MA32957B1 - Derives de quinazolinone utiles comme antagonistes vanilloides - Google Patents

Derives de quinazolinone utiles comme antagonistes vanilloides

Info

Publication number
MA32957B1
MA32957B1 MA34004A MA34004A MA32957B1 MA 32957 B1 MA32957 B1 MA 32957B1 MA 34004 A MA34004 A MA 34004A MA 34004 A MA34004 A MA 34004A MA 32957 B1 MA32957 B1 MA 32957B1
Authority
MA
Morocco
Prior art keywords
derivatives useful
quinazolinone derivatives
vanilloid antagonists
vanilloid
antagonists
Prior art date
Application number
MA34004A
Other languages
Arabic (ar)
English (en)
Inventor
Weichun Chen
Hong-Yong Kim
Jessica Liang
Michael Mutz
Mahavir Prashad
Christopher Towler
Ruoqiu Wu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42167396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32957(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32957B1 publication Critical patent/MA32957B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UNE NOUVELLE FORME POLYMORPHE DU 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE AYANT LA FORMULE DE STRUCTURE I(B) ET SON PROCÉDÉ DE PRÉPARATION. L'INVENTION CONCERNE EN OUTRE UN PROCÉDÉ DE FABRICATION DE COMPOSÉS DE QUINAZOLINONE PHARMACEUTIQUEMENT ACTIFS DE FORMULE (I), DANS LAQUELLE LES SYMBOLES ONT LES SIGNIFICATIONS DONNÉES DANS LA DESCRIPTION, LEDIT PROCÉDÉ COMPRENANT LA RÉACTION D'UN COMPOSÉ DE FORMULE (II), DANS LAQUELLE R4* REPRÉSENTE R1*-C(=O)- DANS LAQUELLE R1* EST INDÉPENDAMMENT CHOISI DANS LE GROUPE DE SIGNIFICATIONS DE R1 TEL QUE DÉFINI POUR UN COMPOSÉ DE FORMULE (I) DE SORTE QUE R1* ET R1 SOIENT IDENTIQUES OU DIFFÉRENTS L'UN DE L'AUTRE, OU R4* REPRÉSENTE EN PARTICULIER H, ET R1 ET R3, R5 ET R6 SONT TELS QUE DÉFINIS POUR UN COMPOSÉ DE FORMULE (I), OU UN SEL DE CELUI-CI, DANS DES CONDITIONS DE CYCLISATION ET DE CONDENSATION SIMULTANÉES OU CONSÉCUTIVES AVEC UN COMPOSÉ ANILINE DE FORMULE (III), DANS LAQUELLE R2 ET M SONT TELS QUE DÉFINIS POUR UN COMPOSÉ DE FORMULE (I). D'AUTRES RÉACTIONS ET MODES DE RÉALISATION APPARENTÉS SONT ÉGALEMENT REVENDIQUÉS ET DÉCRITS.
MA34004A 2009-01-13 2010-01-12 Derives de quinazolinone utiles comme antagonistes vanilloides MA32957B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14425009P 2009-01-13 2009-01-13
PCT/EP2010/050243 WO2010084050A2 (fr) 2009-01-13 2010-01-12 Dérivés de quinazolinone utiles comme antagonistes vanilloïdes

Publications (1)

Publication Number Publication Date
MA32957B1 true MA32957B1 (fr) 2012-01-02

Family

ID=42167396

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34004A MA32957B1 (fr) 2009-01-13 2010-01-12 Derives de quinazolinone utiles comme antagonistes vanilloides

Country Status (28)

Country Link
US (2) US8349852B2 (fr)
EP (1) EP2387440B1 (fr)
JP (1) JP2012515150A (fr)
KR (1) KR20110104996A (fr)
CN (1) CN102281920A (fr)
AR (1) AR075006A1 (fr)
AU (1) AU2010206233B2 (fr)
BR (1) BRPI1006909A2 (fr)
CA (2) CA2946304A1 (fr)
CO (1) CO6400202A2 (fr)
CR (1) CR20110369A (fr)
CU (1) CU20110148A7 (fr)
EA (1) EA201101063A1 (fr)
EC (1) ECSP11011195A (fr)
ES (1) ES2614612T3 (fr)
IL (1) IL213869A0 (fr)
MA (1) MA32957B1 (fr)
MX (1) MX2011007444A (fr)
NZ (1) NZ593877A (fr)
PE (1) PE20110776A1 (fr)
PL (1) PL2387440T3 (fr)
PT (1) PT2387440T (fr)
SG (1) SG172808A1 (fr)
TN (1) TN2011000326A1 (fr)
TW (1) TW201036951A (fr)
UY (1) UY32381A (fr)
WO (1) WO2010084050A2 (fr)
ZA (1) ZA201104873B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
PE20142083A1 (es) * 2011-09-16 2014-12-30 Fovea Pharmaceuticals Derivados de anilina, su preparacion y su aplicacion terapeutica
KR101789430B1 (ko) * 2016-06-28 2017-10-25 동국대학교 산학협력단 Smo 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물
CN108863949B (zh) * 2018-07-09 2021-01-15 湖南博隽生物医药有限公司 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法
JP6994061B2 (ja) * 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
EP4431497A1 (fr) 2019-02-15 2024-09-18 Bausch + Lomb Ireland Limited Formes cristallines de 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile et leurs formulations
CA3130038A1 (fr) * 2019-02-15 2020-08-20 Novartis Ag Procedes de traitement de la douleur de surface oculaire
WO2021009664A1 (fr) 2019-07-15 2021-01-21 Novartis Ag Méthodes de traitement d'un dysfonctionnement de la glande de meibomius avec des agonistes du récepteur x du foie
MX2022006783A (es) 2019-12-10 2022-07-11 Hoffmann La Roche Nuevos derivados de metilquinazolinona.
CN116419918A (zh) 2020-08-06 2023-07-11 诺华股份有限公司 4-(7-羟基-2-异丙基-4-氧代-4h-喹唑啉-3-基)-苄腈的结晶形式及其配制品
EP4225279A1 (fr) 2020-10-07 2023-08-16 Novartis AG Inserts oculaires contenant un médicament et leur procédé d'utilisation
WO2022105792A1 (fr) * 2020-11-17 2022-05-27 苏州晶云药物科技股份有限公司 Nouvelles formes cristallines de dérivé de quinazolinone et procédé de préparation associé

Family Cites Families (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
DE19735879A1 (de) 1997-08-19 1999-02-25 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von 2-Carboxy-5-nitro-benzolsulfonsäure und deren Salzen durch Oxidation
GB9802251D0 (en) 1998-02-03 1998-04-01 Ciba Geigy Ag Organic compounds
CN1187048C (zh) 1998-10-02 2005-02-02 诺瓦提斯公司 mGLuR拮抗剂用于治疗疼痛和焦虑
US6525203B1 (en) 1999-03-12 2003-02-25 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
GB0028702D0 (en) 2000-11-24 2001-01-10 Novartis Ag Organic compounds
WO2002076946A2 (fr) 2001-03-26 2002-10-03 Novartis Ag Derivee de la pyridine
JP3894035B2 (ja) 2001-07-04 2007-03-14 東レ株式会社 炭素繊維強化基材、それからなるプリフォームおよび複合材料
TW200306839A (en) 2002-02-06 2003-12-01 Novartis Ag Quinazolinone derivatives and their use as CB agonists
US6696468B2 (en) 2002-05-16 2004-02-24 Dainippon Pharmaceutical Co., Ltd. (s)-4-amino-5-chloro-2-methoxy-n-[1-[1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
SE0201940D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
DOP2003000703A (es) 2002-09-20 2004-03-31 Pfizer Compuestos de imidazopiradina como agonistas del receptor 5-ht4
GB0223730D0 (en) 2002-10-11 2002-11-20 Novartis Ag Organic compounds
AR042206A1 (es) 2002-11-26 2005-06-15 Novartis Ag Acidos fenilaceticos y derivados
GB0302876D0 (en) 2003-02-07 2003-03-12 Novartis Ag Organic compounds
JP2004277319A (ja) 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd １−（４−ピペリジニルメチル）ピペリジニルアミド誘導体およびそれを含有する医薬組成物
JP2004277318A (ja) 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd １−（１−置換カルボニル−４−ピペリジニルメチル）ピペリジン誘導体およびそれを含有する医薬組成物
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
EP1505064A1 (fr) 2003-08-05 2005-02-09 Bayer HealthCare AG Dérivés de 2-aminopyrimidine
DE602004009200T2 (de) 2003-08-12 2008-07-10 F. Hoffmann-La Roche Ag Tetrahydrochinazolinderivate als cfr-antagonisten
WO2005013997A1 (fr) 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Tetrahydroquinazolines spiro-substituees utilisees en tant qu'antagonistes du facteur de liberation de la corticotrophine (crf)
WO2005068448A1 (fr) 2003-08-29 2005-07-28 Ionix Pharmaceuticals Limited Sulfonamides a action antagoniste sur des canaux calcium de type n
PL1664036T3 (pl) 2003-09-03 2012-04-30 Pfizer Związki benzimidazolonu wykazujące działanie agonistyczne względem receptora 5-ht4
AU2004274403A1 (en) 2003-09-03 2005-03-31 Aventis Pharmaceuticals Inc. 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds
JP2005082508A (ja) 2003-09-05 2005-03-31 Dainippon Pharmaceut Co Ltd ２−アルコキシ−６−アミノ−５−ハロゲノ−ｎ−（１−置換−４−ピペリジニル）ピリジン−３−カルボキサミド誘導体およびそれを含有する医薬組成物
ZA200601978B (en) 2003-09-05 2007-05-30 Neurogen Corp Heteroaryl fused pyridines, pyrazines and pyrimidines as CRF1 receptor ligands
AU2004272437A1 (en) 2003-09-09 2005-03-24 Ono Pharmaceutical Co., Ltd. CRF antagonists and heterobicyclic compounds
GB0322612D0 (en) 2003-09-26 2003-10-29 Novartis Ag Organic compounds
AU2004278372B2 (en) 2003-09-30 2010-02-18 Janssen Pharmaceutica N.V. Quinoxaline compounds
DE602004020364D1 (de) 2003-09-30 2009-05-14 Janssen Pharmaceutica Nv Benzoimidazolverbindungen
JP2005104896A (ja) 2003-09-30 2005-04-21 Dainippon Pharmaceut Co Ltd ２−アルコキシ−６−アミノ−５−ハロゲノピリジン−３−カルボキサミド誘導体およびそれを含有する医薬組成物
EP1677791A4 (fr) 2003-10-31 2007-08-15 Takeda Pharmaceutical Composes heterocycliques accoles contenant de l'azote
EP1677789A1 (fr) 2003-10-31 2006-07-12 AstraZeneca AB Alkynes i
DE602004031667D1 (de) 2003-11-10 2011-04-14 Merck & Co Inc Substituierte trialzole als blocker des natriumkanals
US7208596B2 (en) 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
WO2005054239A1 (fr) 2003-12-05 2005-06-16 Bayer Healthcare Ag Derives de 2-aminopyrimidine
US7211568B2 (en) 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US20070255061A1 (en) 2003-12-19 2007-11-01 Astrazeneca Ab 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5
JP2005206590A (ja) 2003-12-25 2005-08-04 Mitsubishi Pharma Corp ナトリウムチャネルサイト２選択的阻害剤
EP1704146B1 (fr) 2004-01-07 2010-04-14 Aryx Therapeutics Composes stereo-isomeres et methodes de traitement de troubles gastro-intestinaux et du systeme nerveux central
TW200530181A (en) 2004-01-13 2005-09-16 Bristol Myers Squibb Co Heterocyclic compounds useful as growth hormone secretagogues
ATE388146T1 (de) 2004-01-29 2008-03-15 Pfizer 1-isopropyl-2-oxo-1,2-dihydropyridin-3- carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor
WO2005077373A2 (fr) 2004-02-03 2005-08-25 Astrazeneca Ab Nouveau traitement du reflux gastro-oesophagien pathologique ii
WO2005077345A1 (fr) 2004-02-03 2005-08-25 Astrazeneca Ab Composes pour le traitement de la maladie du reflux gastro-oesophagien
WO2005080379A1 (fr) 2004-02-18 2005-09-01 Astrazeneca Ab Composes de triazole et leur utilisation en tant qu'antagonistes du recepteur metabotrope du glutamate
MY145075A (en) 2004-02-18 2011-12-15 Astrazeneca Ab Tetrazole compounds and their use as metabotropic glutamate receptor antagonists.
AU2005214380A1 (en) 2004-02-18 2005-09-01 Astrazeneca Ab Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders
ES2309718T3 (es) 2004-02-18 2008-12-16 Astrazeneca Ab Compuestos heterociclicos condensados y su uso como antagonistas de los receptores metabotropicos para el tratamiento de trastornos gastrointestinales.
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
CN1934097A (zh) 2004-02-18 2007-03-21 阿斯利康(瑞典)有限公司 炔基化哌嗪化合物及其作为代谢型谷氨酸受体拮抗剂的应用
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
RU2381226C2 (ru) 2004-02-18 2010-02-10 Астразенека Аб Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата
TW200538180A (en) 2004-02-20 2005-12-01 Astrazeneca Ab New compounds
WO2005092882A1 (fr) 2004-03-01 2005-10-06 Pfizer Japan, Inc. Derives de 4-amino-5-halogeno-benzamide utiles comme agonistes du recepteur 5-ht4 dans le traitement des troubles gastro-intestinaux, du systeme nerveux central, neurologiques et cardio-vasculaires
CA2560896C (fr) 2004-03-25 2013-06-18 Janssen Pharmaceutica, N.V. Composes d'imidazole
WO2005097136A1 (fr) 2004-03-29 2005-10-20 Merck & Co., Inc. Pyrazinones substituees par biaryle utilisees comme bloquants des canaux sodiques
EP1789409A4 (fr) 2004-04-02 2010-09-08 Elixir Pharmaceuticals Inc Sulfonamides et utilisations de ceux-ci
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US20080015196A1 (en) 2004-04-16 2008-01-17 Neurogen Corporation Imidazopyrazines, Imidazopyridines, and Imidazopyrimidines as Crf1 Receptor Ligands
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0412768D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
AR049300A1 (es) 2004-06-15 2006-07-12 Schering Corp Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos
KR100875558B1 (ko) 2004-06-15 2008-12-23 화이자 인코포레이티드 벤즈이미다졸론 카복실산 유도체
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
US20060035939A1 (en) 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
RU2392278C2 (ru) 2004-07-15 2010-06-20 Джапан Тобакко Инк. Конденсированное производное бензамида и ингибитор активности подтипа 1 рецептора ваниллоида (vr1)
ATE447953T1 (de) 2004-07-19 2009-11-15 Inst Rech Developpement Ird Pharmazeutische zusammensetzungen zur behandlung von leishmaniasis
PE20060574A1 (es) 2004-07-28 2006-06-24 Glaxo Group Ltd Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs)
ITMI20041566A1 (it) 2004-07-30 2004-10-30 Indena Spa "trpv1 agonisti, formulazioni che li contengono e loro usi"
WO2006016218A1 (fr) 2004-08-03 2006-02-16 Pfizer Japan Inc. Dérivés arylcarbonyliques ou hétéroarylcarbonyliques utiles comme antagonistes du récepteur vanilloïde de type 1 (vr1)
WO2006023757A2 (fr) 2004-08-19 2006-03-02 University Of Virginia Patent Foundation Nouveaux amines tricycliques, bicycliques, monocycliques et acycliques utiles comme agents bloquants puissants des canaux de sodium
AU2005284904A1 (en) 2004-09-13 2006-03-23 Amgen Inc. Vanilloid receptor ligands and their use in treatments
GB0420424D0 (en) 2004-09-14 2004-10-20 Ionix Pharmaceuticals Ltd Therapeutic compounds
SE0402284D0 (sv) 2004-09-21 2004-09-21 Astrazeneca Ab New heterocyclic amides
WO2006036932A2 (fr) 2004-09-27 2006-04-06 Elixir Pharmaceuticals, Inc. Sulfonamides et leurs utilisations
WO2006038594A1 (fr) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Inhibiteur de canal de calcium de type n
JP5635727B2 (ja) 2004-10-07 2014-12-03 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法
US20080070946A1 (en) 2004-10-08 2008-03-20 Astrazeneca Ab Hydroxymethylbenzothiazoles Amides
US8143425B2 (en) 2004-10-12 2012-03-27 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
US7439360B2 (en) 2004-10-15 2008-10-21 Amgen Inc. Vanilloid receptor ligands and their use in treatments
ATE430746T1 (de) 2004-10-19 2009-05-15 Smithkline Beecham Cork Ltd Crf-rezeptor-antagonisten und zugehörige verfahren
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
CA2584167A1 (fr) 2004-10-22 2006-05-04 Amgen Inc. Ligands du recepteur vanilloide et leur utilisation dans des traitements
EP1809620B1 (fr) 2004-11-04 2010-12-29 Addex Pharma SA Nouveaux derives de tetrazole utilises comme modulateurs allosteriques positifs des recepteurs de glutamate metabotropiques
ATE441646T1 (de) 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
JP5042028B2 (ja) 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
CA2586316A1 (fr) 2004-11-11 2006-05-18 Argenta Discovery Ltd. Composes pyrimidine utilises comme modulateurs de l'histamine
CA2588909A1 (fr) 2004-11-24 2006-06-22 Abbott Laboratories Composes de chromanyluree inhibant le recepteur du sous-type 1 du recepteur de vanilloide et leurs utilisations
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
WO2006058338A2 (fr) 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. Modulateurs de 4-piperidinecarboxamide du recepteur vanilloide vr1
US7875627B2 (en) 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
US20060128710A1 (en) 2004-12-09 2006-06-15 Chih-Hung Lee Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
US7615570B2 (en) 2004-12-13 2009-11-10 Abbott Laboratories Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
SE0403117D0 (sv) 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
SE0403118D0 (sv) 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 2
ATE469897T1 (de) 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
SE0403171D0 (sv) 2004-12-23 2004-12-23 Astrazeneca Ab New compounds
WO2006074884A1 (fr) 2005-01-14 2006-07-20 F.Hoffmann-La Roche Ag Derives de thiazole-4-carboxamide en tant qu'antagonistes du mglur5
US20080085901A1 (en) 2005-01-14 2008-04-10 Neurogen Corporation Heteroaryl Substituted Quinolin-4-Ylamine Analogues
WO2006078907A1 (fr) 2005-01-20 2006-07-27 Amgen Inc. Dérivés de benzimidazole substitué en position 2 servant de ligands de récepteur vanilloïde et utilisation de ceux-ci dans des traitements
WO2006089311A1 (fr) 2005-02-15 2006-08-24 Amgen Inc. Ligands des recepteurs vanilloides et leurs utilisations therapeutiques
JP2008530225A (ja) 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
GB0503646D0 (en) 2005-02-22 2005-03-30 Novartis Ag Organic compounds
DE602006014531D1 (de) 2005-03-03 2010-07-08 Janssen Pharmaceutica Nv Substituierte oxadiazaspiro-ä5.5ü-undecanonderivate und ihre verwendung als neurokininantagonisten
WO2006095263A1 (fr) 2005-03-10 2006-09-14 Pfizer Japan Inc. Composes a base de n-sulfonylaminophenylethyl-2-phenoxy acetamide substitues
US20060211710A1 (en) 2005-03-17 2006-09-21 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
CA2602583A1 (fr) 2005-03-24 2006-09-28 Janssen Pharmaceutica N.V. Amides derives de biaryle modulateurs de recepteur vanilloide vr1
GB0506147D0 (en) 2005-03-24 2005-05-04 Merck Sharp & Dohme Therapeutic agents
WO2006105117A2 (fr) 2005-03-28 2006-10-05 Dynogen Pharmaceuticals, Inc. Procede destine a traiter des troubles et des conditions au moyen d'inhibiteurs et d'antagonistes a peripherie restreinte
TWI377206B (en) 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
US20060235036A1 (en) 2005-04-15 2006-10-19 Doherty Elizabeth M Vanilloid receptor ligands and their use in treatments
EP1883632A1 (fr) 2005-04-25 2008-02-06 Amgen Inc. Ligands des recepteurs vanilloides et leur utilisation therapeutique
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508318D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0509573D0 (en) 2005-05-11 2005-06-15 Merck Sharp & Dohme Therapeutic compounds
US20090298856A1 (en) 2005-05-11 2009-12-03 Rebecca Elizabeth Brown 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1)
MX2007014048A (es) 2005-05-11 2008-02-05 Abbott Lab Antagonistas del receptor vaniloide subtipo 1 (vr1) y usos de los mismos.
MX2007013931A (es) 2005-05-12 2008-01-11 Amgen Inc Agentes antipireticos contra incrementos en la temperatura corporal inducidos por antagonista del receptor vainilloide 1.
DE102005023588A1 (de) 2005-05-18 2006-11-23 Grünenthal GmbH Salze substituierter Allophansäureester und deren Verwendung in Arzneimitteln
DE102005038947A1 (de) 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
GB0510140D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B2
EA015813B1 (ru) 2005-05-18 2011-12-30 Аддекс Фарма Са Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510142D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
GB0510141D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
DE102005044814A1 (de) 2005-05-19 2006-11-23 Grünenthal GmbH Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005044813A1 (de) 2005-05-19 2007-10-04 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005023784A1 (de) 2005-05-19 2006-11-30 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005024012A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Verwendung von 2,5-disubstituierten Thiazol-4-on-Derivaten in Arzneimitteln
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
US7317022B2 (en) 2005-06-07 2008-01-08 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists
CA2611493A1 (fr) 2005-06-10 2006-12-21 Elixir Pharmaceuticals, Inc. Composes sulfonamide et leurs utilisations
MX2007015606A (es) 2005-06-23 2008-02-25 Astrazeneca Ab Nuevos derivados de azetidina como antagonistas del receptor de neuroquinina para el tratamiento de enfermedades gastrointestinales.
JP2008546768A (ja) 2005-06-23 2008-12-25 アストラゼネカ・アクチエボラーグ 胃腸疾患を治療するためのニューロキニン受容体アンタゴニストとしての新規なアゼチジン誘導体
US20090170872A1 (en) 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
JP2009500419A (ja) 2005-07-05 2009-01-08 アリックス セラピューティクス、インコーポレイテッド 立体異性体のピリジル及びピリドニル化合物並びに消化管障害及び中枢神経系障害の治療方法
JP2009501199A (ja) 2005-07-12 2009-01-15 グラクソ グループ リミテッド Ｇｐｒ３８アゴニストとしてのピペラジンヘテロアリール誘導体
CA2616396C (fr) 2005-07-22 2013-07-23 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Secretagogues de l'hormone de croissance
EP1910340B1 (fr) 2005-07-22 2009-11-18 Pfizer, Inc. Derives d'indazolecarboxamides en tant qu'agonistes des recepteurs 5ht4
EP1757290A1 (fr) 2005-08-16 2007-02-28 Zentaris GmbH Derivés de triazole comme ligands du recepteur de l'hormone de croissance
WO2007023242A1 (fr) 2005-08-24 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tétrahydroquinolinones et leur usage en tant que modulateurs des récepteurs de glutamate métabotropiques
WO2007023245A1 (fr) 2005-08-25 2007-03-01 Merz Pharma Gmbh & Co. Kgaa Tetrahydroquinolinones et leur utilisation en tant que modulateurs des recepteurs metabotropes du glutamate
EP1940785A2 (fr) 2005-09-08 2008-07-09 SmithKline Beecham Corporation 1,4-diamines acycliques et leurs utilisations
BRPI0615880A2 (pt) 2005-09-13 2011-05-31 Palau Pharma Sa compostos derivados de 2-aminopirimidina como moduladores da atividade de receptor da histamina h4, uso dos mesmos e composição farmacêutica
AR056087A1 (es) 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk
AR057828A1 (es) 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
UY29796A1 (es) 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
HUP0500920A2 (en) 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
HUP0500921A2 (en) 2005-10-05 2007-07-30 Richter Gedeon Nyrt Tetrazole derivatives, process for their preparation and their use
JP2009511465A (ja) 2005-10-07 2009-03-19 グレンマーク・ファーマシューティカルズ・エスエー 置換ベンゾ縮合誘導体およびバニロイド受容体リガンドとしてのその使用
KR101347102B1 (ko) 2005-10-19 2014-01-03 그뤼넨탈 게엠베하 신규한 바닐로이드 수용체 리간드 및 약제를 제조하기 위한이의 용도
US20070088073A1 (en) 2005-10-19 2007-04-19 Allergan, Inc. Method for treating pain
US7902251B2 (en) 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
AU2006306146A1 (en) 2005-10-28 2007-05-03 Abbott Laboratories Indazole derivatives that inhibit TRPV1 receptor
US20070105920A1 (en) 2005-11-08 2007-05-10 Akzo Nobel N.V. 2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
NL2000323C2 (nl) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.
WO2007090854A1 (fr) 2006-02-10 2007-08-16 Cellzome (Uk) Ltd. Composés d'amino pyrimidine d'azétidine destinés à traiter des troubles inflammatoires
EP1829879A1 (fr) 2006-02-10 2007-09-05 Cellzome (UK) Ltd. Dérivés de amino pyrimidine pour le traitment des maladies inflammatoires
WO2007090853A1 (fr) 2006-02-10 2007-08-16 Cellzome (Uk) Ltd. Enantiomères de composes d'amino pyrimidine destinés à traiter des troubles inflammatoires
ES2349237T3 (es) 2006-03-31 2010-12-29 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas como moduladores del receptor de histamina h4.
US7507737B2 (en) 2006-03-31 2009-03-24 Janssen Pharmaceutica, N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor
US7713978B2 (en) 2006-03-31 2010-05-11 Nigel Paul King Compounds
EP2010172B1 (fr) 2006-04-07 2012-08-29 Janssen Pharmaceutica N.V. Indoles et benzoimidazoles modulateurs du récepteur de l'histamine h4
JP2010523466A (ja) 2006-04-13 2010-07-15 グラクソ グループ リミテッド 成長ホルモン分泌促進因子受容体アゴニストとしてのアリールおよびヘテロアリールスルホンアミド類

Also Published As

Publication number Publication date
CA2749529A1 (fr) 2010-07-29
MX2011007444A (es) 2011-08-12
SG172808A1 (en) 2011-08-29
ES2614612T3 (es) 2017-06-01
PL2387440T3 (pl) 2017-09-29
BRPI1006909A2 (pt) 2016-02-16
CN102281920A (zh) 2011-12-14
US8349852B2 (en) 2013-01-08
EA201101063A1 (ru) 2012-02-28
PE20110776A1 (es) 2011-11-04
UY32381A (es) 2010-08-31
CU20110148A7 (es) 2012-02-15
US20100197705A1 (en) 2010-08-05
AR075006A1 (es) 2011-03-02
US20130060029A1 (en) 2013-03-07
CO6400202A2 (es) 2012-03-15
PT2387440T (pt) 2017-01-17
IL213869A0 (en) 2011-07-31
ZA201104873B (en) 2012-07-25
CA2749529C (fr) 2017-04-04
EP2387440B1 (fr) 2016-11-09
WO2010084050A3 (fr) 2011-01-27
ECSP11011195A (es) 2011-08-31
AU2010206233A1 (en) 2011-07-28
WO2010084050A2 (fr) 2010-07-29
KR20110104996A (ko) 2011-09-23
TN2011000326A1 (en) 2012-12-17
EP2387440A2 (fr) 2011-11-23
NZ593877A (en) 2012-11-30
CA2946304A1 (fr) 2010-07-29
AU2010206233B2 (en) 2012-07-26
TW201036951A (en) 2010-10-16
JP2012515150A (ja) 2012-07-05
CR20110369A (es) 2011-08-26

Similar Documents

Publication Publication Date Title
MA32957B1 (fr) Derives de quinazolinone utiles comme antagonistes vanilloides
ECSP12011581A (es) Inhibidores de bace
CR11776A (es) Inhibidores de bace
SMT201600198B (it) Derivati di 1,2,4-triazina-4-ammina
CR20120121A (es) Compuestos de benzoxazepina como inhibidores de la pi3k y métodos de uso
BRPI0908849A2 (pt) Composto e composições como c-kit e inibidores de pdgfr quinase
CR20120641A (es) Compuestos macrocìclicos como inhibidores de quinasa trk
NI201200023A (es) Derivados de 5-fluoropirimidinona
RU2458924C3 (ru) Соединения замещенных диазепанов в качестве антагонистов орексиновых рецепторов
BRPI0811516A2 (pt) Compostos e composições como inibidores de c-kit e pdgfr cinase
CR20130369A (es) Novedosos derivados heterocíclicos
UY34300A (es) COMPUESTOS Y COMPOSICIONES COMO INHIBIDORES DE LA QUINASA c-Kit
CR20120297A (es) Espironucleósidos uracílicos oxetánicos
BR112013008527A2 (pt) derivados de pirazolo-quinazolina substituídos como inibidores de cinase
BR112012005237A2 (pt) utilização de composições ternárias
BR112012007300A2 (pt) derivador de pirimidina como inibidores proteína tirosina cinase 2
UA108101C2 (xx) Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів
CR11742A (es) Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6
CU23857B1 (es) Nuevos derivados de benzamida como antagonistas de la bradiquinina
EA201101675A1 (ru) Спироэпоксиды как промежуточные продукты синтеза
UA106889C2 (uk) Похідні n1-ацил-5-фторпіримідинону
SMT201500156B (it) Composti di diidropirrolonaftiridinione come inibitori di jak
ECSP12011652A (es) Derivados de 5-fluoro-2-oxopirimidinona-1 (2h)-carboxamida substituida-n1
CR20130625A (es) Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
CR20130541A (es) Derivados de 2-amino-3-(imidazol-2-il)-piridin-4-ona, y su uso como receptores vegf de inhibidores de cinasa