MA40882A - Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf - Google Patents

Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Info

Publication number
MA40882A
MA40882A MA040882A MA40882A MA40882A MA 40882 A MA40882 A MA 40882A MA 040882 A MA040882 A MA 040882A MA 40882 A MA40882 A MA 40882A MA 40882 A MA40882 A MA 40882A
Authority
MA
Morocco
Prior art keywords
binding molecules
trimer
antigen binding
tnf family
molecules including
Prior art date
Application number
MA040882A
Other languages
English (en)
Other versions
MA40882B1 (fr
Inventor
Maria Amann
Peter Bruenker
Christina Claus
Koller Claudia Ferrara
Sandra Grau-Richards
Christian Klein
Viktor Levitsky
Ekkehard Moessner
Joerg Thomas Regula
Pablo Umaña
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54695680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40882(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA40882A publication Critical patent/MA40882A/fr
Publication of MA40882B1 publication Critical patent/MA40882B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouvelles molécules de liaison à l'antigène comprenant un ligand trimérique de la famille du tnf comprenant (a) au moins une partie capable de se lier de manière spécifique à un antigène d'une cellule cible et (b) un premier et un second polypeptides liés l'un à l'autre par un pont disulfure, et caractérisés par le fait que le premier polypeptide comprend deux ectodomaines d'un membre de la famille des ligands du tnf ou des fragments de ce dernier, liés l'un à l'autre par un peptide lieur, et que le second polypeptide comprend un seul ectodomaine dudit membre de la famille des ligands du tnf ou un fragment de ce dernier.
MA40882A 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf MA40882B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14193260 2014-11-14
EP15183736 2015-09-03
EP15188142 2015-10-02
PCT/EP2015/076528 WO2016075278A1 (fr) 2014-11-14 2015-11-13 Molécules de liaison à l'antigène comprenant un ligand trimèrique de la famille du tnf

Publications (2)

Publication Number Publication Date
MA40882A true MA40882A (fr) 2017-10-04
MA40882B1 MA40882B1 (fr) 2020-05-29

Family

ID=54695680

Family Applications (2)

Application Number Title Priority Date Filing Date
MA40882A MA40882B1 (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
MA053242A MA53242A (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA053242A MA53242A (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Country Status (32)

Country Link
US (5) US10392445B2 (fr)
EP (3) EP3224275B1 (fr)
JP (2) JP6873901B2 (fr)
KR (2) KR20230146133A (fr)
CN (3) CN113372434B (fr)
AU (3) AU2015345024B2 (fr)
CA (1) CA2963718A1 (fr)
CL (2) CL2017001000A1 (fr)
CO (1) CO2017003212A2 (fr)
CR (1) CR20170194A (fr)
DK (2) DK3489256T3 (fr)
EA (1) EA037557B1 (fr)
ES (2) ES2871045T3 (fr)
HK (1) HK1255482A1 (fr)
HR (2) HRP20200679T1 (fr)
HU (2) HUE054122T2 (fr)
IL (2) IL282922B (fr)
LT (2) LT3224275T (fr)
MA (2) MA40882B1 (fr)
MX (2) MX2017006250A (fr)
MY (1) MY191428A (fr)
NZ (1) NZ767674A (fr)
PE (2) PE20170896A1 (fr)
PH (1) PH12017500892A1 (fr)
PL (2) PL3489256T3 (fr)
PT (1) PT3224275T (fr)
RS (2) RS60201B1 (fr)
SG (1) SG11201703597TA (fr)
SI (2) SI3489256T1 (fr)
TW (2) TWI713474B (fr)
UA (1) UA125577C2 (fr)
WO (1) WO2016075278A1 (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062960A2 (fr) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire
EP3708584A1 (fr) 2013-02-26 2020-09-16 Roche Glycart AG Molécules bispécifiques de liaison à l'antigène activant des lymphocytes t
KR20210157418A (ko) 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
WO2015010108A1 (fr) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature de la voie de signalisation de tl1a (tnfsf15)
IL282922B (en) 2014-11-14 2022-08-01 Hoffmann La Roche Antigen binding molecules containing a trimer of a tnf family ligand
MA41460A (fr) 2015-02-03 2017-12-12 Oncomed Pharm Inc Agents de liaison à la tnfrsf et leurs utilisations
EP3277305B1 (fr) 2015-03-31 2021-07-21 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
AR106188A1 (es) * 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
AU2016330807B2 (en) * 2015-10-02 2023-08-10 F. Hoffmann-La Roche Ag Anti-human CD19 antibodies with high affinity
JP7044700B2 (ja) * 2015-10-02 2022-03-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ｃｅａｘｃｄ３ ｔ細胞活性化抗原結合分子
CN108026177B (zh) * 2015-10-02 2021-11-26 豪夫迈·罗氏有限公司 双特异性抗cd19xcd3 t细胞活化性抗原结合分子
CN108137699B (zh) 2015-10-02 2022-05-27 豪夫迈·罗氏有限公司 对pd1和tim3特异性的双特异性抗体
CA2992863A1 (fr) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anticorps bispecifiques specifiques d'un recepteur de co-stimulation du tnf
EP3374399A1 (fr) 2015-11-11 2018-09-19 Opi Vi- IP Holdco LLC Composition et méthodes pour anticorps anti-tnfr2
KR20180097615A (ko) 2016-01-08 2018-08-31 에프. 호프만-라 로슈 아게 Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
KR102464372B1 (ko) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법
CN109071652B (zh) * 2016-05-11 2022-09-23 豪夫迈·罗氏有限公司 包含tnf家族配体三聚体和生腱蛋白结合模块的抗原结合分子
EP3243836A1 (fr) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison à un antigène contenant un trimère d'un ligand de la famille du tnf fusionné en terminaison c
EP3243832A1 (fr) * 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf et un fragment de liaison pd1
WO2018073365A1 (fr) 2016-10-19 2018-04-26 F. Hoffmann-La Roche Ag Procédé de production d'un immunoconjugué
SG11201903737PA (en) 2016-10-26 2019-05-30 Cedars Sinai Medical Center Neutralizing anti-tl1a monoclonal antibodies
JP7125400B2 (ja) * 2016-12-19 2022-08-24 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 標的化４－１ｂｂ（ｃｄ１３７）アゴニストとの併用療法
JP7247091B2 (ja) 2016-12-20 2023-03-28 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 抗ｃｄ２０／抗ｃｄ３二重特異性抗体と４－１ｂｂ（ｃｄ１３７）アゴニストの併用療法
BR112019013189A2 (pt) 2017-01-03 2019-12-10 Hoffmann La Roche moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa
WO2018127916A1 (fr) 2017-01-05 2018-07-12 Kahr Medical Ltd. Protéine de fusion pd1-cd70 et ses procédés d'utilisation
DK3565579T3 (da) 2017-01-05 2023-09-04 Kahr Medical Ltd Pd1-41bbl-fusionsprotein og fremgangsmåder til anvendelse deraf
RU2769769C2 (ru) 2017-01-05 2022-04-05 Кахр Медикал Лтд. СЛИТЫЙ БЕЛОК SIRPα-4-1BBL И СПОСОБЫ ЕГО ПРИМЕНЕНИЯ
US20200291089A1 (en) * 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
EP3601346A1 (fr) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
WO2018178055A1 (fr) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
LT3606946T (lt) 2017-04-03 2022-10-25 F. Hoffmann-La Roche Ag Anti-pd-1 antikūno imunokonjugatai su mutantiniu il-2 arba su il-15
MX2019011910A (es) 2017-04-05 2020-01-09 Hoffmann La Roche Anticuerpos biespecificos de union especifica a pd1 y lag3.
WO2018200422A1 (fr) * 2017-04-24 2018-11-01 Alexion Pharmaceuticals, Inc. Protéines de fusion d'inhibiteur de cellules immunitaires d'anticorps
EP3703746A1 (fr) * 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du tnf
EP3502140A1 (fr) * 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t
AU2019203917B2 (en) * 2018-01-15 2020-04-02 I-Mab Biopharma Us Limited Modified CK and CH1 domains
TWI841551B (zh) * 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
MX2020009468A (es) * 2018-03-13 2020-10-22 Hoffmann La Roche Terapias de combinacion de agonistas de 4-1bb con anticuerpos anti-cd20.
AR114284A1 (es) * 2018-04-13 2020-08-12 Hoffmann La Roche Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl
CN112585165A (zh) 2018-04-25 2021-03-30 普罗米修斯生物科学公司 优化的抗tl1a抗体
JP2021528988A (ja) 2018-07-04 2021-10-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 新規の二重特異性アゴニスト４−１ｂｂ抗原結合分子
MX2021000263A (es) * 2018-07-11 2021-05-12 Kahr Medical Ltd Proteina de fusion variante sirpalfa-4-1bbl y procedimientos de uso de la misma.
MX2021000047A (es) * 2018-07-11 2021-05-12 Kahr Medical Ltd Proteina de fusion variante pd1-4-1bbl y procedimientos de uso de la misma.
CN112955468B (zh) 2018-10-01 2024-08-09 豪夫迈·罗氏有限公司 包含抗fap克隆212的双特异性抗原结合分子
TWI839395B (zh) * 2018-10-09 2024-04-21 瑞士商Ｎｕｍａｂ治療公司 靶向cd137的抗體及其使用方法
UA128001C2 (uk) 2018-12-21 2024-03-06 Ф. Хоффманн-Ля Рош Аг Націлені на пухлину агоністичні cd28-антигензв'язувальні молекули
AR119080A1 (es) 2019-06-04 2021-11-24 Molecular Partners Ag Proteínas multiespecíficas
CN114450308A (zh) * 2019-06-12 2022-05-06 黑曜石疗法公司 用于调节性调控的ca2组合物和方法
MX2021015888A (es) 2019-06-26 2022-03-22 Hoffmann La Roche Fusión de un anticuerpo que se une a cea y 4-1bbl.
CN117821393A (zh) 2019-06-26 2024-04-05 豪夫迈·罗氏有限公司 具有sirt-1基因敲除的哺乳动物细胞系
AR119382A1 (es) 2019-07-12 2021-12-15 Hoffmann La Roche Anticuerpos de pre-direccionamiento y métodos de uso
MX2022004942A (es) 2019-10-24 2022-07-27 Prometheus Biosciences Inc Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos.
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN113512116B (zh) * 2020-04-10 2022-09-20 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
CN113234139A (zh) * 2020-04-17 2021-08-10 百奥赛图江苏基因生物技术有限公司 Tnfsf9基因人源化的非人动物及其构建方法和应用
CN115836084A (zh) 2020-05-15 2023-03-21 阿珀吉尼科斯股份公司 多特异性免疫调节剂
MX2022016069A (es) 2020-06-19 2023-02-02 Hoffmann La Roche Anticuerpos que se unen a cd3 y cd19.
AU2021303508A1 (en) 2020-07-10 2023-02-02 F. Hoffmann-La Roche Ag Antibodies which bind to cancer cells and target radionuclides to said cells
AU2021311034A1 (en) * 2020-07-24 2023-02-23 F. Hoffmann-La Roche Ag Method for the expression of an antibody-multimer-fusion
EP4277705A1 (fr) 2021-01-12 2023-11-22 F. Hoffmann-La Roche AG Anticorps fragmentés se liant à des cellules cancéreuses et ciblant ces cellules avec des radionucléides
KR20230131205A (ko) 2021-01-13 2023-09-12 에프. 호프만-라 로슈 아게 병용 요법
EP4304723A1 (fr) 2021-03-09 2024-01-17 F. Hoffmann-La Roche AG Polythérapie d'immunoconjugués variants d'il-2 ciblant pd-1 et de molécules de liaison fap/4-1bb
WO2022243261A1 (fr) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène cd40 agonistes ciblant cea
EP4148067A1 (fr) * 2021-09-08 2023-03-15 F. Hoffmann-La Roche AG Procédé d'expression d'une fusion anticorps-multimère
TW202325742A (zh) 2021-11-01 2023-07-01 瑞士商赫孚孟拉羅股份公司 使用 HLA-A2/WT1 x CD3 雙特異性抗體及 4-1BB (CD137) 促效劑治療癌症
WO2023088889A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Ligand cd137
WO2023088876A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Modulateurs immunitaires multi-spécifiques
WO2023110788A1 (fr) 2021-12-14 2023-06-22 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps bispécifique hla-a2/mage-a4 x cd3 et d'un agoniste de 4-1bb (cd137)
CN114426585B (zh) * 2022-02-15 2023-10-03 广东香雪干细胞再生医学科技有限公司 融合蛋白及其表达细胞株与应用
CN116640226B (zh) * 2022-04-02 2024-04-26 广东东阳光药业股份有限公司 一种抑制宿主抗外源免疫细胞hvg反应的嵌合受体
CN114805564B (zh) * 2022-06-10 2023-06-06 郑州大学 特异性识别SARS-CoV-2 S蛋白NTD区域的单克隆抗体及应用
WO2024056862A1 (fr) 2022-09-15 2024-03-21 Avidicure Ip B.V. Protéines multispécifiques de liaison à l'antigène pour le ciblage tumoral de cellules nk et leur utilisation
WO2024094741A1 (fr) 2022-11-03 2024-05-10 F. Hoffmann-La Roche Ag Polythérapie avec un anticorps bispécifique anti-cd19/anti-cd28
WO2024184287A1 (fr) 2023-03-06 2024-09-12 F. Hoffmann-La Roche Ag Polythérapie à base d'un anticorps anti-egfrviii/anti-cd3 et d'un agoniste de 4-1bb ciblant une tumeur
WO2024188966A1 (fr) 2023-03-13 2024-09-19 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps bispécifique anti-hla-g/anti-cd3 et d'un agoniste de 4-1bb (cd137)

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156905B (it) 1977-04-18 1987-02-04 Hitachi Metals Ltd Articolo di ornamento atto ad essere fissato mediante un magnete permanente
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE68913658T3 (de) 1988-11-11 2005-07-21 Stratagene, La Jolla Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
CA2372813A1 (fr) 1992-02-06 1993-08-19 L.L. Houston Proteine fixatrice biosynthetique pour marqueur du cancer
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AU757627B2 (en) 1997-06-24 2003-02-27 Genentech Inc. Methods and compositions for galactosylated glycoproteins
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
JP2001521909A (ja) 1997-10-31 2001-11-13 ジェネンテク・インコーポレイテッド 糖タンパク質グリコフォームを含む方法及び組成物
BR9813365A (pt) 1997-12-05 2004-06-15 Scripps Research Inst Método para produção e humanização de um anticorpo monoclonal de rato
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
DE60022369T2 (de) 1999-10-04 2006-05-18 Medicago Inc., Sainte Foy Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
LT2857516T (lt) * 2000-04-11 2017-09-11 Genentech, Inc. Multivalentiniai antikūnai ir jų panaudojimas
WO2002020565A2 (fr) 2000-09-08 2002-03-14 Universität Zürich Groupes de proteines a domaines de repetition comprenant des modules de repetition
NZ592087A (en) 2001-08-03 2012-11-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
AU2002337935B2 (en) 2001-10-25 2008-05-01 Genentech, Inc. Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US7432063B2 (en) 2002-02-14 2008-10-07 Kalobios Pharmaceuticals, Inc. Methods for affinity maturation
AU2003277828B2 (en) 2002-10-29 2009-06-04 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
KR20050108349A (ko) * 2003-02-06 2005-11-16 마이크로메트 에이지 영속적인 티 세포 반응을 유도하는 삼량체 폴리펩티드 구조물
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
WO2005003156A1 (fr) 2003-07-04 2005-01-13 Affibody Ab Polypeptides presentant une affinite de liaison pour le recepteur 2 du facteur de croissance epidermique humain (her2)
AU2003275958A1 (en) 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of tear lipocalin
ME03330B (fr) 2003-11-05 2019-10-20 Roche Glycart Ag Anticorps anti-CD20 avec une augmentation de l'affinité au récepteur à Fc et de la fonction effectrice
CN1946417A (zh) 2003-12-05 2007-04-11 阿德内克休斯治疗公司 2型血管内皮生长因子受体的抑制剂
ZA200608130B (en) 2004-03-31 2008-12-31 Genentech Inc Humanized anti-TGF-beta antibodies
CA2885854C (fr) 2004-04-13 2017-02-21 F. Hoffmann-La Roche Ag Anticorps anti-p-selectine
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
US7521541B2 (en) 2004-09-23 2009-04-21 Genetech Inc. Cysteine engineered antibodies and conjugates
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
AU2011265482B2 (en) * 2005-05-06 2013-08-29 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
AU2013263717B2 (en) 2005-05-06 2016-05-19 Providence Health & Services - Oregon Trimeric OX40L-immunoglobulin fusion protein and methods of use
EP1736482A1 (fr) 2005-06-20 2006-12-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Ligand recombinant trimeric de 4-1BB
DE102005036542A1 (de) 2005-08-03 2007-02-08 Universität Stuttgart CTL-Prodrug
ME01786B (me) 2006-08-14 2014-09-20 Xencor Inc Optimizovana antitela usmerena na cd19
EP1958957A1 (fr) 2007-02-16 2008-08-20 NascaCell Technologies AG Polypeptide comprenant un partie caractéristique des protéines appellées "Knottins"
EP2009022A1 (fr) 2007-06-26 2008-12-31 Apogenix GmbH Ligands trimériques avec activité améliorée (tenascine)
GB0718843D0 (en) 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
PL2235064T3 (pl) 2008-01-07 2016-06-30 Amgen Inc Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
DK2604693T3 (en) * 2008-07-21 2016-05-30 Apogenix Gmbh Single-chain TNFSF molecules
US20110318380A1 (en) * 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
RU2583876C2 (ru) 2009-08-17 2016-05-10 Роше Гликарт Аг Иммуноконъюгаты направленного действия
CN102574921B (zh) 2009-09-29 2016-05-04 罗切格利卡特公司 双特异性死亡受体激动型抗体
ES2638521T5 (es) 2010-03-05 2021-03-02 Univ Johns Hopkins Composiciones y métodos para anticuerpos y proteínas de fusión inmunomoduladores dirigidos contra dianas
WO2011147834A1 (fr) 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
US8552024B2 (en) 2010-08-13 2013-10-08 Hoffman-La Roche Inc. Azacyclic compounds
MX358859B (es) 2010-08-13 2018-09-05 Roche Glycart Ag Anticuerpos anti-fap y métodos de utilización.
AU2012215573B2 (en) 2011-02-10 2015-11-26 Roche Glycart Ag Mutant interleukin-2 polypeptides
JP5926791B2 (ja) 2011-03-29 2016-05-25 ロシュ グリクアート アーゲー 抗体Ｆｃ変種
CA2831820C (fr) 2011-04-01 2021-05-25 Universitat Stuttgart Polypeptides recombines membres de la famille des ligands tnf ayant un domaine de liaison a l'anticorps et leurs utilisations
NZ729633A (en) 2012-04-30 2019-03-29 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
CA2876285A1 (fr) 2012-08-08 2014-02-13 Roche Glycart Ag Proteines de fusion de l'interleukine-10 et leurs utilisations
EP2948475A2 (fr) * 2013-01-23 2015-12-02 AbbVie Inc. Procédés et compositions pour la modulation du systéme immunitaire
EP3708584A1 (fr) * 2013-02-26 2020-09-16 Roche Glycart AG Molécules bispécifiques de liaison à l'antigène activant des lymphocytes t
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
CA2907597A1 (fr) 2013-05-07 2014-11-13 F. Hoffmann-La Roche Ag Molecules trimeriques de liaison a l'antigene
CN106061997A (zh) 2014-02-06 2016-10-26 豪夫迈·罗氏有限公司 白介素‑10免疫缀合物
UA117289C2 (uk) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
GB2532817A (en) 2014-05-29 2016-06-01 Medimmune Llc OX40L fusion proteins and uses thereof
TWI707872B (zh) 2014-05-29 2020-10-21 美商宏觀基因股份有限公司 特異性結合多種癌症抗原的三特異性結合分子和其使用方法
IL282922B (en) 2014-11-14 2022-08-01 Hoffmann La Roche Antigen binding molecules containing a trimer of a tnf family ligand
EP3277305B1 (fr) 2015-03-31 2021-07-21 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
AU2016330807B2 (en) 2015-10-02 2023-08-10 F. Hoffmann-La Roche Ag Anti-human CD19 antibodies with high affinity
CN108290958B (zh) 2015-10-02 2021-12-28 豪夫迈·罗氏有限公司 多特异性抗体
CN108026177B (zh) 2015-10-02 2021-11-26 豪夫迈·罗氏有限公司 双特异性抗cd19xcd3 t细胞活化性抗原结合分子
CA2992863A1 (fr) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anticorps bispecifiques specifiques d'un recepteur de co-stimulation du tnf
MY193013A (en) 2015-10-07 2022-09-22 Hoffmann La Roche Bispecific antibodies with tetravalency for a costimulatory tnf receptor
EP3231813A1 (fr) 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Molécules de liaison d'antigène costimulantes trimères contenant un ligand de la famille du tnf
EP3243836A1 (fr) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison à un antigène contenant un trimère d'un ligand de la famille du tnf fusionné en terminaison c
CN109791067B (zh) 2016-07-08 2021-09-07 豪夫迈·罗氏有限公司 用于处理实验室样品的装置、实验室自动化系统和用于对实验室样品进行移液的方法
JP7125400B2 (ja) 2016-12-19 2022-08-24 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 標的化４－１ｂｂ（ｃｄ１３７）アゴニストとの併用療法
JP7247091B2 (ja) 2016-12-20 2023-03-28 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 抗ｃｄ２０／抗ｃｄ３二重特異性抗体と４－１ｂｂ（ｃｄ１３７）アゴニストの併用療法
BR112019013189A2 (pt) 2017-01-03 2019-12-10 Hoffmann La Roche moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa
KR20200079492A (ko) 2017-11-01 2020-07-03 에프. 호프만-라 로슈 아게 이중특이성 2+1 컨터체
EP3703746A1 (fr) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du tnf
TWI841551B (zh) 2018-03-13 2024-05-11 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
MX2020009468A (es) 2018-03-13 2020-10-22 Hoffmann La Roche Terapias de combinacion de agonistas de 4-1bb con anticuerpos anti-cd20.
JP2021528988A (ja) 2018-07-04 2021-10-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 新規の二重特異性アゴニスト４−１ｂｂ抗原結合分子
WO2020208049A1 (fr) 2019-04-12 2020-10-15 F. Hoffmann-La Roche Ag Molécules bispécifiques de liaison à un antigène comprenant des mutéines de lipocalines

Also Published As

Publication number Publication date
HRP20210739T1 (hr) 2021-06-25
LT3224275T (lt) 2020-05-25
IL282922B (en) 2022-08-01
PE20170896A1 (es) 2017-07-12
NZ730933A (en) 2024-02-23
US20220259327A1 (en) 2022-08-18
SI3489256T1 (sl) 2021-08-31
IL251317B (en) 2021-05-31
KR102588377B1 (ko) 2023-10-12
ES2788979T3 (es) 2020-10-23
JP7184938B2 (ja) 2022-12-06
PL3489256T3 (pl) 2021-08-23
AU2015345024A1 (en) 2017-04-20
MX2020012798A (es) 2022-04-07
WO2016075278A1 (fr) 2016-05-19
AU2015345024B2 (en) 2020-10-15
AU2022201144A1 (en) 2022-03-17
EP3738609A1 (fr) 2020-11-18
US20160200833A1 (en) 2016-07-14
JP2021097674A (ja) 2021-07-01
AU2020264337B2 (en) 2021-12-02
BR112017009006A2 (pt) 2018-04-10
SG11201703597TA (en) 2017-06-29
PL3224275T3 (pl) 2020-09-07
CN113372434A (zh) 2021-09-10
PH12017500892A1 (en) 2017-11-06
PT3224275T (pt) 2020-05-04
HRP20200679T1 (hr) 2020-07-24
DK3224275T3 (da) 2020-05-04
AU2020264337A1 (en) 2021-01-28
CN108064237A (zh) 2018-05-22
TW201629094A (zh) 2016-08-16
US20190382507A1 (en) 2019-12-19
US20220259326A1 (en) 2022-08-18
ES2871045T3 (es) 2021-10-28
US10392445B2 (en) 2019-08-27
US11306154B2 (en) 2022-04-19
RS60201B1 (sr) 2020-06-30
CN113372434B (zh) 2024-06-04
RS61870B1 (sr) 2021-06-30
HUE049982T2 (hu) 2020-11-30
MA40882B1 (fr) 2020-05-29
US11267903B2 (en) 2022-03-08
CN108064237B (zh) 2022-02-11
CN114634570A (zh) 2022-06-17
IL282922A (en) 2021-06-30
UA125577C2 (uk) 2022-04-27
MA53242A (fr) 2021-06-23
LT3489256T (lt) 2021-06-10
CL2017001000A1 (es) 2018-01-12
JP6873901B2 (ja) 2021-05-19
PE20221909A1 (es) 2022-12-23
EP3489256A1 (fr) 2019-05-29
CO2017003212A2 (es) 2017-09-20
MY191428A (en) 2022-06-27
SI3224275T1 (sl) 2020-07-31
TWI757803B (zh) 2022-03-11
CL2019003728A1 (es) 2020-07-17
KR20230146133A (ko) 2023-10-18
HK1255482A1 (zh) 2019-08-16
CR20170194A (es) 2017-07-10
JP2018503356A (ja) 2018-02-08
HUE054122T2 (hu) 2021-08-30
EP3489256B1 (fr) 2021-03-17
NZ767674A (en) 2024-07-05
NZ767672A (en) 2024-02-23
EA201791057A1 (ru) 2017-10-31
IL251317A0 (en) 2017-05-29
EP3224275B1 (fr) 2020-03-04
MX2017006250A (es) 2017-11-17
KR20170085552A (ko) 2017-07-24
EP3224275A1 (fr) 2017-10-04
DK3489256T3 (da) 2021-05-25
US20200247904A1 (en) 2020-08-06
TW202041527A (zh) 2020-11-16
EA037557B1 (ru) 2021-04-14
TWI713474B (zh) 2020-12-21
CA2963718A1 (fr) 2016-05-19

Similar Documents

Publication Publication Date Title
MA40882A (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
PH12018502367A1 (en) Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
MY195993A (en) Antibodies and Antibody Fragments for Site-Specific Conjugation
MA40801A1 (fr) Anticorps anti-cd3, anticorps anti-cd123 et anticorps bispécifiques se liant spécifiquement à cd3 et/ou cd123
BR112019007920A2 (pt) moléculas multiméricas à base de il-15
PH12019500609A1 (en) Cd123 binding proteins and related compositions and methods
EA201891066A1 (ru) Антитела к ror1
PE20211272A1 (es) POLIPEPTIDOS DE IL-22 Y PROTEINAS DE FUSION DE IL-22 Fc Y METODOS DE USO
WO2016094873A3 (fr) Protéine de liaison au récepteur orphelin de type récepteur à tyrosine kinase et compositions et procédés associés
MX356433B (es) Polipéptidos de fusión con domino de proteína ácida del suero, y métodos de uso de los mismos.
EA201790438A1 (ru) Антигенсвязывающие белки, которые связываются с cxcr5
MX2020003503A (es) Proteinas de union al antigeno del receptor de oncostatina m.
BRPI0908496A2 (pt) inibição de angiogênese
MA38797A1 (fr) Protéine de fusion thérapeutique
PE20170768A1 (es) Anticuerpos de union a protofibrillas ab mejorados
CY1120803T1 (el) Πρωτεϊνες δεσμευσης με αντιγονο ειδικες για το συστατικο ρ αμυλοειδους ορου
MX2021012047A (es) Polipeptidos de fusion de serpina y metodos para utilizar los mismos.
DE602006020333D1 (de) Multimere fc-rezeptor-polypeptide
MX2018005831A (es) Gradientes de ph-sal opuestos para separaciones de proteina mejoradas.
MA47671B1 (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
WO2017089781A3 (fr) Peptides
MX2021004684A (es) Anticuerpos especificos para apoj glucosilada y usos de los mismos.
MA38497A1 (fr) Polypeptides d'il-22 et protéines de fusion fc il-22 et leurs procédés d'utilisation
EA202090582A3 (ru) Полипептиды il-22, химерные белки il-22 fc и их применение