MA38194A1 - Anticorps anti-ceacam5 et leurs utilisations - Google Patents

Anticorps anti-ceacam5 et leurs utilisations

Info

Publication number
MA38194A1
MA38194A1 MA38194A MA38194A MA38194A1 MA 38194 A1 MA38194 A1 MA 38194A1 MA 38194 A MA38194 A MA 38194A MA 38194 A MA38194 A MA 38194A MA 38194 A1 MA38194 A1 MA 38194A1
Authority
MA
Morocco
Prior art keywords
antibodies
immunoconjugates
ceacam5 antibodies
conjugated
vectors
Prior art date
Application number
MA38194A
Other languages
English (en)
Other versions
MA38194B1 (fr
Inventor
Pierre-Francois Berne
Francis Blanche
Hervé Bouchard
Béatrice Cameron
Tarik Dabdoubi
Stéphanie Decary
Paul Ferrari
Alexey Rak
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA38194A1 publication Critical patent/MA38194A1/fr
Publication of MA38194B1 publication Critical patent/MA38194B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6853—Carcino-embryonic antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des anticorps qui se lient à des protéines ceacam5 humaines et de macaca fascicularis ainsi que des acides nucléiques isolés, des vecteurs et des cellules hôtes comprenant une séquence codant pour les anticorps. L'invention concerne également des immunoconjugués comprenant les anticorps conjugués ou liés à un agent d'inhibition de croissance, et des compositions pharmaceutiques comprenant des anticorps ou des immunoconjugués. Les anticorps ou les immunoconjugués de l'invention sont utilisés pour traiter le cancer ou à des fins de diagnostic.
MA38194A 2012-11-20 2013-11-20 Anticorps anti-ceacam5 et leurs utilisations MA38194B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306444 2012-11-20
PCT/EP2013/074291 WO2014079886A1 (fr) 2012-11-20 2013-11-20 Anticorps anti-ceacam5 et leurs utilisations

Publications (2)

Publication Number Publication Date
MA38194A1 true MA38194A1 (fr) 2018-02-28
MA38194B1 MA38194B1 (fr) 2018-12-31

Family

ID=47257727

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38194A MA38194B1 (fr) 2012-11-20 2013-11-20 Anticorps anti-ceacam5 et leurs utilisations

Country Status (39)

Country Link
US (4) US9617345B2 (fr)
EP (3) EP3199552B1 (fr)
JP (1) JP6324399B2 (fr)
KR (4) KR20240063172A (fr)
CN (2) CN104918958B (fr)
AR (1) AR093557A1 (fr)
AU (2) AU2013349733C1 (fr)
BR (1) BR112015010993B1 (fr)
CA (2) CA3207769A1 (fr)
CL (1) CL2015001321A1 (fr)
CR (1) CR20150258A (fr)
CY (1) CY1119219T1 (fr)
DK (2) DK3199552T3 (fr)
DO (1) DOP2015000110A (fr)
EA (1) EA039377B1 (fr)
EC (1) ECSP15025845A (fr)
ES (2) ES2625742T3 (fr)
HK (1) HK1215444A1 (fr)
HR (2) HRP20170743T1 (fr)
HU (1) HUE033369T2 (fr)
IL (1) IL238559B (fr)
LT (2) LT2922875T (fr)
MA (1) MA38194B1 (fr)
MX (1) MX358321B (fr)
MY (1) MY171100A (fr)
NZ (1) NZ708528A (fr)
PE (1) PE20151180A1 (fr)
PH (1) PH12015501092B1 (fr)
PL (2) PL3199552T3 (fr)
PT (2) PT3199552T (fr)
RS (2) RS55987B1 (fr)
SG (1) SG11201503285TA (fr)
SI (2) SI3199552T1 (fr)
TN (1) TN2015000177A1 (fr)
TW (2) TW201940519A (fr)
UA (1) UA120247C2 (fr)
UY (1) UY35147A (fr)
WO (1) WO2014079886A1 (fr)
ZA (1) ZA201502959B (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3199552T3 (da) 2012-11-20 2020-03-30 Sanofi Sa Anti-ceacam5-antistoffer og anvendelser heraf
US9753036B2 (en) * 2014-04-29 2017-09-05 Edp Biotech Corporation Methods and compositions for screening and detecting biomarkers
MA42561A (fr) * 2014-09-02 2018-04-25 Immunogen Inc Procédés de formulation de compositions de conjugués anticorps-médicament
EP3356410B1 (fr) 2015-10-02 2021-10-20 F. Hoffmann-La Roche AG Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-ceaxcd3
AR107303A1 (es) 2016-01-08 2018-04-18 Hoffmann La Roche Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit
ES2968264T3 (es) * 2016-10-10 2024-05-08 Singapore Health Serv Pte Ltd Anticuerpos anti-CEACAM6 y métodos de utilización
MA46851A (fr) 2016-11-18 2019-09-25 Astellas Pharma Inc NOUVEAU FRAGMENT Fab D'ANTICORPS ANTI-MUC1 HUMAIN
CN106749667B (zh) * 2016-12-04 2020-07-14 深圳市国创纳米抗体技术有限公司 一种抗癌胚抗原的纳米抗体及其应用
CN108341876B (zh) * 2017-01-22 2021-06-04 中国人民解放军第四军医大学 抗人ceacam5单克隆抗体及其制备方法和应用
CN106946989B (zh) * 2017-03-02 2020-02-18 深圳市国创纳米抗体技术有限公司 抗cea抗原vhh结构域及含有其的双特异性抗体
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
SG11202000197PA (en) * 2017-07-11 2020-02-27 Pfizer Immunogenic compositions comprising cea muc1 and tert
EP3502140A1 (fr) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t
MX2020009469A (es) 2018-03-13 2021-01-29 Zymeworks Inc Conjugados de anticuerpo y farmaco anti-her2 biparatopicos y metodos de uso.
CN113226367A (zh) 2018-04-06 2021-08-06 Atyr 医药公司 包括抗nrp2抗体的组合物和方法
WO2019204827A2 (fr) * 2018-04-20 2019-10-24 The Regents Of The University Of California Traitement du cancer de la prostate au moyen de récepteurs antigéniques chimériques
KR20210029158A (ko) 2018-06-03 2021-03-15 람카프 바이오 베타 엘티디. Ceacam5 및 cd47에 대한 이중특이성 항체
CN110684107B (zh) * 2018-07-06 2021-03-23 中国人民解放军第四军医大学 抗MG7-Ag的单克隆抗体(MGd1)及其用途
CN110684108B (zh) * 2018-07-06 2021-06-04 中国人民解放军第四军医大学 抗MG7-Ag的单克隆抗体(CEA37)及其用途
AU2019328290B2 (en) 2018-08-30 2024-10-10 Immunitybio, Inc. Multi-chain chimeric polypeptides and uses thereof
US11730762B2 (en) 2018-08-30 2023-08-22 HCW Biologics, Inc. Methods for stimulating proliferation or differentiation of an immune cell with a multi-chain chimeric polypeptide
AU2019328313A1 (en) 2018-08-30 2021-02-25 Immunitybio, Inc. Single-chain chimeric polypeptides and uses thereof
SG11202103670XA (en) 2018-10-10 2021-05-28 Astellas Pharma Inc Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
CN111487411B (zh) * 2019-01-29 2023-05-09 瑞博奥(广州)生物科技股份有限公司 Ceacam1多肽的新应用
EP3693023A1 (fr) 2019-02-11 2020-08-12 Sanofi Utilisation d'immuno-conjugués anti-ceacam5 pour le traitement du cancer du poumon
KR20210124260A (ko) * 2019-02-07 2021-10-14 사노피 폐암을 치료하기 위한 항-ceacam5 면역접합체의 용도
JP2022530050A (ja) * 2019-04-23 2022-06-27 サノフイ 安定な低粘度抗体製剤およびその使用
US20220235142A1 (en) * 2019-06-04 2022-07-28 Shanghai GenBase Biotechnology Co., Ltd. Anti-ceacam5 monoclonal antibody, preparation method thereof and use thereof
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
CA3142887A1 (fr) 2019-06-13 2020-12-17 Bolt Biotherapeutics, Inc. Composes d'aminobenzazepine, immunoconjugues et leurs utilisations
EP3987010A1 (fr) 2019-06-21 2022-04-27 HCW Biologics, Inc. Polypeptides chimériques à chaînes multiples et leurs utilisations
CN114531878A (zh) 2019-06-27 2022-05-24 豪夫迈·罗氏有限公司 新颖icos抗体及包含它们的肿瘤靶向抗原结合分子
EP4025254A1 (fr) 2019-09-03 2022-07-13 Bolt Biotherapeutics, Inc. Composés aminoquinoline, immunoconjugués et leurs utilisations
WO2021053587A1 (fr) 2019-09-18 2021-03-25 Klaus Strein Anticorps bispécifiques dirigés contre ceacam5 et cd3
AU2020359446A1 (en) 2019-09-30 2022-04-21 Bolt Biotherapeutics, Inc. Amide-linked, aminobenzazepine immunoconjugates, and uses thereof
JP2022553702A (ja) 2019-10-25 2022-12-26 ボルト バイオセラピューティクス、インコーポレーテッド チエノアゼピン、イムノコンジュゲート、及びそれらの使用
EP3831849A1 (fr) 2019-12-02 2021-06-09 LamKap Bio beta AG Anticorps bispécifiques contre ceacam5 et cd47
AU2021219720A1 (en) 2020-02-11 2022-08-04 Immunitybio, Inc. Chromatography resin and uses thereof
IL295083A (en) 2020-02-11 2022-09-01 Hcw Biologics Inc Methods for activating regulatory t cells
CA3169231A1 (fr) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methodes de traitement de maladies liees a l'age et inflammatoires
MX2022013405A (es) * 2020-04-24 2022-11-14 Sanofi Sa Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5 y folfox.
JP2023522392A (ja) * 2020-04-24 2023-05-30 サノフイ 抗ｃｅａｃａｍ５抗体コンジュゲートおよびフォルフィリを含有する抗腫瘍組み合わせ
MX2022013406A (es) 2020-04-24 2022-11-14 Sanofi Sa Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5 y cetuximab.
WO2021214222A1 (fr) 2020-04-24 2021-10-28 Sanofi Combinaisons antitumorales contenant des conjugués anticorps anti-ceacam5, de la trifluridine et du tipiracil
AU2021262794A1 (en) 2020-04-29 2022-11-24 Immunitybio, Inc. Anti-CD26 proteins and uses thereof
JP2023524271A (ja) 2020-05-08 2023-06-09 ボルト バイオセラピューティクス、インコーポレーテッド エラスターゼ－基質ペプチドリンカーイムノコンジュゲート、及びそれらの使用
WO2021247003A1 (fr) 2020-06-01 2021-12-09 HCW Biologics, Inc. Méthodes de traitement de troubles liés au vieillissement
WO2021247604A1 (fr) 2020-06-01 2021-12-09 HCW Biologics, Inc. Méthodes de traitement de troubles liés au vieillissement
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
CN111690061B (zh) * 2020-06-28 2022-08-23 中国人民解放军东部战区疾病预防控制中心 人源化抗鼠疫耶尔森菌抗原f1的抗体及应用
CN113105548B (zh) * 2020-08-04 2022-03-29 中山大学附属第五医院 抗ceacam5纳米抗体
MX2023001679A (es) 2020-08-13 2023-02-22 Bolt Biotherapeutics Inc Inmunoconjugados de pirazolazepina y usos de estos.
EP4100028A4 (fr) 2020-08-20 2023-07-26 A2 Biotherapeutics, Inc. Compositions et méthodes de traitement de cancers positifs à la mésothéline
AU2021329375A1 (en) 2020-08-20 2023-04-20 A2 Biotherapeutics, Inc. Compositions and methods for treating ceacam positive cancers
JP2023547707A (ja) * 2020-11-10 2023-11-13 サノフイ Ｃｅａｃａｍ５抗体－薬物コンジュゲート製剤
WO2022116079A1 (fr) * 2020-12-03 2022-06-09 上海吉倍生物技术有限公司 Anticorps anti-ceacam5 humanisé et son procédé de préparation et son utilisation
US20220195066A1 (en) 2020-12-11 2022-06-23 Bolt Biotherapeutics, Inc. Anti-cea immunoconjugates, and uses thereof
CA3200051A1 (fr) 2020-12-11 2022-06-16 Shelley Erin ACKERMAN Immunoconjugues anti-cea et leurs utilisations
CN112521509B (zh) * 2020-12-23 2022-07-08 姚雪英 一种抗ceacam5人源化抗体、其缀合物及其用途
EP4313161A1 (fr) 2021-03-26 2024-02-07 Bolt Biotherapeutics, Inc. Immunoconjugués de 2-amino-4-carboxamide-benzazépine et utilisations associées
EP4313162A1 (fr) 2021-03-26 2024-02-07 Bolt Biotherapeutics, Inc. Immunoconjugués de 2-amino-4-carboxamide-benzazépine et leurs utilisations
EP4341299A1 (fr) * 2021-05-21 2024-03-27 BeiGene Switzerland GmbH Anticorps anti-cea et méthodes d'utilisation
WO2023057564A1 (fr) 2021-10-07 2023-04-13 Sanofi Composés imidazo[4,5-c]quinoléine-4-amine et leurs conjugués, leur préparation et leurs applications thérapeutiques
IL312519A (en) 2021-11-05 2024-07-01 Lilly Co Eli Anticancer combinations containing antibody-drug conjugates anti-CEACAM5 and anti-VEGFR-2 antibodies
AU2022402334A1 (en) 2021-12-02 2024-07-18 Sanofi Ceacam5 adc–anti-pd1/pd-l1 combination therapy
IL313224A (en) 2021-12-02 2024-07-01 Sanofi Sa CEA test to select patients in cancer treatment
WO2023164610A2 (fr) * 2022-02-25 2023-08-31 Atyr Pharma, Inc. Compositions et méthodes comprenant des anticorps anti-nrp2b
WO2023168363A1 (fr) 2022-03-02 2023-09-07 HCW Biologics, Inc. Méthode de traitement du cancer du pancréas
WO2023170239A1 (fr) * 2022-03-09 2023-09-14 Merck Patent Gmbh Procédés et outils de conjugaison à des anticorps
AU2023237620A1 (en) 2022-03-23 2024-08-29 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen
WO2024035662A2 (fr) 2022-08-10 2024-02-15 Merck Sharp & Dohme Llc Protéines se liant à nkg2d, cd16 et ceacam5
WO2024140905A1 (fr) * 2022-12-28 2024-07-04 Full-Life Technologies Hk Limited Anticorps se liant spécifiquement au ceacam5
WO2024180192A1 (fr) 2023-03-01 2024-09-06 Sanofi Utilisation d'immunoconjugués anti-ceacam5 pour le traitement de cancers neuroendocriniens exprimant ceacam5
EP4427763A1 (fr) 2023-03-06 2024-09-11 Sanofi Combinaisons antitumorales contenant des conjugués anticorps anti-ceacam5-médicament, anticorps anti-vegfr-2 et anticorps anti-pd1/pd-l1

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US192A (en) 1837-05-15 Machine for cutting
US689A (en) 1838-04-13 Julius austin
US4791A (en) 1846-10-03 john g
US4640A (en) 1846-07-14 Book-lock
US5204A (en) 1847-07-24 james cantelo
US4670A (en) 1846-07-28 Improvement in fish-hooks
US244A (en) 1837-06-30 Edward flint
US144A (en) 1837-03-11 Improvement in scythe-snaths
US4301A (en) 1845-12-11 Ebenezbr barrows
US4496A (en) 1846-05-02 Machinery for
US835A (en) 1838-07-12 X i i i x
US417A (en) 1837-09-28 Endless-ghain horse-power for driving iviaci-iii
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (fr) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotique C-15003 PHO et sa préparation
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1981001145A1 (fr) 1979-10-18 1981-04-30 Univ Illinois Medicaments "pro-drugs" pouvant etre actives par des enzymes hydrolytiques
WO1982001188A1 (fr) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd Composes 4,5-deoxymaytansinoide et leur procede de preparation
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
EP0206448B1 (fr) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hémoglobine liée à un poly(oxyde d'alkylène)
AU606320B2 (en) 1985-11-01 1991-02-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
WO1987005330A1 (fr) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Procede pour ameliorer la stabilite des glycoproteines
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5278056A (en) 1988-02-05 1994-01-11 The Trustees Of Columbia University In The City Of New York Retroviral packaging cell lines and process of using same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
WO1992022653A1 (fr) 1991-06-14 1992-12-23 Genentech, Inc. Procede de production d'anticorps humanises
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5215534A (en) 1991-12-02 1993-06-01 Lawrence De Harde Safety syringe system
EP0563475B1 (fr) 1992-03-25 2000-05-31 Immunogen Inc Conjugués d'agents ciblés et de dérivés du CC-1065
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
DE69329503T2 (de) 1992-11-13 2001-05-03 Idec Pharma Corp Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma
DE69434860T2 (de) 1993-02-22 2007-03-15 The Rockefeller University Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion
FR2712812B1 (fr) 1993-11-23 1996-02-09 Centre Nat Rech Scient Composition pour la production de produits thérapeutiques in vivo.
KR100261941B1 (ko) 1994-07-13 2000-07-15 나가야마 오사무 사람의 인터루킨-8에 대한 재구성 사람항체
IL116816A (en) 1995-01-20 2003-05-29 Rhone Poulenc Rorer Sa Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
AU690474B2 (en) 1995-09-11 1998-04-23 Kyowa Hakko Kirin Co., Ltd. Antibody againts alpha-chain of human interleukin 5 receptor
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
WO1998045322A2 (fr) 1997-04-10 1998-10-15 Royal Netherlands Academy Of Arts And Sciences Reactifs pour diagnostics et procede correspondant
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AU2003259163B2 (en) 2002-08-16 2008-07-03 Immunogen, Inc. Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
US20050003403A1 (en) 2003-04-22 2005-01-06 Rossi Edmund A. Polyvalent protein complex
EP2527370A1 (fr) 2005-12-21 2012-11-28 Amgen Research (Munich) GmbH Composés ayant une résistance à CEA soluble
EP2044122B1 (fr) 2006-07-18 2018-03-28 Sanofi Anticorps antagoniste contre epha2 pour le traitement du cancer
ES2579323T3 (es) * 2007-07-16 2016-08-09 Genentech, Inc. Anticuerpos anti-CD79B e inmunoconjugados y métodos de uso
SG10201407388XA (en) 2007-08-29 2015-01-29 Sanofi Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
EP2050764A1 (fr) 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
US8236319B2 (en) 2008-04-30 2012-08-07 Immunogen, Inc. Cross-linkers and their uses
EP2478110B1 (fr) * 2009-09-16 2016-01-06 Immunomedics, Inc. Anticorps anti-cea de classe i et leurs utilisations
US9427531B2 (en) 2010-06-28 2016-08-30 Sanofi-Aventis Deutschland Gmbh Auto-injector
LT2681244T (lt) * 2011-03-02 2018-02-12 Roche Glycart Ag Cea antikūnai
US9248242B2 (en) 2012-04-20 2016-02-02 Safety Syringes, Inc. Anti-needle stick safety device for injection device
DK3199552T3 (da) 2012-11-20 2020-03-30 Sanofi Sa Anti-ceacam5-antistoffer og anvendelser heraf
US20140155827A1 (en) 2012-12-03 2014-06-05 Mylan, Inc. Medicament information system and method
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
CN104948958A (zh) * 2015-07-01 2015-09-30 上海顿格电子贸易有限公司 一种利用热敏电阻限流的led灯
CN108341876B (zh) * 2017-01-22 2021-06-04 中国人民解放军第四军医大学 抗人ceacam5单克隆抗体及其制备方法和应用
WO2020006486A1 (fr) * 2018-06-29 2020-01-02 Krystal Biotech, Inc. Compositions et procédés d'administration d'anticorps
KR20210124260A (ko) * 2019-02-07 2021-10-14 사노피 폐암을 치료하기 위한 항-ceacam5 면역접합체의 용도
JP2023547707A (ja) * 2020-11-10 2023-11-13 サノフイ Ｃｅａｃａｍ５抗体－薬物コンジュゲート製剤
WO2024108053A1 (fr) * 2022-11-17 2024-05-23 Sanofi Conjugués anticorps-médicaments de ceacam5 et leurs méthodes d'utilisation

Also Published As

Publication number Publication date
KR20240063172A (ko) 2024-05-09
LT2922875T (lt) 2017-06-12
PT3199552T (pt) 2020-03-25
ES2778823T3 (es) 2020-08-12
HUE033369T2 (en) 2017-11-28
CA3207769A1 (fr) 2014-05-30
KR20200143527A (ko) 2020-12-23
ZA201502959B (en) 2016-01-27
US20200102401A1 (en) 2020-04-02
AU2013349733B2 (en) 2018-08-23
EP2922875B1 (fr) 2017-03-15
KR20220084193A (ko) 2022-06-21
DK2922875T3 (en) 2017-06-06
TN2015000177A1 (en) 2016-10-03
JP6324399B2 (ja) 2018-05-16
US20160108131A1 (en) 2016-04-21
KR102194748B1 (ko) 2020-12-23
UY35147A (es) 2014-06-30
PE20151180A1 (es) 2015-08-12
CN104918958B (zh) 2019-12-10
US11332542B2 (en) 2022-05-17
UA120247C2 (uk) 2019-11-11
AU2013349733C1 (en) 2020-10-01
CA2889962A1 (fr) 2014-05-30
KR102408660B1 (ko) 2022-06-15
SI3199552T1 (sl) 2020-06-30
CA2889962C (fr) 2023-10-24
ES2625742T3 (es) 2017-07-20
CN104918958A (zh) 2015-09-16
PT2922875T (pt) 2017-05-31
PL2922875T3 (pl) 2017-08-31
EP3199552B1 (fr) 2019-12-25
BR112015010993B1 (pt) 2022-08-30
RS55987B1 (sr) 2017-09-29
AU2018267636A1 (en) 2018-12-13
EP2922875A1 (fr) 2015-09-30
IL238559A0 (en) 2015-06-30
DK3199552T3 (da) 2020-03-30
BR112015010993A2 (fr) 2017-08-22
JP2016506370A (ja) 2016-03-03
KR20150085828A (ko) 2015-07-24
RS60043B1 (sr) 2020-04-30
MX2015006374A (es) 2015-10-09
PH12015501092A1 (en) 2015-07-27
HRP20200415T1 (hr) 2020-06-26
AR093557A1 (es) 2015-06-10
CN109180815B (zh) 2022-06-21
PH12015501092B1 (en) 2015-07-27
KR102661801B1 (ko) 2024-04-26
IL238559B (en) 2018-10-31
CR20150258A (es) 2015-06-11
MA38194B1 (fr) 2018-12-31
CN109180815A (zh) 2019-01-11
HRP20170743T1 (hr) 2017-07-28
US9617345B2 (en) 2017-04-11
SI2922875T1 (sl) 2017-06-30
HK1215444A1 (zh) 2016-08-26
EA039377B1 (ru) 2022-01-20
WO2014079886A1 (fr) 2014-05-30
US20180022817A1 (en) 2018-01-25
TW201940519A (zh) 2019-10-16
EP3199552A1 (fr) 2017-08-02
US10457739B2 (en) 2019-10-29
EP3594243A1 (fr) 2020-01-15
DOP2015000110A (es) 2015-08-16
PL3199552T3 (pl) 2020-06-01
NZ708528A (en) 2020-07-31
AU2013349733A1 (en) 2015-06-11
SG11201503285TA (en) 2015-05-28
LT3199552T (lt) 2020-04-10
MY171100A (en) 2019-09-25
MX358321B (es) 2018-08-14
ECSP15025845A (es) 2016-01-29
TW201427997A (zh) 2014-07-16
US20220340682A1 (en) 2022-10-27
CL2015001321A1 (es) 2015-07-17
CY1119219T1 (el) 2018-02-14
EA201590986A1 (ru) 2016-05-31
TWI664192B (zh) 2019-07-01

Similar Documents

Publication Publication Date Title
MA38194B1 (fr) Anticorps anti-ceacam5 et leurs utilisations
MA45280B1 (fr) Conjugués anticorps-médicament à base d'éribuline et leurs procédés d'utilisation
MA45029B1 (fr) Anticorps anti pd-1 et anti-lag3 pour le traitement du cancer
MA44312A (fr) Anticorps et leurs méthodes d'utilisation
MA56289B1 (fr) Mutéines d'interleukine-21 et méthodes de traitement
MA40813A1 (fr) Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre diverses tumeurs
MA41393A1 (fr) Nouveaux peptides et combinaisons de peptides et échafaudages formés de ceux-ci destinés à être utilisés en immunothérapie contre le carcinome colorectal (crc) et d'autres cancers
MA43466A1 (fr) Traitements du cancer de l'utérus
MA49158B1 (fr) Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers
MA46022A (fr) Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de la prostate et d'autres cancers
EA201790986A1 (ru) Антитела к cd73 и их применения
MA38986B1 (fr) Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate
MA38478A1 (fr) Anticorps anti-pac1 humains
MA37946A1 (fr) Traitement de la polyarthrite rhumatoïde
MA37407A1 (fr) Anticorps dirigés contre les ligands des récepteurs b1 de la bradykinine
EA202090372A1 (ru) Универсальные соединения авт и их применение
MA40791A (fr) Ciblage lysosomal d'enzymes et utilisations associées
MA53069A1 (fr) Anticorps igf-1r et son utilisation comme véhicule d'adressage pour le traitement du cancer
MX2023002330A (es) Anticuerpos anti molecula de adhesion celular 5 relacionada con el antigeno carcinoembrionario (ceacam5) y conjugados y usos de los mismos.
MA46913B1 (fr) Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers
MA47976B1 (fr) Anticorps dirigés contre trem2 et leur utilisation
MA50737B1 (fr) Anticorps humains contre la protéine de pic monoclonal du coronavirus du syndrome respiratoire du moyen-orient
MA37464A1 (fr) Anticorps anti-egfr et leurs utilisations
MA40375B1 (fr) Anticorps humains contre l'hémagglutinine de la grippe
MA38794A1 (fr) Nouvelle immunothérapie contre plusieurs tumeurs, tels que le cancer du poumon, comprenant le cancer du poumon à grandes cellules