EP4100028A4 - Compositions et méthodes de traitement de cancers positifs à la mésothéline - Google Patents
Compositions et méthodes de traitement de cancers positifs à la mésothéline Download PDFInfo
- Publication number
- EP4100028A4 EP4100028A4 EP21859151.9A EP21859151A EP4100028A4 EP 4100028 A4 EP4100028 A4 EP 4100028A4 EP 21859151 A EP21859151 A EP 21859151A EP 4100028 A4 EP4100028 A4 EP 4100028A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- positive cancers
- mesothelin positive
- treating mesothelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003735 Mesothelin Human genes 0.000 title 1
- 108090000015 Mesothelin Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/464468—Mesothelin [MSLN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/30—Coculture with; Conditioned medium produced by tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063068245P | 2020-08-20 | 2020-08-20 | |
US202063085971P | 2020-09-30 | 2020-09-30 | |
PCT/US2021/046751 WO2022040454A1 (fr) | 2020-08-20 | 2021-08-19 | Compositions et méthodes de traitement de cancers positifs à la mésothéline |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4100028A1 EP4100028A1 (fr) | 2022-12-14 |
EP4100028A4 true EP4100028A4 (fr) | 2023-07-26 |
Family
ID=80323179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21859151.9A Pending EP4100028A4 (fr) | 2020-08-20 | 2021-08-19 | Compositions et méthodes de traitement de cancers positifs à la mésothéline |
Country Status (9)
Country | Link |
---|---|
US (2) | US11602543B2 (fr) |
EP (1) | EP4100028A4 (fr) |
JP (1) | JP2023538114A (fr) |
KR (1) | KR20230051677A (fr) |
AU (1) | AU2021329371A1 (fr) |
CA (1) | CA3188862A1 (fr) |
IL (1) | IL300500A (fr) |
MX (1) | MX2023002041A (fr) |
WO (1) | WO2022040454A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023538114A (ja) | 2020-08-20 | 2023-09-06 | エー2 バイオセラピューティクス, インコーポレイテッド | メソテリン陽性がんを治療するための組成物及び方法 |
IL314114A (en) * | 2022-01-28 | 2024-09-01 | A2 Biotherapeutics Inc | Compositions and methods for the treatment of mesothelin-positive types of cancer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015090230A1 (fr) * | 2013-12-19 | 2015-06-25 | Novartis Ag | Récepteurs antigéniques chimériques de la mésothéline humaine et leurs utilisations |
WO2019068007A1 (fr) * | 2017-09-28 | 2019-04-04 | Immpact-Bio Ltd. | Plate-forme universelle pour préparer un récepteur d'antigène chimérique inhibiteur (icar) |
WO2020065406A2 (fr) * | 2018-09-28 | 2020-04-02 | Immpact-Bio Ltd. | Procédés pour identifier des paires récepteur antigénique activateur (acar)/récepteur antigénique chimérique inhibiteur (icar) destinées à être utilisées en cancérothérapies |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
US6809184B1 (en) | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
JP2002504372A (ja) | 1998-02-25 | 2002-02-12 | ザ ダウ ケミカル カンパニー | 高親和性ヒト型化抗−ceaモノクロ−ナル抗体 |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
WO2001029058A1 (fr) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Genes de voies d'interference d'arn en tant qu'outils d'interference genetique ciblee |
US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
IL151287A0 (en) | 2000-02-24 | 2003-04-10 | Xcyte Therapies Inc | A method for stimulation and concentrating cells |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
CA2450285C (fr) | 2001-06-13 | 2016-08-02 | Genmab A/S | Anticorps monoclonaux humains diriges contre le recepteur de facteur de croissance epidermique (egfr) |
US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
AU2005222965B8 (en) | 2004-03-15 | 2010-07-01 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
US7754482B2 (en) | 2004-05-27 | 2010-07-13 | The Trustees Of The University Of Pennsylvania | Artificial antigen presenting cells and uses therefor |
WO2006031221A1 (fr) | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Préparations comprenant des récepteurs cellulaires t et méthodes d'utilisation de ces préparations |
US8012714B2 (en) | 2008-04-14 | 2011-09-06 | Innovative Targeting Solutions, Inc. | Sequence diversity generation in immunoglobulins |
WO2010114129A1 (fr) | 2009-04-03 | 2010-10-07 | 国立大学法人愛媛大学 | Récepteur des lymphocytes t et acide nucléique codant pour le récepteur |
PE20121552A1 (es) | 2009-08-31 | 2012-11-26 | Roche Glycart Ag | Anticuerpos monoclonales anti cea humanizados de afinidad madura |
SG190997A1 (en) | 2010-12-09 | 2013-07-31 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
CA2827722C (fr) | 2011-03-02 | 2020-05-12 | Roche Glycart Ag | Anticorps anti-cea |
WO2013054320A1 (fr) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Anticorps dirigés contre la molécule d'adhésion cellulaire associée à l'antigène carcino-embryonnaire (ceacam) |
SG11201404285VA (en) | 2012-02-22 | 2014-10-30 | Univ Pennsylvania | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
CA3209571A1 (fr) | 2012-03-23 | 2013-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recepteurs d'antigene chimerique anti-mesotheline |
DK2800811T3 (en) | 2012-05-25 | 2017-07-17 | Univ Vienna | METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION |
KR102408660B1 (ko) | 2012-11-20 | 2022-06-15 | 사노피 | 항-ceacam5 항체 및 이의 용도 |
EP3825401A1 (fr) | 2012-12-12 | 2021-05-26 | The Broad Institute, Inc. | Systèmes de composants crispr-cas, procédés et compositions pour la manipulation de séquence |
AU2013359212B2 (en) | 2012-12-12 | 2017-01-19 | Massachusetts Institute Of Technology | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
CN105143270B (zh) | 2013-02-26 | 2019-11-12 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
WO2014145252A2 (fr) | 2013-03-15 | 2014-09-18 | Milone Michael C | Ciblage de cellules cytotoxiques par des récepteurs chimériques pour une immunothérapie adoptive |
IL300508A (en) | 2013-03-15 | 2023-04-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
US10196444B2 (en) | 2013-07-29 | 2019-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
ES2861501T3 (es) | 2013-11-21 | 2021-10-06 | Autolus Ltd | Célula |
US20150344844A1 (en) | 2014-02-04 | 2015-12-03 | Marc Better | Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof |
US11072644B2 (en) | 2014-11-12 | 2021-07-27 | Allogene Therapeutics, Inc. | Inhibitory chimeric antigen receptors |
EP3233095A2 (fr) | 2014-12-17 | 2017-10-25 | Cellectis | Récepteur d'antigène chimérique inhibiteur (icar ou n-car) exprimant un domaine de transduction non lymphocytaire t |
US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
US10590182B2 (en) | 2015-02-24 | 2020-03-17 | The Regents Of The University Of California | Binding-triggered transcriptional switches and methods of use thereof |
CN107683333A (zh) | 2015-03-11 | 2018-02-09 | 塞勒克提斯公司 | 用于工程化同种异体t细胞以增加其在患者中的持久性和/或移植成活率的方法 |
JP6843062B2 (ja) | 2015-03-27 | 2021-03-17 | ユニバーシティ オブ サザン カリフォルニア | Car t細胞免疫療法のための新規標的としてのhla−g |
GB201509413D0 (en) | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
EP3377523A4 (fr) | 2015-11-19 | 2019-06-19 | The Regents of The University of California | Récepteurs de cellules immunitaires répressibles sous conditions et leurs procédés d'utilisation |
EP3380602A4 (fr) | 2015-11-23 | 2019-09-25 | Trustees of Boston University | Procédés et compositions se rapportant à des récepteurs antigéniques chimériques |
WO2017091905A1 (fr) | 2015-12-02 | 2017-06-08 | Innovative Targeting Solutions Inc. | Récepteur de lymphocytes t à domaine variable unique |
CA3017213A1 (fr) | 2016-03-11 | 2017-09-14 | Bluebird Bio, Inc. | Cellules effectrices immunes editees par le genome |
US20190185849A1 (en) | 2016-06-29 | 2019-06-20 | Crispr Therapeutics Ag | Compositions and methods for gene editing |
EP3263595A1 (fr) | 2016-06-30 | 2018-01-03 | Medizinische Hochschule Hannover | Protéine de fusion pour une utilisation dans le traitement de maladie hvg |
EP3504245A4 (fr) | 2016-08-23 | 2020-04-22 | The Regents of The University of California | Polypeptides chimériques clivables de manière protéolytique et leurs procédés d'utilisation |
EP3516044A4 (fr) | 2016-09-23 | 2020-03-11 | Fred Hutchinson Cancer Research Center | Tcr spécifiques de l'antigène ha-1 d'histocompatibilité (h) mineure et ses utilisations |
CN109996871A (zh) | 2016-09-28 | 2019-07-09 | 加维什-加利里生物应用有限公司 | 供靶向癌症的新型抗原标志的car疗法用的通用平台 |
JP2020506700A (ja) | 2017-01-31 | 2020-03-05 | ノバルティス アーゲー | 多重特異性を有するキメラt細胞受容体タンパク質を用いた癌の治療 |
EP3579877A4 (fr) | 2017-02-09 | 2020-12-09 | The Regents of The University of California | Récepteurs antigéniques de lymphocytes t chimériques et leurs procédés d'utilisation |
CR20190431A (es) | 2017-03-27 | 2019-11-01 | Hoffmann La Roche | Formatos mejorados de receptor de unión a antígeno |
EP3609914A4 (fr) | 2017-04-14 | 2021-04-14 | The General Hospital Corporation | Lymphocytes t récepteurs d'antigènes chimériques ciblant le micro-environnement tumoral |
GB201707783D0 (en) | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
US20200188434A1 (en) | 2017-05-15 | 2020-06-18 | Autolus Limited | A cell comprising a chimeric antigen receptor (car) |
GB201707779D0 (en) | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
CN111448215B (zh) | 2017-09-19 | 2024-01-16 | 英属哥伦比亚大学 | 抗-hla-a2抗体及其使用方法 |
US11732257B2 (en) | 2017-10-23 | 2023-08-22 | Massachusetts Institute Of Technology | Single cell sequencing libraries of genomic transcript regions of interest in proximity to barcodes, and genotyping of said libraries |
WO2019090215A2 (fr) | 2017-11-06 | 2019-05-09 | Monticello Daniel J | Systèmes à récepteur antigénique chimérique avec ligand dominant négatif |
WO2019241549A1 (fr) | 2018-06-15 | 2019-12-19 | A2 Biotherapeutics, Inc. | Lymphocytes t régulateurs-car exprimant le foxp3 |
KR20210075117A (ko) | 2018-10-05 | 2021-06-22 | 세인트 안나 킨더크렙스포르슝 | 키메라 항원 수용체(car) 그룹 |
EP3632461A1 (fr) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | Groupe de récepteurs d'antigène chimérique (cars) |
AU2020226401A1 (en) | 2019-02-18 | 2021-10-14 | Memorial Sloan-Kettering Cancer Center | Combinations of multiple chimeric antigen receptors for immunotherapy |
JP2022539344A (ja) | 2019-06-26 | 2022-09-08 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 抗cea抗体及びその応用 |
US20240173352A1 (en) | 2019-08-09 | 2024-05-30 | A2 Biotherapeutics, Inc. | Cell-surface receptors responsive to loss of heterozygosity |
WO2021030182A1 (fr) | 2019-08-09 | 2021-02-18 | A2 Biotherapeutics, Inc. | Récepteurs de lymphocytes t à domaine variable unique bifonctionnel et leurs utilisations |
WO2021030153A2 (fr) | 2019-08-09 | 2021-02-18 | A2 Biotherapeutics, Inc. | Récepteurs de lymphocytes t modifiés et leurs utilisations |
EP4017510A4 (fr) | 2019-08-20 | 2023-11-22 | Senti Biosciences, Inc. | Récepteur inhibiteur chimérique |
KR20220113353A (ko) | 2019-09-18 | 2022-08-12 | 람캅 바이오 알파 에이지 | Ceacam5 및 cd3에 대한 이중특이적 항체 |
WO2021096868A1 (fr) | 2019-11-12 | 2021-05-20 | A2 Biotherapeutics, Inc. | Récepteurs de lymphocytes t modifiés et leurs utilisations |
EP3831849A1 (fr) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Anticorps bispécifiques contre ceacam5 et cd47 |
WO2021119489A1 (fr) | 2019-12-11 | 2021-06-17 | A2 Biotherapeutics, Inc. | Récepteur antigénique chimérique à base de lilrb1 |
WO2021222576A1 (fr) | 2020-05-01 | 2021-11-04 | A2 Biotherapeutics, Inc. | Protéines de fusion pag1 et procédés de production et d'utilisation associés |
WO2021252635A1 (fr) | 2020-06-11 | 2021-12-16 | A2 Biotherapeutics, Inc. | Compositions et méthodes de traitement de cancers |
WO2022036065A2 (fr) | 2020-08-13 | 2022-02-17 | A2 Biotherapeutics, Inc. | Compositions et méthodes pour le traitement de cancers |
JP2023538114A (ja) | 2020-08-20 | 2023-09-06 | エー2 バイオセラピューティクス, インコーポレイテッド | メソテリン陽性がんを治療するための組成物及び方法 |
WO2022040470A1 (fr) | 2020-08-20 | 2022-02-24 | A2 Biotherapeutics, Inc. | Compositions et méthodes de traitement de cancers positifs à ceacam |
IL300497A (en) | 2020-08-20 | 2023-04-01 | A2 Biotherapeutics Inc | Compositions and methods for treating CEACAM-positive cancer |
-
2021
- 2021-08-19 JP JP2023512376A patent/JP2023538114A/ja active Pending
- 2021-08-19 AU AU2021329371A patent/AU2021329371A1/en active Pending
- 2021-08-19 IL IL300500A patent/IL300500A/en unknown
- 2021-08-19 WO PCT/US2021/046751 patent/WO2022040454A1/fr active Application Filing
- 2021-08-19 EP EP21859151.9A patent/EP4100028A4/fr active Pending
- 2021-08-19 CA CA3188862A patent/CA3188862A1/fr active Pending
- 2021-08-19 KR KR1020237007037A patent/KR20230051677A/ko active Search and Examination
- 2021-08-19 MX MX2023002041A patent/MX2023002041A/es unknown
-
2022
- 2022-05-10 US US17/662,766 patent/US11602543B2/en active Active
- 2022-12-07 US US18/062,873 patent/US20230277590A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015090230A1 (fr) * | 2013-12-19 | 2015-06-25 | Novartis Ag | Récepteurs antigéniques chimériques de la mésothéline humaine et leurs utilisations |
WO2019068007A1 (fr) * | 2017-09-28 | 2019-04-04 | Immpact-Bio Ltd. | Plate-forme universelle pour préparer un récepteur d'antigène chimérique inhibiteur (icar) |
WO2020065406A2 (fr) * | 2018-09-28 | 2020-04-02 | Immpact-Bio Ltd. | Procédés pour identifier des paires récepteur antigénique activateur (acar)/récepteur antigénique chimérique inhibiteur (icar) destinées à être utilisées en cancérothérapies |
Non-Patent Citations (3)
Title |
---|
RAFIQ SARWISH ET AL: "Engineering strategies to overcome the current roadblocks in CAR T cell therapy", NATURE REVIEWS CLINICAL ONCOLOGY, NATURE, NY, US, vol. 17, no. 3, 17 December 2019 (2019-12-17), pages 147 - 167, XP037114979, ISSN: 1759-4774, [retrieved on 20191217], DOI: 10.1038/S41571-019-0297-Y * |
See also references of WO2022040454A1 * |
V. D. FEDOROV ET AL: "PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 215, 11 December 2013 (2013-12-11), pages 215ra172 - 215ra172, XP055210508, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3006597 * |
Also Published As
Publication number | Publication date |
---|---|
EP4100028A1 (fr) | 2022-12-14 |
US20220370497A1 (en) | 2022-11-24 |
US11602543B2 (en) | 2023-03-14 |
WO2022040454A1 (fr) | 2022-02-24 |
MX2023002041A (es) | 2023-04-27 |
CA3188862A1 (fr) | 2022-02-24 |
JP2023538114A (ja) | 2023-09-06 |
AU2021329371A1 (en) | 2023-04-20 |
KR20230051677A (ko) | 2023-04-18 |
IL300500A (en) | 2023-04-01 |
US20230277590A1 (en) | 2023-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3947715A4 (fr) | Procédés et compositions pour le traitement du cancer | |
EP3983445A4 (fr) | Compositions et méthodes de traitement du cancer | |
EP3938354A4 (fr) | Compositions et méthodes de traitement du cancer | |
EP4097486A4 (fr) | Compositions et méthodes de traitement de cancers positifs à ceacam | |
EP4136254A4 (fr) | Compositions ciblant l'ace2 et procédés de traitement de la covid-19 | |
EP3908601A4 (fr) | Procédés et compositions pour le traitement du cancer | |
EP4025590A4 (fr) | Procédés et compositions pour le traitement du cancer | |
EP4100028A4 (fr) | Compositions et méthodes de traitement de cancers positifs à la mésothéline | |
EP4149547A4 (fr) | Compositions et méthodes pour le traitement du cancer | |
EP3968785A4 (fr) | Compositions et méthodes de traitement du cancer | |
EP4110822A4 (fr) | Compositions et méthodes pour traiter le cancer | |
EP4096675A4 (fr) | Compositions et procédés de traitement de la covid longue | |
EP3965896A4 (fr) | Compositions et méthodes pour le traitement du cancer | |
EP4003351A4 (fr) | Méthodes et compositions pour le traitement du cancer | |
EP4127722A4 (fr) | Méthodes et compositions pour le traitement du cancer | |
EP3773585A4 (fr) | Compositions et méthodes pour le traitement du cancer | |
EP3959199A4 (fr) | Compositions et méthodes de traitement de cancers à mutation de ras | |
EP4077690A4 (fr) | Méthodes et compositions de traitement du cancer | |
EP4103738A4 (fr) | Compositions et méthodes comprenant des antigènes issus de l'épissage pour le traitement du cancer | |
EP3983014A4 (fr) | Compositions et méthodes pour le traitement du cancer | |
EP3930705A4 (fr) | Méthodes et compositions pour le traitement du cancer | |
IL309662A (en) | Compositions and methods for treating cancer | |
IL312844A (en) | Methods and preparations for the treatment of cancer | |
IL312846A (en) | Methods and preparations for the treatment of cancer | |
IL309120A (en) | Methods and compositions for the treatment of cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220905 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0035170000 Ipc: C07K0014705000 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20230622 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/0783 20100101ALI20230616BHEP Ipc: A61K 39/00 20060101ALI20230616BHEP Ipc: A61P 35/00 20060101ALI20230616BHEP Ipc: C07K 14/74 20060101ALI20230616BHEP Ipc: A61K 35/17 20150101ALI20230616BHEP Ipc: C07K 14/705 20060101AFI20230616BHEP |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40085800 Country of ref document: HK |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) |