PE20080118A1 - Compuestos y derivados de dibencilamina - Google Patents
Compuestos y derivados de dibencilaminaInfo
- Publication number
- PE20080118A1 PE20080118A1 PE2007000255A PE2007000255A PE20080118A1 PE 20080118 A1 PE20080118 A1 PE 20080118A1 PE 2007000255 A PE2007000255 A PE 2007000255A PE 2007000255 A PE2007000255 A PE 2007000255A PE 20080118 A1 PE20080118 A1 PE 20080118A1
- Authority
- PE
- Peru
- Prior art keywords
- trifluoromethyl
- benzyl
- methyl
- metoxy
- cyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C261/00—Derivatives of cyanic acid
- C07C261/04—Cyanamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE A ES -COO(ALQUILO C1-C4), CIANO, -CHO, ENTRE OTROS; B ES -OR17, -S(O)nR18;R17 y R18 SON CADA UNO ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; n ES 0,1ò 2; X ES C o N, DONDE SI X ES N , R4 ESTA AUSENTE; R1, R2, R3, R4, R5, R6 y R7 SON CADA UNO H, HALO, CIANO, NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (3,5- BIS-TRIFLUOROMETIL-BENCIL)-[2-(CICLOHEXIL-METOXI-METIL)-5-TRIFLUOROMETIL-BENCIL]-(2-METIL-2H-TETRAZOL-5-IL)-AMINA; (R)- (3,5- BIS-TRIFLUOROMETIL-BENCIL)-[2-(CICLOHEXIL-METOXI-METIL)-5-TRIFLUOROMETIL-BENCIL]-(2-METIL-2H-TETRAZOL-5-IL)-AMINA; (S) -(3,5- BIS-TRIFLUOROMETIL-BENCIL)-[2-(CICLOHEXIL-METOXI-METIL)-5-TRIFLUOROMETIL-BENCIL]-(2-METIL-2H-TETRAZOL-5-IL)-AMINA; ENTRE OTROS. REFERIDA TAIBEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS AUMENTAN CIERTOS NIVELES DE LIPIDOS EN PLASMA, INCLUYENDO EL COLESTEROL ASOCIADO A LIPOPROTEINAS DE ALTA DENSIDAD, REDUCEN LOS NIVELES PLASMATICOS DE OTROS LIPIDOS TALES COMO EL COLESTEROL-LDL Y LOS TRIGLICERIDOS SIENDO UTILES EN EL TRATAMIENTO DE ATEROSCLEROSIS Y ENFERMEDADES CARDIOVASCULARES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78099306P | 2006-03-10 | 2006-03-10 | |
US11/619,277 US7919506B2 (en) | 2006-03-10 | 2007-01-03 | Dibenzyl amine compounds and derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080118A1 true PE20080118A1 (es) | 2008-02-22 |
Family
ID=38088523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000255A PE20080118A1 (es) | 2006-03-10 | 2007-03-08 | Compuestos y derivados de dibencilamina |
Country Status (26)
Country | Link |
---|---|
US (1) | US7919506B2 (es) |
EP (1) | EP1996564A1 (es) |
JP (1) | JP5075843B2 (es) |
KR (1) | KR101058312B1 (es) |
AP (1) | AP2008004604A0 (es) |
AR (1) | AR059803A1 (es) |
AU (1) | AU2007226261B2 (es) |
BR (1) | BRPI0709003A2 (es) |
CA (2) | CA2645294C (es) |
CR (1) | CR10264A (es) |
DO (1) | DOP2007000047A (es) |
EA (1) | EA200801815A1 (es) |
EC (1) | ECSP088729A (es) |
GT (1) | GT200700020A (es) |
IL (1) | IL193571A (es) |
MA (1) | MA30271B1 (es) |
MX (1) | MX2008010863A (es) |
NL (1) | NL2000514C2 (es) |
NO (1) | NO20083641L (es) |
PE (1) | PE20080118A1 (es) |
RS (1) | RS20080410A (es) |
SG (1) | SG176418A1 (es) |
TN (1) | TNSN08347A1 (es) |
TW (1) | TW200738652A (es) |
UY (1) | UY30196A1 (es) |
WO (1) | WO2007105050A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
BR112013004882A2 (pt) | 2010-08-31 | 2016-05-03 | Snu R&Db Foundation | utilização de reprogramação fetal de agonista ppar delta |
CN103351354B (zh) * | 2013-06-09 | 2015-08-12 | 西安近代化学研究所 | 1-甲基-5-氨基四唑合成方法 |
CN103524445A (zh) * | 2013-09-09 | 2014-01-22 | 南通市华峰化工有限责任公司 | 一种1-甲基-5氨基四氮唑的合成生产方法 |
TW201609661A (zh) * | 2013-12-05 | 2016-03-16 | 拜耳作物科學公司 | N-環烷基-n-{[2-(1-經取代環烷基)苯基]亞甲基}-(硫代)甲醯胺衍生物 |
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-
2007
- 2007-01-03 US US11/619,277 patent/US7919506B2/en not_active Expired - Fee Related
- 2007-02-26 EA EA200801815A patent/EA200801815A1/ru unknown
- 2007-02-26 AP AP2008004604A patent/AP2008004604A0/xx unknown
- 2007-02-26 SG SG2011077658A patent/SG176418A1/en unknown
- 2007-02-26 EP EP07705672A patent/EP1996564A1/en not_active Withdrawn
- 2007-02-26 RS RSP-2008/0410A patent/RS20080410A/sr unknown
- 2007-02-26 WO PCT/IB2007/000527 patent/WO2007105050A1/en active Application Filing
- 2007-02-26 JP JP2008558924A patent/JP5075843B2/ja not_active Expired - Fee Related
- 2007-02-26 CA CA2645294A patent/CA2645294C/en not_active Expired - Fee Related
- 2007-02-26 KR KR1020087022006A patent/KR101058312B1/ko not_active IP Right Cessation
- 2007-02-26 CA CA2717249A patent/CA2717249A1/en not_active Abandoned
- 2007-02-26 BR BRPI0709003-0A patent/BRPI0709003A2/pt not_active Application Discontinuation
- 2007-02-26 AU AU2007226261A patent/AU2007226261B2/en not_active Expired - Fee Related
- 2007-02-26 MX MX2008010863A patent/MX2008010863A/es active IP Right Grant
- 2007-03-01 NL NL2000514A patent/NL2000514C2/nl not_active IP Right Cessation
- 2007-03-08 GT GT200700020A patent/GT200700020A/es unknown
- 2007-03-08 PE PE2007000255A patent/PE20080118A1/es not_active Application Discontinuation
- 2007-03-08 UY UY30196A patent/UY30196A1/es not_active Application Discontinuation
- 2007-03-09 DO DO2007000047A patent/DOP2007000047A/es unknown
- 2007-03-09 AR ARP070100980A patent/AR059803A1/es unknown
- 2007-03-09 TW TW096108174A patent/TW200738652A/zh unknown
-
2008
- 2008-08-20 IL IL193571A patent/IL193571A/en not_active IP Right Cessation
- 2008-08-22 NO NO20083641A patent/NO20083641L/no not_active Application Discontinuation
- 2008-08-29 CR CR10264A patent/CR10264A/es not_active Application Discontinuation
- 2008-09-09 TN TNP2008000347A patent/TNSN08347A1/fr unknown
- 2008-09-10 MA MA31225A patent/MA30271B1/fr unknown
- 2008-09-10 EC EC2008008729A patent/ECSP088729A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2645294A1 (en) | 2007-09-20 |
GT200700020A (es) | 2007-11-15 |
AR059803A1 (es) | 2008-04-30 |
CR10264A (es) | 2008-09-23 |
US7919506B2 (en) | 2011-04-05 |
SG176418A1 (en) | 2011-12-29 |
NO20083641L (no) | 2008-09-29 |
EA200801815A1 (ru) | 2009-02-27 |
DOP2007000047A (es) | 2007-09-15 |
MX2008010863A (es) | 2008-09-03 |
CA2645294C (en) | 2011-08-30 |
CA2717249A1 (en) | 2007-09-20 |
JP2009531312A (ja) | 2009-09-03 |
AU2007226261A1 (en) | 2007-09-20 |
IL193571A (en) | 2012-12-31 |
UY30196A1 (es) | 2007-10-31 |
EP1996564A1 (en) | 2008-12-03 |
US20070213371A1 (en) | 2007-09-13 |
JP5075843B2 (ja) | 2012-11-21 |
RS20080410A (en) | 2009-09-08 |
TW200738652A (en) | 2007-10-16 |
MA30271B1 (fr) | 2009-03-02 |
AP2008004604A0 (en) | 2008-10-31 |
KR101058312B1 (ko) | 2011-08-22 |
WO2007105050A1 (en) | 2007-09-20 |
BRPI0709003A2 (pt) | 2011-06-21 |
AU2007226261B2 (en) | 2012-08-16 |
NL2000514C2 (nl) | 2009-03-31 |
TNSN08347A1 (fr) | 2009-12-29 |
KR20080091861A (ko) | 2008-10-14 |
ECSP088729A (es) | 2008-10-31 |
NL2000514A1 (nl) | 2007-09-11 |
IL193571A0 (en) | 2009-05-04 |
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