MA31983B1 - Dérivés d'acide phosphonique et leur utilisation en tant qu'antagonistes du récepteur p2y12 - Google Patents
Dérivés d'acide phosphonique et leur utilisation en tant qu'antagonistes du récepteur p2y12Info
- Publication number
- MA31983B1 MA31983B1 MA32897A MA32897A MA31983B1 MA 31983 B1 MA31983 B1 MA 31983B1 MA 32897 A MA32897 A MA 32897A MA 32897 A MA32897 A MA 32897A MA 31983 B1 MA31983 B1 MA 31983B1
- Authority
- MA
- Morocco
- Prior art keywords
- phosphonic acid
- antagonists
- receptor
- acid derivatives
- vascular
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 abstract 2
- OXPDQFOKSZYEMJ-UHFFFAOYSA-N 2-phenylpyrimidine Chemical class C1=CC=CC=C1C1=NC=CC=N1 OXPDQFOKSZYEMJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940127424 P2Y12 Receptor Antagonists Drugs 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne les dérivés de 2-phényl-pyrimidine contenant un motif d'acide phosphonique et leur utilisation comme antagonistes du récepteur p2y12 dans le traitement et/ou la prévention de maladies vasculaires périphériques, viscérales, hépatiques et vasculaires rénales, cardiovasculaires et cérébrovasculaires ou de troubles associés à l'agrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2007054850 | 2007-11-29 | ||
PCT/IB2008/055002 WO2009069100A1 (fr) | 2007-11-29 | 2008-11-28 | Dérivés d'acide phosphonique et leur utilisation en tant qu'antagonistes du récepteur p2y12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31983B1 true MA31983B1 (fr) | 2011-01-03 |
Family
ID=40445499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32897A MA31983B1 (fr) | 2007-11-29 | 2010-06-08 | Dérivés d'acide phosphonique et leur utilisation en tant qu'antagonistes du récepteur p2y12 |
Country Status (25)
Country | Link |
---|---|
US (1) | US8518912B2 (fr) |
EP (1) | EP2225253B1 (fr) |
JP (1) | JP4729133B2 (fr) |
KR (1) | KR101178319B1 (fr) |
CN (1) | CN101868469B (fr) |
AR (1) | AR069494A1 (fr) |
AU (1) | AU2008331163B2 (fr) |
BR (1) | BRPI0819696B1 (fr) |
CA (1) | CA2706475C (fr) |
CY (1) | CY1113151T1 (fr) |
DK (1) | DK2225253T3 (fr) |
ES (1) | ES2388958T3 (fr) |
HK (1) | HK1148287A1 (fr) |
HR (1) | HRP20120735T1 (fr) |
IL (1) | IL205947A (fr) |
MA (1) | MA31983B1 (fr) |
MX (1) | MX2010005519A (fr) |
MY (1) | MY153749A (fr) |
NZ (1) | NZ586445A (fr) |
PL (1) | PL2225253T3 (fr) |
PT (1) | PT2225253E (fr) |
RU (1) | RU2483072C2 (fr) |
SI (1) | SI2225253T1 (fr) |
TW (1) | TWI361690B (fr) |
WO (1) | WO2009069100A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
BRPI0819831A2 (pt) | 2007-11-29 | 2019-09-24 | Boehringer Ingelheim Int | derivados de amidas de áciodo 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-carboxílico |
AR071653A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
AR071652A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
US8288385B2 (en) | 2009-04-08 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
US8664203B2 (en) | 2009-04-22 | 2014-03-04 | Actelion Pharmaceuticals Ltd. | Thiazole derivatives and their use as P2Y12 receptor antagonists |
EP2750676B1 (fr) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Procédés et compositions pour traiter le diabète insipide néphrogénique |
JP2017528448A (ja) | 2014-08-21 | 2017-09-28 | エスアールエックス カーディオ,エル エル シー | プロタンパク質コンバターゼであるスブチリシン/ケキシンタイプ9(pcsk9)のタンパク質活性のモジュレーションのための、結合リガンドとしての小分子の組成物およびその使用方法 |
WO2017063755A1 (fr) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Composés macrocycliques à conformation limitée |
WO2017063757A1 (fr) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Composés macrocycliques à conformation limitée |
MA46266B1 (fr) | 2016-09-22 | 2022-02-28 | Idorsia Pharmaceuticals Ltd | Formes cristallines |
CN106831866A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类烷氧噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106831869A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106831871A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106749408A (zh) * | 2017-02-09 | 2017-05-31 | 广东赛博科技有限公司 | 一种硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106831868A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一种胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106831867A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一种腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CN106831870A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
CA3050831A1 (fr) | 2017-03-15 | 2018-09-20 | Idorsia Pharmaceuticals Ltd | Administration sous-cutanee d'un antagoniste du recepteur p2y12 |
US11524944B2 (en) | 2017-11-21 | 2022-12-13 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as AHR inhibitors |
US20230174562A1 (en) | 2020-05-08 | 2023-06-08 | Tonix Pharmaceuticals, Inc. | Radio-and chemo-protective compounds |
TW202216150A (zh) | 2020-07-15 | 2022-05-01 | 瑞士商愛杜西亞製藥有限公司 | 包含p2y12受體拮抗劑的水性醫藥組合物 |
CN112500354A (zh) * | 2020-12-08 | 2021-03-16 | 烟台凯博医药科技有限公司 | 一种4-氯-6-环丙基嘧啶-5-胺的合成方法 |
KR20240033005A (ko) | 2021-07-13 | 2024-03-12 | 이도르시아 파마슈티컬스 리미티드 | 4-((r)-2-{[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노}-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법 |
WO2023174810A1 (fr) | 2022-03-14 | 2023-09-21 | Idorsia Pharmaceuticals Ltd | Procédé de synthèse d'acide ( r)-2-(( tert-butoxycarbonyl)amino)-3-(diéthoxyphosphoryl)propanoïque ou de dérivés de phosphonate de celui-ci |
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EA201100956A1 (ru) | 2003-07-09 | 2012-01-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
AU2004259661B2 (en) | 2003-07-09 | 2011-11-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
CA2530352A1 (fr) * | 2003-07-24 | 2005-02-03 | Astellas Pharma Inc. | Derive de quinolone ou sel de ce dernier |
EP2332904A3 (fr) | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derives des composes de tetracycline |
TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
CN101300241A (zh) | 2005-10-21 | 2008-11-05 | 埃科特莱茵药品有限公司 | 作为抗疟疾剂的哌嗪衍生物 |
CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
CN101663293B (zh) | 2007-04-23 | 2013-07-31 | 塞诺菲-安万特股份有限公司 | 作为p2y12拮抗剂的喹啉-甲酰胺衍生物 |
EP2238127B1 (fr) | 2007-12-26 | 2012-08-15 | Sanofi | Dérivés de pyrazole-carboxamide utiles en tant qu'antagonistes de p2y12 |
JP5504171B2 (ja) | 2007-12-26 | 2014-05-28 | サノフイ | P2y12アンタゴニストとしてのヘテロサイクリックピラゾール−カルボキサミド |
AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
US8288385B2 (en) | 2009-04-08 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
US8664203B2 (en) | 2009-04-22 | 2014-03-04 | Actelion Pharmaceuticals Ltd. | Thiazole derivatives and their use as P2Y12 receptor antagonists |
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2008
- 2008-11-28 PT PT08855100T patent/PT2225253E/pt unknown
- 2008-11-28 TW TW097146477A patent/TWI361690B/zh active
- 2008-11-28 US US12/745,358 patent/US8518912B2/en active Active
- 2008-11-28 PL PL08855100T patent/PL2225253T3/pl unknown
- 2008-11-28 CA CA2706475A patent/CA2706475C/fr active Active
- 2008-11-28 DK DK08855100.7T patent/DK2225253T3/da active
- 2008-11-28 EP EP08855100A patent/EP2225253B1/fr active Active
- 2008-11-28 ES ES08855100T patent/ES2388958T3/es active Active
- 2008-11-28 RU RU2010126048/04A patent/RU2483072C2/ru active
- 2008-11-28 SI SI200830722T patent/SI2225253T1/sl unknown
- 2008-11-28 BR BRPI0819696A patent/BRPI0819696B1/pt active IP Right Grant
- 2008-11-28 AU AU2008331163A patent/AU2008331163B2/en active Active
- 2008-11-28 MX MX2010005519A patent/MX2010005519A/es active IP Right Grant
- 2008-11-28 AR ARP080105205A patent/AR069494A1/es active IP Right Grant
- 2008-11-28 CN CN200880116983.8A patent/CN101868469B/zh active Active
- 2008-11-28 JP JP2010535498A patent/JP4729133B2/ja active Active
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- 2008-11-28 WO PCT/IB2008/055002 patent/WO2009069100A1/fr active Application Filing
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