MA41415A - Dinucléotides cycliques utiles pour traiter, entre autres, le cancer - Google Patents
Dinucléotides cycliques utiles pour traiter, entre autres, le cancerInfo
- Publication number
- MA41415A MA41415A MA041415A MA41415A MA41415A MA 41415 A MA41415 A MA 41415A MA 041415 A MA041415 A MA 041415A MA 41415 A MA41415 A MA 41415A MA 41415 A MA41415 A MA 41415A
- Authority
- MA
- Morocco
- Prior art keywords
- cancer
- treating
- cyclic dinucleotides
- useful
- dinucleotides useful
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1501462.4A GB201501462D0 (en) | 2015-01-29 | 2015-01-29 | Novel compounds |
| US201562262621P | 2015-12-03 | 2015-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA41415A true MA41415A (fr) | 2017-12-05 |
Family
ID=52705427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA041415A MA41415A (fr) | 2015-01-29 | 2016-01-26 | Dinucléotides cycliques utiles pour traiter, entre autres, le cancer |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10047115B2 (fr) |
| EP (1) | EP3250573A1 (fr) |
| JP (1) | JP6722682B2 (fr) |
| KR (1) | KR20170102362A (fr) |
| CN (1) | CN107108684B (fr) |
| AU (1) | AU2016212085B2 (fr) |
| BR (1) | BR112017016006A2 (fr) |
| CA (1) | CA2973806A1 (fr) |
| CL (1) | CL2017001932A1 (fr) |
| CO (1) | CO2017007293A2 (fr) |
| CR (1) | CR20170350A (fr) |
| DO (1) | DOP2017000175A (fr) |
| EA (1) | EA031728B1 (fr) |
| GB (1) | GB201501462D0 (fr) |
| IL (1) | IL252935A0 (fr) |
| MA (1) | MA41415A (fr) |
| MX (1) | MX2017009837A (fr) |
| PE (1) | PE20171322A1 (fr) |
| PH (1) | PH12017501233A1 (fr) |
| SG (1) | SG11201705077VA (fr) |
| WO (1) | WO2016120305A1 (fr) |
| ZA (1) | ZA201704732B (fr) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE043262T2 (hu) | 2012-12-13 | 2019-08-28 | Aduro Biotech Inc | Meghatározott sztereokémiájú ciklikus purindinukleotidokat tartalmazó készítmények, valamint eljárások elõállításukra és alkalmazásukra |
| PE20160167A1 (es) | 2013-04-29 | 2016-04-21 | Sloan Kettering Inst Cancer | Composiciones y metodos para alterar la senalizacion del segundo mensajero |
| SG11201508273RA (en) | 2013-05-18 | 2015-12-30 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
| EP3152217B1 (fr) | 2014-06-04 | 2018-08-01 | GlaxoSmithKline Intellectual Property Development Limited | Di-nucléotides cycliques utilisés comme modulateurs de sting |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| JO3746B1 (ar) | 2015-03-10 | 2021-01-31 | Aduro Biotech Inc | تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون" |
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| WO2017027645A1 (fr) | 2015-08-13 | 2017-02-16 | Merck Sharp & Dohme Corp. | Composés di-nucléotidiques cycliques en tant qu'agonistes de sting |
| TW201726700A (zh) * | 2015-10-28 | 2017-08-01 | 艾杜諾生物科技公司 | 用於活化「干擾素基因刺激子」依賴性訊號之組合物及方法 |
| EP3322713B1 (fr) * | 2015-12-03 | 2021-01-20 | GlaxoSmithKline Intellectual Property Development Limited | Dinucléotides cycliques de purine à titre de modulateurs du sting |
| PE20181330A1 (es) | 2016-01-11 | 2018-08-20 | Innate Tumor Immunity Inc | Dinucleotidos ciclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferon (sting) tales como cancer |
| EP3429596B1 (fr) | 2016-03-18 | 2022-08-31 | Immune Sensor, LLC | Composés di-nucléotides cycliques et leurs procédés d'utilisation |
| US10696985B1 (en) | 2016-06-06 | 2020-06-30 | Vanderbilt University | Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery |
| WO2018009466A1 (fr) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Composés dinucléotidiques cycliques d'acide nucléique bloqué et leurs utilisations |
| CA3029644A1 (fr) | 2016-07-06 | 2018-01-11 | Sperovie Biosciences, Inc. | Composes, compositions et methodes de traitement de maladie |
| US10537590B2 (en) * | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| PT3523287T (pt) | 2016-10-04 | 2021-10-06 | Merck Sharp & Dohme | Compostos de benzo[b]tiofeno como agonistas de sting |
| US10266558B2 (en) * | 2016-10-07 | 2019-04-23 | Alexandre Vasilievich Ivachtchenko | Macroheterocyclic nucleoside derivatives and their analogues, production and use thereof |
| JOP20170188A1 (ar) * | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| JOP20170192A1 (ar) * | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| JP2020503303A (ja) * | 2016-12-20 | 2020-01-30 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がんの処置のための環状ジヌクレオチドｓｔｉｎｇアゴニスト |
| WO2018138684A1 (fr) * | 2017-01-27 | 2018-08-02 | Janssen Biotech, Inc. | Dinucléotides cycliques utilisés en tant qu'agonistes de sting |
| JP7275031B2 (ja) * | 2017-01-27 | 2023-05-17 | ヤンセン バイオテツク，インコーポレーテツド | Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| WO2018156625A1 (fr) * | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Dinucléotides cycliques utilisés en tant qu'agonistes du stimulateur de la signalisation dépendante du gène de l'interféron |
| JOP20190218A1 (ar) | 2017-03-22 | 2019-09-22 | Boehringer Ingelheim Int | مركبات ثنائية النيوكليوتيدات حلقية معدلة |
| EP3609922A2 (fr) | 2017-04-13 | 2020-02-19 | Aduro Biotech Holdings, Europe B.V. | Anticorps anti-sirp alpha |
| WO2018208667A1 (fr) * | 2017-05-12 | 2018-11-15 | Merck Sharp & Dohme Corp. | Composés dinucléotidiques cycliques en tant qu'agonistes sting |
| WO2019027858A1 (fr) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | Agonistes benzo[b]thiophène de sting pour le traitement du cancer |
| JP2020529421A (ja) | 2017-08-04 | 2020-10-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がんの処置のためのＰＤ−１アンタゴニストおよびベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニストの組み合わせ |
| JP7311514B2 (ja) * | 2017-08-30 | 2023-07-19 | ベイジン シュエンイー ファーマサイエンシズ カンパニー， リミテッド | インターフェロン遺伝子刺激因子調節薬としての環状ジヌクレオチド |
| JP7270608B2 (ja) | 2017-08-31 | 2023-05-10 | エフ－スター・セラピューティクス・インコーポレイテッド | 化合物、組成物、及び疾患の治療方法 |
| JP7208225B2 (ja) * | 2017-08-31 | 2023-01-18 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| WO2019046496A1 (fr) * | 2017-08-31 | 2019-03-07 | Bristol-Myers Squibb Company | Dinucléotides cycliques utilisés en tant qu'agents anticancéreux |
| JP7209697B2 (ja) * | 2017-08-31 | 2023-01-20 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| WO2019051489A1 (fr) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | Composés, compositions et méthodes de traitement de maladie |
| US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2019084060A1 (fr) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | Conjugués et leurs procédés d'utilisation pour l'administration sélective d'agents immunomodulateurs |
| EP3707151B1 (fr) | 2017-11-10 | 2022-01-05 | Takeda Pharmaceutical Company Limited | Composés modulateurs de sting, et procédés de fabrication et d'utilisation |
| JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する２’３’環状ジヌクレオチド |
| EP3727401A4 (fr) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | Composés dinucléotidiques cycliques utilisés comme agonistes sting |
| EP3728283B1 (fr) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting |
| CN110016025B (zh) * | 2018-01-08 | 2021-08-06 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| TWI741268B (zh) * | 2018-03-15 | 2021-10-01 | 美商輝瑞股份有限公司 | 干擾素基因刺激劑（ｓｔｉｎｇ）的環戊烷為主體之調節劑 |
| CN110272462B (zh) * | 2018-03-15 | 2023-03-10 | 南开大学 | 制备化合物的方法 |
| US20210322327A1 (en) | 2018-03-23 | 2021-10-21 | Codiak Biosciences, Inc. | Extracellular vesicles comprising sting-agonist |
| WO2019180683A1 (fr) | 2018-03-23 | 2019-09-26 | Takeda Pharmaceutical Company Limited | Composés modulateurs de sting incorporant des liaisons de sulfamate, et procédés de fabrication et d'utilisation |
| WO2019185477A1 (fr) | 2018-03-27 | 2019-10-03 | Boehringer Ingelheim International Gmbh | Composés dinucléotidiques cycliques contenant 2-aza-hypoxanthine ou 6h-pytazolo[1,5-d][1,2,4]triazine-7-one en tant qu'agonistes de sting |
| US20210024567A1 (en) | 2018-03-27 | 2021-01-28 | Boehringer Ingelheim International Gmbh | Modified cyclic dinucleotide compounds |
| MX2020010407A (es) | 2018-04-03 | 2020-10-22 | Merck Sharp & Dohme | Benzotiofenos y compuestos relacionados como agonistas de sting. |
| US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| MA52754A (fr) | 2018-05-25 | 2021-04-14 | Incyte Corp | Composés hétérocycliques tricycliques en tant qu'activateurs de sting |
| SG11202011434SA (en) * | 2018-06-01 | 2020-12-30 | Eisai R&D Man Co Ltd | Methods for the treatment of bladder cancer |
| WO2020010451A1 (fr) * | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Amides imidazolyle hétéroaromatiques fusionnés, compositions et utilisations de ceux-ci en tant qu'agonistes de sting |
| WO2020028566A1 (fr) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Composés amides hétéroaryles en tant qu'activateurs de sting |
| US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
| WO2020036199A1 (fr) | 2018-08-16 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Sels de composés et cristaux de ceux-ci |
| MA53438A (fr) | 2018-08-24 | 2021-09-15 | Codiak Biosciences Inc | Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées |
| AU2019339344A1 (en) | 2018-09-12 | 2021-03-18 | Silverback Therapeutics, Inc. | Compositions for the treatment of disease with immune stimulatory conjugates |
| CN110938104B (zh) | 2018-09-21 | 2024-07-12 | 上海迪诺医药科技有限公司 | 环状二核苷酸类似物、其药物组合物及应用 |
| US20220008346A1 (en) | 2018-10-30 | 2022-01-13 | Vanderbilt University | Graft copolymers, methods of forming graft copolymers, and methods of use thereof |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| AU2020232761A1 (en) * | 2019-03-05 | 2021-10-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US20220168415A1 (en) | 2019-03-21 | 2022-06-02 | Codiak Biosciences, Inc. | Extracellular vesicles for vaccine delivery |
| WO2020205323A1 (fr) * | 2019-03-29 | 2020-10-08 | Merck Sharp & Dohme Corp. | Formulations stables de composés agonistes de sting à base de dinucléotides cycliques et leurs méthodes d'utilisation |
| WO2020205688A1 (fr) | 2019-04-04 | 2020-10-08 | Merck Sharp & Dohme Corp. | Inhibiteurs d'histone désacétylase -3 utiles pour le traitement du cancer, de l'inflammation, de maladies neurodégénératives et du diabète |
| EP3966222A4 (fr) | 2019-05-09 | 2023-10-04 | Aligos Therapeutics, Inc. | Composés di-nucléosidiques cycliques modifiés servant de modulateurs sting |
| US20220409734A1 (en) | 2019-05-10 | 2022-12-29 | Yutaka Nishimoto | Antibody drug conjugates |
| US20220251200A1 (en) | 2019-07-03 | 2022-08-11 | Codiak Biosciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| JP2022538690A (ja) | 2019-07-05 | 2022-09-05 | タンボ・インコーポレイテッド | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
| BR112022001931A2 (pt) | 2019-08-02 | 2022-06-21 | Mersana Therapeutics Inc | Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer |
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| AU2016212085A1 (en) | 2017-07-20 |
| MX2017009837A (es) | 2018-02-09 |
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