MA30868B1 - Derives de 2-aminocarbonyl-pyridine - Google Patents
Derives de 2-aminocarbonyl-pyridineInfo
- Publication number
- MA30868B1 MA30868B1 MA31845A MA31845A MA30868B1 MA 30868 B1 MA30868 B1 MA 30868B1 MA 31845 A MA31845 A MA 31845A MA 31845 A MA31845 A MA 31845A MA 30868 B1 MA30868 B1 MA 30868B1
- Authority
- MA
- Morocco
- Prior art keywords
- aminocarbonyl
- pyridine derivatives
- vascular
- viscerovascular
- hepato
- Prior art date
Links
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title abstract 2
- 208000019553 vascular disease Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
- C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
LA PRÉSENTE INVENTION CONCERNE DES DÉRIVÉS DE 2-AMINOCARBONYL-PYRIDINE ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE P2YI2 DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE MALADIES OU D'AFFECTIONS VASCULAIRES PÉRIPHÉRIQUES, VISCÉRO-VASCULAIRES, HÉPATO-VASCULAIRES ET VASCULAIRES RÉNALES, CARDIOVASCULAIRES ET CÉRÉBRO-VASCULAIRES ASSOCIÉES À L'AGRÉGATION DES PLAQUETTES, Y COMPRIS LA THROMBOSE, CHEZ LES HUMAINS ET D'AUTRES MAMMIFÈRES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2006053773 | 2006-10-13 | ||
IB2006053817 | 2006-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30868B1 true MA30868B1 (fr) | 2009-11-02 |
Family
ID=39167796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31845A MA30868B1 (fr) | 2006-10-13 | 2009-05-06 | Derives de 2-aminocarbonyl-pyridine |
Country Status (17)
Country | Link |
---|---|
US (1) | US8093250B2 (fr) |
EP (1) | EP2081903B1 (fr) |
JP (1) | JP5341763B2 (fr) |
KR (1) | KR101525260B1 (fr) |
AR (1) | AR063258A1 (fr) |
AU (1) | AU2007305925A1 (fr) |
BR (1) | BRPI0720193A2 (fr) |
CA (1) | CA2664579C (fr) |
CL (1) | CL2007002920A1 (fr) |
ES (1) | ES2473609T3 (fr) |
IL (1) | IL198059A0 (fr) |
MA (1) | MA30868B1 (fr) |
MX (1) | MX2009003724A (fr) |
NO (1) | NO20091838L (fr) |
RU (1) | RU2009117705A (fr) |
TW (1) | TW200823190A (fr) |
WO (1) | WO2008044217A2 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
AR063258A1 (es) | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
RU2483072C2 (ru) | 2007-11-29 | 2013-05-27 | Актелион Фармасьютиклз Лтд | Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12 |
EP2262766B1 (fr) | 2008-02-29 | 2015-11-11 | Evotec AG | Composés amides, compositions à base de ces composés et leurs utilisations |
AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
EP2346825A2 (fr) | 2008-09-18 | 2011-07-27 | Evotec AG | Composés amides, compositions et utilisations des composés et compositions |
SG175075A1 (en) | 2009-04-08 | 2011-11-28 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adp receptor antagonists |
ES2469847T3 (es) | 2009-04-22 | 2014-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de tiazol y su uso como antagonistas del receptor P2Y12 |
EP2593434A1 (fr) * | 2010-07-16 | 2013-05-22 | Purdue Pharma LP | Composés pyridines comme bloqueurs des canaux sodiques |
WO2013033178A1 (fr) | 2011-08-30 | 2013-03-07 | University Of Utah Research Foundation | Procédés et compositions pour traiter le diabète insipide néphrogénique |
WO2013136170A1 (fr) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Pyridines substituées en tant que bloqueurs des canaux sodiques |
EP2935257B1 (fr) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Sulfonamides cycliques en tant que bloquants des canaux sodiques |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
CN109715639B (zh) | 2016-09-22 | 2022-04-19 | 爱杜西亚药品有限公司 | 结晶形式 |
MA49887A (fr) | 2017-03-15 | 2020-06-24 | Idorsia Pharmaceuticals Ltd | Administration sous-cutanée d'un antagoniste du récepteur p2y12 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
CA2020437A1 (fr) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Derive de cinnamamide |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
WO1999006402A1 (fr) * | 1997-07-31 | 1999-02-11 | Ube Industries, Ltd. | Composes amides n-acylamino acides et intermediaires utiles dans la preparation de ceux-ci |
AU5414000A (en) | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
DE60333866D1 (de) * | 2002-12-11 | 2010-09-30 | Bayer Schering Pharma Ag | 2-aminocarbonlyl-chinolin-verbindungen als adenosin diphosphat plättchenrezeptor antagonisten |
TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
AR057836A1 (es) * | 2005-10-21 | 2007-12-19 | Actelion Pharmaceuticals Ltd | Piperizinas como agentes contra la malaria |
AR063258A1 (es) | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
RU2483072C2 (ru) | 2007-11-29 | 2013-05-27 | Актелион Фармасьютиклз Лтд | Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12 |
AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
SG175075A1 (en) | 2009-04-08 | 2011-11-28 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adp receptor antagonists |
ES2469847T3 (es) | 2009-04-22 | 2014-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de tiazol y su uso como antagonistas del receptor P2Y12 |
-
2007
- 2007-10-11 AR ARP070104514A patent/AR063258A1/es unknown
- 2007-10-11 CL CL200702920A patent/CL2007002920A1/es unknown
- 2007-10-12 US US12/445,352 patent/US8093250B2/en active Active
- 2007-10-12 KR KR1020097009599A patent/KR101525260B1/ko active IP Right Grant
- 2007-10-12 ES ES07826720.0T patent/ES2473609T3/es active Active
- 2007-10-12 WO PCT/IB2007/054155 patent/WO2008044217A2/fr active Application Filing
- 2007-10-12 MX MX2009003724A patent/MX2009003724A/es unknown
- 2007-10-12 CA CA2664579A patent/CA2664579C/fr active Active
- 2007-10-12 TW TW096138326A patent/TW200823190A/zh unknown
- 2007-10-12 AU AU2007305925A patent/AU2007305925A1/en not_active Withdrawn
- 2007-10-12 RU RU2009117705/04A patent/RU2009117705A/ru unknown
- 2007-10-12 EP EP07826720.0A patent/EP2081903B1/fr active Active
- 2007-10-12 JP JP2009531969A patent/JP5341763B2/ja active Active
- 2007-10-12 BR BRPI0720193-1A patent/BRPI0720193A2/pt not_active IP Right Cessation
-
2009
- 2009-04-07 IL IL198059A patent/IL198059A0/en unknown
- 2009-05-06 MA MA31845A patent/MA30868B1/fr unknown
- 2009-05-12 NO NO20091838A patent/NO20091838L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20090086075A (ko) | 2009-08-10 |
EP2081903A2 (fr) | 2009-07-29 |
JP5341763B2 (ja) | 2013-11-13 |
CL2007002920A1 (es) | 2008-06-06 |
ES2473609T3 (es) | 2014-07-07 |
MX2009003724A (es) | 2009-04-22 |
CA2664579C (fr) | 2014-09-30 |
WO2008044217A2 (fr) | 2008-04-17 |
US20100035895A1 (en) | 2010-02-11 |
TW200823190A (en) | 2008-06-01 |
WO2008044217A3 (fr) | 2008-06-19 |
RU2009117705A (ru) | 2010-11-20 |
US8093250B2 (en) | 2012-01-10 |
AR063258A1 (es) | 2009-01-14 |
EP2081903B1 (fr) | 2014-05-07 |
AU2007305925A1 (en) | 2008-04-17 |
NO20091838L (no) | 2009-05-12 |
KR101525260B1 (ko) | 2015-06-02 |
JP2010505940A (ja) | 2010-02-25 |
CA2664579A1 (fr) | 2008-04-17 |
BRPI0720193A2 (pt) | 2013-12-31 |
IL198059A0 (en) | 2009-12-24 |
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