MA33429B1 - Production de poliovirus à titres élevés pour la production de vaccins - Google Patents

Production de poliovirus à titres élevés pour la production de vaccins

Info

Publication number
MA33429B1
MA33429B1 MA34534A MA34534A MA33429B1 MA 33429 B1 MA33429 B1 MA 33429B1 MA 34534 A MA34534 A MA 34534A MA 34534 A MA34534 A MA 34534A MA 33429 B1 MA33429 B1 MA 33429B1
Authority
MA
Morocco
Prior art keywords
production
poliovirus
high quantity
vaccine
cells
Prior art date
Application number
MA34534A
Other languages
Arabic (ar)
English (en)
Inventor
John Alfred Lewis
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of MA33429B1 publication Critical patent/MA33429B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32651—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne un procédé de production de poliovirus consistant à : a) fournir une culture cellulaire en suspension sans sérum, les cellules étant des cellules PER.C6, b) infecter lesdites cellules avec le poliovirus avec une densité cellulaire comprise entre 2 x 10
MA34534A 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins MA33429B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27103809P 2009-07-16 2009-07-16
EP09165620 2009-07-16
PCT/EP2010/059796 WO2011006823A1 (fr) 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins

Publications (1)

Publication Number Publication Date
MA33429B1 true MA33429B1 (fr) 2012-07-03

Family

ID=41412431

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34534A MA33429B1 (fr) 2009-07-16 2010-07-08 Production de poliovirus à titres élevés pour la production de vaccins

Country Status (33)

Country Link
US (4) US8546123B2 (fr)
EP (1) EP2454364B1 (fr)
JP (1) JP5845178B2 (fr)
KR (1) KR101548790B1 (fr)
CN (1) CN102482647B (fr)
AP (1) AP3140A (fr)
AR (1) AR077314A1 (fr)
AU (1) AU2010272685B2 (fr)
BR (1) BR112012000942B8 (fr)
CA (1) CA2763091C (fr)
CO (1) CO6491042A2 (fr)
CU (1) CU20120006A7 (fr)
DK (1) DK2454364T3 (fr)
EA (1) EA020563B1 (fr)
ES (1) ES2484093T3 (fr)
HK (1) HK1164922A1 (fr)
HR (1) HRP20140597T1 (fr)
IL (1) IL217465A (fr)
MA (1) MA33429B1 (fr)
MX (1) MX2011012648A (fr)
MY (1) MY183385A (fr)
NZ (1) NZ596880A (fr)
PE (1) PE20120571A1 (fr)
PL (1) PL2454364T3 (fr)
PT (1) PT2454364E (fr)
RS (1) RS53377B (fr)
SG (1) SG177655A1 (fr)
SI (1) SI2454364T1 (fr)
SM (1) SMT201400079B (fr)
TN (1) TN2011000628A1 (fr)
TW (1) TWI477606B (fr)
WO (1) WO2011006823A1 (fr)
ZA (1) ZA201108271B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9254318B2 (en) 2006-03-31 2016-02-09 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
MX2011004292A (es) 2008-11-03 2011-05-31 Crucell Holland Bv Metodo para la produccion de vectores adenovirales.
PT2454364E (pt) 2009-07-16 2014-07-04 Crucell Holland Bv Produção de poliovírus com elevados títulos para produção de vacina
WO2011056591A1 (fr) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation Virus recombinants de la grippe de titre élevé à réplication améliorée dans les cellules vero
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
EP2954055B1 (fr) 2013-02-05 2018-04-11 University of Georgia Research Foundation, Inc. Lignées cellulaires pour la production de virus et procédés d'utilisation
PE20151720A1 (es) 2013-03-08 2015-12-10 Crucell Holland Bv Vacuna acelular contra pertussis
CN105121634B (zh) 2013-03-13 2019-07-26 易木农麦克斯有限公司 具有提高的病毒生产能力的细胞系及其生产方法
KR20140112255A (ko) 2013-03-13 2014-09-23 고려대학교 산학협력단 바이러스 생산능이 증가된 세포주 및 그 제조방법
GB201305361D0 (en) 2013-03-25 2013-05-08 Univ Edinburgh Enhanced expression
ES2689150T3 (es) 2013-06-17 2018-11-08 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Métodos para la prevención de agregación de componentes víricos
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
US20160053281A1 (en) * 2013-08-15 2016-02-25 The University Court Of The University Of Edinburgh Enhanced Expression Of RNA Vectors
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
BR112016028936A2 (pt) 2014-06-17 2017-10-31 Janssen Vaccines & Prevention Bv atenuação viral adaptada ao frio (cava) e cepas de poliovírus atenuadas inovadoras
WO2015194770A1 (fr) 2014-06-18 2015-12-23 고려대학교산학협력단 Procédé pour favoriser l'infection virale et augmenter la production de virus, en utilisant une lignée cellulaire présentant des fonctions perdues du gène bst2
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CA2955877A1 (fr) * 2014-07-24 2016-01-28 Janssen Vaccines & Prevention B.V. Procede de purification du virus de la poliomyelite a partir de cultures cellulaires
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
WO2017007839A1 (fr) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Réplication améliorée du virus de la grippe pour l'élaboration de vaccin
CA3014435C (fr) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Replication amelioree du virus de la grippe b pour l'elaboration de vaccin
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US10372100B2 (en) * 2016-08-29 2019-08-06 Ge Healthcare Bio-Sciences Corp. Manufacturing system for biopharmaceutical products
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
CN107723279B (zh) * 2017-10-18 2020-11-10 成都远睿生物技术有限公司 一种缺陷型腺病毒AdC68-GP的培养方法
SG11202007503WA (en) * 2018-02-07 2020-09-29 Bharat Biotech Int Ltd A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
WO2020229581A1 (fr) 2019-05-16 2020-11-19 Janssen Vaccines & Prevention B.V. Méthodes pour induire une réponse immunitaire sûre contre le virus de la polio
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) * 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
CA2222140C (fr) 1995-06-15 2010-11-23 Introgene B.V. Systemes d'empaquetage pour adenovirus recombinant chez l'homme, destine a la therapie genique
EP1103610A1 (fr) * 1999-11-26 2001-05-30 Introgene B.V. Production de vaccins de lignées de cellules mammifère immortalisées
US7521220B2 (en) 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
EP1256803A1 (fr) 2001-05-07 2002-11-13 Crucell Holland B.V. Méthodes pour l'identification des composés antiviraux
AU2003288273A1 (en) 2002-10-23 2004-05-13 Crucell Holland B.V. New settings for recombinant adenoviral-based vaccines
SG156535A1 (en) 2002-12-17 2009-11-26 Crucell Holland Bv Recombinant viral-based malaria vaccines
WO2004099396A1 (fr) 2003-05-09 2004-11-18 Crucell Holland B.V. Cultures de cellules immortalisees par e1 et procedes de culture de ces dernieres visant a en augmenter les rendements de produits
EP2308958A3 (fr) 2004-03-05 2011-08-10 DSM IP Assets B.V. Culture de cellules en perfusion continue et flux alternatif tangentiel
MX2007002372A (es) 2004-08-27 2007-05-08 Panacea Biotec Ltd Vacuna para la poliomielitis inactivada derivada de la cepa sabin del virus de la polio.
AU2005293572B2 (en) 2004-10-14 2011-08-04 Crucell Holland B.V. Malaria prime/boost vaccines
CN100500827C (zh) * 2004-11-26 2009-06-17 中国医学科学院医学生物学研究所 用人胚肺二倍体细胞培养繁殖脊髓灰质炎病毒的方法
WO2008059041A2 (fr) 2006-11-16 2008-05-22 Crucell Holland B.V. Complémentation d'un déficit de facteur xi par mutants de facteur v
PT2454364E (pt) 2009-07-16 2014-07-04 Crucell Holland Bv Produção de poliovírus com elevados títulos para produção de vacina
KR20120070015A (ko) 2010-12-21 2012-06-29 (주)창조바이오텍 알파-피넨을 유효성분으로 포함하는 스쿠티카충 구제용 조성물

Also Published As

Publication number Publication date
PL2454364T3 (pl) 2014-09-30
CU20120006A7 (es) 2012-10-15
TW201118173A (en) 2011-06-01
BR112012000942B1 (pt) 2020-10-27
MX2011012648A (es) 2012-01-12
AR077314A1 (es) 2011-08-17
EP2454364B1 (fr) 2014-04-23
US8546123B2 (en) 2013-10-01
EA020563B1 (ru) 2014-12-30
KR20120033334A (ko) 2012-04-06
ES2484093T3 (es) 2014-08-11
EA201270173A1 (ru) 2012-06-29
TN2011000628A1 (en) 2013-05-24
JP2012532616A (ja) 2012-12-20
US9022240B2 (en) 2015-05-05
US20130052224A1 (en) 2013-02-28
NZ596880A (en) 2013-10-25
AP2012006075A0 (en) 2012-02-29
RS53377B (en) 2014-10-31
US20140242670A1 (en) 2014-08-28
IL217465A0 (en) 2012-02-29
CA2763091C (fr) 2019-07-23
BR112012000942A2 (pt) 2016-03-15
PE20120571A1 (es) 2012-06-06
MY183385A (en) 2021-02-18
JP5845178B2 (ja) 2016-01-20
TWI477606B (zh) 2015-03-21
SMT201400079B (it) 2014-09-08
SG177655A1 (en) 2012-02-28
CA2763091A1 (fr) 2011-01-20
AU2010272685A1 (en) 2011-12-08
ZA201108271B (en) 2012-07-25
HK1164922A1 (en) 2012-09-28
US20110027317A1 (en) 2011-02-03
BR112012000942B8 (pt) 2021-05-25
IL217465A (en) 2016-05-31
EP2454364A1 (fr) 2012-05-23
AU2010272685B2 (en) 2015-02-26
CO6491042A2 (es) 2012-07-31
CN102482647A (zh) 2012-05-30
CN102482647B (zh) 2015-12-16
AP3140A (en) 2015-02-28
WO2011006823A1 (fr) 2011-01-20
KR101548790B1 (ko) 2015-08-31
HRP20140597T1 (hr) 2014-09-12
DK2454364T3 (da) 2014-07-21
PT2454364E (pt) 2014-07-04
US20130273106A1 (en) 2013-10-17
SI2454364T1 (sl) 2014-08-29

Similar Documents

Publication Publication Date Title
MA33429B1 (fr) Production de poliovirus à titres élevés pour la production de vaccins
FR2981643B1 (fr) Procede de preparation d'un materiau composite silicium/carbone, materiau ainsi prepare, et electrode notamment electrode negative, comprenant ce materiau.
WO2010096588A3 (fr) Milieu de culture cellulaire contenant des combinaisons de protéines
CY1116226T1 (el) Χρηση toy rna για επαναπρογραμματισμο σωματικων κυτταρων
MY185887A (en) Cell culture improvements
GB2449772A (en) Large scale production of stem cells
MY156588A (en) Systems using cell culture for production of isoprene
NZ734670A (en) Cells for producing recombinant iduronate-2-sulfatase
MX2021000211A (es) Metodos y productos para transfeccion de celulas.
MX2010000348A (es) Cultivo de celulas madre pluripotentes individuales.
AR052111A1 (es) Supresiones geneticas dirigidas para polisacaridos formadores de limo
MX2010001319A (es) Metodo para producir proteinas heterogeneas.
IN2012DN00384A (fr)
MX367078B (es) Cocteles de enzimas preparados a partir de cultivos mezclados.
EP2516624A4 (fr) Lignée cellulaire 3m
MX343113B (es) Medios de cultivo de celulas granulados en seco.
NZ599479A (en) Improved reverse genetics methods for virus rescue
MX2009007790A (es) Mejora del crecimiento celular.
GB2450599A (en) Automated culture of stem cells
MY195435A (en) Anticancer Compounds
ES2351296B8 (es) Cepas de s. cerevisiae capaces de crecer en medios con melibiosa, estaquiosa y rafinosa.
EA201100845A1 (ru) СПОСОБ ПОЛУЧЕНИЯ pH-СТАБИЛЬНЫХ ПОКРЫТЫХ ОБОЛОЧКОЙ ВИРУСОВ
MX2015010887A (es) Formulaciones y metodos para aumentar la produccion de proteinas recombinantes.
MX2012007283A (es) Composiciones para vacunas.
RU2011115880A (ru) Способ получения селенсодержащего препарата биомассы laetiporus sulphureus mz-22