MA30271B1 - Dibenzylamines et derives - Google Patents

Dibenzylamines et derives

Info

Publication number
MA30271B1
MA30271B1 MA31225A MA31225A MA30271B1 MA 30271 B1 MA30271 B1 MA 30271B1 MA 31225 A MA31225 A MA 31225A MA 31225 A MA31225 A MA 31225A MA 30271 B1 MA30271 B1 MA 30271B1
Authority
MA
Morocco
Prior art keywords
cholesterol
dibenzylamines
derivatives
ldl
triglycerides
Prior art date
Application number
MA31225A
Other languages
English (en)
Inventor
George Chang
Ravi Shanker Garigipati
Bruce Allen Lefker
David Austen Perry
Dongxiang Zeng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA30271B1 publication Critical patent/MA30271B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • C07C261/04—Cyanamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Dibenzylamines et dérivés Des dibenzylamines et dérivés de dibenzylamines, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés pour élever les taux plasmatiques de certains lipides, comprenant le cholestérol-liprotéines haute densité et pour abaisser les taux plasmatiques de certains autres lipides, tels que le cholestérol-LDL et les triglycérides et, en conséquence, pour traiter des maladies qui sont exacerbées par des taux bas de cholestérol-HDL et/ou des taux élevés de cholestérol-LDL et de triglycérides, telles que l'athérosclérose et des maladies cardiovasculaires chez certains mammifères, y compris les êtres humains.
MA31225A 2006-03-10 2008-09-10 Dibenzylamines et derives MA30271B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78099306P 2006-03-10 2006-03-10
US11/619,277 US7919506B2 (en) 2006-03-10 2007-01-03 Dibenzyl amine compounds and derivatives

Publications (1)

Publication Number Publication Date
MA30271B1 true MA30271B1 (fr) 2009-03-02

Family

ID=38088523

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31225A MA30271B1 (fr) 2006-03-10 2008-09-10 Dibenzylamines et derives

Country Status (26)

Country Link
US (1) US7919506B2 (fr)
EP (1) EP1996564A1 (fr)
JP (1) JP5075843B2 (fr)
KR (1) KR101058312B1 (fr)
AP (1) AP2008004604A0 (fr)
AR (1) AR059803A1 (fr)
AU (1) AU2007226261B2 (fr)
BR (1) BRPI0709003A2 (fr)
CA (2) CA2645294C (fr)
CR (1) CR10264A (fr)
DO (1) DOP2007000047A (fr)
EA (1) EA200801815A1 (fr)
EC (1) ECSP088729A (fr)
GT (1) GT200700020A (fr)
IL (1) IL193571A (fr)
MA (1) MA30271B1 (fr)
MX (1) MX2008010863A (fr)
NL (1) NL2000514C2 (fr)
NO (1) NO20083641L (fr)
PE (1) PE20080118A1 (fr)
RS (1) RS20080410A (fr)
SG (1) SG176418A1 (fr)
TN (1) TNSN08347A1 (fr)
TW (1) TW200738652A (fr)
UY (1) UY30196A1 (fr)
WO (1) WO2007105050A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383660B2 (en) * 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
EP2612669A4 (fr) 2010-08-31 2014-05-14 Snu R&Db Foundation Utilisation de la reprogrammation f tale d'un agoniste des ppar
CN103351354B (zh) * 2013-06-09 2015-08-12 西安近代化学研究所 1-甲基-5-氨基四唑合成方法
CN103524445A (zh) * 2013-09-09 2014-01-22 南通市华峰化工有限责任公司 一种1-甲基-5氨基四氮唑的合成生产方法
CN105793243A (zh) * 2013-12-05 2016-07-20 拜耳作物科学股份公司 N-环烷基-n-{[2-(1-取代的环烷基)苯基]亚甲基}-(硫代)甲酰胺衍生物

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562A (en) 1844-04-25 Improvement in seed-planters
US30577A (en) 1860-11-06 Truss-bridge
US2161938A (en) 1934-07-31 1939-06-13 Soc Of Chemical Ind Imidazolines
DE905738C (de) 1943-06-11 1954-11-02 Diwag Chemische Fabriken Ag Verfahren zur Herstellung basischer Thymoldimethylaminoaethylaether
FR1165845A (fr) 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
CH366523A (de) 1958-04-14 1963-01-15 Eprova Ag Verfahren zur Herstellung der neuen 1,3,4,6- und 1,3,4,5-Tetranicotinoyl-fructose
BE578515A (fr) 1958-05-07
US2970082A (en) 1958-10-07 1961-01-31 Walker Lab Inc Aluminum nicotinate compositions for hypercholesteremia
DE1102973B (de) 1960-03-25 1961-03-23 Bayer Ag Verfahren zur Herstellung von hoch gereinigten Kallikrein-Praeparaten
DE1170417B (de) 1960-11-08 1964-05-21 Recip Ab Verfahren zur Herstellung eines Diphenyl-butylamins mit die Coronargefaesse erweiternder Wirkung
DE1154810B (de) 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
GB984810A (en) 1961-10-05 1965-03-03 Farmaceutici Italia Polypeptides
US3262977A (en) 1962-03-10 1966-07-26 Chinoin Gyogyszer Es Vegyeszet N-aralkyl-1, 1-diphenyl-propylamine derivatives
US3228943A (en) 1962-06-11 1966-01-11 Lumilysergol derivatives
US3338899A (en) 1962-07-09 1967-08-29 Aron Samuel 3-phenyl-5-amino-1, 2, 4-oxadiazole compounds
US3238215A (en) 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
NL127065C (fr) 1964-04-22
NL6514807A (fr) 1964-11-18 1966-05-20
FR1460571A (fr) 1965-06-10 1966-03-04 Innothera Lab Sa Composés thiényl acétiques et leur préparation
FR6087M (fr) 1967-01-10 1968-06-04
DE1670827C3 (de) 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US3511836A (en) 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
FR2003097A1 (en) 1968-03-02 1969-11-07 Takeda Chemical Industries Ltd Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive
GB1218591A (en) 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
FR2092133B1 (fr) 1970-05-06 1974-03-22 Orsymonde
US3669968A (en) 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines
BE795735A (fr) 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire
GB1435139A (en) 1972-08-17 1976-05-12 Sumitomo Chemical Co Thiazole derivatives
US3985758A (en) 1973-02-20 1976-10-12 Yamanouchi Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives
US4146643A (en) 1973-12-18 1979-03-27 Sandoz Ltd. Increasing vigilance or treating cerebral insufficiency with substituted vincamines
NL175059C (nl) 1974-02-23 Boehringer Mannheim Gmbh Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
US4338322A (en) 1975-07-02 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same
US4466972A (en) 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
DE2733747C2 (de) 1977-07-27 1979-09-27 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von 2,2 Dichlorhydrazobenzol
US4188390A (en) 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
JPS55301A (en) 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
IT1094076B (it) 1978-04-18 1985-07-26 Acraf Cicloalchiltriazoli
SE429652B (sv) 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2845770A1 (de) 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
EP0094159B1 (fr) 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dérivés de la dihydropyridine, leur préparation et leur application
DE3382204D1 (de) 1982-10-15 1991-04-18 Kyowa Hakko Kogyo Kk 1,4-dihydropyridin-derivate.
US4567175A (en) 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US4672068A (en) 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
NZ212895A (en) 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
WO1987000838A1 (fr) 1985-07-29 1987-02-12 Santen Pharmaceutical Co., Ltd. Nouveaux derives de benzothiazine
US4885284A (en) 1986-01-22 1989-12-05 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic propylene ester
DK171349B1 (da) 1986-11-14 1996-09-16 Hoffmann La Roche Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler
ATE61588T1 (de) 1987-08-03 1991-03-15 Delagrange Lab 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0832069B1 (fr) 1995-06-07 2003-03-05 Pfizer Inc. DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)
EP0944602A1 (fr) 1996-11-27 1999-09-29 Pfizer Inc. Amides inhibant la secretion d'apo b et/ou la proteine mtp
JP2894445B2 (ja) 1997-02-12 1999-05-24 日本たばこ産業株式会社 Ｃｅｔｐ活性阻害剤として有効な化合物
PA8471201A1 (es) 1998-06-16 2000-09-29 Pfizer Prod Inc Combinaciones terapeuticas que comprenden un modulador del receptor de estrogenos selectivo y hormona paratiroidea
JP2003221376A (ja) 2001-11-21 2003-08-05 Japan Tobacco Inc Ｃｅｔｐ活性阻害剤
DK1533292T3 (da) 2002-08-30 2007-06-04 Japan Tobacco Inc Dibenzylaminforbindelse og medicinsk anvendelse deraf
JP3630676B2 (ja) * 2002-08-30 2005-03-16 日本たばこ産業株式会社 ジベンジルアミン化合物及びその医薬用途
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
WO2005100298A1 (fr) 2004-04-13 2005-10-27 Merck & Co., Inc. Inhibiteurs de cetp
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
JP2008520645A (ja) 2004-11-23 2008-06-19 ファイザー・プロダクツ・インク ジベンジルアミン化合物および誘導体
UY30117A1 (es) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compuesto amina trisustituido

Also Published As

Publication number Publication date
DOP2007000047A (es) 2007-09-15
KR20080091861A (ko) 2008-10-14
EP1996564A1 (fr) 2008-12-03
SG176418A1 (en) 2011-12-29
US20070213371A1 (en) 2007-09-13
CR10264A (es) 2008-09-23
MX2008010863A (es) 2008-09-03
NO20083641L (no) 2008-09-29
TNSN08347A1 (fr) 2009-12-29
IL193571A0 (en) 2009-05-04
CA2645294A1 (fr) 2007-09-20
PE20080118A1 (es) 2008-02-22
EA200801815A1 (ru) 2009-02-27
CA2645294C (fr) 2011-08-30
RS20080410A (en) 2009-09-08
AP2008004604A0 (en) 2008-10-31
JP5075843B2 (ja) 2012-11-21
AR059803A1 (es) 2008-04-30
GT200700020A (es) 2007-11-15
UY30196A1 (es) 2007-10-31
ECSP088729A (es) 2008-10-31
US7919506B2 (en) 2011-04-05
TW200738652A (en) 2007-10-16
NL2000514C2 (nl) 2009-03-31
CA2717249A1 (fr) 2007-09-20
IL193571A (en) 2012-12-31
KR101058312B1 (ko) 2011-08-22
AU2007226261A1 (en) 2007-09-20
WO2007105050A1 (fr) 2007-09-20
NL2000514A1 (nl) 2007-09-11
JP2009531312A (ja) 2009-09-03
BRPI0709003A2 (pt) 2011-06-21
AU2007226261B2 (en) 2012-08-16

Similar Documents

Publication Publication Date Title
TNSN07200A1 (fr) Dibenzylamines et derives
MA30272B1 (fr) Derives de dibenzylamines servant d'inhibiteurs de cetp.
TNSN06447A1 (fr) Composes heteroaryle et phenylsulfamoyle substitues
MA27532A1 (fr) Piperidines a substituant phenyle, destinees a etre utilisees comme activateurs de ppar
TNSN07100A1 (fr) Derives de 1, 2, 3, 4- tetrahydroquinoleine substitues en position 2 et a substituant 4-amino
MA31683B1 (fr) Composes et procedes pour moduler fxr
MA33119B1 (fr) Derives de benzofuranyle utilises comme inhibiteurs de la glucokinase
RS20050395A (en) Ppar activators
MA30271B1 (fr) Dibenzylamines et derives
TW200610525A (en) Substituted heteroaryl-and phenylsulfamoyl compounds
MA32035B1 (fr) Composes tricycliques servant de modulateurs de synthese de tnf-alpha et d'inhibiteurs de pde4
MA31087B1 (fr) Derives d'amide et d'ester d'indazolyle pour traiter des troubles medies par le recepteur de glucocorticoïde.
WO2010079431A3 (fr) Composés pour la prévention et le traitement de maladies cardiovasculaires
TW200508222A (en) Quinoline and quinoxaline compounds
ATE332887T1 (de) Naturstoffe und deren derivate zur prävention und behandlung von herzkreislauf-, leber- und nierenerkrankungen und für kosmetische anwendungen
MA32150B1 (fr) Inhibiteurs heterocycliques de la stearoyl-coa desaturase
WO2009048249A3 (fr) Composition destinée à prévenir ou à traiter des troubles du métabolisme lipidique contenant de la fucoxanthine ou un extrait de plante marine la contenant
AP2002002427A0 (en) Ppar compounds.
DE60141636D1 (de) Phospholipidderivate von valproinsäure und ihre kombinationen
NZ596130A (en) Fragrance composition having good sleep-inducing effect
TW200616964A (en) Quinoline compounds
TNSN08346A1 (fr) Derives de dibenzylamines servant d'inhibiteurs de cetp
MX2007009108A (es) Derivados de imidazol.
MA37748A1 (fr) Composés d'azétidine et de pipéridine utiles comme inhibiteurs de pde10
EA201070459A1 (ru) Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений