénoviraux simiens possédant une stabilité d'entreposage améliorée
WO2020014539A1 (fr) 2018-07-11 2020-01-16 Epicentrx, Inc. Procédés et compositions pour cibler des cellules cancéreuses pour un traitement
WO2020022897A1 (fr) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Procédé de préparation de compositions immunogènes spécifiques à un sujet en s'appuyant sur une base de données de néo-peptides à cadre ouvert de lecture
GB201812647D0 (en) 2018-08-03 2018-09-19 Chancellor Masters And Scholars Of The Univ Of Oxford Viral vectors and methods for the prevention or treatment of cancer
CN112996917A (zh) 2018-09-15 2021-06-18 纪念斯隆凯特琳癌症中心 用于癌症免疫疗法的重组痘病毒
WO2020072371A1 (fr) 2018-10-01 2020-04-09 The Wistar Institute Compositions de vaccins canins contre le mélanome et leurs méthodes d'utilisation
JP2022512595A (ja) 2018-10-05 2022-02-07 バヴァリアン・ノルディック・アクティーゼルスカブ 組み換えｍｖａ、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法
WO2020073045A1 (fr) 2018-10-05 2020-04-09 Nantcell, Inc. Combo cd40 et cd40l dans un véhicule de vaccin à adénovirus
KR20210081325A (ko) 2018-10-19 2021-07-01 노우스콤 아게 경골어류 불변 사슬 암 백신
MA54192A (fr) 2018-11-07 2021-09-15 Modernatx Inc Vaccins à arn contre le cancer
CA3119752A1 (fr) 2018-11-07 2020-05-14 Gritstone Oncology, Inc. Vecteurs de neoantigenes d'alphavirus et inhibiteurs d'interferons
CN113424264B (zh) 2018-11-15 2024-04-12 Nouscom股份公司 用于生成个性化癌症疫苗的癌症突变选择
EP3883599A1 (fr) 2018-11-20 2021-09-29 Bavarian Nordic A/S Thérapie pour le traitement du cancer par une administration intratumorale et/ou intraveineuse d'un mva recombinant codant pour 4-1bbl (cd137l) et/ou cd40l
EP3893925A4 (fr) 2018-12-13 2023-01-18 Rhode Island Hospital Inhibition de l'asph exprimant la croissance et la progression d'une tumeur
CA3121430A1 (fr) 2018-12-14 2020-06-18 Glaxosmithkline Biologicals Sa Compositions et methodes heterologues de primo-vaccination et de rappel
WO2020131586A2 (fr) 2018-12-17 2020-06-25 The Broad Institute, Inc. Méthodes d'identification de néo-antigènes
CN109806390A (zh) 2019-01-07 2019-05-28 康希诺生物股份公司 一种SamRNA疫苗及其制备方法
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
CN115120716A (zh) 2019-01-14 2022-09-30 健泰科生物技术公司 用pd-1轴结合拮抗剂和rna疫苗治疗癌症的方法
CN113507963A (zh) 2019-01-21 2021-10-15 赛诺菲 用于晚期实体瘤癌症的治疗性rna及抗pd1抗体
TW202102543A (zh) 2019-03-29 2021-01-16 美商安進公司 溶瘤病毒在癌症新輔助療法中之用途
EP3721899A1 (fr) 2019-04-08 2020-10-14 China Medical University Polythérapies comprenant un vaccin basé sur des cellules dendritiques et inhibiteur de point de contrôle immunitaire
CA3140019A1 (fr) 2019-05-30 2020-12-03 Gritstone Bio, Inc. Adenovirus modifies
WO2020247547A1 (fr) 2019-06-03 2020-12-10 Geovax, Inc. Compositions de vaccins contre le cancer et leurs méthodes d'utilisation

Also Published As

Publication number Publication date
BR112021013507A2 (pt) 2021-11-16
UY38542A (es) 2020-07-31
CR20210370A (es) 2021-09-09
JP2022516770A (ja) 2022-03-02
PE20211660A1 (es) 2021-08-26
CA3126462A1 (fr) 2020-07-16
WO2020144615A1 (fr) 2020-07-16
AU2020207641A1 (en) 2021-07-22
MX2021008392A (es) 2021-10-26
US20200222478A1 (en) 2020-07-16
CN113573729A (zh) 2021-10-29
CL2022000373A1 (es) 2022-10-28
EP3908311A1 (fr) 2021-11-17
ECSP21056536A (es) 2023-02-28
KR20210113655A (ko) 2021-09-16
US20240139265A1 (en) 2024-05-02
SG11202107274VA (en) 2021-07-29
TW202043256A (zh) 2020-12-01
CL2021001835A1 (es) 2022-01-21
IL284561A (en) 2021-08-31
US11793843B2 (en) 2023-10-24
CO2021010006A2 (es) 2021-08-30
WO2020144614A1 (fr) 2020-07-16
JOP20210186A1 (ar) 2023-01-30

Similar Documents

Publication Publication Date Title
MA54693A (fr) Néo-antigènes de la prostate et leurs utilisations
MA50618A (fr) Polyrhérapies et leurs utilisations
MA50256A (fr) Composés de pyrazolopyrimidinone et leurs utilisations
MA47789A (fr) Anticorps anti-phf-tau et leurs utilisations
MA46708A (fr) Anticorps anti-pd1 et leurs utilisations
MA53184A (fr) Anticorps anti-ox40 et leurs utilisations
MA52426A (fr) Conjugués d'il-15 et leurs utilisations
MA50144A (fr) Anticorps anti-peptides bêta-amyloïdes n3pglu et utilisations associées
MA52483A (fr) Dérivés de gip et leurs utilisations
MA49683A (fr) Anticorps anti-cd8 et leurs utilisations
MA56462A (fr) Inhibiteurs de hpk1 et leurs utilisations
MA49687A (fr) Anticorps anti-ctla-4 et leurs utilisations
MA52949A (fr) Anticorps anti-pd-1 et leurs utilisations
MA45125A (fr) Anticorps anti-alpha-synucléine et leurs utilisations
MA50397A (fr) Anticorps anti-tau et leurs utilisations
MA49886A (fr) Anticorps anti-par2 et leurs utilisations
MA45943A (fr) Compositions ignifuges et leurs utilisations
MA43821A (fr) Pyrimidines et variantes de celles-ci, et leurs utilisations
MA50265A (fr) Conjugués anticorps-récepteur alpha anti-folate et leurs utilisations
MA43567A (fr) Anticorps pacap et leurs utilisations
MA55565A (fr) Agents de dégradation de stat et leurs utilisations
MA46704A (fr) Anticorps anti-pyroglutamate- amyloïde-beta et leurs utilisations
MA55083A (fr) Polyribonucléotides et leurs utilisations cosmétiques
MA44489A (fr) Pyrimidines et variants de celles-ci, et leurs utilisations
MA46945A (fr) Exopolysaccharides et leurs utilisations