EA201070459A1 - Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений - Google Patents

Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений

Info

Publication number
EA201070459A1
EA201070459A1 EA201070459A EA201070459A EA201070459A1 EA 201070459 A1 EA201070459 A1 EA 201070459A1 EA 201070459 A EA201070459 A EA 201070459A EA 201070459 A EA201070459 A EA 201070459A EA 201070459 A1 EA201070459 A1 EA 201070459A1
Authority
EA
Eurasian Patent Office
Prior art keywords
androstanes
treatment
cardiovascular disorders
amine
substituted
Prior art date
Application number
EA201070459A
Other languages
English (en)
Other versions
EA017497B1 (ru
Inventor
Альберто Черри
Джузеппе Бьянки
Джорджо Федрицци
Патриция Феррари
Мауро Гоббини
Джузеппе Марацци
Марко Торри
Вальтер Кабри
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA201070459A1 publication Critical patent/EA201070459A1/ru
Publication of EA017497B1 publication Critical patent/EA017497B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описаны новые аминооксимные производные в положении 3 2- и/или 4-замещенных андростанов и андростенов, способы их получения и фармацевтические композиции, содержащие их, для лечения сердечно-сосудистых нарушений, таких как сердечная недостаточность и гипертензия. В частности, описаны соединения общей формулы (I), в которой радикалы имеют значения, подробно описанные в заявке.
EA201070459A 2007-10-12 2008-09-18 Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений EA017497B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07118362 2007-10-12
PCT/EP2008/062483 WO2009047101A1 (en) 2007-10-12 2008-09-18 Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders

Publications (2)

Publication Number Publication Date
EA201070459A1 true EA201070459A1 (ru) 2010-10-29
EA017497B1 EA017497B1 (ru) 2012-12-28

Family

ID=39351068

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070459A EA017497B1 (ru) 2007-10-12 2008-09-18 Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений

Country Status (22)

Country Link
US (1) US8664210B2 (ru)
EP (1) EP2209795B1 (ru)
JP (1) JP5436432B2 (ru)
KR (1) KR101585275B1 (ru)
CN (1) CN101861328B (ru)
AR (1) AR068747A1 (ru)
AU (1) AU2008309791B2 (ru)
BR (1) BRPI0818540A2 (ru)
CA (1) CA2702111C (ru)
EA (1) EA017497B1 (ru)
ES (1) ES2412259T3 (ru)
HK (1) HK1148754A1 (ru)
IL (1) IL204957A (ru)
MX (1) MX2010003869A (ru)
MY (1) MY152099A (ru)
NZ (1) NZ584429A (ru)
PL (1) PL2209795T3 (ru)
PT (1) PT2209795E (ru)
SG (1) SG185288A1 (ru)
TW (1) TWI418354B (ru)
WO (1) WO2009047101A1 (ru)
ZA (1) ZA201003277B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130303500A1 (en) 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
CN112500311B (zh) * 2020-12-02 2023-03-24 河南普美济华医药科技有限公司 一种o-3-氯-2-丙烯基羟胺游离碱的制备工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
DE19633349A1 (de) 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
IT1317031B1 (it) * 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Also Published As

Publication number Publication date
EA017497B1 (ru) 2012-12-28
AU2008309791B2 (en) 2013-02-14
CN101861328A (zh) 2010-10-13
US20100324003A1 (en) 2010-12-23
PL2209795T3 (pl) 2013-09-30
BRPI0818540A2 (pt) 2015-06-16
AU2008309791A1 (en) 2009-04-16
ES2412259T3 (es) 2013-07-10
TWI418354B (zh) 2013-12-11
CA2702111A1 (en) 2009-04-16
KR20100087162A (ko) 2010-08-03
MX2010003869A (es) 2010-04-27
TW200930376A (en) 2009-07-16
CN101861328B (zh) 2014-08-13
WO2009047101A1 (en) 2009-04-16
JP2011500524A (ja) 2011-01-06
US8664210B2 (en) 2014-03-04
SG185288A1 (en) 2012-11-29
EP2209795A1 (en) 2010-07-28
JP5436432B2 (ja) 2014-03-05
HK1148754A1 (en) 2011-09-16
NZ584429A (en) 2011-08-26
IL204957A0 (en) 2010-11-30
KR101585275B1 (ko) 2016-01-14
AR068747A1 (es) 2009-12-02
PT2209795E (pt) 2013-06-04
CA2702111C (en) 2015-11-24
ZA201003277B (en) 2011-04-28
MY152099A (en) 2014-08-15
IL204957A (en) 2016-02-29
EP2209795B1 (en) 2013-04-24

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU