MA32277B1 - Derives de 2-phenyl-4- cyclopropyl-pyrimidine - Google Patents

Derives de 2-phenyl-4- cyclopropyl-pyrimidine

Info

Publication number
MA32277B1
MA32277B1 MA33296A MA33296A MA32277B1 MA 32277 B1 MA32277 B1 MA 32277B1 MA 33296 A MA33296 A MA 33296A MA 33296 A MA33296 A MA 33296A MA 32277 B1 MA32277 B1 MA 32277B1
Authority
MA
Morocco
Prior art keywords
cyclopropyl
phenyl
pyrimidine derivatives
vascular
viscerascular
Prior art date
Application number
MA33296A
Other languages
Arabic (ar)
English (en)
Inventor
Emmanuel Meyer
Eva Caroff
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA32277B1 publication Critical patent/MA32277B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de 2-phényl-4-cyclopropyl-pyrimidine et leur utilisation comme antagonistes du récepteur p2y12 dans le traitement et/ou la prévention des maladies vasculaires périphériques, viscéro-vasculaires, hépato-vasculaires et réno-vasculaires, cardiovasculaires et cérébrovasculaires ou des états associés à l'agrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères.
MA33296A 2008-04-11 2010-11-01 Derives de 2-phenyl-4- cyclopropyl-pyrimidine MA32277B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008051389 2008-04-11
PCT/IB2009/051498 WO2009125365A1 (fr) 2008-04-11 2009-04-09 Dérivés de 2-phényl-4-cyclopropyl-pyrimidine

Publications (1)

Publication Number Publication Date
MA32277B1 true MA32277B1 (fr) 2011-05-02

Family

ID=40790423

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33296A MA32277B1 (fr) 2008-04-11 2010-11-01 Derives de 2-phenyl-4- cyclopropyl-pyrimidine

Country Status (17)

Country Link
US (1) US8466156B2 (fr)
EP (1) EP2283011B1 (fr)
JP (1) JP5374578B2 (fr)
KR (1) KR101610417B1 (fr)
CN (1) CN101998953B (fr)
AR (1) AR071653A1 (fr)
AT (1) ATE534634T1 (fr)
AU (1) AU2009235123A1 (fr)
CA (1) CA2719569C (fr)
ES (1) ES2376820T3 (fr)
IL (1) IL208548A0 (fr)
MA (1) MA32277B1 (fr)
MX (1) MX2010010932A (fr)
NZ (1) NZ589169A (fr)
TW (1) TW200944516A (fr)
WO (1) WO2009125365A1 (fr)
ZA (1) ZA201008052B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200640877A (en) 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
AR063258A1 (es) 2006-10-13 2009-01-14 Actelion Pharmaceuticals Ltd Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
AR063518A1 (es) 2006-10-25 2009-01-28 Actelion Pharmaceuticals Ltd Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
AR071652A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
SG175075A1 (en) 2009-04-08 2011-11-28 Actelion Pharmaceuticals Ltd 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adp receptor antagonists
ES2469847T3 (es) 2009-04-22 2014-06-20 Actelion Pharmaceuticals Ltd. Derivados de tiazol y su uso como antagonistas del receptor P2Y12
WO2013033178A1 (fr) 2011-08-30 2013-03-07 University Of Utah Research Foundation Procédés et compositions pour traiter le diabète insipide néphrogénique
CN109715639B (zh) 2016-09-22 2022-04-19 爱杜西亚药品有限公司 结晶形式
MA49887A (fr) 2017-03-15 2020-06-24 Idorsia Pharmaceuticals Ltd Administration sous-cutanée d'un antagoniste du récepteur p2y12

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2020437A1 (fr) 1989-07-05 1991-01-06 Yoshihide Fuse Derive de cinnamamide
JPH05303586A (ja) 1992-04-07 1993-11-16 Nec Corp 高精度連立一次方程式解析装置
AU5414000A (en) 1999-06-14 2001-01-02 Eli Lilly And Company Compounds
US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
DE60333866D1 (de) 2002-12-11 2010-09-30 Bayer Schering Pharma Ag 2-aminocarbonlyl-chinolin-verbindungen als adenosin diphosphat plättchenrezeptor antagonisten
WO2004092189A1 (fr) 2003-04-09 2004-10-28 Wyeth Derives d'acide 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonique et leur utilisation comme antagonistes du recepteur n-methyl-d-aspartate (nmda)
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
AR057836A1 (es) 2005-10-21 2007-12-19 Actelion Pharmaceuticals Ltd Piperizinas como agentes contra la malaria
AR063258A1 (es) 2006-10-13 2009-01-14 Actelion Pharmaceuticals Ltd Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
AR063518A1 (es) 2006-10-25 2009-01-28 Actelion Pharmaceuticals Ltd Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
MX2009011089A (es) 2007-04-23 2009-10-30 Sanofi Aventis Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12.
RU2483072C2 (ru) 2007-11-29 2013-05-27 Актелион Фармасьютиклз Лтд Производные фосфоновой кислоты и их применение в качестве антагонистов рецептора p2y12
EP2238127B1 (fr) 2007-12-26 2012-08-15 Sanofi Dérivés de pyrazole-carboxamide utiles en tant qu'antagonistes de p2y12
EP2238128B1 (fr) 2007-12-26 2012-08-22 Sanofi Pyrazole-carboxamides hétérocycliques utilisés en tant qu'antagonistes du récepteur p2y12
AR071652A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
SG175075A1 (en) 2009-04-08 2011-11-28 Actelion Pharmaceuticals Ltd 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adp receptor antagonists
ES2469847T3 (es) 2009-04-22 2014-06-20 Actelion Pharmaceuticals Ltd. Derivados de tiazol y su uso como antagonistas del receptor P2Y12

Also Published As

Publication number Publication date
ATE534634T1 (de) 2011-12-15
CA2719569A1 (fr) 2009-10-15
ES2376820T3 (es) 2012-03-20
CN101998953B (zh) 2014-12-17
JP2011516539A (ja) 2011-05-26
EP2283011B1 (fr) 2011-11-23
US8466156B2 (en) 2013-06-18
CN101998953A (zh) 2011-03-30
CA2719569C (fr) 2016-06-07
ZA201008052B (en) 2012-04-25
WO2009125365A1 (fr) 2009-10-15
AR071653A1 (es) 2010-07-07
TW200944516A (en) 2009-11-01
IL208548A0 (en) 2010-12-30
AU2009235123A1 (en) 2009-10-15
NZ589169A (en) 2012-06-29
JP5374578B2 (ja) 2013-12-25
MX2010010932A (es) 2010-11-05
US20110028484A1 (en) 2011-02-03
EP2283011A1 (fr) 2011-02-16
KR20100132541A (ko) 2010-12-17
KR101610417B1 (ko) 2016-04-07

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