SI2225253T1 - Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12 - Google Patents

Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12

Info

Publication number
SI2225253T1
SI2225253T1 SI200830722T SI200830722T SI2225253T1 SI 2225253 T1 SI2225253 T1 SI 2225253T1 SI 200830722 T SI200830722 T SI 200830722T SI 200830722 T SI200830722 T SI 200830722T SI 2225253 T1 SI2225253 T1 SI 2225253T1
Authority
SI
Slovenia
Prior art keywords
phosphonic acid
receptor antagonists
acid derivates
derivates
antagonists
Prior art date
Application number
SI200830722T
Other languages
English (en)
Inventor
Eva Caroff
Kurt Hilpert
Francis Hubler
Emmanuel Meyer
Dorte Renneberg
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40445499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2225253(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of SI2225253T1 publication Critical patent/SI2225253T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200830722T 2007-11-29 2008-11-28 Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12 SI2225253T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2007054850 2007-11-29
EP08855100A EP2225253B1 (en) 2007-11-29 2008-11-28 Phosphonic acid derivates and their use as p2y12 receptor antagonists
PCT/IB2008/055002 WO2009069100A1 (en) 2007-11-29 2008-11-28 Phosphonic acid derivates and their use as p2y12 receptor antagonists

Publications (1)

Publication Number Publication Date
SI2225253T1 true SI2225253T1 (sl) 2012-09-28

Family

ID=40445499

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830722T SI2225253T1 (sl) 2007-11-29 2008-11-28 Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12

Country Status (25)

Country Link
US (1) US8518912B2 (sl)
EP (1) EP2225253B1 (sl)
JP (1) JP4729133B2 (sl)
KR (1) KR101178319B1 (sl)
CN (1) CN101868469B (sl)
AR (1) AR069494A1 (sl)
AU (1) AU2008331163B2 (sl)
BR (1) BRPI0819696B1 (sl)
CA (1) CA2706475C (sl)
CY (1) CY1113151T1 (sl)
DK (1) DK2225253T3 (sl)
ES (1) ES2388958T3 (sl)
HK (1) HK1148287A1 (sl)
HR (1) HRP20120735T1 (sl)
IL (1) IL205947A (sl)
MA (1) MA31983B1 (sl)
MX (1) MX2010005519A (sl)
MY (1) MY153749A (sl)
NZ (1) NZ586445A (sl)
PL (1) PL2225253T3 (sl)
PT (1) PT2225253E (sl)
RU (1) RU2483072C2 (sl)
SI (1) SI2225253T1 (sl)
TW (1) TWI361690B (sl)
WO (1) WO2009069100A1 (sl)

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AR063518A1 (es) 2006-10-25 2009-01-28 Actelion Pharmaceuticals Ltd Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis
BRPI0819831A2 (pt) 2007-11-29 2019-09-24 Boehringer Ingelheim Int derivados de amidas de áciodo 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-carboxílico
AR071653A1 (es) * 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
AR071652A1 (es) * 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
US8288385B2 (en) 2009-04-08 2012-10-16 Actelion Pharmaceuticals Ltd. 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines
US8664203B2 (en) 2009-04-22 2014-03-04 Actelion Pharmaceuticals Ltd. Thiazole derivatives and their use as P2Y12 receptor antagonists
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WO2017063755A1 (en) 2015-10-12 2017-04-20 Polyphor Ag Conformationally constrained macrocyclic compounds
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CN106831866A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类烷氧噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831869A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831871A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106749408A (zh) * 2017-02-09 2017-05-31 广东赛博科技有限公司 一种硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831868A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一种胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831867A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一种腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CN106831870A (zh) * 2017-02-09 2017-06-13 广东赛博科技有限公司 一类腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途
CA3050831A1 (en) 2017-03-15 2018-09-20 Idorsia Pharmaceuticals Ltd Subcutaneous administration of a p2y12 receptor antagonist
US11524944B2 (en) 2017-11-21 2022-12-13 Bayer Aktiengesellschaft 2-phenylpyrimidine-4-carboxamides as AHR inhibitors
US20230174562A1 (en) 2020-05-08 2023-06-08 Tonix Pharmaceuticals, Inc. Radio-and chemo-protective compounds
TW202216150A (zh) 2020-07-15 2022-05-01 瑞士商愛杜西亞製藥有限公司 包含p2y12受體拮抗劑的水性醫藥組合物
CN112500354A (zh) * 2020-12-08 2021-03-16 烟台凯博医药科技有限公司 一种4-氯-6-环丙基嘧啶-5-胺的合成方法
KR20240033005A (ko) 2021-07-13 2024-03-12 이도르시아 파마슈티컬스 리미티드 4-((r)-2-{[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노}-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법
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IL205947A (en) 2015-02-26
NZ586445A (en) 2012-06-29
IL205947A0 (en) 2010-11-30
BRPI0819696B1 (pt) 2018-10-23
ES2388958T3 (es) 2012-10-22
KR20100082366A (ko) 2010-07-16
US8518912B2 (en) 2013-08-27
MX2010005519A (es) 2010-06-11
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CA2706475A1 (en) 2009-06-04
CA2706475C (en) 2016-05-03
HRP20120735T1 (hr) 2012-10-31
BRPI0819696A8 (pt) 2017-12-26
RU2010126048A (ru) 2012-01-10
EP2225253B1 (en) 2012-06-27
PT2225253E (pt) 2012-09-19
AR069494A1 (es) 2010-01-27
AU2008331163A1 (en) 2009-06-04
CN101868469B (zh) 2014-04-02
EP2225253A1 (en) 2010-09-08
AU2008331163B2 (en) 2014-01-30
RU2483072C2 (ru) 2013-05-27
MA31983B1 (fr) 2011-01-03
JP4729133B2 (ja) 2011-07-20
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